Detailed Information

Research Field/Keywords for Research Field

• Immunology

Education

• 1986/03, Graduated
• 1993/03, Doctor Course, Completed

Employment Experience

• 1986/05 - 1989/03
• 1993/04 - 1993/09
• 1993/10 - 2001/03 Research Associate
• 2001/04 - 2001/11 Research Associate
• 2001/12 - 2003/08 Associate Professor
• 2003/09 - 2003/09 Professor
• 2003/10 -  *  Professor, Medicine, Faculty of Medicine, Saga University
• 2008/04 - 2010/03 Analytical Research Center for Experimental Sciences, Saga University
• 2010/04 - 2012/03 Analytical Research Center for Experimental Sciences, Saga University
• 2010/04 - 2012/03 Saga University
• 2011/10 - 2014/10 Saga University
• 2012/04 - 2014/03 Analytical Research Center for Experimental Sciences, Saga University
• 2013/10 - 2014/04 Saga University
• 2014/04 - 2016/03 Analytical Research Center for Experimental Sciences, Saga University
• 2016/04 - 2018/03 Analytical Research Center for Experimental Sciences, Saga University
• 2018/04 -  *  Analytical Research Center for Experimental Sciences, Saga University

Field of Specialization

• Immunology, Parasitology (including sanitary zoology), Laboratory animal science, Cell biology

Research Topics and Results

• Unique features of Entamoeba histolytica glycerophospholipid metabolism; has the E. histolytica lipid metabolism network evolved through gene loss and gain to enable parasitic life cycle adaptation?  2023/08
• Pleiotropic Roles of Cholesteryl Sulfate during Entamoeba Encystation: Involvement in Cell Rounding and Development of Membrane Impermeability  2022/08
• Identification of leukocyte immunoglobulin-like receptor A1 (LILRA1) as a specific receptor for Aspergillus fumigatus conidia 2022
• Cholesterol 25-hydroxylase is a metabolic switch to constrain T cell-mediated inflammation in the skin 2021/10
• Entamoeba Chitinase is Required for Mature Round Cyst Formation  2021/09
• TREM2 is a receptor for non-glycosylated mycolic acids of mycobacteria that limits anti-mycobacterial macrophage activation  2021/04
• Hypericum perforatum extract and hyperforin inhibit the growth of neurotropic parasite Toxoplasma gondii and infection-induced inflammatory responses of glial cells in vitro 2021/03
• Stage-Specific De Novo Synthesis of Very-Long-Chain Dihydroceramides Confers Dormancy to Entamoeba Parasites 2021/03
• Toxoplasma Infection Induces Sustained Up-Regulation of Complement Factor B and C5a Receptor in the Mouse Brain via Microglial Activation: Implication for the Alternative Complement Pathway Activation and Anaphylatoxin Signaling in Cerebral Toxoplasmosis  2021/02
• Apoptosis is involved in maintaining the character of the midbrain and the diencephalon roof plate after neural tube closure 2020/12
• IL-27 plays an important role in anti-desmoglein 3 antibody production in pemphigus vulgaris mouse model 2020/12
• Identification of novel lipophilic ligands of siglec receptors that modulate innate immunity. 2020/11
• The dynamics of ultrastructural changes during Entamoeba invadens encystation 2020/10
• Adjuvant activity of Mycobacteria-derived mycolic acids 2020/05
• Activation and IL-10 production of specific CD4 + T cells are regulated by IL-27 during chronic infection with Plasmodium chabaudi 2020/02
• Hypericum erectum alcoholic extract inhibits Toxoplasma growth and Entamoeba encystation: an exploratory study on the anti-protozoan potential 2020/01
• Identification of lipophilic ligands of Siglec5 and -14 that modulate innate immune responses 2019/11
• Unique Features of Entamoeba Sulfur Metabolism; Compartmentalization, Physiological Roles of Terminal Products, Evolution and Pharmaceutical Exploitation. 2019/10
• Characterization of Entamoeba histolytica adenosine 5′-phosphosulfate (APS) kinase; validation as a target and provision of leads for the development of new drugs against amoebiasis. 2019/08
• Essential roles of C-type lectin Mincle in induction of neuropathic pain in mice 2019/01
• The Role of IL-27 in Pain due to Hip Osteoarthritis 2019
• A new method for dissecting the cell differentiation process of Entamoeba encystation.  2019
• Uniqueness of Entamoeba sulfur metabolism; fatty alcohol disulfates, novel sulfur metabolites, play an important role in trophozoite proliferation.  2019
• Novel immune evasion strategy of P. gingivalis via inhibitory receptor, Siglec 2019
• Interleukin-27 controls basal pain threshold in physiological and pathological conditions 2018/07
• Apaf1 plays a negative regulatory role in T cell responses by suppressing activation of antigen-stimulated T cells 2018/03
• A Flow Cytometry Method for Dissecting the Cell Differentiation Process of Entamoeba Encystation. 2018
• Interleukin-27 controls basal pain threshold in physiological and pathological conditions 2018
• Uniqueness of Entamoeba sulfur metabolism.  2018
• Apaf1 plays a negative regulatory role in T cell responses by suppressing activation of antigen-stimulated T cells 2018
• Novel immune evasion strategy of P. gingivalis via inhibitory receptor, Siglec 2018
• Immunomodulatory effects of Interleukin-27 on chronic malaria infection 2018
• Porphyromonas gingivalis negatively regulates host immune responses through inhibitory receptor, Siglec. 2018
• Immunosuppressive receptor, Siglec5 recognizes lipophilic ligands extracted from pathogenic fungus, Trichophyton mentagrophytes. 2018
• IL-17A contributes to reducing IFN-γ/IL-4 ratio and persistence of Entamoeba histolytica during intestinal amebiasis. 2017/09
• IL-35 Suppresses Lipopolysaccharide-Induced Airway Eosinophilia in EBI3-Deficient Mice 2017
• Uniqueness of Entamoeba sulfur metabolism: sulfolipid metabolism that plays pleiotropic roles in the parasitic life cycle 2017
• Pertussis toxin targets the innate immunity through DAP12, FcRgamma, and MyD88 adaptor proteins 2017
• Interleukin-27 inhibits the generation of memory CD4+ T cells during malaria infection 2017
• Entamoeba mitosomes play an important role in cell differentiation from proliferative form into dormant form (encystation) by association with cholesteryl sulfate synthesis. 2017
• Pathogenic fungus, Trichopyton mentagrophytes, negatively regulates host immune responses via Siglec receptors 2017
• Interleukin 27 controls pain sensitivity in pathophysiological conditions; to immunity and beyon! 2017
• Role of Il-35 in Lipopolysaccharide-induced airway eosinophilia 2017
• Interleukin-27-dependent loss of Cd4+ T cell-memory during malaria infection 2017
• Immunosuppressive receptor, Siglec binds to pathogenic fungus, Trichophyton mentagrophytes, and negatively regulates host immune responses 2017
• Apaf1 plays a negative regulatory role in T cell responses by suppressing activation of antigen-stimulated T cells 2017
• Regulation of Immune Responses by IL-27-producing CD4+ T cells Induced during Marlaria Infection 2016/10
• Possible contribution of the C-type lectin receptor, Mincle, to induction of neuropathic pain after peripheral nerve injury in mice 2016/09
• Interleukin-27-Producing CD4+ T Cells Regulate Protective Immunity during Malaria Parasite Infection 2016/03
• Promotion of Expansion and Differentiation of Hematopoietic Stem Cells by Interleukin-27 into Myeloid Progenitors to Control Infection in Emergency Myelopoiesis 2016
• Entamoeba Encystation: New Targets to Prevent the Transmission of Amebiasis 2016
• The potential for repositioning antithyroid agents as antiasthma drugs 2016
• Regulation of innate immunity through ITAM-coupled reeptors ininfluenza virus infection 2016
• Interleukin-27 inhibits the generation of memory CD4+ T cells against malaria infection 2016
• Entamoeba mitosomes play an important role in encystation by association with cholesteryl sulfate synthesis 2015/05
• Loss of CARD9-mediated innate activation attenuates severe influenza pneumonia without compromising host viral immunity 2015
• Evidence that the Entamoeba histolytica Mitochondrial Carrier Family Links Mitosomal and Cytosolic Pathways through Exchange of 3'-Phosphoadenosine 5'-Phosphosulfate and ATP. 2015
• Evidence for TLR4 and FcRγ-CARD9 activation by cholera toxin B subunit and its direct bindings to TREM2 and LMIR5 receptors 2015
• Clustering of CARMA1 through SH3-GUK domain interactions is required for its activation of NF-κB signaling 2015
• The immunobiology of interleukin-27 2015
• C-type lectin receptor MCL stabilizes Mincle through complex formation for enhancement of inflammatory cytokine production upon mycobacterial infection 2015
• Phospholipids bind to siglec-9 and induce immunosuppressive effect against LPS stimulation. 2015
• Phospholipids bind to siglec-9 and induce immunosuppressive effect against LPS stimulation 2015
• IL-27-producing CD4+ T cells induced during malaria infection are distinct from Tr1 cells. 2015
• An ITAM-Syk-CARD9 signalling axis triggers contact hypersensitivity by stimulating IL-1 production in dendritic cells. 2014/10
• EBI3 is pivotal for the initiation of experimental autoimmune uveitis. 2014/09
• IL-27 affects helper T cell responses via regulation of PGE2 production by macrophages. 2014/08
• An ITAM-Syk-CARD9 signalling axis triggers contact hypersensitivity by stimulating IL-1 production in dendritic cells 2014/05
• Mycobacterium tuberculosis-derived mycolic acid shows an adjuvant activity by activation of the ITAM receptor/CARD9-mediated innate immunity. 2014
• Activation of innate immunity mediated by the IgSFR2/CARD9 pathway is involved in severe influenza pneumonia 2014
• Innate recognition of mycolic acid-containing lipids in mycobacteria. 2014
• IL-27-producing malaria-specific CD4+ T cells regulate protective immune responses. 2014
• Role of cholesteryl sulfate of Entamoeba 2014
• Interleukin 27 inhibits atherosclerosis via immunoregulation of macrophages in mice. 2013
• Egr-2 transcription factor is required for Blimp-1 mediated IL-10 production in IL-27 stimulated CD4(+) T cells. 2013
• Local Apoptosis Modulates Early Mammalian Brain Development through the Elimination of Morphogen-Producing Cells. 2013
• Interleukin 27 inhibits hepatic steatosis induced by high fat diet in mice. 2013
• IL-27 affects helper T cell responses via regulation of PGE2 production by macrophages. 2013
• Identification of novel innate pattern recoginition receptors for mycobacterium tuberculosis. 2013
• Essential role of ITAM-Syk-IL-1 axis in skin dendritic cells for the sensitization of allergic contact dermatitis. 2013
• IL-27 affects helper T cell response via regulation of PGE2 production by macrophages. 2013
• Interleukin 27 inhibits atherosclerosis via immunoregulation of macrophages in mice. 2013
• Activation of innate immunity through the CARD9 pathway is involved in severe influenza pneumonia. 2013
• IL-1 released by skn dendritic cells activated through Syk and CARD9 pathway is essential for the sensitization of allergic contact dermatitis. 2013
• IL-27 afects helper t cell response via reguation of PGE2 production by macrophages. 2013
• Identification and analysis of two novel pattern recoginition receptors for Mycobacterium tuberculosis. 2013
• Exacervation of delayed-type hypersensitivity responses in mice with T cell-specific deletion of Apaf1. 2013
• Adjuvant activity of Mycobacterium tubeculosis-derived mycolic acid through activation of the ITAM receptor/CARD9-mediated innate immunity. 2013
• Il-27 is produced by CD4+ T cells during infection with malaria parasites and inhibits protective immune responses. 2013
• Identification of an ITAM-coupled pattern recognition receptor that recognizes the mycobacterial cell wall compontent mycolic acids. 2013
• Analysis for the role of Syk-CARD9-regulated IL-1 secretion pathway in DCs in contact hypersensitivity by the mixed-chimera diphtheria toxin receptor (DTR)-mediated conditional cell knockout (MixC-Treck) method, a novel method for conditional gene targeting in mice. 2013
• IL-27 inhibits pathophysiological intraocular neovascularization due to laser burn. 2012
• Activation of innate immunity through ITAM-receptor and Syk-CARD9-Bcl10 signaling pathway is critically involved in control of Leishmania major Infection 2012
• Activation of the Syk-CARD9-Bcl10-mediated novel innate immune system is critically involved in defense against Leishmania major Infection. 2012
• Interleukin 27 Ameriolates Atherosclerosis by Inhibiting Bone Marrow-Derived Macrophage Activation in Arterial Walls in Mice. 2012
• Contact allergy to chemical sensitizers requires innate immune activation by coupling of the ITAM-Syk-CARD9 pathway and NLRP3 inflammasome. 2012
• Innate immune activation through ITAM-Syk-CARD9 signaling coupling to inflammasome is essential for the development of allergy to organic chemical allergens. 2012
• Role of Card9-mediated signaling in contact hypersensitivity. 2012
• Innate immune activation through ITAM-Syk-CARD9 signaling coupling to NLRP3 inflammasome is esseintial for the development of allergy to contact sensitizers. 2012
• Activation of innate immunity through the CARD9 pathway is involved in severe influenza pneumonia. 2012
• IL-27 affects immune responses via rgulation of prostagrandin E2 production by macrophages. 2012
• CD4 T cells produce EBI-3+ cytokine inhibiting their own protective immune responses during infection with malaria parasites. 2012
• A novel IL-27 signaling pathway mediated by Egr-2 regulates IL-10 production in naive T cells. 2012
• Identification and funcitional analysis of novel mycobacerium receptors. 2012
• Essential role for intra- and intermolecular SH3-GUK interactions of CARMA1 in antigen receptor-induced NF-kB and JNK activation. 2012
• MGL1-dependent IL-10 induction in colonic macrophages by commensal bacteria is mediated by the Syk-CARD9 pathway. 2012
• Activation of innate immunity through Syk-CARD9-Bcl10 signaling pathway is involved in control of Leishmania major infection. 2012
• Sulfate activation in mitosomes plays an important role in Entamoeba histolytica 2012
• Role of CARD9-mediated activation of innate immunity in anti-protozoan defense 2010/09
• Interleukin 27 Inhibits Hyperglycemia and Pancreatic Islet Inflammation Induced by Streptozotocin in Mice. 2010/08
• Interleukin 27 ameliorates atherosclerosis by inhibiting bone marrow-derived macrophage activation in arterial walls in mice 2010/08
• Role of CARD9-mediated activation of innate immunity in anti-protozoan defense 2010/08
• Cytokine regulation of inflammation in atherosclerosis 2010/08
• Role of CARD9-mediated activation of innate immunity in anti-protozoan defense 2010/04
• IL-27 ABROGATES RANKL-MEDIATED OSTEOCLASTOGENESIS THROUGH STAT1- DEPENDENT INHIBITION OF C-FOS. 2010/02
• Role of CARD9-mediated activation of innate immunity in anti-protozoan defense 2010/01
• Exacerbation of delayed-type hypersensitivity responses in EBV-induced gene-3 (EBI-3)-deficient mice 2010
• Maturation of the olfactory sensory neurons by Apaf-1/caspase-9-mediated caspase activity 2010
• IL-17 is necessary for host protection against acute-phase Trypanosoma cruzi infection 2010
• Apaf-1-independent programmed cell death in mouse development 2010
• L-CBM signaling in lymphocyte development and function 2010
• Aberrant IL-4 production by SOCS3-over-expressing T cells during infection with Leishmania major exacerbates disease manifestations 2010
• Tumor-specific cytotoxic T cell generation and dendritic cell function are differentially regulated by interleukin 27 during development of anti-tumor immunity 2008/06
• Cell Type-Specific Regulation of ITAM-Mediated NF-{kappa}B Activation by the Adaptors, CARMA1 and CARD9 2008/01
• Interleukin 27 signaling pathways in regulation of immune and autoimmune responses 2008
• Amelioration of delayed-type hypersensitivity responses by IL-27 administration 2008
• Regulation of immune responses by interleukin-27 2008
• Augmentation of Antigen-Presenting and Th1-Promoting Functions of Dendritic Cells by WSX-1(IL-27R) Deficiency 2007
• Differential roles for IFN-gamma and IL-17 in experimental autoimmune uveoretinitis 2007
• Amelioration of human lupus-like phenotypes in MRL/lpr mice by overexpression of IL-27R{alpha} (WSX-1) 2007
• Incudomalleal joint formation: the roles of apoptosis, migration and downregulation 2007
• Interleuking-17 plays a role in successful resolution of Trypanosoma cruzi infection. 2007
• Interleukin-17 plays a role in successful resolution of Trypanosoma cruzi infection. 2007
• IL-27 signaling as a target for autoimmune disease treatment 2007
• The role of IL-27/WSX-1 (IL-27R) in experimental allergic rhinitis 2007
• Exacerbation of Experimental Allergic Asthma by Augmented Th2 Responses in WSX-1-Deficient Mice 2005
• Membranous Glomerulonephritis Development with Th2-Type Immune Deviations in MRL/lpr Mice Deficient for IL-27 Receptor (WSX-1) 2005
• WSX-1 is required for resistance to Trypanosoma cruzi infection by regulation of Th2 responses and pro-inflammatory cytokine production. 2003/12
• Hyper production of pro-inflammatory cytokines by WSX-1-deficient NKT cells in Con A-induced hepatitis. 2003/12
• WSX-1 is required for resistance to Trypanosoma cruzi infection by regulation of Th2 responses and pro-inflammatory cytokine production. 2003/08
• Critical role of IL-27/WSX-1 signaling in the commitment of Th1 development． 2003/03
• Cutting Edge Role of IL-27/WSX-1 Signaling for Induction of T-Bet Through Activation of STATI During Initia1 Th1 Commitment. 2003
• WSX-1 Is Required for Resistance to Trypanosoma cruzi Infection by Regulation of Proinflammatory Cytokine Production. 2003

