氏 名川口 真一フリガナカワグチ シンイチ
欧文氏名KAWAGUCHI Shinichi
所 属農学部附属アグリ創生教育研究センター
職 名准教授学位(工学)(2012年03月)
電子メールskawacc.saga-u.ac.jpリンクティーチングポートフォリオ
ホームページhttp://tennenshigen.ag.saga-u.ac.jp/

教員詳細情報

研究分野・キーワード

  • 有機化学、創薬化学、天然資源化学、典型元素化学、リン、化粧品科学

学歴

  • 2005年03月, 大阪府立大学, 工学部, 応用化学科, 卒業
  • 2009年03月, 大阪府立大学, 工学研究科, 物質・化学系専攻, 修士課程・博士前期課程, 修了
  • 2012年03月, 大阪府立大学, 工学研究科, 物質・化学系専攻, 博士課程・博士後期課程, 修了

職歴

  • 2010年04月 - 2010年12月 ウプサラ大学 BioMedical Center  研究員
  • 2012年04月 - 2015年03月 東北大学 医学系研究科 日本学術振興会特別研究員
  • 2015年04月 - 2016年02月 大阪府立大学大学院工学研究科 大学等非常勤研究員
  • 2016年03月 - 2019年03月 佐賀大学農学部アグリ創生教育研究センター 特任助教
  • 2019年04月 - 継続中 佐賀大学農学部 附属アグリ創生教育研究センター天然資源化学分野 准教授
  • 2019年04月 - 継続中 佐賀大学先進健康科学研究科健康機能分子科学コース 准教授
  • 2019年04月 - 継続中 佐賀大学鹿児島大学大学院連合農学研究科応用生命科学専攻 准教授

