日本語フィールド
著者：Daisuke Kimura, Mana Miyakoda, Kazumi Kimura, Kiri Honma, Hiromitsu Hara, Hiroki Yoshida, Katsuyuki Yui題名：Interleukin-27-Producing CD4+ T Cells Regulate Protective Immunity
during Malaria Parasite Infection発表情報：Immunity. 巻: 44 号: 3 ページ: 672-82.キーワード：概要：Interleukin-27 (IL-27) is a heterodimeric regulatory cytokine of the IL-12 family, which is produced by macrophages, dendritic cells, and B cells upon stimulation through innate immune receptors. Here, we described regulatory CD4+ T cells that produce IL-27 in response to T cell receptor stimu- lation during malaria infection, inhibiting IL-2 pro- duction and clonal expansion of other T cells in an IL-27-dependent manner. IL-27-producing CD4+ T cells were Foxp3 CD11a+CD49d+ malaria antigen-specific CD4+ T cells and were distinct from interferon-g (IFN-g) producing Th1 or IL-10 producing Tr1 cells. In mice lacking IL-27 in T cells, IL-2 production was restored and clonal expansion and IFN-g production by specific CD4+ T cells were improved, culminating in reduced parasite burden. This study highlights a unique population of IL-27 producing regulatory CD4+ T cells and their critical role in the regulation of the protective immune response against malaria parasites.抄録：Interleukin-27 (IL-27) is a heterodimeric regulatory cytokine of the IL-12 family, which is produced by macrophages, dendritic cells, and B cells upon stimulation through innate immune receptors. Here, we described regulatory CD4+ T cells that produce IL-27 in response to T cell receptor stimu- lation during malaria infection, inhibiting IL-2 pro- duction and clonal expansion of other T cells in an IL-27-dependent manner. IL-27-producing CD4+ T cells were Foxp3 CD11a+CD49d+ malaria antigen-specific CD4+ T cells and were distinct from interferon-g (IFN-g) producing Th1 or IL-10 producing Tr1 cells. In mice lacking IL-27 in T cells, IL-2 production was restored and clonal expansion and IFN-g production by specific CD4+ T cells were improved, culminating in reduced parasite burden. This study highlights a unique population of IL-27 producing regulatory CD4+ T cells and their critical role in the regulation of the protective immune response against malaria parasites.英語フィールド
Author：Daisuke Kimura, Mana Miyakoda, Kazumi Kimura, Kiri Honma, Hiromitsu Hara, Hiroki Yoshida, Katsuyuki YuiTitle：Interleukin-27-Producing CD4+ T Cells Regulate Protective Immunity
during Malaria Parasite InfectionAnnouncement information:Immunity. Vol: 44 Issue: 3 Page: 672-82.An abstract：Interleukin-27 (IL-27) is a heterodimeric regulatory cytokine of the IL-12 family, which is produced by macrophages, dendritic cells, and B cells upon stimulation through innate immune receptors. Here, we described regulatory CD4+ T cells that produce IL-27 in response to T cell receptor stimu- lation during malaria infection, inhibiting IL-2 pro- duction and clonal expansion of other T cells in an IL-27-dependent manner. IL-27-producing CD4+ T cells were Foxp3 CD11a+CD49d+ malaria antigen-specific CD4+ T cells and were distinct from interferon-g (IFN-g) producing Th1 or IL-10 producing Tr1 cells. In mice lacking IL-27 in T cells, IL-2 production was restored and clonal expansion and IFN-g production by specific CD4+ T cells were improved, culminating in reduced parasite burden. This study highlights a unique population of IL-27 producing regulatory CD4+ T cells and their critical role in the regulation of the protective immune response against malaria parasites.An abstract：Interleukin-27 (IL-27) is a heterodimeric regulatory cytokine of the IL-12 family, which is produced by macrophages, dendritic cells, and B cells upon stimulation through innate immune receptors. Here, we described regulatory CD4+ T cells that produce IL-27 in response to T cell receptor stimu- lation during malaria infection, inhibiting IL-2 pro- duction and clonal expansion of other T cells in an IL-27-dependent manner. IL-27-producing CD4+ T cells were Foxp3 CD11a+CD49d+ malaria antigen-specific CD4+ T cells and were distinct from interferon-g (IFN-g) producing Th1 or IL-10 producing Tr1 cells. In mice lacking IL-27 in T cells, IL-2 production was restored and clonal expansion and IFN-g production by specific CD4+ T cells were improved, culminating in reduced parasite burden. This study highlights a unique population of IL-27 producing regulatory CD4+ T cells and their critical role in the regulation of the protective immune response against malaria parasites.