Books

• Interleukin 27 signaling pathways in regulation of immune and autoimmune responses;　2008
  ANNOUNCEMENT INFO.;　Int J Biochem Cell Biol, 40, 11, 2379-2383
  AUTHOR;　Yoshida, H. Miyazaki, Y.
  
• Regulation of defense responses against protozoan infection by interleukin-27 and related cytokines.;　2007
  ANNOUNCEMENT INFO.;　J Biomed Biotech. on line
  AUTHOR;　Yoshida, H., S. Hamano, S. Wang, and Y. Miyazaki.
  
• Yin and Yang of IL-27 in immune regulation during parasitic infection.;　2007
  ANNOUNCEMENT INFO.;　Curt Trends Microbiol. in press
  AUTHOR;　Yoshida, H., S. Wang, and Y. Miyazaki.
  
• The Double Identity of WSX-1 (Il-27R) as an Initiator and Attenuator of Immune Responses;　2005
  ANNOUNCEMENT INFO.;　Current Immunology Reviews
  AUTHOR;　Yoshida，H.,Hamano，S., and Miyazaki Y.
  
• The role of WSX-1(IL-27R) as an initiator and attenuator of immune responses and innammation.;　2004
  ANNOUNCEMENT INFO.;　Recent Res. Devel. Immunology(Research Signpost.), 123-134
  AUTHOR;　Yoshida H,Hamano S,Miyazaki Y.
  
• Double identity of WSX-1 (IL-27R) as an initiator and attenuator of immune responses:Regulation by WSX-1 of pro-inflammatory cytokine produdion in the liver.;　2004
  ANNOUNCEMENT INFO.;　Mucosal Immunology Update, 12, 7-9
  AUTHOR;　Yoshida，H.,Hamano，S., and Miyazaki Y.
  
• The role of apaf-1 in programmed cell death from worm to tumor.;　2003
  ANNOUNCEMENT INFO.;　Cell Struct. Funct., 28, 3-9
  AUTHOR;　Yoshida H
  

Original Articles

• Unique features of Entamoeba histolytica glycerophospholipid metabolism; has the E. histolytica lipid metabolism network evolved through gene loss and gain to enable parasitic life cycle adaptation? ;　2023/08
  ANNOUNCEMENT INFO.;　mSphere, e0017423
  AUTHOR;　Mi-Ichi F, Tsugawa H, Yoshida H, Arita M
  
• Pleiotropic Roles of Cholesteryl Sulfate during Entamoeba Encystation: Involvement in Cell Rounding and Development of Membrane Impermeability ;　2022/08
  ANNOUNCEMENT INFO.;　mSphere, 7, 4, e0029922
  AUTHOR;　Fumika Mi-Ichi, Hiroshi Tsugawa, Makoto Arita, Hiroki Yoshida
  
• Cholesterol 25-hydroxylase is a metabolic switch to constrain T cell-mediated inflammation in the skin;　2021/10
  ANNOUNCEMENT INFO.;　Sci Immunol, 6, 64, eabb6444
  AUTHOR;　*H Takahashi, H Nomura, H Iriki, A Kubo, K Isami, Y Mikami, M Mukai, T Sasaki, J Yamagami, J Kudoh, H Ito, A Kamata, Y Kurebayashi, H Yoshida, A Yoshimura, H W Sun, M Suematsu, J J O'Shea, Y Kanno, M Amagai
  
• Entamoeba Chitinase is Required for Mature Round Cyst Formation ;　2021/09
  ANNOUNCEMENT INFO.;　Microbiol Spectr, 9, 1, e0051121
  AUTHOR;　Fumika Mi-Ichi, Miako Sakaguchi, Shinjiro Hamano, Hiroki Yoshida
  
• TREM2 is a receptor for non-glycosylated mycolic acids of mycobacteria that limits anti-mycobacterial macrophage activation ;　2021/04
  ANNOUNCEMENT INFO.;　Nat Commun, 12, 1, 2299
  AUTHOR;　*Ei'ichi Iizasa, Yasushi Chuma, Takayuki Uematsu, Mio Kubota, Hiroaki Kawaguchi, Masayuki Umemura, Kenji Toyonaga, Hideyasu Kiyohara, Ikuya Yano, Marco Colonna, Masahiko Sugita, Goro Matsuzaki, Sho Yamasaki, Hiroki Yoshida, Hiromitsu Hara
  
• Hypericum perforatum extract and hyperforin inhibit the growth of neurotropic parasite Toxoplasma gondii and infection-induced inflammatory responses of glial cells in vitro;　2021/03
  ANNOUNCEMENT INFO.;　J Ethnopharmacol, 267, 113525
  AUTHOR;　*Noriko Shinjyo, Hideyuki Nakayama, Li Li, Kanji Ishimaru, Kenji Hikosaka, Noriyuki Suzuki, Hiroki Yoshida, Kazumi Norose
  
• Stage-Specific De Novo Synthesis of Very-Long-Chain Dihydroceramides Confers Dormancy to Entamoeba Parasites;　2021/03
  ANNOUNCEMENT INFO.;　mSphere, 6, 2, e00174-21
  AUTHOR;　Fumika Mi-Ichi, Kazutaka Ikeda, Hiroshi Tsugawa, Sharmina Deloer, Hiroki Yoshida, Makoto Arita
  
• Toxoplasma Infection Induces Sustained Up-Regulation of Complement Factor B and C5a Receptor in the Mouse Brain via Microglial Activation: Implication for the Alternative Complement Pathway Activation and Anaphylatoxin Signaling in Cerebral Toxoplasmosis ;　2021/02
  ANNOUNCEMENT INFO.;　Front Immunol, 11, 603924
  AUTHOR;　*Noriko Shinjyo, Kenji Hikosaka, Yasutoshi Kido, Hiroki Yoshida, Kazumi Norose
  
