Interleukin 27 signaling pathways in regulation of immune and autoimmune responses; 2008年 発表情報; Int J Biochem Cell Biol, 40, 11, 2379-2383 著者; Yoshida, H.
Miyazaki, Y.
Regulation of defense responses against protozoan infection by interleukin-27 and related cytokines.; 2007年 発表情報; J Biomed Biotech. on line 著者; Yoshida, H., S. Hamano, S. Wang, and Y. Miyazaki.
Yin and Yang of IL-27 in immune regulation during parasitic infection.; 2007年 発表情報; Curt Trends Microbiol. in press 著者; Yoshida, H., S. Wang, and Y. Miyazaki.
The Double Identity of WSX-1 (Il-27R) as an Initiator and Attenuator of Immune Responses; 2005年 発表情報; Current Immunology Reviews 著者; Yoshida,H.,Hamano,S., and Miyazaki Y.
The role of WSX-1(IL-27R) as an initiator and attenuator of immune responses and innammation.; 2004年 発表情報; Recent Res. Devel. Immunology(Research Signpost.), 123-134 著者; Yoshida H,Hamano S,Miyazaki Y.
Double identity of WSX-1 (IL-27R) as an initiator and attenuator of immune responses:Regulation by WSX-1 of pro-inflammatory cytokine produdion in the liver.; 2004年 発表情報; Mucosal Immunology Update, 12, 7-9 著者; Yoshida,H.,Hamano,S., and Miyazaki Y.
The role of apaf-1 in programmed cell death from worm to tumor.; 2003年 発表情報; Cell Struct. Funct., 28, 3-9 著者; Yoshida H
原著論文
Unique features of Entamoeba histolytica glycerophospholipid metabolism; has the E. histolytica lipid metabolism network evolved through gene loss and gain to enable parasitic life cycle adaptation? ; 2023年08月 発表情報; mSphere, e0017423 著者; Mi-Ichi F, Tsugawa H, Yoshida H, Arita M
Pleiotropic Roles of Cholesteryl Sulfate during Entamoeba Encystation: Involvement in Cell Rounding and Development of Membrane Impermeability ; 2022年08月 発表情報; mSphere, 7, 4, e0029922 著者; Fumika Mi-Ichi, Hiroshi Tsugawa, Makoto Arita, Hiroki Yoshida
Cholesterol 25-hydroxylase is a metabolic switch to constrain T cell-mediated inflammation in the skin; 2021年10月 発表情報; Sci Immunol, 6, 64, eabb6444 著者; *H Takahashi, H Nomura, H Iriki, A Kubo, K Isami, Y Mikami, M Mukai, T Sasaki, J Yamagami, J Kudoh, H Ito, A Kamata, Y Kurebayashi, H Yoshida, A Yoshimura, H W Sun, M Suematsu, J J O'Shea, Y Kanno, M Amagai
Entamoeba Chitinase is Required for Mature Round Cyst Formation ; 2021年09月 発表情報; Microbiol Spectr, 9, 1, e0051121 著者; Fumika Mi-Ichi, Miako Sakaguchi, Shinjiro Hamano, Hiroki Yoshida
TREM2 is a receptor for non-glycosylated mycolic acids of mycobacteria that limits anti-mycobacterial macrophage activation ; 2021年04月 発表情報; Nat Commun, 12, 1, 2299 著者; *Ei'ichi Iizasa, Yasushi Chuma, Takayuki Uematsu, Mio Kubota, Hiroaki Kawaguchi, Masayuki Umemura, Kenji Toyonaga, Hideyasu Kiyohara, Ikuya Yano, Marco Colonna, Masahiko Sugita, Goro Matsuzaki, Sho Yamasaki, Hiroki Yoshida, Hiromitsu Hara
Hypericum perforatum extract and hyperforin inhibit the growth of neurotropic parasite Toxoplasma gondii and infection-induced inflammatory responses of glial cells in vitro; 2021年03月 発表情報; J Ethnopharmacol, 267, 113525 著者; *Noriko Shinjyo, Hideyuki Nakayama, Li Li, Kanji Ishimaru, Kenji Hikosaka, Noriyuki Suzuki, Hiroki Yoshida, Kazumi Norose
Stage-Specific De Novo Synthesis of Very-Long-Chain Dihydroceramides Confers Dormancy to Entamoeba Parasites; 2021年03月 発表情報; mSphere, 6, 2, e00174-21 著者; Fumika Mi-Ichi, Kazutaka Ikeda, Hiroshi Tsugawa, Sharmina Deloer, Hiroki Yoshida, Makoto Arita
Toxoplasma Infection Induces Sustained Up-Regulation of Complement Factor B and C5a Receptor in the Mouse Brain via Microglial Activation: Implication for the Alternative Complement Pathway Activation and Anaphylatoxin Signaling in Cerebral Toxoplasmosis ; 2021年02月 発表情報; Front Immunol, 11, 603924 著者; *Noriko Shinjyo, Kenji Hikosaka, Yasutoshi Kido, Hiroki Yoshida, Kazumi Norose
Apoptosis is involved in maintaining the character of the midbrain and the diencephalon roof plate after neural tube closure; 2020年12月 発表情報; Dev Biol, 468, 1-2, 101-109 著者; *Yudai Matsumoto, Yoshifumi Yamaguchi, Misato Hamachi, Keiko Nonomura, Yukiko Muramatsu, Hiroki Yoshida, Masayuki Miura
Activation and IL-10 production of specific CD4 + T cells are regulated by IL-27 during chronic infection with Plasmodium chabaudi; 2020年02月 発表情報; Parasitol Int, 74, 101994 著者; *Odsuren Sukhbaatar, Daisuke Kimura, Mana Miyakoda, Sayuri Nakamae, Kazumi Kimura , Hiromitsu Hara, Hiroki Yoshida, Shin-Ichi Inoue, Katsuyuki Yui
Hypericum erectum alcoholic extract inhibits Toxoplasma growth and Entamoeba encystation: an exploratory study on the anti-protozoan potential; 2020年01月 発表情報; J Nat Med, 74, 1, 294 - 305 著者; *Shinjyo, Noriko; Nakayama, Hideyuki; Ishimaru, Kanji; Hikosaka, Kenji; Mi-ichi, Fumika; Norose, Kazumi; Yoshida, Hiroki
Identification of lipophilic ligands of Siglec5 and -14 that modulate innate immune responses; 2019年11月 発表情報; J Biol Chem. , 294, 45, 16776-16788 著者; Suematsu R, Miyamoto T, Saijo S, Yamasaki S, Tada Y, Yoshida H, Miyake Y
Characterization of Entamoeba histolytica adenosine 5′-phosphosulfate (APS) kinase; validation as a target and provision of leads for the development of new drugs against amoebiasis.; 2019年08月 発表情報; PLoS Negl Trop Dis. , 13, 8, e0007633 著者; Mi-ichi F, Ishikawa T, Tam VK, Deloer S, Hamano S, Hamada T, and Yoshida H.
赤痢アメーバ"含硫脂質代謝"を標的とする阻害剤の探索; 2019年06月 発表情報; 脂質生化学研究, 61, 177-179 著者; 見市 文香, Tam Vo Kha, Deloer Sharmina, 吉田 裕樹
Essential roles of C-type lectin Mincle in induction of neuropathic pain in mice; 2019年01月 発表情報; Sci Rep. , 9, 1, 872 著者; Ishikawa A, Miyake Y, Kobayashi K, Murata Y, Iizasa S, Iizasa E, Yamasaki S, Hirakawa N, Hara H Yoshida H, Yasaka T
A flow cytometry method for dissecting the cell differentiation process of Entamoeba encystation; 2018年07月 発表情報; Frontiers 著者; Fumika Mi-Ichi
Yasunobu Miyake
Tam Kha Vo
Hiroki Yoshida
Murine gamma-Herpesvirus 68 Induces Severe Lung Inflammation in IL-27-Deficient Mice with Liver Dysfunction Preventable by Oral Neomycin; 2018年04月 発表情報; J Immunol, 200, 8, 2703-2713 著者; Kanai, K.
Park, A. M.
Watanabe, A.
Arikawa, T.
Yasui, T.
Yoshida, H.
Tsunoda, I.
Yoshie, O.
