日本語フィールド
著者：Tomoko Sasaguri
Toru Taguchi
Yuzo Murata
Kimiko Kobayashi
Sayaka Iizasa
Ei’ichi Iizasa
Makoto Tsuda
Naomi Hirakawa
Hiromitsu Hara
Hiroki Yoshida
Toshiharu Yasaka題名：Interleukin-27 controls basal pain threshold in physiological and pathological conditions発表情報：Tomoko Sasaguri^D
Toru Taguchi
Yuzo Murata
Kimiko Kobayashi
Sayaka Iizasa
Ei’ichi Iizasa
Makoto Tsuda
Naomi Hirakawa
Hiromitsu Hara
Hiroki Yoshida
Toshiharu Yasaka 巻: 8 ページ: Article number: 11022 (2018)キーワード：概要：抄録：Numerous studies have shown that pain sensation is affected by various immune molecules, such as cytokines, in tissues comprising the sensory pathway. Specifically, it has been shown that interleukin (IL)-17 promotes pain behaviour, but IL-10 suppresses it. IL-27 has been reported to have an anti-inflammatory effect through regulation of T cell differentiation, resulting in reduced IL-17 and induction of IL-10. Thus, we hypothesised that IL-27 would have some regulatory role in pain sensation. Here, we provide evidence that endogenous IL-27 constitutively controls thresholds for thermal and mechanical sensation in physiological and pathological conditions. Mice lacking IL-27 or its receptor WSX-1 spontaneously showed chronic pain-like hypersensitivity. Reconstitution of IL-27 in IL-27-deficient mice reversed thermal and mechanical hypersensitive behaviours. Thus, unlike many other cytokines induced by inflammatory events, IL-27 appears to be constitutively produced and to control pain sensation. Furthermore, mice lacking IL-27/WSX-1 signalling showed additional hypersensitivity when subjected to inflammatory or neuropathic pain models. Our results suggest that the mechanisms underlying hypersensitive behaviours caused by the ablation of IL-27/WSX-1 signalling are different from those underlying established chronic pain models. This novel pain control mechanism mediated by IL-27 might indicate a new mechanism for the chronic pain hypersensitivity.英語フィールド
Author：Tomoko Sasaguri
Toru Taguchi
Yuzo Murata
Kimiko Kobayashi
Sayaka Iizasa
Ei’ichi Iizasa
Makoto Tsuda
Naomi Hirakawa
Hiromitsu Hara
Hiroki Yoshida
Toshiharu YasakaTitle：Interleukin-27 controls basal pain threshold in physiological and pathological conditionsAnnouncement information:Sci Rep Vol: 8 Page: Article number: 11022 (2018)An abstract：Numerous studies have shown that pain sensation is affected by various immune molecules, such as cytokines, in tissues comprising the sensory pathway. Specifically, it has been shown that interleukin (IL)-17 promotes pain behaviour, but IL-10 suppresses it. IL-27 has been reported to have an anti-inflammatory effect through regulation of T cell differentiation, resulting in reduced IL-17 and induction of IL-10. Thus, we hypothesised that IL-27 would have some regulatory role in pain sensation. Here, we provide evidence that endogenous IL-27 constitutively controls thresholds for thermal and mechanical sensation in physiological and pathological conditions. Mice lacking IL-27 or its receptor WSX-1 spontaneously showed chronic pain-like hypersensitivity. Reconstitution of IL-27 in IL-27-deficient mice reversed thermal and mechanical hypersensitive behaviours. Thus, unlike many other cytokines induced by inflammatory events, IL-27 appears to be constitutively produced and to control pain sensation. Furthermore, mice lacking IL-27/WSX-1 signalling showed additional hypersensitivity when subjected to inflammatory or neuropathic pain models. Our results suggest that the mechanisms underlying hypersensitive behaviours caused by the ablation of IL-27/WSX-1 signalling are different from those underlying established chronic pain models. This novel pain control mechanism mediated by IL-27 might indicate a new mechanism for the chronic pain hypersensitivity.