• Apoptosis is involved in maintaining the character of the midbrain and the diencephalon roof plate after neural tube closure;　2020/12
  ANNOUNCEMENT INFO.;　Dev Biol, 468, 1-2, 101-109
  AUTHOR;　*Yudai Matsumoto, Yoshifumi Yamaguchi, Misato Hamachi, Keiko Nonomura, Yukiko Muramatsu, Hiroki Yoshida, Masayuki Miura
  
• The dynamics of ultrastructural changes during Entamoeba invadens encystation;　2020/10
  ANNOUNCEMENT INFO.;　Parasitology, 147, 12, 1305-1312
  AUTHOR;　*Eman Abdelazeem Abuelwafa Mousa, Miako Sakaguchi, Risa Nakamura, Osama Hussein Abdella, Hiroki Yoshida, Shinjiro Hamano, Fumika Mi-Ichi
  
• Adjuvant activity of Mycobacteria-derived mycolic acids;　2020/05
  ANNOUNCEMENT INFO.;　Heliyon, 6, 5, e04064
  AUTHOR;　*Kubota, Mio; Iizasa, Ei'ichi; Chuuma, Yasushi; Kiyohara, Hideyasu; Hara, Hiromitsu; Yoshida, Hiroki
  
• Activation and IL-10 production of specific CD4 + T cells are regulated by IL-27 during chronic infection with Plasmodium chabaudi;　2020/02
  ANNOUNCEMENT INFO.;　Parasitol Int, 74, 101994
  AUTHOR;　*Odsuren Sukhbaatar, Daisuke Kimura, Mana Miyakoda, Sayuri Nakamae, Kazumi Kimura , Hiromitsu Hara, Hiroki Yoshida, Shin-Ichi Inoue, Katsuyuki Yui
  
• Hypericum erectum alcoholic extract inhibits Toxoplasma growth and Entamoeba encystation: an exploratory study on the anti-protozoan potential;　2020/01
  ANNOUNCEMENT INFO.;　J Nat Med, 74, 1, 294 - 305
  AUTHOR;　*Shinjyo, Noriko; Nakayama, Hideyuki; Ishimaru, Kanji; Hikosaka, Kenji; Mi-ichi, Fumika; Norose, Kazumi; Yoshida, Hiroki
  
• Identification of lipophilic ligands of Siglec5 and -14 that modulate innate immune responses;　2019/11
  ANNOUNCEMENT INFO.;　J Biol Chem. , 294, 45, 16776-16788
  AUTHOR;　Suematsu R, Miyamoto T, Saijo S, Yamasaki S, Tada Y, Yoshida H, Miyake Y
  
• Characterization of Entamoeba histolytica adenosine 5′-phosphosulfate (APS) kinase; validation as a target and provision of leads for the development of new drugs against amoebiasis.;　2019/08
  ANNOUNCEMENT INFO.;　PLoS Negl Trop Dis. , 13, 8, e0007633
  AUTHOR;　Mi-ichi F, Ishikawa T, Tam VK, Deloer S, Hamano S, Hamada T, and Yoshida H.
  
• Essential roles of C-type lectin Mincle in induction of neuropathic pain in mice;　2019/01
  ANNOUNCEMENT INFO.;　Sci Rep. , 9, 1, 872
  AUTHOR;　Ishikawa A, Miyake Y, Kobayashi K, Murata Y, Iizasa S, Iizasa E, Yamasaki S, Hirakawa N, Hara H Yoshida H, Yasaka T
  
• A flow cytometry method for dissecting the cell differentiation process of Entamoeba encystation;　2018/07
  ANNOUNCEMENT INFO.;　Frontiers
  AUTHOR;　Fumika Mi-Ichi Yasunobu Miyake Tam Kha Vo Hiroki Yoshida
  
• Interleukin-27 controls basal pain threshold in physiological and pathological conditions;　2018/07
  ANNOUNCEMENT INFO.;　Sci Rep, 8, Article number: 11022 (2018)
  AUTHOR;　Tomoko Sasaguri Toru Taguchi Yuzo Murata Kimiko Kobayashi Sayaka Iizasa Ei’ichi Iizasa Makoto Tsuda Naomi Hirakawa Hiromitsu Hara Hiroki Yoshida Toshiharu Yasaka
  
• Murine gamma-Herpesvirus 68 Induces Severe Lung Inflammation in IL-27-Deficient Mice with Liver Dysfunction Preventable by Oral Neomycin;　2018/04
  ANNOUNCEMENT INFO.;　J Immunol, 200, 8, 2703-2713
  AUTHOR;　Kanai, K. Park, A. M. Watanabe, A. Arikawa, T. Yasui, T. Yoshida, H. Tsunoda, I. Yoshie, O.
  
• Apaf1 plays a negative regulatory role in T cell responses by suppressing activation of antigen-stimulated T cells;　2018/03
  ANNOUNCEMENT INFO.;　PLOS ONE
  AUTHOR;　Tong, Honglian Miyake, Yasunobu Mi-ichi, Fumika Iwakura, Yoichiro Hara, Hiromitsu Yoshida, Hiroki
  
• A Flow Cytometry Method for Dissecting the Cell Differentiation Process of Entamoeba Encystation.;　2018
  ANNOUNCEMENT INFO.;　Front. Cell. Infect. Microbiol. , 8, 250
  AUTHOR;　Mi-Ichi F, Miyake Y, Tam VK, Yoshida H
  
• Interleukin-27 controls basal pain threshold in physiological and pathological conditions;　2018
  ANNOUNCEMENT INFO.;　Sci Rep., 8, 1, 11022
  AUTHOR;　○ Sasaguri T, Taguchi T, Murata Y, Kobayashi K, Iizasa S, Iizasa E, Tsuda M, Hirakawa N, Hara H, Yoshida H, Yasaka, T.
  
• IL-17A contributes to reducing IFN-γ/IL-4 ratio and persistence of Entamoeba histolytica during intestinal amebiasis.;　2017/09
  ANNOUNCEMENT INFO.;　Parasitol Int., 66, 6, 817-823
  AUTHOR;　*Deloer S, Nakamura R, Kikuchi M, Moriyasu T, Kalenda Y D J, Mohammed E S, Senba M, Iwakura Y, Yoshida H, Hamano S
  
• IL-35 Suppresses Lipopolysaccharide-Induced Airway Eosinophilia in EBI3-Deficient Mice;　2017
  ANNOUNCEMENT INFO.;　J Immunol., 198, 1, 119-127
  AUTHOR;　*Kanai K, Park AM, Yoshida H, Tsunoda I, Yoshie O
  
• Uniqueness of Entamoeba sulfur metabolism: sulfolipid metabolism that plays pleiotropic roles in the parasitic life cycle;　2017
  ANNOUNCEMENT INFO.;　Mol Microbiol. , 106, 3, 479-491
  AUTHOR;　Mi-Ichi F, Miyamoto T, Yoshida H
  
• Pertussis toxin targets the innate immunity through DAP12, FcRgamma, and MyD88 adaptor proteins;　2017
  ANNOUNCEMENT INFO.;　Immunobiology. , 222, 4, 664-671
  AUTHOR;　*Phongsisay V, Iizasa E, Hara H, Yoshida H
  
• Interleukin-27-Producing CD4+ T Cells Regulate Protective Immunity during Malaria Parasite Infection;　2016/03
  ANNOUNCEMENT INFO.;　Immunity., 44, 3, 672-82.
  AUTHOR;　Daisuke Kimura, Mana Miyakoda, Kazumi Kimura, Kiri Honma, Hiromitsu Hara, Hiroki Yoshida, Katsuyuki Yui
  
• Promotion of Expansion and Differentiation of Hematopoietic Stem Cells by Interleukin-27 into Myeloid Progenitors to Control Infection in Emergency Myelopoiesis;　2016
  ANNOUNCEMENT INFO.;　PLoS Pathog, 12, 3, e1005507
  AUTHOR;　* Furusawa J, Mizoguchi I, Chiba Y, Hisada M, Kobayashi F, Yoshida H, Nakae S,Tsuchida A, Matsumoto T, Ema H, Mizuguchi J, Yoshimoto T.
  
• The potential for repositioning antithyroid agents as antiasthma drugs;　2016
  ANNOUNCEMENT INFO.;　J Allergy Clin Immunol, 138, 5, 1458-1461.e8
  AUTHOR;　○ Suzuki S, Ogawa M, Ohta S, Arima K, Nunomura S, Nanri Y, Mitamura Y, Yoshihara T, Nakamura Y, Yamauchi K, Chibana K, Ishii Y, Lee JJ, Aratani Y, Kakuta S, Kubo S, Iwakura Y, Yoshida H, Izuhara K.
  
• Entamoeba mitosomes play an important role in encystation by association with cholesteryl sulfate synthesis;　2015/05
  ANNOUNCEMENT INFO.;　Proc Natl Acad Sci U S A., 112, 22, E2884-E2890
  AUTHOR;　Fumika Mi-ichia, Tomofumi Miyamoto, Shouko Takaoa, Ghulam Jeelani, Tetsuo Hashimoto, Hiromitsu Hara, Tomoyoshi Nozaki, and Hiroki Yoshida
  
• Loss of CARD9-mediated innate activation attenuates severe influenza pneumonia without compromising host viral immunity;　2015
  ANNOUNCEMENT INFO.;　Sci Rep. 5:17577
  AUTHOR;　Uematsu. T., Iizasa. E., Kobayashi. N., Yoshida. H., Hara. H.
  
• Evidence that the Entamoeba histolytica Mitochondrial Carrier Family Links Mitosomal and Cytosolic Pathways through Exchange of 3'-Phosphoadenosine 5'-Phosphosulfate and ATP.;　2015
  ANNOUNCEMENT INFO.;　Eukaryot Cell., 14, 11, 1144-50
  AUTHOR;　Mi-Ichi F, Nozawa A, Yoshida H, Tozawa Y, Nozaki T.
  
• Evidence for TLR4 and FcRγ-CARD9 activation by cholera toxin B subunit and its direct bindings to TREM2 and LMIR5 receptors;　2015
  ANNOUNCEMENT INFO.;　Mol Immunol., 66, 2, 463-71
  AUTHOR;　*Phongsisay V, Iizasa E, Hara H, Yoshida H
  
• Clustering of CARMA1 through SH3-GUK domain interactions is required for its activation of NF-κB signaling;　2015
  ANNOUNCEMENT INFO.;　Nat Commun., 6, 5555
  AUTHOR;　*Hara H, Yokosuka T, Hirakawa H, Ishihara C, Yasukawa S, Yamazaki M, Koseki H, Yoshida H, and Saito T
  
• An ITAM-Syk-CARD9 signalling axis triggers contact hypersensitivity by stimulating IL-1 production in dendritic cells.;　2014/10
  ANNOUNCEMENT INFO.;　Nat. Commun. 5:3755 doi: 10.1038/ncomms4755.
  AUTHOR;　Yasukawa S, Miyazaki Y, Yoshii C, Nakaya M, Ozaki N, Toda S, Kuroda E, Ishibashi K, Yasuda T, Natsuaki Y, Mi-ichi F, Iizasa E, Nakahara T, Yamazaki M, Kabashima K, Iwakura Y, Takai T, Saito T, Kurosaki T, Malissen B, Ohno N, Furue M, Yoshida H, Hara H.
  
• EBI3 is pivotal for the initiation of experimental autoimmune uveitis.;　2014/09
  ANNOUNCEMENT INFO.;　Exp. Eye Res. doi: 10.1016/j.exer.2014.06.004., 125, 107-13
  AUTHOR;　*Takeda A, Hasegawa E, Fukuhara T, Hirakawa S, Yamada H, Yang Y, Yoshimura T, Hisatomi T, Oshima Y, Yoshida H, Sonoda KH, Ishibashi T.
  