Apaf1 plays a negative regulatory role in T cell responses by suppressing activation of antigen-stimulated T cells; 2018年03月 発表情報; PLOS ONE 著者; Tong, Honglian
Miyake, Yasunobu
Mi-ichi, Fumika
Iwakura, Yoichiro
Hara, Hiromitsu
Yoshida, Hiroki
A Flow Cytometry Method for Dissecting the Cell Differentiation Process of Entamoeba Encystation.; 2018年 発表情報; Front. Cell. Infect. Microbiol. , 8, 250 著者; Mi-Ichi F, Miyake Y, Tam VK, Yoshida H
Interleukin-27 controls basal pain threshold in physiological and pathological conditions; 2018年 発表情報; Sci Rep., 8, 1, 11022 著者; ○ Sasaguri T, Taguchi T, Murata Y, Kobayashi K, Iizasa S, Iizasa E, Tsuda M, Hirakawa N, Hara H, Yoshida H, Yasaka, T.
IL-17A contributes to reducing IFN-γ/IL-4 ratio and persistence of Entamoeba histolytica during intestinal amebiasis.; 2017年09月 発表情報; Parasitol Int., 66, 6, 817-823 著者; *Deloer S, Nakamura R, Kikuchi M, Moriyasu T, Kalenda Y D J, Mohammed E S, Senba M, Iwakura Y, Yoshida H, Hamano S
IL-35 Suppresses Lipopolysaccharide-Induced Airway Eosinophilia in EBI3-Deficient Mice; 2017年 発表情報; J Immunol., 198, 1, 119-127 著者; *Kanai K, Park AM, Yoshida H, Tsunoda I, Yoshie O
Uniqueness of Entamoeba sulfur metabolism: sulfolipid metabolism that plays pleiotropic roles in the parasitic life cycle; 2017年 発表情報; Mol Microbiol. , 106, 3, 479-491 著者; Mi-Ichi F, Miyamoto T, Yoshida H
Pertussis toxin targets the innate immunity through DAP12, FcRgamma, and MyD88 adaptor proteins; 2017年 発表情報; Immunobiology. , 222, 4, 664-671 著者; *Phongsisay V, Iizasa E, Hara H, Yoshida H
Interleukin-27-Producing CD4+ T Cells Regulate Protective Immunity
during Malaria Parasite Infection; 2016年03月 発表情報; Immunity., 44, 3, 672-82. 著者; Daisuke Kimura, Mana Miyakoda, Kazumi Kimura, Kiri Honma, Hiromitsu Hara, Hiroki Yoshida, Katsuyuki Yui
Promotion of Expansion and Differentiation of Hematopoietic Stem Cells by Interleukin-27 into Myeloid Progenitors to Control Infection in Emergency Myelopoiesis; 2016年 発表情報; PLoS Pathog, 12, 3, e1005507 著者; * Furusawa J, Mizoguchi I, Chiba Y, Hisada M, Kobayashi F, Yoshida H, Nakae S,Tsuchida A, Matsumoto T, Ema H, Mizuguchi J, Yoshimoto T.
The potential for repositioning antithyroid agents as antiasthma drugs; 2016年 発表情報; J Allergy Clin Immunol, 138, 5, 1458-1461.e8 著者; ○ Suzuki S, Ogawa M, Ohta S, Arima K, Nunomura S, Nanri Y, Mitamura Y, Yoshihara T, Nakamura Y, Yamauchi K, Chibana K, Ishii Y, Lee JJ, Aratani Y, Kakuta S, Kubo S, Iwakura Y, Yoshida H, Izuhara K.
Entamoeba mitosomes play an important role in encystation by association with cholesteryl sulfate synthesis; 2015年05月 発表情報; Proc Natl Acad Sci U S A., 112, 22, E2884-E2890 著者; Fumika Mi-ichia, Tomofumi Miyamoto, Shouko Takaoa, Ghulam Jeelani, Tetsuo Hashimoto, Hiromitsu Hara, Tomoyoshi Nozaki, and Hiroki Yoshida
Loss of CARD9-mediated innate activation attenuates severe influenza pneumonia without compromising host viral immunity; 2015年 発表情報; Sci Rep. 5:17577 著者; Uematsu. T., Iizasa. E., Kobayashi. N., Yoshida. H., Hara. H.
Evidence that the Entamoeba histolytica Mitochondrial Carrier Family Links Mitosomal and Cytosolic Pathways through Exchange of 3'-Phosphoadenosine 5'-Phosphosulfate and ATP.; 2015年 発表情報; Eukaryot Cell., 14, 11, 1144-50 著者; Mi-Ichi F, Nozawa A, Yoshida H, Tozawa Y, Nozaki T.
Evidence for TLR4 and FcRγ-CARD9 activation by cholera toxin B subunit and its direct bindings to TREM2 and LMIR5 receptors; 2015年 発表情報; Mol Immunol., 66, 2, 463-71 著者; *Phongsisay V, Iizasa E, Hara H, Yoshida H
Clustering of CARMA1 through SH3-GUK domain interactions is required for its activation of NF-κB signaling; 2015年 発表情報; Nat Commun., 6, 5555 著者; *Hara H, Yokosuka T, Hirakawa H, Ishihara C, Yasukawa S, Yamazaki M, Koseki H, Yoshida H, and Saito T
An ITAM-Syk-CARD9 signalling axis triggers contact hypersensitivity by stimulating IL-1 production in dendritic cells.; 2014年10月 発表情報; Nat. Commun. 5:3755 doi: 10.1038/ncomms4755. 著者; Yasukawa S, Miyazaki Y, Yoshii C, Nakaya M, Ozaki N, Toda S, Kuroda E, Ishibashi K, Yasuda T, Natsuaki Y, Mi-ichi F, Iizasa E, Nakahara T, Yamazaki M, Kabashima K, Iwakura Y, Takai T, Saito T, Kurosaki T, Malissen B, Ohno N, Furue M, Yoshida H, Hara H.
EBI3 is pivotal for the initiation of experimental autoimmune uveitis.; 2014年09月 発表情報; Exp. Eye Res. doi: 10.1016/j.exer.2014.06.004., 125, 107-13 著者; *Takeda A, Hasegawa E, Fukuhara T, Hirakawa S, Yamada H, Yang Y, Yoshimura T, Hisatomi T, Oshima Y, Yoshida H, Sonoda KH, Ishibashi T.
IL-27 affects helper T cell responses via regulation of PGE2 production by macrophages.; 2014年08月 発表情報; Biochem. Biophys. Res. Commun., 451, 2, 215-21 著者; Sato Y, Hara H, Okuno T, Ozaki N, Suzuki S, Yokomizo T, Kaisho T, Yoshida H
An ITAM-Syk-CARD9 signalling axis triggers contact hypersensitivity by stimulating IL-1 production in dendritic cells; 2014年05月 発表情報; Nature Communications, 5 著者; Shinsuke Yasukawa
Yoshiyuki Miyazaki
Chika Yoshii
Mako Nakaya
Naoko Ozaki
Shuji Toda
Etsushi Kuroda
Ken-ichi Ishibashi
Tomoharu Yasuda
Yohei Natsuaki
Fumika Mi-ichi
Ei’ichi Iizasa
Takeshi Nakahara
Masanori Yamazaki
Kenji Kabashima
Yoichiro Iwakura
Toshiyuki Takai
Takashi Saito
Tomohiro Kurosaki
Bernard Malissen
Naohito Ohno
Masutaka Furue
Hiroki Yoshida
Hiromitsu Hara
Local Apoptosis Modulates Early Mammalian Brain Development through the Elimination of Morphogen-Producing Cells; 2013年12月 発表情報; Developmental Cell, 27, 6, 621-634 著者; Keiko Nonomura, Yoshifumi Yamaguchi, Misato Hamachi, Masato Koike, Yasuo Uchiyama, Kenichi Nakazato, Atsushi Mochizuki, Asako Sakaue-Sawano, Atsushi Miyawaki, Hiroki Yoshida, Keisuke Kuida, Masayuki Miura
Egr-2 transcription factor is required for Blimp-1 mediated IL-10 production in IL-27 stimulated CD4+ T cells; 2013年01月 発表情報; European Journal of Immunology
DOI: 10.1002/eji.201242942 著者; Yukiko Iwasaki
Keishi Fujio
Tomohisa Okamura
Atsushi Yanai
Shuji Sumitomo
Hirofumi Shoda
Tomohiko Tamura
Hiroki Yoshida
Patrick Charnay
Kazuhiko Yamamoto
Interleukin 27 inhibits atherosclerosis via immunoregulation of macrophages in mice.; 2013年 発表情報; Am. J. Physiol. Heart Circ. Physiol., 305, 3, H420-H429 著者; *Hirase T, Hara H, Miyazaki Y, Ide N, Nishimoto-Hazuku A, Fujimoto H, Saris CJM, Yoshida H, Node K