• IL-27 affects helper T cell responses via regulation of PGE2 production by macrophages.;　2014/08
  ANNOUNCEMENT INFO.;　Biochem. Biophys. Res. Commun., 451, 2, 215-21
  AUTHOR;　Sato Y, Hara H, Okuno T, Ozaki N, Suzuki S, Yokomizo T, Kaisho T, Yoshida H
  
• An ITAM-Syk-CARD9 signalling axis triggers contact hypersensitivity by stimulating IL-1 production in dendritic cells;　2014/05
  ANNOUNCEMENT INFO.;　Nature Communications, 5
  AUTHOR;　Shinsuke Yasukawa Yoshiyuki Miyazaki Chika Yoshii Mako Nakaya Naoko Ozaki Shuji Toda Etsushi Kuroda Ken-ichi Ishibashi Tomoharu Yasuda Yohei Natsuaki Fumika Mi-ichi Ei’ichi Iizasa Takeshi Nakahara Masanori Yamazaki Kenji Kabashima Yoichiro Iwakura Toshiyuki Takai Takashi Saito Tomohiro Kurosaki Bernard Malissen Naohito Ohno Masutaka Furue Hiroki Yoshida Hiromitsu Hara
  
• Local Apoptosis Modulates Early Mammalian Brain Development through the Elimination of Morphogen-Producing Cells;　2013/12
  ANNOUNCEMENT INFO.;　Developmental Cell, 27, 6, 621-634
  AUTHOR;　Keiko Nonomura, Yoshifumi Yamaguchi, Misato Hamachi, Masato Koike, Yasuo Uchiyama, Kenichi Nakazato, Atsushi Mochizuki, Asako Sakaue-Sawano, Atsushi Miyawaki, Hiroki Yoshida, Keisuke Kuida, Masayuki Miura
  
• Egr-2 transcription factor is required for Blimp-1 mediated IL-10 production in IL-27 stimulated CD4+ T cells;　2013/01
  ANNOUNCEMENT INFO.;　European Journal of Immunology DOI: 10.1002/eji.201242942
  AUTHOR;　Yukiko Iwasaki Keishi Fujio Tomohisa Okamura Atsushi Yanai Shuji Sumitomo Hirofumi Shoda Tomohiko Tamura Hiroki Yoshida Patrick Charnay Kazuhiko Yamamoto
  
• Interleukin 27 inhibits atherosclerosis via immunoregulation of macrophages in mice.;　2013
  ANNOUNCEMENT INFO.;　Am. J. Physiol. Heart Circ. Physiol., 305, 3, H420-H429
  AUTHOR;　*Hirase T, Hara H, Miyazaki Y, Ide N, Nishimoto-Hazuku A, Fujimoto H, Saris CJM, Yoshida H, Node K
  
• Egr-2 transcription factor is required for Blimp-1 mediated IL-10 production in IL-27 stimulated CD4(+) T cells.;　2013
  ANNOUNCEMENT INFO.;　Eur J Immunol, 43, 4, 1063-1073
  AUTHOR;　*Iwasaki Y., Fujio K, Okamura T, Yanai A, Sumitomo S, Shoda H, Tamura T, Yoshida H, Charnay P, Yamamoto K
  
• Local Apoptosis Modulates Early Mammalian Brain Development through the Elimination of Morphogen-Producing Cells.;　2013
  ANNOUNCEMENT INFO.;　Developmental cell, 27, 6, 621-634
  AUTHOR;　*Nonomura K, Yamaguchi Y, Hamachi M, Koike M, Uchiyama Y, Nakazato K, Mochizuki A, Sakaue-Sawano A, Miyawaki A, Yoshida H, Kuida K, Miura M
  
• Syk-dependent signaling pathways in neutrophils and macrophages are indispensable in the pathogenesis of anti-collagen antibody-induced arthritis;　2012/08
  ANNOUNCEMENT INFO.;　International Immunology, 24, 9, 539-550
  AUTHOR;　Naoko Ozaki, Shinobu Suzuki, Masato Ishida, Yasuyo Harada, Kohji Tanaka, Yayoi Sato, Takeshi Kono, Masato Kubo, Daisuke Kitamura, Jeffrey Encinas, Hiromitsu Hara and Hiroki Yoshida
  
• Probiotic Bifidobacterium breve Induces IL-10-Producing Tr1 Cells in the Colon;　2012/05
  ANNOUNCEMENT INFO.;　PLoS Pathog 8(5): e1002714. doi:10.1371/journal.ppat.1002714, 8, 5
  AUTHOR;　Seong Gyu Jeon, Hisako Kayama, Yoshiyasu Ueda, Takuya Takahashi, Takashi Asahara, Hirokazu Tsuji, Noriko M. Tsuji, Hiroshi Kiyono, Ji Su Ma, Takashi Kusu, Ryu Okumura, Hiromitsu Hara, Hiroki Yoshida, Masahiro Yamamoto, Koji Nomoto, Kiyoshi Takeda
  
• IL-27 inhibits pathophysiological intraocular neovascularization due to laser burn.;　2012
  ANNOUNCEMENT INFO.;　J Leukoc Biol., 91, 2, 267-273
  AUTHOR;　Hasegawa E, Oshima Y, Takeda A, Saeki K, Yoshida H, Sonoda KH, Ishibashi T
  
• IL-27 inhibits pathophysiological intraocular neovascularization due to laser burn;　2011/11
  ANNOUNCEMENT INFO.;　Epub ahead of print 2011 Nov　(J Leukoc Biol 91(2):267-273)
  AUTHOR;　Eiichi Hasegawa Yuji Oshima Atsunobu Takeda Kazuko Saeki Hiroki Yoshida Koh-Hei Sonoda Tatsuro Ishibashi
  
• IL-27 inhibits hyperglycemia and pancreatic islet inflammation induced by streptozotocin in mice;　2011/10
  ANNOUNCEMENT INFO.;　Am J Pathol, 179, 5, 2327-2336
  AUTHOR;　Fujimoto, H. Hirase, T. Miyazaki, Y. Hara, H. Ide-Iwata, N. Nishimoto-Hazuku, A. Saris, C. J. Yoshida, H. Node, K.
  
• The transcription factor FBI-1/OCZF/LRF is expressed in osteoclasts and regulates RANKL-induced osteoclast formation in vitro and in vivo;　2011/09
  ANNOUNCEMENT INFO.;　Arthritis Rheum, 63, 9, 2744-2754
  AUTHOR;　Kukita, A. Kukita, T. Nagata, K. Teramachi, J. Li, Y. J. Yoshida, H. Miyamoto, H. Gay, S. Pessler, F. Shobuike, T.
  
• T cell-specific overexpression of interleukin-27 receptor alpha-subunit (WSX-1) prevents spontaneous skin inflammation in MRL/lpr mice;　2011
  ANNOUNCEMENT INFO.;　Br J Dermatol　, 164, 6, 1214-1220
  AUTHOR;　Kido, Makiko Takeuchi, Satoshi Sugiyama, Naonobu Esaki, Hitokazu Nakashima, Hitoshi Yoshida, Hiroki Furue, Masutaka
  
• Exacerbation of delayed-type hypersensitivity responses in EBV-induced gene-3 (EBI-3)-deficient mice;　2010
  ANNOUNCEMENT INFO.;　Immunol Lett, 128, 2, 108-115
  AUTHOR;　Tong, H. Miyazaki, Y. Yamazaki, M. Hara, H. Waldmann, H. Hori, S. Yoshida, H.
  
• Maturation of the olfactory sensory neurons by Apaf-1/caspase-9-mediated caspase activity;　2010
  ANNOUNCEMENT INFO.;　Proc Natl Acad Sci U S A, 107, 30, 13366-13371
  AUTHOR;　Ohsawa, S. Hamada, S. Kuida, K. Yoshida, H. Igaki, T. Miura, M.
  
• IL-17 is necessary for host protection against acute-phase Trypanosoma cruzi infection;　2010
  ANNOUNCEMENT INFO.;　J Immunol, 185, 2, 1150-1157
  AUTHOR;　Miyazaki, Y. Hamano, S. Wang, S. Shimanoe, Y. Iwakura, Y. Yoshida, H.
  
• Apaf-1-independent programmed cell death in mouse development;　2010
  ANNOUNCEMENT INFO.;　Cell Death Differ, 17, 6, 931-941
  AUTHOR;　Nagasaka, A. Kawane, K. Yoshida, H. Nagata, S.
  
• Aberrant IL-4 production by SOCS3-over-expressing T cells during infection with Leishmania major exacerbates disease manifestations;　2010
  ANNOUNCEMENT INFO.;　International Immunology, in press
  AUTHOR;　Nakaya M, Hamano S, Kawasumi M, Yoshida H, Yoshimura A, Kobayashi T
  
• Alternative cell death of Apaf1-deficient neural progenitor cells induced by withdrawal of EGF or insulin.;　2009
  ANNOUNCEMENT INFO.;　Biochim Biophys Acta 10.1016/j.bbagen.2009.1011.1008.
  AUTHOR;　○Shiraishi H, Okamoto H, Hara H and Yoshida H.
  
• Apaf-1-independent programmed cell death in mouse development.;　2009
  ANNOUNCEMENT INFO.;　Cell Death Differ. 1476-5403 (Electronic)
  AUTHOR;　*Nagasaka A, Kawane K, Yoshida H and Nagata S.
  
• SOCS3 in T and NKT Cells Negatively Regulates Cytokine Production and Ameliorates ConA-Induced Hepatitis.;　2009
  ANNOUNCEMENT INFO.;　 J Immunol. 183:7047-7053, 183, 7047-7053
  AUTHOR;　Nakaya M, Hashimoto M, Nakagawa R, et al. .
  
• Caspase-9 activation revealed by semaphorin 7A cleavage is independent of apoptosis in the aged olfactory bulb.;　2009
  ANNOUNCEMENT INFO.;　J Neurosci. 29:11385-11392., 29, 11385-11392
  AUTHOR;　*Ohsawa S, Hamada S, Asou H, et al.
  
• IL-27 abrogates receptor activator of NF-kappaB ligand-mediated osteoclastogenesis of human granulocyte-macrophage colony-forming unit cells through STAT1-dependent inhibition of c-Fos. .;　2009
  ANNOUNCEMENT INFO.;　J Immunol. 183:2397-2406, 183, 2397-2406
  AUTHOR;　*Furukawa M, Takaishi H, Takito J, et al.
  
• Deficiency in EBV-induced gene 3 (EBI3) in MRL/lpr mice results in pathological alteration of autoimmune glomerulonephritis and sialadenitis.;　2009
  ANNOUNCEMENT INFO.;　Mod Rheumatol. 2009;19:33-41., 19, 33-41
  AUTHOR;　*Igawa T, Nakashima H, Sadanaga A, et al.
  
• Amelioration of experimental allergic rhinitis with suppression of topical immune responses by lack of IL-27/WSX-1 signaling.;　2009
  ANNOUNCEMENT INFO.;　Ann Allergy Asthma Immunol. 102:223-232., 102, 223-232
  AUTHOR;　Shimanoe Y, Miyazaki Y, Hara H, Inokuchi A and Yoshida H.
  
• Caspase-mediated changes in histone H1 in early apoptosis: prolonged caspase activation in developing olfactory sensory neurons;　2008/09
  ANNOUNCEMENT INFO.;　Cell Death Differ, 15, 9, 1429-1439
  AUTHOR;　Ohsawa, S. Hamada, S. Yoshida, H. Miura, M.
  
• Tumor-specific cytotoxic T cell generation and dendritic cell function are differentially regulated by interleukin 27 during development of anti-tumor immunity;　2008/06
  ANNOUNCEMENT INFO.;　Int J Cancer, 124, 6, 1372-1378
  AUTHOR;　Shinozaki, Y. Wang, S. Miyazaki, Y. Miyazaki, K. Yamada, H. Yoshikai, Y. Hara, H. Yoshida, H.
  
• Cell Type-Specific Regulation of ITAM-Mediated NF-{kappa}B Activation by the Adaptors, CARMA1 and CARD9;　2008/01
  ANNOUNCEMENT INFO.;　J Immunol, 181, 2, 918-930
  AUTHOR;　Hara, H. Ishihara, C. Takeuchi, A. Xue, L. Morris, S. W. Penninger, J. M. Yoshida, H. Saito, T.
  