Egr-2 transcription factor is required for Blimp-1 mediated IL-10 production in IL-27 stimulated CD4(+) T cells.; 2013年 発表情報; Eur J Immunol, 43, 4, 1063-1073 著者; *Iwasaki Y., Fujio K, Okamura T, Yanai A, Sumitomo S, Shoda H, Tamura T, Yoshida H, Charnay P, Yamamoto K
Local Apoptosis Modulates Early Mammalian Brain Development through the Elimination of Morphogen-Producing Cells.; 2013年 発表情報; Developmental cell, 27, 6, 621-634 著者; *Nonomura K, Yamaguchi Y, Hamachi M, Koike M, Uchiyama Y, Nakazato K, Mochizuki A, Sakaue-Sawano A, Miyawaki A, Yoshida H, Kuida K, Miura M
Syk-dependent signaling pathways in neutrophils and macrophages are indispensable in the pathogenesis of anti-collagen antibody-induced arthritis; 2012年08月 発表情報; International Immunology, 24, 9, 539-550 著者; Naoko Ozaki, Shinobu Suzuki, Masato Ishida, Yasuyo Harada, Kohji Tanaka, Yayoi Sato, Takeshi Kono, Masato Kubo, Daisuke Kitamura, Jeffrey Encinas, Hiromitsu Hara and Hiroki Yoshida
Probiotic Bifidobacterium breve Induces IL-10-Producing Tr1 Cells in the Colon; 2012年05月 発表情報; PLoS Pathog 8(5): e1002714. doi:10.1371/journal.ppat.1002714, 8, 5 著者; Seong Gyu Jeon, Hisako Kayama, Yoshiyasu Ueda, Takuya Takahashi, Takashi Asahara, Hirokazu Tsuji, Noriko M. Tsuji, Hiroshi Kiyono, Ji Su Ma, Takashi Kusu, Ryu Okumura, Hiromitsu Hara, Hiroki Yoshida, Masahiro Yamamoto, Koji Nomoto, Kiyoshi Takeda
IL-27 inhibits pathophysiological intraocular neovascularization due to laser burn.; 2012年 発表情報; J Leukoc Biol., 91, 2, 267-273 著者; Hasegawa E, Oshima Y, Takeda A, Saeki K, Yoshida H, Sonoda KH, Ishibashi T
IL-27 inhibits pathophysiological intraocular neovascularization due to laser burn; 2011年11月 発表情報; Epub ahead of print 2011 Nov (J Leukoc Biol 91(2):267-273) 著者; Eiichi Hasegawa
Yuji Oshima
Atsunobu Takeda
Kazuko Saeki
Hiroki Yoshida
Koh-Hei Sonoda
Tatsuro Ishibashi
IL-27 inhibits hyperglycemia and pancreatic islet inflammation induced by streptozotocin in mice; 2011年10月 発表情報; Am J Pathol, 179, 5, 2327-2336 著者; Fujimoto, H.
Hirase, T.
Miyazaki, Y.
Hara, H.
Ide-Iwata, N.
Nishimoto-Hazuku, A.
Saris, C. J.
Yoshida, H.
Node, K.
The transcription factor FBI-1/OCZF/LRF is expressed in osteoclasts and regulates RANKL-induced osteoclast formation in vitro and in vivo; 2011年09月 発表情報; Arthritis Rheum, 63, 9, 2744-2754 著者; Kukita, A.
Kukita, T.
Nagata, K.
Teramachi, J.
Li, Y. J.
Yoshida, H.
Miyamoto, H.
Gay, S.
Pessler, F.
Shobuike, T.
Exacerbation of delayed-type hypersensitivity responses in EBV-induced gene-3 (EBI-3)-deficient mice; 2010年 発表情報; Immunol Lett, 128, 2, 108-115 著者; Tong, H.
Miyazaki, Y.
Yamazaki, M.
Hara, H.
Waldmann, H.
Hori, S.
Yoshida, H.
Maturation of the olfactory sensory neurons by Apaf-1/caspase-9-mediated caspase activity; 2010年 発表情報; Proc Natl Acad Sci U S A, 107, 30, 13366-13371 著者; Ohsawa, S.
Hamada, S.
Kuida, K.
Yoshida, H.
Igaki, T.
Miura, M.
IL-17 is necessary for host protection against acute-phase Trypanosoma cruzi infection; 2010年 発表情報; J Immunol, 185, 2, 1150-1157 著者; Miyazaki, Y.
Hamano, S.
Wang, S.
Shimanoe, Y.
Iwakura, Y.
Yoshida, H.
Apaf-1-independent programmed cell death in mouse development; 2010年 発表情報; Cell Death Differ, 17, 6, 931-941 著者; Nagasaka, A.
Kawane, K.
Yoshida, H.
Nagata, S.
Aberrant IL-4 production by SOCS3-over-expressing T cells during infection with Leishmania major exacerbates disease manifestations; 2010年 発表情報; International Immunology, in press 著者; Nakaya M, Hamano S, Kawasumi M, Yoshida H, Yoshimura A, Kobayashi T
Alternative cell death of Apaf1-deficient neural progenitor cells induced by withdrawal of EGF or insulin.; 2009年 発表情報; Biochim Biophys Acta 10.1016/j.bbagen.2009.1011.1008. 著者; ○Shiraishi H, Okamoto H, Hara H and Yoshida H.
Apaf-1-independent programmed cell death in mouse development.; 2009年 発表情報; Cell Death Differ. 1476-5403 (Electronic) 著者; *Nagasaka A, Kawane K, Yoshida H and Nagata S.
SOCS3 in T and NKT Cells Negatively Regulates Cytokine Production and Ameliorates ConA-Induced Hepatitis.; 2009年 発表情報; J Immunol. 183:7047-7053, 183, 7047-7053 著者; Nakaya M, Hashimoto M, Nakagawa R, et al. .
Caspase-9 activation revealed by semaphorin 7A cleavage is independent of apoptosis in the aged olfactory bulb.; 2009年 発表情報; J Neurosci. 29:11385-11392., 29, 11385-11392 著者; *Ohsawa S, Hamada S, Asou H, et al.
IL-27 abrogates receptor activator of NF-kappaB ligand-mediated osteoclastogenesis of human granulocyte-macrophage colony-forming unit cells through STAT1-dependent inhibition of c-Fos. .; 2009年 発表情報; J Immunol. 183:2397-2406, 183, 2397-2406 著者; *Furukawa M, Takaishi H, Takito J, et al.
Deficiency in EBV-induced gene 3 (EBI3) in MRL/lpr mice results in pathological alteration of autoimmune glomerulonephritis and sialadenitis.; 2009年 発表情報; Mod Rheumatol. 2009;19:33-41., 19, 33-41 著者; *Igawa T, Nakashima H, Sadanaga A, et al.
Amelioration of experimental allergic rhinitis with suppression of topical immune responses by lack of IL-27/WSX-1 signaling.; 2009年 発表情報; Ann Allergy Asthma Immunol. 102:223-232., 102, 223-232 著者; Shimanoe Y, Miyazaki Y, Hara H, Inokuchi A and Yoshida H.
Caspase-mediated changes in histone H1 in early apoptosis: prolonged caspase activation in developing olfactory sensory neurons; 2008年09月 発表情報; Cell Death Differ, 15, 9, 1429-1439 著者; Ohsawa, S.
Hamada, S.
Yoshida, H.
Miura, M.
Tumor-specific cytotoxic T cell generation and dendritic cell function are differentially regulated by interleukin 27 during development of anti-tumor immunity; 2008年06月 発表情報; Int J Cancer, 124, 6, 1372-1378 著者; Shinozaki, Y.
Wang, S.
Miyazaki, Y.
Miyazaki, K.
Yamada, H.
Yoshikai, Y.
Hara, H.
Yoshida, H.
Cell Type-Specific Regulation of ITAM-Mediated NF-{kappa}B Activation by the Adaptors, CARMA1 and CARD9; 2008年01月 発表情報; J Immunol, 181, 2, 918-930 著者; Hara, H.
Ishihara, C.
Takeuchi, A.
Xue, L.
Morris, S. W.
Penninger, J. M.
Yoshida, H.
Saito, T.
Amelioration of delayed-type hypersensitivity responses by IL-27 administration; 2008年 発表情報; Biochem Biophys Res Commun, 373, 3, 397-402 著者; Miyazaki, Y.
Shimanoe, Y.
Wang, S.
Yoshida, H.
Apaf-1-deficient fog mouse cell apoptosis involves hypo-polarization of the mitochondrial inner membrane, ATP depletion and citrate accumulation; 2008年 発表情報; Cell Res 1748-7838 (Electronic) 著者; Katoh, I.
Sato, S.
Fukunishi, N.
Yoshida, H.
Imai, T.
Kurata, S. I.
Different initial steps of apoptosis induced by two types of antineoplastic drugs; 2008年 発表情報; Biochem Pharmacol, 76, 3, 303-311 著者; Takagi, Y.
Hidaka, M.
Sanada, M.
Yoshida, H.
Sekiguchi, M.
WSX-1 plays a significant role for the initiation of experimental autoimmune uveitis.; 2007年03月 発表情報; Int Immunol, 19, 93 著者; Sonoda, K. H., T. Yoshimura, A. Takeda, T. Ishibashi, S. Hamano, and H. Yoshida.
The adaptor protein CARD9 is essential for the activation of myeloid cells through ITAM-associated and Toll-like receptors.; 2007年 発表情報; Nat Immunol, 8, 619 著者; Hara, H., C. Ishihara, A. Takeuchi, T. Imanishi, L. Xue, S. W. Morris, M. Inui, T. Takai, A. Shibuya, S. Saijo, Y. Iwakura, N. Ohno, H. Koseki, H. Yoshida, J. M. Penninger, and T. Saito.
Augmentation of Antigen-Presenting and Th1-Promoting Functions of Dendritic Cells by WSX-1(IL-27R) Deficiency; 2007年 発表情報; J. Immunol., 179, 6421 著者; Wang, S. et al.
Differential roles for IFN-gamma and IL-17 in experimental autoimmune uveoretinitis; 2007年 発表情報; J. Immunol., 20, 209 著者; Yoshimura et al.
Amelioration of human lupus-like phenotypes in MRL/lpr mice by overexpression of IL-27R{alpha} (WSX-1); 2007年 発表情報; Ann Rheum Dis 著者; Sugiyama, N. et al.
Incudomalleal joint formation: the roles of apoptosis, migration and downregulation; 2007年 発表情報; BMC Developmental Biology 著者; Amin, S. et al.
Suppressor of cytokine signalling 1 in lymphocytes regulates the development of intestinal inflammation in mice; 2006年 発表情報; Gut 著者; Inagaki-Ohara, K.
Sasaki, A.
Matsuzaki, G.
Ikeda, T.
Hotokezaka, M.
Chijiiwa, K.
Kubo, M.
Yoshida, H.
Nawa, Y.
Yoshimura, A.
Histological analyses of normally grown, fertile Apaf1-deficient mice; 2006年 発表情報; Cell Death Differ 著者; Okamoto, H.
Shiraishi, H.
Yoshida, H.
Differential contribution of Puma and Noxa in dual regulation of p53-mediated apoptotic pathways.; 2006年 発表情報; Embo J, 25, 4952 著者; Shibue, T., S. Suzuki, H. Okamoto, H. Yoshida, Y. Ohba, A. Takaoka, and T. Taniguchi.
Two-Sided Roles of IL-27: Induction of Th1 Differentiation on Naive CD4+ T Cells versus Suppression of Proinflammatory Cytokine Production Including IL-23-Induced IL-17 on Activated CD4+ T Cells Partially Through STAT3-Dependent Mechanism.; 2006年 発表情報; J Immunol, 177, 5377 著者; Yoshimura, T., A. Takeda, S. Hamano, Y. Miyazaki, I. Kinjyo, T. Ishibashi, A. Yoshimura, and H. Yoshida.
ER stress-induced apoptosis and caspase-12 activation occurs downstream of mitochondrial apoptosis involving Apaf-1.; 2006年 発表情報; J Cell Sci, 119, 3958 著者; Shiraishi, H., H. Okamoto, A. Yoshimura, and H. Yoshida.
Generation and Characterization of B7-H4/B7S1/B7x-Deficient Mice.; 2006年 発表情報; Mol Cell Biol, 26, 6403 著者; Suh, W. K., S. Wang, G. S. Duncan, Y. Miyazaki, E. Cates, T. Walker, B. U. Gajewska, E. Deenick, W. Dawicki, H. Okada, A. Wakeham, A. Itie, T. H. Watts, P. S. Ohashi, M. Jordana, H. Yoshida, and T. W. Mak.
The IL-27 Receptor Chain WSX-1 Differentially Regulates Antibacterial Immunity and Survival during Experimental Tuberculosis; 2005年 発表情報; J Immunol 著者; Holscher, C.
Holscher, A.
Ruckerl, D.
Yoshimoto, T.
Yoshida, H.
Mak, T.
Saris, C.
Ehlers, S.
WSX-1 over-expression in CD4+ T cells leads to hyperproliferation and cytokine hyperproduction in response to TCR stimulation; 2005年 発表情報; Int Immunol 著者; Takeda, A.
Hamano, S.
Shiraishi, H.
Yoshimura, T.
Ogata, H.
Ishii, K.
Ishibashi, T.
Yoshimura, A.
Yoshida, H.
Exacerbation of Experimental Allergic Asthma by Augmented Th2 Responses in WSX-1-Deficient Mice; 2005年 発表情報; J Immunol 著者; Miyazaki, Y.
Inoue, H.
Matsumura, M.
Matsumoto, K.
Nakano, T.
Tsuda, M.
Hamano, S.
Yoshimura, A.
Yoshida, H.
Autoamplification of NFATc1 expression determines its essential role in bone homeostasis; 2005年 発表情報; J. Exp. Med. 著者; Asagiri, Masataka
Sato, Kojiro
Usami, Takako
Ochi, Sae
Nishina, Hiroshi
Yoshida, Hiroki
Morita, Ikuo
Wagner, Erwin F.
Mak, Tak W.
Serfling, Edgar
Takayanagi, Hiroshi
T Helper 1-Inducing Property of IL-27/WSX-1 Signaling Is Required for the Induction of Experimental Colitis; 2005年 発表情報; Inflamm Bowel Dis 著者; Honda, K.
Nakamura, K.
Matsui, N.
Takahashi, M.
Kitamura, Y.
Mizutani, T.
Harada, N.
Nawata, H.
Hamano, S.
Yoshida, H.
Membranous Glomerulonephritis Development with Th2-Type Immune Deviations in MRL/lpr Mice Deficient for IL-27 Receptor (WSX-1); 2005年 発表情報; J Immunol 著者; Shimizu, S.
Sugiyama, N.
Masutani, K.
Sadanaga, A.
Miyazaki, Y.
Inoue, Y.
Akahoshi, M.
Katafuchi, R.
Hirakata, H.
Harada, M.
Hamano, S.
Nakashima, H.
Yoshida, H.
The IL-27 Receptor Chain WSX-1 Differentially Regulates Antibacterial Immunity and Survival during Experimental Tuberculosis; 2005年 発表情報; J Immunol 著者; Holscher, C.
Holscher, A.
Ruckerl, D.
Yoshimoto, T.
Yoshida, H.
Mak, T.
Saris, C.
Ehlers, S.
Stress Induces Mitochondria-mediated A poptosis Independent of SAPK/JNK Activation in Embryonic Stem Cells.; 2004年 発表情報; J. Biol. Chem., 279, 1621-1626 著者; Nishitai G,Shimizu N,Negishi T,Kishimoto H,Nakagawa K,Kitagawa D,Watanabe T,Momose H,Ohata S,Tanemura S,Asaka S,Kubota J,Saito R,Yoshida H,Mak TW,Wada T,Penninger JM,Azuma N,Nishina H,Katada T.
Hyperproduction of Proiflammatory Cytokines by WSX-1-Deficient NKT Cells in Concanavalin A-Induced Hepatitis.; 2004年 発表情報; J. Immunol., 172, 3590-3596 著者; Yamanaka A,Hamano S,MiyazakiY,Ishii K,Takeda A,Mak TW,Himeno K,Yoshimura A, and Yoshida H.
WSX-1: A Key Role in Induction of Chronic Intestina1 Nematode Infedion.; 2004年 発表情報; J. Immunol., 172, 7635-7641 著者; Bancroft AJ,Humphreys NE,Worthington JJ,Yoshida H, and Grencis RK
The IL-27 receptor (WSX-1) is an inhibitor of innate and adaptive elements of type 2 immunity.; 2004年 発表情報; J. Immunol., 173, 5626-5634 著者; Artis D,Villarino A,Silverman M,He W,Thornton EM,Mu S,Summer S,Covey TM,Huang E,Yoshida H,Koretzky G,Goldschmidt M,Wu GD, de Sauvage F,Miller HR,Saris CJ,Scott P,Hunter CA.