• Amelioration of delayed-type hypersensitivity responses by IL-27 administration;　2008
  ANNOUNCEMENT INFO.;　Biochem Biophys Res Commun, 373, 3, 397-402
  AUTHOR;　Miyazaki, Y. Shimanoe, Y. Wang, S. Yoshida, H.
  
• Apaf-1-deficient fog mouse cell apoptosis involves hypo-polarization of the mitochondrial inner membrane, ATP depletion and citrate accumulation;　2008
  ANNOUNCEMENT INFO.;　Cell Res　1748-7838 (Electronic)
  AUTHOR;　Katoh, I. Sato, S. Fukunishi, N. Yoshida, H. Imai, T. Kurata, S. I.
  
• Different initial steps of apoptosis induced by two types of antineoplastic drugs;　2008
  ANNOUNCEMENT INFO.;　Biochem Pharmacol, 76, 3, 303-311
  AUTHOR;　Takagi, Y. Hidaka, M. Sanada, M. Yoshida, H. Sekiguchi, M.
  
• WSX-1 plays a significant role for the initiation of experimental autoimmune uveitis.;　2007/03
  ANNOUNCEMENT INFO.;　 Int Immunol, 19, 93
  AUTHOR;　Sonoda, K. H., T. Yoshimura, A. Takeda, T. Ishibashi, S. Hamano, and H. Yoshida.
  
• The adaptor protein CARD9 is essential for the activation of myeloid cells through ITAM-associated and Toll-like receptors.;　2007
  ANNOUNCEMENT INFO.;　Nat Immunol, 8, 619
  AUTHOR;　Hara, H., C. Ishihara, A. Takeuchi, T. Imanishi, L. Xue, S. W. Morris, M. Inui, T. Takai, A. Shibuya, S. Saijo, Y. Iwakura, N. Ohno, H. Koseki, H. Yoshida, J. M. Penninger, and T. Saito.
  
• Augmentation of Antigen-Presenting and Th1-Promoting Functions of Dendritic Cells by WSX-1(IL-27R) Deficiency;　2007
  ANNOUNCEMENT INFO.;　J. Immunol., 179, 6421
  AUTHOR;　Wang, S. et al.
  
• Differential roles for IFN-gamma and IL-17 in experimental autoimmune uveoretinitis;　2007
  ANNOUNCEMENT INFO.;　J. Immunol., 20, 209
  AUTHOR;　Yoshimura et al.
  
• Amelioration of human lupus-like phenotypes in MRL/lpr mice by overexpression of IL-27R{alpha} (WSX-1);　2007
  ANNOUNCEMENT INFO.;　Ann Rheum Dis
  AUTHOR;　Sugiyama, N. et al.
  
• Incudomalleal joint formation: the roles of apoptosis, migration and downregulation;　2007
  ANNOUNCEMENT INFO.;　BMC Developmental Biology
  AUTHOR;　Amin, S. et al.
  
• Suppressor of cytokine signalling 1 in lymphocytes regulates the development of intestinal inflammation in mice;　2006
  ANNOUNCEMENT INFO.;　Gut
  AUTHOR;　Inagaki-Ohara, K. Sasaki, A. Matsuzaki, G. Ikeda, T. Hotokezaka, M. Chijiiwa, K. Kubo, M. Yoshida, H. Nawa, Y. Yoshimura, A.
  
• Histological analyses of normally grown, fertile Apaf1-deficient mice;　2006
  ANNOUNCEMENT INFO.;　Cell Death Differ
  AUTHOR;　Okamoto, H. Shiraishi, H. Yoshida, H.
  
• Differential contribution of Puma and Noxa in dual regulation of p53-mediated apoptotic pathways.;　2006
  ANNOUNCEMENT INFO.;　Embo J, 25, 4952
  AUTHOR;　Shibue, T., S. Suzuki, H. Okamoto, H. Yoshida, Y. Ohba, A. Takaoka, and T. Taniguchi.
  
• Two-Sided Roles of IL-27: Induction of Th1 Differentiation on Naive CD4+ T Cells versus Suppression of Proinflammatory Cytokine Production Including IL-23-Induced IL-17 on Activated CD4+ T Cells Partially Through STAT3-Dependent Mechanism.;　2006
  ANNOUNCEMENT INFO.;　J Immunol, 177, 5377
  AUTHOR;　Yoshimura, T., A. Takeda, S. Hamano, Y. Miyazaki, I. Kinjyo, T. Ishibashi, A. Yoshimura, and H. Yoshida.
  
• ER stress-induced apoptosis and caspase-12 activation occurs downstream of mitochondrial apoptosis involving Apaf-1.;　2006
  ANNOUNCEMENT INFO.;　J Cell Sci, 119, 3958
  AUTHOR;　Shiraishi, H., H. Okamoto, A. Yoshimura, and H. Yoshida.
  
• Generation and Characterization of B7-H4/B7S1/B7x-Deficient Mice.;　2006
  ANNOUNCEMENT INFO.;　Mol Cell Biol, 26, 6403
  AUTHOR;　Suh, W. K., S. Wang, G. S. Duncan, Y. Miyazaki, E. Cates, T. Walker, B. U. Gajewska, E. Deenick, W. Dawicki, H. Okada, A. Wakeham, A. Itie, T. H. Watts, P. S. Ohashi, M. Jordana, H. Yoshida, and T. W. Mak.
  
• The IL-27 Receptor Chain WSX-1 Differentially Regulates Antibacterial Immunity and Survival during Experimental Tuberculosis;　2005
  ANNOUNCEMENT INFO.;　J Immunol
  AUTHOR;　Holscher, C. Holscher, A. Ruckerl, D. Yoshimoto, T. Yoshida, H. Mak, T. Saris, C. Ehlers, S.
  
• WSX-1 over-expression in CD4+ T cells leads to hyperproliferation and cytokine hyperproduction in response to TCR stimulation;　2005
  ANNOUNCEMENT INFO.;　Int Immunol
  AUTHOR;　Takeda, A. Hamano, S. Shiraishi, H. Yoshimura, T. Ogata, H. Ishii, K. Ishibashi, T. Yoshimura, A. Yoshida, H.
  
• Exacerbation of Experimental Allergic Asthma by Augmented Th2 Responses in WSX-1-Deficient Mice;　2005
  ANNOUNCEMENT INFO.;　J Immunol
  AUTHOR;　Miyazaki, Y. Inoue, H. Matsumura, M. Matsumoto, K. Nakano, T. Tsuda, M. Hamano, S. Yoshimura, A. Yoshida, H.
  
• Autoamplification of NFATc1 expression determines its essential role in bone homeostasis;　2005
  ANNOUNCEMENT INFO.;　J. Exp. Med.
  AUTHOR;　Asagiri, Masataka Sato, Kojiro Usami, Takako Ochi, Sae Nishina, Hiroshi Yoshida, Hiroki Morita, Ikuo Wagner, Erwin F. Mak, Tak W. Serfling, Edgar Takayanagi, Hiroshi
  
• T Helper 1-Inducing Property of IL-27/WSX-1 Signaling Is Required for the Induction of Experimental Colitis;　2005
  ANNOUNCEMENT INFO.;　Inflamm Bowel Dis
  AUTHOR;　Honda, K. Nakamura, K. Matsui, N. Takahashi, M. Kitamura, Y. Mizutani, T. Harada, N. Nawata, H. Hamano, S. Yoshida, H.
  
• Membranous Glomerulonephritis Development with Th2-Type Immune Deviations in MRL/lpr Mice Deficient for IL-27 Receptor (WSX-1);　2005
  ANNOUNCEMENT INFO.;　J Immunol
  AUTHOR;　Shimizu, S. Sugiyama, N. Masutani, K. Sadanaga, A. Miyazaki, Y. Inoue, Y. Akahoshi, M. Katafuchi, R. Hirakata, H. Harada, M. Hamano, S. Nakashima, H. Yoshida, H.
  
• The IL-27 Receptor Chain WSX-1 Differentially Regulates Antibacterial Immunity and Survival during Experimental Tuberculosis;　2005
  ANNOUNCEMENT INFO.;　J Immunol
  AUTHOR;　Holscher, C. Holscher, A. Ruckerl, D. Yoshimoto, T. Yoshida, H. Mak, T. Saris, C. Ehlers, S.
  
• Stress Induces Mitochondria-mediated A poptosis Independent of SAPK/JNK Activation in Embryonic Stem Cells.;　2004
  ANNOUNCEMENT INFO.;　J. Biol. Chem., 279, 1621-1626
  AUTHOR;　Nishitai G,Shimizu N,Negishi T,Kishimoto H,Nakagawa K,Kitagawa D,Watanabe T,Momose H,Ohata S,Tanemura S,Asaka S,Kubota J,Saito R,Yoshida H,Mak TW,Wada T,Penninger JM,Azuma N,Nishina H,Katada T.
  
• Hyperproduction of Proiflammatory Cytokines by WSX-1-Deficient NKT Cells in Concanavalin A-Induced Hepatitis.;　2004
  ANNOUNCEMENT INFO.;　J. Immunol., 172, 3590-3596
  AUTHOR;　Yamanaka A,Hamano S,MiyazakiY,Ishii K,Takeda A,Mak TW,Himeno K,Yoshimura A, and Yoshida H.
  
• WSX-1: A Key Role in Induction of Chronic Intestina1 Nematode Infedion.;　2004
  ANNOUNCEMENT INFO.;　J. Immunol., 172, 7635-7641
  AUTHOR;　Bancroft AJ,Humphreys NE,Worthington JJ,Yoshida H, and Grencis RK
  
• The IL-27 receptor (WSX-1) is an inhibitor of innate and adaptive elements of type 2 immunity.;　2004
  ANNOUNCEMENT INFO.;　J. Immunol., 173, 5626-5634
  AUTHOR;　Artis D,Villarino A,Silverman M,He W,Thornton EM,Mu S,Summer S,Covey TM,Huang E,Yoshida H,Koretzky G,Goldschmidt M,Wu GD, de Sauvage F,Miller HR,Saris CJ,Scott P,Hunter CA.
  
• Different Properties of SEK1 and MKK7 in Dual Phosphorylation of Stress-induced Activated Protein Kinase SAPK/JNK in Embryonic Stem Cells.;　2003
  ANNOUNCEMENT INFO.;　J. Biol. Chem. , 278, 16595-16601
  AUTHOR;　Kishimoto H, Nakagawa K, Watanabe T, Kitagawa D, Momose H, Seo J, Nishitai G, Shimizu N, Ohata S, Tanemura S, Asaka S, Goto T, Fukushi H, Yoshida H, Suzuki A, Sasaki T, Wada T, Penninger JM, Nishina H, Katada T
  
• Cutting Edge Role of IL-27/WSX-1 Signaling for Induction of T-Bet Through Activation of STATI During Initia1 Th1 Commitment.;　2003
  ANNOUNCEMENT INFO.;　J. Immunol. , 170, 4886-4890
  AUTHOR;　Takeda A, Hamano S, Yamanaka A, Hanada T, Ishibashi T, Mak TW, Yoshimura A, Yoshida H
  
• Suppressor of cytokine signaling-1 is essential for suppressing dendritic cell activation and systemic autoimmunity.;　2003
  ANNOUNCEMENT INFO.;　Immunity , 19, 437-450
  AUTHOR;　Hanada T, Yoshida H, Kato S, Tanaka K, Masutani K, Tsukada J, Nomura Y, Mimata H, Kubo M, Yoshimura A
  
• The IL-27R(WSX-1) Is Required to Suppress T Cell Hyperactivity during Infection.;　2003
  ANNOUNCEMENT INFO.;　Immunity , 19, 645-655
  AUTHOR;　Villarino A, Hibbert L, Lieberman L, Wilson E, Mak T, Yoshida H, Kastelein RA, Saris C, Hunter CA
  
• WSX-1 Is Required for Resistance to Trypanosoma cruzi Infection by Regulation of Proinflammatory Cytokine Production.;　2003
  ANNOUNCEMENT INFO.;　Immunity, 19, 657-667
  AUTHOR;　Hamano S, Himeno K, Miyazaki Y, Ishii K, Yamanaka A, Takeda A, Zhang M, Hisaeda H, Mak TW, Yoshimura A, Yoshida H
  

General Lectures

• Identification of leukocyte immunoglobulin-like receptor A1 (LILRA1) as a specific receptor for Aspergillus fumigatus conidia;　2022
  ANNOUNCEMENT INFO.;　The 51st Annual Meeting of the Japanese Society for Immunology(hybrid event), 2022,12, 7-9(on-site+on-line), 2022,12,10-2023, 1,10(On-demand)
  AUTHOR;　Miyake Y, Yoshida H
  
• IL-27 plays an important role in anti-desmoglein 3 antibody production in pemphigus vulgaris mouse model;　2020/12
  ANNOUNCEMENT INFO.;　The 45th Annual Meeting of The Japanese Society for Investigative Dermatology（Virtual Meeting）, 2020, 12, 11 - 13
  AUTHOR;　
  
• Identification of novel lipophilic ligands of siglec receptors that modulate innate immunity.;　2020/11
  ANNOUNCEMENT INFO.;　Cytokines 2020: 8th Annual Meeting of the International Cytokine & Interferon Society（Virtual Meeting）, 2020, 11, 1-4（On Line）, 2020, 11, 1 - 18（On Demand）
  AUTHOR;　Miyake Y, Yoshida H
  
• The Role of IL-27 in Pain due to Hip Osteoarthritis;　2019
  ANNOUNCEMENT INFO.;　ORS 2019 Annual Meeting, 2019，2，2-5
  AUTHOR;　○Sonohata M, Yoshida H, Miyake Y, Suematsu R, Kitajima M, Kawano S, Mawatari M
  
• A new method for dissecting the cell differentiation process of Entamoeba encystation. ;　2019
  ANNOUNCEMENT INFO.;　U.S.-Japan Cooperative Medical Sciences Program (USJCMSP) 21st International Conference On Emerging Infectious Diseases In The Pacific Rim, 2019, 2, 26-3, 1
  AUTHOR;　Mi-ichi F, Miyake Y, Tam VK, Yoshida H
  
• Uniqueness of Entamoeba sulfur metabolism; fatty alcohol disulfates, novel sulfur metabolites, play an important role in trophozoite proliferation. ;　2019
  ANNOUNCEMENT INFO.;　60th International Conference on the Bioscience of Lipids, 2019, 6, 17-21
  AUTHOR;　Mi-ichi F, Miuamoto T, Yoshida H
  
• Novel immune evasion strategy of P. gingivalis via inhibitory receptor, Siglec;　2019
  ANNOUNCEMENT INFO.;　The 18th Awaji International Forum on Infection and Immunity, 2019, 9, 10-13
  AUTHOR;　Yoshida H, Miyake Y
  
• Uniqueness of Entamoeba sulfur metabolism. ;　2018
  ANNOUNCEMENT INFO.;　The 48th Annual Japan-U.S. Joint Conference on Parasitic Diseases, 2018, 2, 16
  AUTHOR;　Fumika Mi-ichi, Tomofumi Miuamoto, Hiroki Yoshida.
  
• Apaf1 plays a negative regulatory role in T cell responses by suppressing activation of antigen-stimulated T cells;　2018
  ANNOUNCEMENT INFO.;　11th International Congress on Autoimmunity, 2018, 5, 16-20
  AUTHOR;　Tong H, Miyake Y, Mi-ichi F, Iwakura Y, Hara H, Yoshida H
  
• Immunomodulatory effects of Interleukin-27 on chronic malaria infection;　2018
  ANNOUNCEMENT INFO.;　The 17th Awaji International Forum on Infection and Immunity, 2018，9, 4-7
  AUTHOR;　Sukhbaatar O, Kimura D, Miyakoda M, Nakamae S, Kimura K, Yoshida H, Yui K.
  
• Porphyromonas gingivalis negatively regulates host immune responses through inhibitory receptor, Siglec.;　2018
  ANNOUNCEMENT INFO.;　The 47th Annual Meeting of the Japanese Soceity for Immunology, 2018.12.10-12
  AUTHOR;　Miyake Y, Yamasaki S, Yoshida H
  
• Immunosuppressive receptor, Siglec5 recognizes lipophilic ligands extracted from pathogenic fungus, Trichophyton mentagrophytes.;　2018
  ANNOUNCEMENT INFO.;　The 47th Annual Meeting of the Japanese Soceity for Immunology, 2018.12.10-12
  AUTHOR;　Suematsu E, Miyake Y, Saijo S, Yoshida H
  
• Interleukin-27 inhibits the generation of memory CD4+ T cells during malaria infection;　2017
  ANNOUNCEMENT INFO.;　5th Annual Meeting of the International Cytokine and Interferon Society, 2017，10，29-11，2
  AUTHOR;　*Kimura D, Nakamae S, Sukhbaatar O, Miyakoda M, Akbari M, Kimura K, Hara H, Yoshida H, Yui K
  
• Entamoeba mitosomes play an important role in cell differentiation from proliferative form into dormant form (encystation) by association with cholesteryl sulfate synthesis.;　2017
  ANNOUNCEMENT INFO.;　58th International Conference on the Bioscience of Lipids, 2017, 9, 10-14
  AUTHOR;　Mi-ichi F, Yoshida H
  
• Pathogenic fungus, Trichopyton mentagrophytes, negatively regulates host immune responses via Siglec receptors;　2017
  ANNOUNCEMENT INFO.;　5th Annual Meeting of the International Cytokine and Interferon Society, 2017，10，29-11，2
  AUTHOR;　Miyake Y, Suematsu R, Saijo S, Yamasaki S, Yoshida H
  
• Role of Il-35 in Lipopolysaccharide-induced airway eosinophilia;　2017
  ANNOUNCEMENT INFO.;　The 46th Annual Meeting of the Japanese Soceity for Immunology, 2017, 12, 12-14
  AUTHOR;　*Kanai K, Yoshida H, Yoshie O
  
• Interleukin-27-dependent loss of Cd4+ T cell-memory during malaria infection;　2017
  ANNOUNCEMENT INFO.;　The 46th Annual Meeting of the Japanese Soceity for Immunology, 2017, 12, 12-14
  AUTHOR;　*Kimura D, Miyakoda M, Bayarsaikhan G, Nakamae S, Sukhbaatar O, Kimura K, Hara H, Yoshida H, Yui K
  
• Immunosuppressive receptor, Siglec binds to pathogenic fungus, Trichophyton mentagrophytes, and negatively regulates host immune responses;　2017
  ANNOUNCEMENT INFO.;　The 46th Annual Meeting of the Japanese Soceity for Immunology, 2017, 12, 12-14
  AUTHOR;　Miyake Y, Suematsu R, Shinobu Saijo S, Yamasaki S, Yoshida H
  
• Apaf1 plays a negative regulatory role in T cell responses by suppressing activation of antigen-stimulated T cells;　2017
  ANNOUNCEMENT INFO.;　The 46th Annual Meeting of the Japanese Soceity for Immunology, 2017, 12, 12-14
  AUTHOR;　Tong H, Miyake Y, Iwakura Y, Hara H, Yoshida H
  
• Regulation of Immune Responses by IL-27-producing CD4+ T cells Induced during Marlaria Infection;　2016/10
  ANNOUNCEMENT INFO.;　4th Annual Meeting of the International Cytokine and Interferon Scoedty (ICIS), 2016.10.16-19
  AUTHOR;　Yoshida H, Kimura D, Hara H, Yui K
  
• Possible contribution of the C-type lectin receptor, Mincle, to induction of neuropathic pain after peripheral nerve injury in mice;　2016/09
  ANNOUNCEMENT INFO.;　16th World Congress on Pain, 2016.9.26-30
  AUTHOR;　○ Ishikawa A, Yasaka T, Miyake Y, Murata Y, Sasaguri T, Yamasaki S, Hara H, Yoshida H, Hirakawa H
  
• Regulation of innate immunity through ITAM-coupled reeptors ininfluenza virus infection;　2016
  ANNOUNCEMENT INFO.;　The 45th Annual Meeting of the Japanese Society for Immunology, 2016.12.5-7
  AUTHOR;　Uematsu, Takayuki, Iizasa, E, Kobayashi, Noritada, Yoshida, H, Hara, H
  
• Interleukin-27 inhibits the generation of memory CD4+ T cells against malaria infection;　2016
  ANNOUNCEMENT INFO.;　The 45th Annual Meeting of the Japanese Society for Immunology, 2016.12.5-7
  AUTHOR;　Kimura, D, Miyakoda, M, Akbari, Masoud, Kimura, K, Hara, H, Yoshida, H, Yui, K
  
• C-type lectin receptor MCL stabilizes Mincle through complex formation for enhancement of inflammatory cytokine production upon mycobacterial infection;　2015
  ANNOUNCEMENT INFO.;　Cytokines 2015 (3rd Anual Meeting of the International Cytokine and Interferon Society (ICIS)), 2015, 10, 11-14
  AUTHOR;　Yasunobu Miyake, Sho Yamasaki, Hiroki, Yoshida
  
• Phospholipids bind to siglec-9 and induce immunosuppressive effect against LPS stimulation.;　2015
  ANNOUNCEMENT INFO.;　The 44th annual meeting of the Japanese Society for Immunology, 2015. 11. 18-20
  AUTHOR;　Yasunobu Miyake, Sho Yamasaki, Hiroki Yoshida
  
• IL-27-producing CD4+ T cells induced during malaria infection are distinct from Tr1 cells.;　2015
  ANNOUNCEMENT INFO.;　The 44th annual meeting of the Japanese Society for Immunology, 2015. 11. 18-20
  AUTHOR;　*Kimura, D Miyakoda, M Doe, Henrietta Terko Kimura, K Hara, H Yoshida, H Yui, K
  
• Mycobacterium tuberculosis-derived mycolic acid shows an adjuvant activity by activation of the ITAM receptor/CARD9-mediated innate immunity.;　2014
  ANNOUNCEMENT INFO.;　2nd Anual Meeting of the International Cytokine and Interferon Society, 2014, 10, 26-29
  AUTHOR;　Kubota M, Iizasa E, Kiyohara H, Chuma Y, Hara H, Yoshida H
  
• Activation of innate immunity mediated by the IgSFR2/CARD9 pathway is involved in severe influenza pneumonia;　2014
  ANNOUNCEMENT INFO.;　The 43rd annual meeting of the Japanese Society for Immunology, 2014, 12, 10-12
  AUTHOR;　Uematsu T, Iizasa E, Kobayashi N, Yoshida H, Hara H
  
• Innate recognition of mycolic acid-containing lipids in mycobacteria.;　2014
  ANNOUNCEMENT INFO.;　The 43rd annual meeting of the Japanese Society for Immunology, 2014, 12, 10-12
  AUTHOR;　Iizasa E, Uematsu T, Kubota M, Kiyohara H, Chuma Y, Matsuzak, G, Yamasaki S, Yoshida H, Hara H
  
• IL-27-producing malaria-specific CD4+ T cells regulate protective immune responses.;　2014
  ANNOUNCEMENT INFO.;　The 43rd annual meeting of the Japanese Society for Immunology, 2014, 12, 10-12
  AUTHOR;　*Kimura D, Miyakoda M, Kimura K, Honma K, Hara H, Yoshida H, Yui K
  
• Role of cholesteryl sulfate of Entamoeba;　2014
  ANNOUNCEMENT INFO.;　第７回寄生虫感染免疫研究会, 2014, 3, 6-7
  AUTHOR;　Fumika Mi-ichi,　Tomofumi Miyamoto,　Ghulam Jeelani, Hiromitsu Hara,　Tomoyoshi Nozaki,　Hiroki Yoshida
  
• Interleukin 27 inhibits hepatic steatosis induced by high fat diet in mice.;　2013
  ANNOUNCEMENT INFO.;　Cell Symposia; Immunometabolism: from Mechanisms to Therapy. 2013，6.9-11
  AUTHOR;　*Hirase T, Fujimoto H, Hiromitsu H, Yoshida H, Node K
  