Different Properties of SEK1 and MKK7 in Dual Phosphorylation of Stress-induced Activated Protein Kinase SAPK/JNK in Embryonic Stem Cells.; 2003年 発表情報; J. Biol. Chem. , 278, 16595-16601 著者; Kishimoto H, Nakagawa K, Watanabe T, Kitagawa D, Momose H, Seo J, Nishitai G, Shimizu N, Ohata S, Tanemura S, Asaka S, Goto T, Fukushi H, Yoshida H, Suzuki A, Sasaki T, Wada T, Penninger JM, Nishina H, Katada T
Cutting Edge Role of IL-27/WSX-1 Signaling for Induction of T-Bet Through Activation of STATI During Initia1 Th1 Commitment.; 2003年 発表情報; J. Immunol. , 170, 4886-4890 著者; Takeda A, Hamano S, Yamanaka A, Hanada T, Ishibashi T, Mak TW, Yoshimura A, Yoshida H
Suppressor of cytokine signaling-1 is essential for suppressing dendritic cell activation and systemic autoimmunity.; 2003年 発表情報; Immunity , 19, 437-450 著者; Hanada T, Yoshida H, Kato S, Tanaka K, Masutani K, Tsukada J, Nomura Y, Mimata H, Kubo M, Yoshimura A
The IL-27R(WSX-1) Is Required to Suppress T Cell Hyperactivity during Infection.; 2003年 発表情報; Immunity , 19, 645-655 著者; Villarino A, Hibbert L, Lieberman L, Wilson E, Mak T, Yoshida H, Kastelein RA, Saris C, Hunter CA
WSX-1 Is Required for Resistance to Trypanosoma cruzi Infection by Regulation of Proinflammatory Cytokine Production.; 2003年 発表情報; Immunity, 19, 657-667 著者; Hamano S, Himeno K, Miyazaki Y, Ishii K, Yamanaka A, Takeda A, Zhang M, Hisaeda H, Mak TW, Yoshimura A, Yoshida H
Identification of leukocyte immunoglobulin-like receptor A1 (LILRA1) as a specific receptor for Aspergillus fumigatus conidia; 2022年 発表情報; 第51回日本免疫学会学術集会(Hybrid開催), 2022,12, 7-9(現地+オンライン開催), 2022,12,10-2023, 1,10(オンデマンド配信) 著者; 三宅靖延, 吉田裕樹
IL-27 inhibits the generation and/or maitenance of Plasmodium-specific memory CD4+ T cells during malaria infection; 2021年04月 発表情報; 第90回日本寄生虫学会 第32回日本臨床寄生虫学会 合同大会(ハイブリッド形式開催), 2021, 4,16-17(現地及びWeb開催) 著者; *Macalinao M L M, Inoue S-I, Tsogtsaikhan S, Bayarsaikhan G, Jian J-Y, Kimura K, Fernandez-Ruiz D, Heath W R, Hafalla Julius C, Yoshida H, Kimura D, Yui K
IL-27 plays an important role in anti-desmoglein 3 antibody production in pemphigus vulgaris mouse model; 2020年12月 発表情報; 日本研究皮膚科学会 第45回年次学術大会・総会(WEB開催), 2020, 12, 11 - 13 著者; *Kamata A, Takahashi H, Yoshida H, Yamagami J, Amagai M
Identification of novel lipophilic ligands of siglec receptors that modulate innate immunity.; 2020年11月 発表情報; Cytokines 2020: 8th Annual Meeting of the International Cytokine & Interferon Society(Virtual Meeting), 2020, 11, 1-4(On Line), 2020, 11, 1 - 18(On Demand) 著者; Miyake Y, Yoshida H
The Role of IL-27 in Pain due to Hip Osteoarthritis; 2019年 発表情報; ORS 2019 Annual Meeting, 2019,2,2-5 著者; ○Sonohata M, Yoshida H, Miyake Y, Suematsu R, Kitajima M, Kawano S, Mawatari M
A new method for dissecting the cell differentiation process of Entamoeba encystation. ; 2019年 発表情報; U.S.-Japan Cooperative Medical Sciences Program (USJCMSP) 21st International Conference On Emerging Infectious Diseases In The Pacific Rim, 2019, 2, 26-3, 1 著者; Mi-ichi F, Miyake Y, Tam VK, Yoshida H
Uniqueness of Entamoeba sulfur metabolism; fatty alcohol disulfates, novel sulfur metabolites, play an important role in trophozoite proliferation. ; 2019年 発表情報; 60th International Conference on the Bioscience of Lipids, 2019, 6, 17-21 著者; Mi-ichi F, Miuamoto T, Yoshida H
Novel immune evasion strategy of P. gingivalis via inhibitory receptor, Siglec; 2019年 発表情報; The 18th Awaji International Forum on Infection and Immunity, 2019, 9, 10-13 著者; Yoshida H, Miyake Y
Identification of novel lipophilic ligands of Siglec5 and 14 that modulate innate immune responses.; 2019年 発表情報; 第48回 日本免疫学会学術集会, 2019. 12. 11-13 著者; Miyake Y, Suematsu R, Yoshida H
Uniqueness of Entamoeba sulfur metabolism. ; 2018年 発表情報; The 48th Annual Japan-U.S. Joint Conference on Parasitic Diseases, 2018, 2, 16 著者; Fumika Mi-ichi, Tomofumi Miuamoto, Hiroki Yoshida.
Apaf1 plays a negative regulatory role in T cell responses by suppressing activation of antigen-stimulated T cells; 2018年 発表情報; 11th International Congress on Autoimmunity, 2018, 5, 16-20 著者; Tong H, Miyake Y, Mi-ichi F, Iwakura Y, Hara H, Yoshida H
Immunomodulatory effects of Interleukin-27 on chronic malaria infection; 2018年 発表情報; The 17th Awaji International Forum on Infection and Immunity, 2018,9, 4-7 著者; Sukhbaatar O, Kimura D, Miyakoda M, Nakamae S, Kimura K, Yoshida H, Yui K.
Porphyromonas gingivalis negatively regulates host immune responses through inhibitory receptor, Siglec.; 2018年 発表情報; The 47th Annual Meeting of the Japanese Soceity for Immunology, 2018.12.10-12 著者; Miyake Y, Yamasaki S, Yoshida H
Immunosuppressive receptor, Siglec5 recognizes lipophilic ligands extracted from pathogenic fungus, Trichophyton mentagrophytes.; 2018年 発表情報; The 47th Annual Meeting of the Japanese Soceity for Immunology, 2018.12.10-12 著者; Suematsu E, Miyake Y, Saijo S, Yoshida H
Interleukin-27 inhibits the generation of memory CD4+ T cells during malaria infection; 2017年 発表情報; 5th Annual Meeting of the International Cytokine and Interferon Society, 2017,10,29-11,2 著者; *Kimura D, Nakamae S, Sukhbaatar O, Miyakoda M, Akbari M, Kimura K, Hara H, Yoshida H, Yui K
Entamoeba mitosomes play an important role in cell differentiation from proliferative form into dormant form (encystation) by association with cholesteryl sulfate synthesis.; 2017年 発表情報; 58th International Conference on the Bioscience of Lipids, 2017, 9, 10-14 著者; Mi-ichi F, Yoshida H
Pathogenic fungus, Trichopyton mentagrophytes, negatively regulates host immune responses via Siglec receptors; 2017年 発表情報; 5th Annual Meeting of the International Cytokine and Interferon Society, 2017,10,29-11,2 著者; Miyake Y, Suematsu R, Saijo S, Yamasaki S, Yoshida H
Role of Il-35 in Lipopolysaccharide-induced airway eosinophilia; 2017年 発表情報; The 46th Annual Meeting of the Japanese Soceity for Immunology, 2017, 12, 12-14 著者; *Kanai K, Yoshida H, Yoshie O
Interleukin-27-dependent loss of Cd4+ T cell-memory during malaria infection; 2017年 発表情報; The 46th Annual Meeting of the Japanese Soceity for Immunology, 2017, 12, 12-14 著者; *Kimura D, Miyakoda M, Bayarsaikhan G, Nakamae S, Sukhbaatar O, Kimura K, Hara H, Yoshida H, Yui K
Immunosuppressive receptor, Siglec binds to pathogenic fungus, Trichophyton mentagrophytes, and negatively regulates host immune responses; 2017年 発表情報; The 46th Annual Meeting of the Japanese Soceity for Immunology, 2017, 12, 12-14 著者; Miyake Y, Suematsu R, Shinobu Saijo S, Yamasaki S, Yoshida H
Apaf1 plays a negative regulatory role in T cell responses by suppressing activation of antigen-stimulated T cells; 2017年 発表情報; The 46th Annual Meeting of the Japanese Soceity for Immunology, 2017, 12, 12-14 著者; Tong H, Miyake Y, Iwakura Y, Hara H, Yoshida H