• IL-27 affects helper T cell responses via regulation of PGE2 production by macrophages.;　2013
  ANNOUNCEMENT INFO.;　15th International Congress of Immunology, 2013，8.22-27
  AUTHOR;　Sato Y, Hara H, Suzuki S, Kaisho T, Yoshida H
  
• Identification of novel innate pattern recoginition receptors for mycobacterium tuberculosis.;　2013
  ANNOUNCEMENT INFO.;　15th International Congress of Immunology, 2013，8.22-27
  AUTHOR;　Iizasa E, Miyamoto T, Uematsu T, Ishikawa T, Yamasaki S, Matsuzaki G, Yoshida H, Hara H
  
• Essential role of ITAM-Syk-IL-1 axis in skin dendritic cells for the sensitization of allergic contact dermatitis.;　2013
  ANNOUNCEMENT INFO.;　15th International Congress of Immunology, 2013，8.22-27
  AUTHOR;　Hara H, Yasukawa S, Yoshida H, Furue M
  
• IL-27 affects helper T cell response via regulation of PGE2 production by macrophages.;　2013
  ANNOUNCEMENT INFO.;　Inaugural meeting of the international cytokine and interferon society (ICIS), 2013, 9.29-10.3
  AUTHOR;　Sato Y, Hara H, Suzuki S, Kaisho T, Yoshida H
  
• Interleukin 27 inhibits atherosclerosis via immunoregulation of macrophages in mice.;　2013
  ANNOUNCEMENT INFO.;　Autoimmunity Congress Asia, 2013, 11.20-22
  AUTHOR;　Yoshida H, Hirase T, Hara H, Node K
  
• Activation of innate immunity through the CARD9 pathway is involved in severe influenza pneumonia.;　2013
  ANNOUNCEMENT INFO.;　15th International Congress of Immunology, 2013，8.22-27
  AUTHOR;　Uematsu T, Iizasa E, Kobayashi N, Yoshida H, Hara H
  
• IL-1 released by skn dendritic cells activated through Syk and CARD9 pathway is essential for the sensitization of allergic contact dermatitis.;　2013
  ANNOUNCEMENT INFO.;　IMMUNOLOGY 2013 AAI Annual Meeting, 2013, 5.3-7
  AUTHOR;　Hara H, Yasukawa S, Furue M, Yoshida H
  
• IL-27 afects helper t cell response via reguation of PGE2 production by macrophages.;　2013
  ANNOUNCEMENT INFO.;　The joint international meeting of the 78th meeting of the Japanese societyt of interferon and cytokine research + the 21st international symposium on molecular cell biology of macrophages, 2013, 5.20-21
  AUTHOR;　Sato Y, Hara H, Suzuki S, Kaisho T, Yoshida H
  
• Identification and analysis of two novel pattern recoginition receptors for Mycobacterium tuberculosis.;　2013
  ANNOUNCEMENT INFO.;　The joint international meeting of the 78th meeting of the Japanese societyt of interferon and cytokine research + the 21st international symposium on molecular cell biology of macrophages, 2013, 5.20-21
  AUTHOR;　Iizasa E, Miyamoto T, Uematsu T, Ishikawa T, Yamasaki S, Yoshida H, Hara H
  
• Exacervation of delayed-type hypersensitivity responses in mice with T cell-specific deletion of Apaf1.;　2013
  ANNOUNCEMENT INFO.;　
  AUTHOR;　Tong H, Iizasa E, Hara H, Yoshida H
  
• Adjuvant activity of Mycobacterium tubeculosis-derived mycolic acid through activation of the ITAM receptor/CARD9-mediated innate immunity.;　2013
  ANNOUNCEMENT INFO.;　
  AUTHOR;　Kubota M, Iizasa E, Kiyohara H, Nakama Y, Hara H, Yoshida H
  
• Il-27 is produced by CD4+ T cells during infection with malaria parasites and inhibits protective immune responses.;　2013
  ANNOUNCEMENT INFO.;　第42回日本免疫学会学術集会 日本 千葉, 2013, 12.11-13
  AUTHOR;　*Kimura D, Miyakoda M, Kimura K, Honma K, Hara H, Hori S, Yoshida H, Yui K
  
• Identification of an ITAM-coupled pattern recognition receptor that recognizes the mycobacterial cell wall compontent mycolic acids.;　2013
  ANNOUNCEMENT INFO.;　
  AUTHOR;　Iizasa E, Uematsu T, Matuzaki G, Yamasaki S, Yoshida H, Hara H
  
• Analysis for the role of Syk-CARD9-regulated IL-1 secretion pathway in DCs in contact hypersensitivity by the mixed-chimera diphtheria toxin receptor (DTR)-mediated conditional cell knockout (MixC-Treck) method, a novel method for conditional gene targeting in mice.;　2013
  ANNOUNCEMENT INFO.;　
  AUTHOR;　Hara H, Yasukawa S, Natsuaki Y, Kabashima K, Furue M, Yoshida H
  
• Activation of innate immunity through ITAM-receptor and Syk-CARD9-Bcl10 signaling pathway is critically involved in control of Leishmania major Infection;　2012
  ANNOUNCEMENT INFO.;　The 12th Biennial International Endotoxin and Innate Immunity Society Meeting., 2012.10.23-26
  AUTHOR;　Yoshida H, Nakaya M, Miichi F, Iizasa E, Hara H
  
• Activation of the Syk-CARD9-Bcl10-mediated novel innate immune system is critically involved in defense against Leishmania major Infection.;　2012
  ANNOUNCEMENT INFO.;　
  AUTHOR;　Yoshida H, Hara H, Nakaya M, Fumika M, Kubota M
  
• Interleukin 27 Ameriolates Atherosclerosis by Inhibiting Bone Marrow-Derived Macrophage Activation in Arterial Walls in Mice.;　2012
  ANNOUNCEMENT INFO.;　The 8th International Congress on Autoimmunity, 2012.5.9-13
  AUTHOR;　Yoshida H, Hirase T, Hiromitsu H, Node K
  
• Contact allergy to chemical sensitizers requires innate immune activation by coupling of the ITAM-Syk-CARD9 pathway and NLRP3 inflammasome.;　2012
  ANNOUNCEMENT INFO.;　The 12th Biennial International Endotoxin and Innate Immunity Society Meeting., 2012.10.23-26
  AUTHOR;　Hara H, Yasukawa S, Furue M, Yoshida H
  
• Innate immune activation through ITAM-Syk-CARD9 signaling coupling to inflammasome is essential for the development of allergy to organic chemical allergens.;　2012
  ANNOUNCEMENT INFO.;　In 10th Joint Annual Meeting of ISC and ISICR, 2012.9.11-14
  AUTHOR;　Hara H, Yasukawa S, Furue M, Yoshida H
  
• Role of Card9-mediated signaling in contact hypersensitivity.;　2012
  ANNOUNCEMENT INFO.;　2nd Eastern Asia Dermatology Congress, 2012.6.13-15
  AUTHOR;　Yasukawa S, Furue M, Yoshida H, Hara H
  
• Innate immune activation through ITAM-Syk-CARD9 signaling coupling to NLRP3 inflammasome is esseintial for the development of allergy to contact sensitizers.;　2012
  ANNOUNCEMENT INFO.;　
  AUTHOR;　Yasukawa S, Furue M, Yoshida H, H. Hara H
  
• Activation of innate immunity through the CARD9 pathway is involved in severe influenza pneumonia.;　2012
  ANNOUNCEMENT INFO.;　
  AUTHOR;　Uematsu T, Iizasa E, Kobayashi N, Yoshida H, Hara H
  
• IL-27 affects immune responses via rgulation of prostagrandin E2 production by macrophages.;　2012
  ANNOUNCEMENT INFO.;　
  AUTHOR;　Sato Y, Suzuki S, Hara H, Kiasho T, Yoshida H
  
• CD4 T cells produce EBI-3+ cytokine inhibiting their own protective immune responses during infection with malaria parasites.;　2012
  ANNOUNCEMENT INFO.;　
  AUTHOR;　*Kimura D, Miyakoda M, Honma K, Kimura K, Hara H, Yoshida H, Yui K
  
• A novel IL-27 signaling pathway mediated by Egr-2 regulates IL-10 production in naive T cells.;　2012
  ANNOUNCEMENT INFO.;　
  AUTHOR;　*Iwasaki Y,Fujio K, Okamura T, Yanai A, Sumitomo S, Shoda H, Tamura T, Yoshida H, Yamamoto K
  
• Identification and funcitional analysis of novel mycobacerium receptors.;　2012
  ANNOUNCEMENT INFO.;　
  AUTHOR;　Iizasa E, Miyamoto T, Ishikawa T, Ishikawa E, Yamasaki S, Matuzaki G, Yoshida H, Hara H
  
• Essential role for intra- and intermolecular SH3-GUK interactions of CARMA1 in antigen receptor-induced NF-kB and JNK activation.;　2012
  ANNOUNCEMENT INFO.;　
  AUTHOR;　Hara H, Yokosuka T, Ishihara C, Yasukawa S, Hirakawa H, Iizasa E, Yoshida H, Saito T
  
• MGL1-dependent IL-10 induction in colonic macrophages by commensal bacteria is mediated by the Syk-CARD9 pathway.;　2012
  ANNOUNCEMENT INFO.;　
  AUTHOR;　*Denda-Nagai K, Kurashina R, Hara H, Yoshida H, Irimura T
  
• Activation of innate immunity through Syk-CARD9-Bcl10 signaling pathway is involved in control of Leishmania major infection.;　2012
  ANNOUNCEMENT INFO.;　The 5th Immunoparasitology Meeting, 2012.3.1-2
  AUTHOR;　HARA H, NAKAYA M, MIICHI F , IIZASA E, DENDA-NAGAI K, IRIMURA T, ADACHI Y, OHNO N, YOSHIDA H
  
• Sulfate activation in mitosomes plays an important role in Entamoeba histolytica;　2012
  ANNOUNCEMENT INFO.;　The 6th Nagasaki Symposium on Tropical and Emerging Infectious Diseases, 2012.12.10-12
  AUTHOR;　Mi-ichi F, Miyamoto T, Hara H, Yoshida H
  
• Role of CARD9-mediated activation of innate immunity in anti-protozoan defense;　2010/09
  ANNOUNCEMENT INFO.;　The 10th Awaji International Forum on Infection and Immunity. 2010, 9, 7-10
  AUTHOR;　Yoshida H, Nakaya M, Hara H and Yamasaki M
  
• Interleukin 27 Inhibits Hyperglycemia and Pancreatic Islet Inflammation Induced by Streptozotocin in Mice.;　2010/08
  ANNOUNCEMENT INFO.;　The 14th International Congress of Immunology (ICI 2010)I. 2010, 8, 22-27
  AUTHOR;　Fujimoto H, Hirase T, Miyazaki Y, Hara H, Ide-Iwata N, Nishimoto-Hazuku A, Saris C J M, Yoshida H and Node K
  
• Interleukin 27 ameliorates atherosclerosis by inhibiting bone marrow-derived macrophage activation in arterial walls in mice;　2010/08
  ANNOUNCEMENT INFO.;　The 14th International Congress of Immunology (ICI 2010)I. 2010, 8, 22-27
  AUTHOR;　Hirase T, Hara H, Miyazaki Y, Ide-Iwata N, Nishimoto-Hazuku A, Fujimoto H, Yoshida H and Node K
  
• Role of CARD9-mediated activation of innate immunity in anti-protozoan defense;　2010/08
  ANNOUNCEMENT INFO.;　The 14th International Congress of Immunology (ICI 2010)I. 2010, 8, 22-27
  AUTHOR;　Nakaya M, Hara H, Yamazaki M and Yoshida H
  
• Cytokine regulation of inflammation in atherosclerosis;　2010/08
  ANNOUNCEMENT INFO.;　US-Japan-Asia Dialogue on Cardiovascular Diseases. 2010, 8, 21
  AUTHOR;　Yoshida H
  