Regulation of Immune Responses by IL-27-producing CD4+ T cells Induced during Marlaria Infection; 2016年10月 発表情報; 4th Annual Meeting of the International Cytokine and Interferon Scoedty (ICIS), 2016.10.16-19 著者; Yoshida H, Kimura D, Hara H, Yui K
Possible contribution of the C-type lectin receptor, Mincle, to induction of neuropathic pain after peripheral nerve injury in mice; 2016年09月 発表情報; 第16回世界疼痛学会, 2016.9.26-30 著者; ○ Ishikawa A, Yasaka T, Miyake Y, Murata Y, Sasaguri T, Yamasaki S, Hara H, Yoshida H, Hirakawa H
Regulation of innate immunity through ITAM-coupled reeptors ininfluenza virus infection; 2016年 発表情報; The 45th Annual Meeting of the Japanese Society for Immunology, 2016.12.5-7 著者; Uematsu, Takayuki, Iizasa, E, Kobayashi, Noritada, Yoshida, H, Hara, H
Interleukin-27 inhibits the generation of memory CD4+ T cells against malaria infection; 2016年 発表情報; The 45th Annual Meeting of the Japanese Society for Immunology, 2016.12.5-7 著者; Kimura, D, Miyakoda, M, Akbari, Masoud, Kimura, K, Hara, H, Yoshida, H, Yui, K
C-type lectin receptor MCL stabilizes Mincle through complex formation for enhancement of inflammatory cytokine production upon mycobacterial infection; 2015年 発表情報; Cytokines 2015 (3rd Anual Meeting of the International Cytokine and Interferon Society (ICIS)), 2015, 10, 11-14 著者; Yasunobu Miyake, Sho Yamasaki, Hiroki, Yoshida
Phospholipids bind to siglec-9 and induce immunosuppressive effect against LPS stimulation.; 2015年 発表情報; The 44th annual meeting of the Japanese Society for Immunology, 2015. 11. 18-20 著者; Yasunobu Miyake, Sho Yamasaki, Hiroki Yoshida
IL-27-producing CD4+ T cells induced during malaria infection are distinct from Tr1 cells.; 2015年 発表情報; The 44th annual meeting of the Japanese Society for Immunology, 2015. 11. 18-20 著者; *Kimura, D Miyakoda, M Doe, Henrietta Terko Kimura, K Hara, H Yoshida, H Yui, K
Mycobacterium tuberculosis-derived mycolic acid shows an adjuvant activity by activation of the ITAM receptor/CARD9-mediated innate immunity.; 2014年 発表情報; 2nd Anual Meeting of the International Cytokine and Interferon Society, 2014, 10, 26-29 著者; Kubota M, Iizasa E, Kiyohara H, Chuma Y, Hara H, Yoshida H
Activation of innate immunity mediated by the IgSFR2/CARD9 pathway is involved in severe influenza pneumonia; 2014年 発表情報; The 43rd annual meeting of the Japanese Society for Immunology, 2014, 12, 10-12 著者; Uematsu T, Iizasa E, Kobayashi N, Yoshida H, Hara H
Innate recognition of mycolic acid-containing lipids in mycobacteria.; 2014年 発表情報; The 43rd annual meeting of the Japanese Society for Immunology, 2014, 12, 10-12 著者; Iizasa E, Uematsu T, Kubota M, Kiyohara H, Chuma Y, Matsuzak, G, Yamasaki S, Yoshida H, Hara H
IL-27-producing malaria-specific CD4+ T cells regulate protective immune responses.; 2014年 発表情報; The 43rd annual meeting of the Japanese Society for Immunology, 2014, 12, 10-12 著者; *Kimura D, Miyakoda M, Kimura K, Honma K, Hara H, Yoshida H, Yui K
Role of cholesteryl sulfate of Entamoeba; 2014年 発表情報; 第7回寄生虫感染免疫研究会, 2014, 3, 6-7 著者; Fumika Mi-ichi, Tomofumi Miyamoto, Ghulam Jeelani, Hiromitsu Hara, Tomoyoshi Nozaki, Hiroki Yoshida
Interleukin 27 inhibits hepatic steatosis induced by high fat diet in mice.; 2013年 発表情報; Cell Symposia; Immunometabolism: from Mechanisms to Therapy. 2013,6.9-11 著者; *Hirase T, Fujimoto H, Hiromitsu H, Yoshida H, Node K
IL-27 affects helper T cell responses via regulation of PGE2 production by macrophages.; 2013年 発表情報; 15th International Congress of Immunology, 2013,8.22-27 著者; Sato Y, Hara H, Suzuki S, Kaisho T, Yoshida H
Identification of novel innate pattern recoginition receptors for mycobacterium tuberculosis.; 2013年 発表情報; 15th International Congress of Immunology, 2013,8.22-27 著者; Iizasa E, Miyamoto T, Uematsu T, Ishikawa T, Yamasaki S, Matsuzaki G, Yoshida H, Hara H
Essential role of ITAM-Syk-IL-1 axis in skin dendritic cells for the sensitization of allergic contact dermatitis.; 2013年 発表情報; 15th International Congress of Immunology, 2013,8.22-27 著者; Hara H, Yasukawa S, Yoshida H, Furue M
IL-27 affects helper T cell response via regulation of PGE2 production by macrophages.; 2013年 発表情報; Inaugural meeting of the international cytokine and interferon society (ICIS), 2013, 9.29-10.3 著者; Sato Y, Hara H, Suzuki S, Kaisho T, Yoshida H
Interleukin 27 inhibits atherosclerosis via immunoregulation of macrophages in mice.; 2013年 発表情報; Autoimmunity Congress Asia, 2013, 11.20-22 著者; Yoshida H, Hirase T, Hara H, Node K
Activation of innate immunity through the CARD9 pathway is involved in severe influenza pneumonia.; 2013年 発表情報; 15th International Congress of Immunology, 2013,8.22-27 著者; Uematsu T, Iizasa E, Kobayashi N, Yoshida H, Hara H
IL-1 released by skn dendritic cells activated through Syk and CARD9 pathway is essential for the sensitization of allergic contact dermatitis.; 2013年 発表情報; IMMUNOLOGY 2013 AAI Annual Meeting, 2013, 5.3-7 著者; Hara H, Yasukawa S, Furue M, Yoshida H
IL-27 afects helper t cell response via reguation of PGE2 production by macrophages.; 2013年 発表情報; The joint international meeting of the 78th meeting of the Japanese societyt of interferon and cytokine research + the 21st international symposium on molecular cell biology of macrophages, 2013, 5.20-21 著者; Sato Y, Hara H, Suzuki S, Kaisho T, Yoshida H
Identification and analysis of two novel pattern recoginition receptors for Mycobacterium tuberculosis.; 2013年 発表情報; The joint international meeting of the 78th meeting of the Japanese societyt of interferon and cytokine research + the 21st international symposium on molecular cell biology of macrophages, 2013, 5.20-21 著者; Iizasa E, Miyamoto T, Uematsu T, Ishikawa T, Yamasaki S, Yoshida H, Hara H
Exacervation of delayed-type hypersensitivity responses in mice with T cell-specific deletion of Apaf1.; 2013年 発表情報; 第42回日本免疫学会学術集会, 日本 千葉, 2013, 12.11-13 著者; Tong H, Iizasa E, Hara H, Yoshida H
Adjuvant activity of Mycobacterium tubeculosis-derived mycolic acid through activation of the ITAM receptor/CARD9-mediated innate immunity.; 2013年 発表情報; 第42回日本免疫学会学術集会 日本 千葉, 2013, 12.11-13 著者; Kubota M, Iizasa E, Kiyohara H, Nakama Y, Hara H, Yoshida H
Il-27 is produced by CD4+ T cells during infection with malaria parasites and inhibits protective immune responses.; 2013年 発表情報; 第42回日本免疫学会学術集会 日本 千葉, 2013, 12.11-13 著者; *Kimura D, Miyakoda M, Kimura K, Honma K, Hara H, Hori S, Yoshida H, Yui K
Identification of an ITAM-coupled pattern recognition receptor that recognizes the mycobacterial cell wall compontent mycolic acids.; 2013年 発表情報; 第42回日本免疫学会学術集会 日本 千葉, 2013, 12.11-13 著者; Iizasa E, Uematsu T, Matuzaki G, Yamasaki S, Yoshida H, Hara H