• Role of CARD9-mediated activation of innate immunity in anti-protozoan defense;　2010/04
  ANNOUNCEMENT INFO.;　The 10th Nagasaki-Singapore Medical Symposium 2010, 4, 15-16
  AUTHOR;　Yoshida H, Nakaya M, Iizasa E I and Hara H
  
• IL-27 ABROGATES RANKL-MEDIATED OSTEOCLASTOGENESIS THROUGH STAT1- DEPENDENT INHIBITION OF C-FOS.;　2010/02
  ANNOUNCEMENT INFO.;　9th International Conference on New Trends in Immunosuppression and Immunotherapy. 2010, 2, 4-6
  AUTHOR;　Yoshida H, Furukawa M and Takaishi H
  
• Role of CARD9-mediated activation of innate immunity in anti-protozoan defense;　2010/01
  ANNOUNCEMENT INFO.;　Adaptive and innate immune responses to neglected tropical diseases conference. 2010, 1, 10-11
  AUTHOR;　Yoshida H
  
• Exacerbation of delayed-type hypersensitivity responses in EBV-induced gene-3 (EBI-3)-deficient mice.;　2009/12
  ANNOUNCEMENT INFO.;　第39回日本免疫学会学術集会 2009, 12, 2-4
  AUTHOR;　Miyazaki Y, Tong H, Yamasaki M, Hara H and Yoshida H
  
• Regulation of defense responses against protozoan infection by interleukin-27.;　2009/11
  ANNOUNCEMENT INFO.;　The 4th Nagasaki Symposium on Tropical and Emerging Infectious Diseases 2009, 11, 26-28(27)
  AUTHOR;　Yoshida H
  
• IL-27 abrogates RANKL-mediated osteoclastogenesis through STAT1-dependent inhibition of c-Fos. Conference);　2009/10
  ANNOUNCEMENT INFO.;　Tri-Society annual Conference (International Society for Interferon and Cytokine Research 2009, 10, 18-21
  AUTHOR;　Yoshida H, Furukawa M and Takaishi H
  
• Analyses of non-apoptotic cell death induced by growth factor withdrawal in Apaf1-deficient neural progenitor cells.;　2009/10
  ANNOUNCEMENT INFO.;　第68回日本癌学会学術総会 2009, 10, 1-3
  AUTHOR;　Yoshida H
  
• Role of CARD9-mediated activation of innate immunity in anti-protozoan defense.;　2009/09
  ANNOUNCEMENT INFO.;　The 9th Awaji International Forum on Infection and Immunity 2009, 9, 8-11
  AUTHOR;　Yoshida H, Nakaya M, Yamasaki M and Hara H
  
• The roles of Interleukin 27 in the Pathogenesis of Lupus Glomerulonephritis in MRL/lpr Mice;　2009/09
  ANNOUNCEMENT INFO.;　The 4th Asian Congress on Autoimmunity 2009, 9, 11-13
  AUTHOR;　Miyakzaki Y, Nakashima H and Yoshida H
  
• Interleukin 27 signaling pathways in regulation of immune and autoimmune responses.;　2009/07
  ANNOUNCEMENT INFO.;　The 5th RCAI-JSI International Symposium on Immunology 2009, 7, 9-10
  AUTHOR;　Yoshida H
  
• Interleukin 27 signaling pathways in regulation of immune and autoimmune responses.;　2009/06
  ANNOUNCEMENT INFO.;　平成21年度グローバルCOEリエゾンラボ研究会 2009, 6, 3
  AUTHOR;　Yoshida H
  
• Therapeutic potential of IL-27 for inflammatory and autoimmune diseases;　2008
  ANNOUNCEMENT INFO.;　7th joint conference of the international cytokine society and the international society for interferon and cytokine research
  AUTHOR;　Miyazaki, Yoshiyuki Nakashima, Hitoshi Hiroki Yoshida
  
• Role of CARD9 in anti-protozoan defense;　2008
  ANNOUNCEMENT INFO.;　The 8th Awaji International forum on Infection and Immunity
  AUTHOR;　Yohei Shimanoe Hara, Hiromitsu Yoshida, Hiroki
  
• Tumor-specific cytotoxic T cell generation and dendritic cell function are differentially regulated by interleukin 27 during development of anti-tumor immunity;　2008
  ANNOUNCEMENT INFO.;　
  AUTHOR;　Shinozaki, Yukari Miyazaki, Yoshiyuki Hara, Hiromitsu Yoshida, Hiroki
  
• Amelioration of Human Lupus-like Phenotypes in MRL/LPR mice by Over Expression of IL-27Ra(WSX-1);　2008
  ANNOUNCEMENT INFO.;　6th International congress on Autoimmunity
  AUTHOR;　Yoshida, Hiroki
  
• Interleukin 27 signaling pathways in regulation of immune and autoimmune responses;　2008
  ANNOUNCEMENT INFO.;　
  AUTHOR;　Yoshida, Hiroki
  
• Differential effects of IL-27 on cytotoxic T lymphocytes and dendritic cells during establishment of tumor immunity;　2008
  ANNOUNCEMENT INFO.;　
  AUTHOR;　
  
• Role of CARD9 in anti-protozoan defense;　2008
  ANNOUNCEMENT INFO.;　
  AUTHOR;　
  
• Interleuking-17 plays a role in successful resolution of Trypanosoma cruzi infection.;　2007
  ANNOUNCEMENT INFO.;　Immunology 2007 (The American Association of Immunologiests)
  AUTHOR;　Yoshida, Hiroki Wang, Sen Iwakura, Yohichiroh Miyazaki, Yoshiyuki
  
• Interleukin-17 is required for protection against trypanosoma cruzi through induction of inflammatory responses;　2007
  ANNOUNCEMENT INFO.;　15th Annual Meeting of the International Cytokine Society
  AUTHOR;　Yoshida, Hiroki Shimanoe, Yohei Wang, Sen Iwakura, Yohichiroh Miyazaki, Yoshiyuki
  
• Interleukin 17 is necessary for host protection against acute phase Trypanosoma cruzi infection;　2007
  ANNOUNCEMENT INFO.;　The 7th Awaji International Forum on Infection and Immunity
  AUTHOR;　Yoshida, Hiroki Shimanoe, Yohei Wang, Sen Hamano, Shinjiro Iwakura, Yohichiroh Miyazaki, Yoshiyuki
  
• Interleukin-17 plays a role in successful resolution of Trypanosoma cruzi infection.;　2007
  ANNOUNCEMENT INFO.;　
  AUTHOR;　
  
• IL-27 signaling as a target for autoimmune disease treatment;　2007
  ANNOUNCEMENT INFO.;　BITeomics (BIT)'s
  AUTHOR;　Yoshida, Hiroki
  
• The role of IL-27/WSX-1 (IL-27R) in experimental allergic rhinitis;　2007
  ANNOUNCEMENT INFO.;　13th International Congress of Mucosal Immunology
  AUTHOR;　Yohei Shimanoe Sen Wang Yoshiyuki Miyazaki Hiromitsu Hara Hiroki Yoshida
  
• Double-sided roles of IL-27 in parasite infection; the initiator and the attenuator of immune reaction.;　2006
  ANNOUNCEMENT INFO.;　The 6th Awaji International forum on Infection and Immunity　(Symposium)
  AUTHOR;　Yoshida, H
  
• Exacervation of Allergen-induced Airway Hyperresponsiveness by Augmented Th2 responses in WSX-1-Deficient Mice;　2004/07
  ANNOUNCEMENT INFO.;　12th International congress of Immunology. July 18-23, 2004. Workshop and poster presentation
  AUTHOR;　Miyazaki Y, Hamano S, Inoue H, Yoshimura A, Yoshida H
  
• The role of WSX-1 Molecule in Acute GVHD;　2004/07
  ANNOUNCEMENT INFO.;　12th International congress of Immunology. July 18-23, 2004. Workshop and poster presentation
  AUTHOR;　Nagata S,Okano S,Yoshida H,Yonemitsu Y,Maehara Y et al.
  
• WSX-1 is required for resistance to Trypanosoma cruzi infection by regulation of Th2 responses and pro-inflammatory cytokine production.;　2003/12
  ANNOUNCEMENT INFO.;　, 8-10
  AUTHOR;　Hamano S,Yoshida H,他
  
• Hyper production of pro-inflammatory cytokines by WSX-1-deficient NKT cells in Con A-induced hepatitis.;　2003/12
  ANNOUNCEMENT INFO.;　, 8-10
  AUTHOR;　Yoshida H,Yamanaka A,Hamano S,Ishii K,Takeda A,Miyazaki Y,Himeno K,Yoshimura A, Mak TW.
  
• WSX-1 is required for resistance to Trypanosoma cruzi infection by regulation of Th2 responses and pro-inflammatory cytokine production.;　2003/08
  ANNOUNCEMENT INFO.;　The 3rd Awaji International forum of Infection and Immunity, 25-28
  AUTHOR;　Hamano S,Yoshida H,他
  
• Critical role of IL-27/WSX-1 signaling in the commitment of Th1 development．;　2003/03
  ANNOUNCEMENT INFO.;　
  AUTHOR;　Yoshida H
  

Review Articles

• Unique Features of Entamoeba Sulfur Metabolism; Compartmentalization, Physiological Roles of Terminal Products, Evolution and Pharmaceutical Exploitation.;　2019/10
  ANNOUNCEMENT INFO.;　Int J Mol Sci. , 20, 19, 4679
  AUTHOR;　Mi-ichi F, Yoshida H.
  
• Entamoeba Encystation: New Targets to Prevent the Transmission of Amebiasis;　2016
  ANNOUNCEMENT INFO.;　PLoS Pathog, 12, 10, e1005845
  AUTHOR;　Mi-Ichi, F., Yoshida, H., Hamano, S.
  
• The immunobiology of interleukin-27;　2015
  ANNOUNCEMENT INFO.;　Annu Rev Immunol., 33, 417-43
  AUTHOR;　Yoshida, H., Hunter, C. A.
  
• L-CBM signaling in lymphocyte development and function;　2010
  ANNOUNCEMENT INFO.;　J Blood Med, 1, 93-104
  AUTHOR;　Hara, H IIzasa, E Nakaya, M Yoshida, H
  
• Interleukin 27: a double-edged sword for offense and defense.;　2009
  ANNOUNCEMENT INFO.;　J Leukoc Biol., 86, 1295-1303., 86, 1295-1303
  AUTHOR;　Yoshida H, Nakaya M and Miyazaki Y.
  
• Regulation of immune responses by interleukin-27;　2008
  ANNOUNCEMENT INFO.;　Immunol Rev, 226, 234-247
  AUTHOR;　Yoshida, H. Miyazaki, Y.
  
• Interleukin 27 signaling pathways in regulation of immune and autoimmune responses;　2008
  ANNOUNCEMENT INFO.;　Int. J. Biochem. Cell Biol., 40, 11, 2379-2383
  AUTHOR;　Yoshida H, Miyazaki Y.
  

Invited Lecture, Special Lecture

• Novel immune evasion strategy of P. gingivalis via inhibitory receptor, Siglec;　2018
  ANNOUNCEMENT INFO.;　6th Annual Meeting of the International Cytokine & Interferon Society (ICIS), 2018, 10, 27-30
  AUTHOR;　Miyake Y, Yoshida H
  
• Interleukin 27 controls pain sensitivity in pathophysiological conditions; to immunity and beyon!;　2017
  ANNOUNCEMENT INFO.;　5th Annual Meeting of the International Cytokine and Interferon Society, 2017，10，29-11，2
  AUTHOR;　Yoshida H, Sasaguri T, Ishikawa A, Murata Y, Yasaka T, Hirakawa N, Hara H
  
• Phospholipids bind to siglec-9 and induce immunosuppressive effect against LPS stimulation;　2015
  ANNOUNCEMENT INFO.;　The 44th annual meeting of the Japanese Society for Immunology, 2015. 11. 18-20
  AUTHOR;　Miyake Yasunobum, Yamasaki Sho, Yoshida H