Analysis for the role of Syk-CARD9-regulated IL-1 secretion pathway in DCs in contact hypersensitivity by the mixed-chimera diphtheria toxin receptor (DTR)-mediated conditional cell knockout (MixC-Treck) method, a novel method for conditional gene targeting in mice.; 2013年 発表情報; 第42回日本免疫学会学術集会 日本 千葉, 2013, 12.11-13 著者; Hara H, Yasukawa S, Natsuaki Y, Kabashima K, Furue M, Yoshida H
Activation of innate immunity through ITAM-receptor and Syk-CARD9-Bcl10 signaling pathway is critically involved in control of Leishmania major Infection; 2012年 発表情報; The 12th Biennial International Endotoxin and Innate Immunity Society Meeting., 2012.10.23-26 著者; Yoshida H, Nakaya M, Miichi F, Iizasa E, Hara H
Activation of the Syk-CARD9-Bcl10-mediated novel innate immune system is critically involved in defense against Leishmania major Infection.; 2012年 発表情報; In 10th Joint Annual Meeting of ISC and ISICR, 2012.9.11-14 著者; Yoshida H, Hara H, Nakaya M, Fumika M, Kubota M
Interleukin 27 Ameriolates Atherosclerosis by Inhibiting Bone Marrow-Derived Macrophage Activation in Arterial Walls in Mice.; 2012年 発表情報; The 8th International Congress on Autoimmunity, 2012.5.9-13 著者; Yoshida H, Hirase T, Hiromitsu H, Node K
Contact allergy to chemical sensitizers requires innate immune activation by coupling of the ITAM-Syk-CARD9 pathway and NLRP3 inflammasome.; 2012年 発表情報; The 12th Biennial International Endotoxin and Innate Immunity Society Meeting., 2012.10.23-26 著者; Hara H, Yasukawa S, Furue M, Yoshida H
Innate immune activation through ITAM-Syk-CARD9 signaling coupling to inflammasome is essential for the development of allergy to organic chemical allergens.; 2012年 発表情報; In 10th Joint Annual Meeting of ISC and ISICR, 2012.9.11-14 著者; Hara H, Yasukawa S, Furue M, Yoshida H
Role of Card9-mediated signaling in contact hypersensitivity.; 2012年 発表情報; 2nd Eastern Asia Dermatology Congress, 2012.6.13-15 著者; Yasukawa S, Furue M, Yoshida H, Hara H
Innate immune activation through ITAM-Syk-CARD9 signaling coupling to NLRP3 inflammasome is esseintial for the development of allergy to contact sensitizers.; 2012年 発表情報; 第41回日本免疫学会学術集会, 2012.12.5-7 著者; Yasukawa S, Furue M, Yoshida H, H. Hara H
Activation of innate immunity through the CARD9 pathway is involved in severe influenza pneumonia.; 2012年 発表情報; 第41回日本免疫学会学術集会, 2012.12.5-7 著者; Uematsu T, Iizasa E, Kobayashi N, Yoshida H, Hara H
IL-27 affects immune responses via rgulation of prostagrandin E2 production by macrophages.; 2012年 発表情報; 第41回日本免疫学会学術集会, 2012.12.5-7 著者; Sato Y, Suzuki S, Hara H, Kiasho T, Yoshida H
CD4 T cells produce EBI-3+ cytokine inhibiting their own protective immune responses during infection with malaria parasites.; 2012年 発表情報; 第41回日本免疫学会学術集会, 2012.12.5-7 著者; *Kimura D, Miyakoda M, Honma K, Kimura K, Hara H, Yoshida H, Yui K
A novel IL-27 signaling pathway mediated by Egr-2 regulates IL-10 production in naive T cells.; 2012年 発表情報; 第41回日本免疫学会学術集会, 2012.12.5-7 著者; *Iwasaki Y,Fujio K, Okamura T, Yanai A, Sumitomo S, Shoda H, Tamura T, Yoshida H, Yamamoto K
Identification and funcitional analysis of novel mycobacerium receptors.; 2012年 発表情報; 第41回日本免疫学会学術集会, 2012.12.5-7 著者; Iizasa E, Miyamoto T, Ishikawa T, Ishikawa E, Yamasaki S, Matuzaki G, Yoshida H, Hara H
Essential role for intra- and intermolecular SH3-GUK interactions of CARMA1 in antigen receptor-induced NF-kB and JNK activation.; 2012年 発表情報; 第41回日本免疫学会学術集会, 2012.12.5-7 著者; Hara H, Yokosuka T, Ishihara C, Yasukawa S, Hirakawa H, Iizasa E, Yoshida H, Saito T
MGL1-dependent IL-10 induction in colonic macrophages by commensal bacteria is mediated by the Syk-CARD9 pathway.; 2012年 発表情報; 第41回日本免疫学会学術集会, 2012.12.5-7 著者; *Denda-Nagai K, Kurashina R, Hara H, Yoshida H, Irimura T
Activation of innate immunity through Syk-CARD9-Bcl10 signaling pathway is involved in control of Leishmania major infection.; 2012年 発表情報; The 5th Immunoparasitology Meeting, 2012.3.1-2 著者; HARA H, NAKAYA M, MIICHI F , IIZASA E, DENDA-NAGAI K, IRIMURA T, ADACHI Y, OHNO N, YOSHIDA H
Sulfate activation in mitosomes plays an important role in Entamoeba histolytica; 2012年 発表情報; The 6th Nagasaki Symposium on Tropical and Emerging Infectious Diseases, 2012.12.10-12 著者; Mi-ichi F, Miyamoto T, Hara H, Yoshida H
Role of CARD9-mediated activation of innate immunity in anti-protozoan defense; 2010年09月 発表情報; The 10th Awaji International Forum on Infection and Immunity. 2010, 9, 7-10 著者; Yoshida H, Nakaya M, Hara H and Yamasaki M
Interleukin 27 Inhibits Hyperglycemia and Pancreatic Islet Inflammation Induced by Streptozotocin in Mice.; 2010年08月 発表情報; The 14th International Congress of Immunology (ICI 2010)I. 2010, 8, 22-27 著者; Fujimoto H, Hirase T, Miyazaki Y, Hara H, Ide-Iwata N, Nishimoto-Hazuku A, Saris C J M, Yoshida H and Node K
Interleukin 27 ameliorates atherosclerosis by inhibiting bone marrow-derived macrophage activation in arterial walls in mice; 2010年08月 発表情報; The 14th International Congress of Immunology (ICI 2010)I. 2010, 8, 22-27 著者; Hirase T, Hara H, Miyazaki Y, Ide-Iwata N, Nishimoto-Hazuku A, Fujimoto H, Yoshida H and Node K
Role of CARD9-mediated activation of innate immunity in anti-protozoan defense; 2010年08月 発表情報; The 14th International Congress of Immunology (ICI 2010)I. 2010, 8, 22-27 著者; Nakaya M, Hara H, Yamazaki M and Yoshida H
Cytokine regulation of inflammation in atherosclerosis; 2010年08月 発表情報; US-Japan-Asia Dialogue on Cardiovascular Diseases. 2010, 8, 21 著者; Yoshida H
Role of CARD9-mediated activation of innate immunity in anti-protozoan defense; 2010年04月 発表情報; The 10th Nagasaki-Singapore Medical Symposium 2010, 4, 15-16 著者; Yoshida H, Nakaya M, Iizasa E I and Hara H
IL-27 ABROGATES RANKL-MEDIATED OSTEOCLASTOGENESIS THROUGH STAT1- DEPENDENT INHIBITION OF C-FOS.; 2010年02月 発表情報; 9th International Conference on New Trends in Immunosuppression and Immunotherapy. 2010, 2, 4-6 著者; Yoshida H, Furukawa M and Takaishi H
Role of CARD9-mediated activation of innate immunity in anti-protozoan defense; 2010年01月 発表情報; Adaptive and innate immune responses to neglected tropical diseases conference. 2010, 1, 10-11 著者; Yoshida H
Exacerbation of delayed-type hypersensitivity responses in EBV-induced gene-3 (EBI-3)-deficient mice.; 2009年12月 発表情報; 第39回日本免疫学会学術集会 2009, 12, 2-4 著者; Miyazaki Y, Tong H, Yamasaki M, Hara H and Yoshida H
原虫感染に対するCARD9を介した自然免疫機構の解明.; 2009年12月 発表情報; 第32回日本分子生物学会学術集会 2009, 12, 9-12 著者; Nakaya M, Hara H and Yoshida H
Regulation of defense responses against protozoan infection by interleukin-27.; 2009年11月 発表情報; The 4th Nagasaki Symposium on Tropical and Emerging Infectious Diseases 2009, 11, 26-28(27) 著者; Yoshida H
IL-27 abrogates RANKL-mediated osteoclastogenesis through STAT1-dependent inhibition of c-Fos. Conference); 2009年10月 発表情報; Tri-Society annual Conference (International Society for Interferon and Cytokine Research 2009, 10, 18-21 著者; Yoshida H, Furukawa M and Takaishi H
Analyses of non-apoptotic cell death induced by growth factor withdrawal in Apaf1-deficient neural progenitor cells.; 2009年10月 発表情報; 第68回日本癌学会学術総会 2009, 10, 1-3 著者; Yoshida H
Role of CARD9-mediated activation of innate immunity in anti-protozoan defense.; 2009年09月 発表情報; The 9th Awaji International Forum on Infection and Immunity 2009, 9, 8-11 著者; Yoshida H, Nakaya M, Yamasaki M and Hara H
The roles of Interleukin 27 in the Pathogenesis of Lupus Glomerulonephritis in MRL/lpr Mice; 2009年09月 発表情報; The 4th Asian Congress on Autoimmunity 2009, 9, 11-13 著者; Miyakzaki Y, Nakashima H and Yoshida H
Interleukin 27 signaling pathways in regulation of immune and autoimmune responses.; 2009年07月 発表情報; The 5th RCAI-JSI International Symposium on Immunology 2009, 7, 9-10 著者; Yoshida H
Therapeutic potential of IL-27 for inflammatory and autoimmune diseases; 2008年 発表情報; 7th joint conference of the international cytokine society and the international society for interferon and cytokine research 著者; Miyazaki, Yoshiyuki
Nakashima, Hitoshi
Hiroki Yoshida
Role of CARD9 in anti-protozoan defense; 2008年 発表情報; The 8th Awaji International forum on Infection and Immunity 著者; Yohei Shimanoe
Hara, Hiromitsu
Yoshida, Hiroki
Tumor-specific cytotoxic T cell generation and dendritic cell function are differentially regulated by interleukin 27 during development of anti-tumor immunity; 2008年 発表情報; 第38回日本免疫学会学術集会 著者; Shinozaki, Yukari
Miyazaki, Yoshiyuki
Hara, Hiromitsu
Yoshida, Hiroki
Amelioration of Human Lupus-like Phenotypes in MRL/LPR mice by Over Expression of IL-27Ra(WSX-1); 2008年 発表情報; 6th International congress on Autoimmunity 著者; Yoshida, Hiroki
Interleukin 27 signaling pathways in regulation of immune and autoimmune responses; 2008年 発表情報; 第38回日本免疫学会学術集会 著者; Yoshida, Hiroki
Differential effects of IL-27 on cytotoxic T lymphocytes and dendritic cells during establishment of tumor immunity; 2008年 発表情報; 第67回日本癌学会学術総会 著者; 篠崎由賀里
宮崎耕二
吉田裕樹
Role of CARD9 in anti-protozoan defense; 2008年 発表情報; 第38回日本免疫学会学術集会 著者; 島ノ江洋平
宮崎義之
原博満
吉田裕樹
Interleuking-17 plays a role in successful resolution of Trypanosoma cruzi infection.; 2007年 発表情報; Immunology 2007 (The American Association of Immunologiests) 著者; Yoshida, Hiroki Wang, Sen Iwakura, Yohichiroh Miyazaki, Yoshiyuki
Interleukin-17 is required for protection against trypanosoma cruzi through induction of inflammatory responses; 2007年 発表情報; 15th Annual Meeting of the International Cytokine Society 著者; Yoshida, Hiroki Shimanoe, Yohei Wang, Sen Iwakura, Yohichiroh Miyazaki, Yoshiyuki
Interleukin 17 is necessary for host protection against acute phase Trypanosoma cruzi infection; 2007年 発表情報; The 7th Awaji International Forum on Infection and Immunity 著者; Yoshida, Hiroki Shimanoe, Yohei Wang, Sen Hamano, Shinjiro Iwakura, Yohichiroh Miyazaki, Yoshiyuki
Interleukin-17 plays a role in successful resolution of Trypanosoma cruzi infection.; 2007年 発表情報; 第76回日本寄生虫学会大会 著者; Yoshida, Hiroki Miyazaki, Yoshiyuki Shimanoe, Yohei Wang, Sen
IL-27 signaling as a target for autoimmune disease treatment; 2007年 発表情報; BITeomics (BIT)'s 著者; Yoshida, Hiroki
The role of IL-27/WSX-1 (IL-27R) in experimental allergic rhinitis; 2007年 発表情報; 13th International Congress of Mucosal Immunology 著者; Yohei Shimanoe Sen Wang Yoshiyuki Miyazaki Hiromitsu Hara Hiroki Yoshida
Double-sided roles of IL-27 in parasite infection; the initiator and the attenuator of immune reaction.; 2006年 発表情報; The 6th Awaji International forum on Infection and Immunity (Symposium) 著者; Yoshida, H
Exacervation of Allergen-induced Airway Hyperresponsiveness by Augmented Th2 responses in WSX-1-Deficient Mice; 2004年07月 発表情報; 12th International congress of Immunology. July 18-23, 2004. Workshop and poster presentation 著者; Miyazaki Y, Hamano S, Inoue H, Yoshimura A, Yoshida H
The role of WSX-1 Molecule in Acute GVHD; 2004年07月 発表情報; 12th International congress of Immunology. July 18-23, 2004. Workshop and poster presentation 著者; Nagata S,Okano S,Yoshida H,Yonemitsu Y,Maehara Y et al.
WSX-1 is required for resistance to Trypanosoma cruzi infection by regulation of Th2 responses and pro-inflammatory cytokine production.; 2003年12月 発表情報; 第33回日本免疫学会総会., 8-10 著者; Hamano S,Yoshida H,他
Hyper production of pro-inflammatory cytokines by WSX-1-deficient NKT cells in Con A-induced hepatitis.; 2003年12月 発表情報; 第33回日本免疫学会総会., 8-10 著者; Yoshida H,Yamanaka A,Hamano S,Ishii K,Takeda A,Miyazaki Y,Himeno K,Yoshimura
A, Mak TW.
WSX-1 is required for resistance to Trypanosoma cruzi infection by regulation of Th2 responses and pro-inflammatory cytokine production.; 2003年08月 発表情報; The 3rd Awaji International forum of Infection and Immunity, 25-28 著者; Hamano S,Yoshida H,他
Critical role of IL-27/WSX-1 signaling in the commitment of Th1 development.; 2003年03月 発表情報; 第一回東大医科研・生医研合同シンポジウム. 著者; 吉田裕樹
Unique Features of Entamoeba Sulfur Metabolism; Compartmentalization, Physiological Roles of Terminal Products, Evolution and Pharmaceutical Exploitation.; 2019年10月 発表情報; Int J Mol Sci. , 20, 19, 4679 著者; Mi-ichi F, Yoshida H.
Entamoeba Encystation: New Targets to Prevent the Transmission of Amebiasis; 2016年 発表情報; PLoS Pathog, 12, 10, e1005845 著者; Mi-Ichi, F., Yoshida, H., Hamano, S.
The immunobiology of interleukin-27; 2015年 発表情報; Annu Rev Immunol., 33, 417-43 著者; Yoshida, H., Hunter, C. A.
Interleukin 27: a double-edged sword for offense and defense.; 2009年 発表情報; J Leukoc Biol., 86, 1295-1303., 86, 1295-1303 著者; Yoshida H, Nakaya M and Miyazaki Y.
Regulation of immune responses by interleukin-27; 2008年 発表情報; Immunol Rev, 226, 234-247 著者; Yoshida, H.
Miyazaki, Y.
Interleukin 27 signaling pathways in regulation of immune and autoimmune responses; 2008年 発表情報; Int. J. Biochem. Cell Biol., 40, 11, 2379-2383 著者; Yoshida H, Miyazaki Y.
Novel immune evasion strategy of P. gingivalis via inhibitory receptor, Siglec; 2018年 発表情報; 6th Annual Meeting of the International Cytokine & Interferon Society (ICIS), 2018, 10, 27-30 著者; Miyake Y, Yoshida H
Interleukin 27 controls pain sensitivity in pathophysiological conditions; to immunity and beyon!; 2017年 発表情報; 5th Annual Meeting of the International Cytokine and Interferon Society, 2017,10,29-11,2 著者; Yoshida H, Sasaguri T, Ishikawa A, Murata Y, Yasaka T, Hirakawa N, Hara H
Phospholipids bind to siglec-9 and induce immunosuppressive effect against LPS stimulation; 2015年 発表情報; The 44th annual meeting of the Japanese Society for Immunology, 2015. 11. 18-20 著者; Miyake Yasunobum, Yamasaki Sho, Yoshida H