専門分野

  • 有機化学, 創薬化学, グリーン・環境化学, 化学系薬学, 生物有機化学

所属学会

  • 公益社団法人日本化学会, 公益社団法人 日本生化学会, 公益社団法人有機合成化学協会, ヨウ素学会, アメリカ化学会

現在実施している研究テーマ

  • 農作物の抽出成分を原料とした化合物の機能性化
  • FIH阻害を利用したHIF制御:選択的低分子FIH阻害剤の開発

これまでの研究テーマ

  • 元素の複合化に基づく革新的な低酸素誘導因子調節薬の開発

主要業績

原著論文

  • Improving lipophilicity of 5-(1-acetyl-5-phenylpyrazolidin-3-ylidene)-1,3-dimethylbarbituric acid increases its efficacy to activate hypoxia-inducible factors; 2022年11月
    発表情報; Bioorganic and Medicinal Chemistry, 73, -
    著者; Sonoda, Kento; Ujike, Saki; Katayama, Akito; Suzuki, Norio; Kawaguchi, Shin ichi; Tsujita, Tadayuki
  • Prolyl Hydroxylase Domain Protein Inhibitor Not Harboring a 2-Oxoglutarate Scaffold Protects against Hypoxic Stress; 2022年05月
    発表情報; ACS Pharmacology and Translational Science, 5, 5, 362 - 372
    著者; Sonoda, Kento; Bogahawaththa, Sudarma; Katayama, Akito; Ujike, Saki; Kuroki, Sae; Kitagawa, Naho; Hirotsuru, Kohichi; Suzuki, Norio; Miyata, Toshio; Kawaguchi, Shin Ichi; Tsujita, Tadayuki
  • Synthesis of diaryl phosphates using orthophosphoric acid as a phosphorus source; 2022年04月
    発表情報; Tetrahedron Letters, 96, -
    著者; Tran, Cong Chi; Asao, Kazuya; Sasaki, Takeshi; Hayakawa, Yasuyuki; Kawaguchi, Shin ichi
  • CHARACTERIZATION AND ANTITUMOR ACTIVITY OF FURAZANO[3,4-g]PTERIDINE-2,4(1H,3H)-DIONE; 2022年01月
    発表情報; Heterocycles, 104, 5, -
    著者; Makita, Yoshimasa; Kawaguchi, Shin Ichi; Fujiwara, Shin Ichi
  • The molecular mechanism of phytosphingosine binding to FFAR4/GPR120 differs from that of other fatty acids; 2021年11月
    発表情報; FEBS Open Bio, 11, 11, 3081 - 3089
    著者; Nagasawa, Tomotaka; Horitani, Masaki; Kawaguchi, Shin ichi; Higashiyama, Shigeki; Hama, Yoichiro; Mitsutake, Susumu
  • Transition-metal-catalyzed diarylation of isocyanides with triarylbismuthines for the selective synthesis of imine derivatives; 2021年08月
    発表情報; Materials, 14, 15, -
    著者; Kodama, Shintaro; Yamamoto, Yuki; Kobiki, Yohsuke; Matsubara, Hitomi; Tran, Cong Chi; Kawaguchi, Shin Ichi; Nomoto, Akihiro; Ogawa, Akiya
  • Photoinduced selective hydrophosphinylation of allylic compounds with diphenylphosphine oxide leading to γ-functionalized P-ligand precursors; 2021年07月
    発表情報; Research on Chemical Intermediates, 47, 7, 3067 - 3078
    著者; Tran, Dat Phuc; Sato, Yuki; Yamamoto, Yuki; Kawaguchi, Shin ichi; Kodama, Shintaro; Nomoto, Akihiro; Ogawa, Akiya
  • Highly regio- And stereoselective phosphinylphosphination of terminal alkynes with tetraphenyldiphosphine monoxide under radical conditions; 2021年04月
    発表情報; Beilstein Journal of Organic Chemistry, 17, 866 - 872
    著者; Tran, Dat Phuc; Sato, Yuki; Yamamoto, Yuki; Kawaguchi, Shin Ichi; Kodama, Shintaro; Nomoto, Akihiro; Ogawa, Akiya
  • Photoinduced selective hydrophosphinylation of allylic compounds with diphenylphosphine oxide leading to γ-functionalized P-ligand precursors; 2021年01月
    発表情報; Research on Chemical Intermediates, -
    著者; Tran, Dat Phuc; Sato, Yuki; Yamamoto, Yuki; Kawaguchi, Shin ichi; Kodama, Shintaro; Nomoto, Akihiro; Ogawa, Akiya
  • Phosphorus-recycling wittig reaction: Design and facile synthesis of a fluorous phosphine and its reusable process in the wittig reaction; 2020年11月
    発表情報; Journal of Organic Chemistry, 85, 22, 14684 - 14696
    著者; Yamamoto, Yuki; Kawaguchi, Shin Ichi; Nishimura, Misaki; Sato, Yuki; Shimada, Yoshihisa; Tabuchi, Akihiro; Nomoto, Akihiro; Ogawa, Akiya
  • Photoinduced syntheses and reactivities of phosphorus-containing interelement compounds; 2020年11月
    発表情報; Journal of Organic Chemistry, 85, 22, 14708 - 14719
    著者; Yamamoto, Yuki; Tanaka, Ryo; Ota, Miyuto; Nishimura, Misaki; Tran, Cong Chi; Kawaguchi, Shin Ichi; Kodama, Shintaro; Nomoto, Akihiro; Ogawa, Akiya
  • Photoinduced Cyclizations of o-Diisocyanoarenes with Organic Diselenides and Thiols that Afford Chalcogenated Quinoxalines; 2020年06月
    発表情報; Journal of Organic Chemistry, 85, 11, 7258 - 7266
    著者; Tran, Cong Chi; Kawaguchi, Shin Ichi; Sato, Fumiya; Nomoto, Akihiro; Ogawa, Akiya
  • Catalytic synthesis of sulfur and phosphorus compounds via atom-economic reactions; 2020年03月
    発表情報; Mendeleev Communications, 30, 2, 129 - 138
    著者; Kawaguchi, Shin ichi; Yamamoto, Yuki; Ogawa, Akiya
  • Palladium-Catalyzed Diarylation of Isocyanides with Tetraarylleads for the Selective Synthesis of Imines and α-Diimines; 2019年09月
    発表情報; Journal of Organic Chemistry, 84, 18, 11741 - 11751
    著者; Tran, Cong Chi; Kawaguchi, Shin Ichi; Kobiki, Yohsuke; Matsubara, Hitomi; Tran, Dat Phuc; Kodama, Shintaro; Nomoto, Akihiro; Ogawa, Akiya
  • Molecular Mechanism of Cellular Oxidative Stress Sensing by Keap1; 2019年07月
    発表情報; Cell Reports, 28, 3, 746 - 758.e4
    著者; Suzuki, Takafumi; Muramatsu, Aki; Saito, Ryota; Iso, Tatsuro; Shibata, Takahiro; Kuwata, Keiko; Kawaguchi, Shin ichi; Iwawaki, Takao; Adachi, Saki; Suda, Hiromi; Morita, Masanobu; Uchida, Koji; Baird, Liam; Yamamoto, Masayuki
  • Reductive Rearrangement of Tetraphenyldiphosphine Disulfide To Trigger the Bisthiophosphinylation of Alkenes and Alkynes; 2019年05月
    発表情報; Chemistry - A European Journal, 25, 27, 6797 - 6806
    著者; Sato, Yuki; Nishimura, Misaki; Kawaguchi, Shin ichi; Nomoto, Akihiro; Ogawa, Akiya
  • Synthesis of Bis(phosphanyl)alkane Monosulfides by the Addition of Diphosphane Monosulfides to Alkenes under Light; 2019年02月
    発表情報; Chemistry - A European Journal, 25, 9, 2295 - 2302
    著者; Sato, Yuki; Kawaguchi, Shin ichi; Nomoto, Akihiro; Ogawa, Akiya
  • Synthesis of Aryl Iodides from Arylhydrazines and Iodine; 2018年08月
    発表情報; ACS Omega, 3, 8, 9814 - 9821
    著者; Dong, Chun Ping; Nakamura, Kentaro; Taniguchi, Toshihide; Mita, Soichiro; Kodama, Shintaro; Kawaguchi, Shin Ichi; Nomoto, Akihiro; Ogawa, Akiya; Mizuno, Takumi
  • Palladium-Catalyzed Cyanothiolation of Internal Alkynes Using Organic Disulfides and tert-Butyl Isocyanide; 2018年05月
    発表情報; Journal of Organic Chemistry, 83, 9, 5267 - 5273
    著者; Higashimae, Shinya; Kurata, Daichi; Kawaguchi, Shin Ichi; Kodama, Shintaro; Sonoda, Motohiro; Nomoto, Akihiro; Ogawa, Akiya
  • Furan- and thiophene-2-carbonyl amino acid derivatives activate hypoxia-inducible factor via inhibition of factor inhibiting hypoxia-inducible factor-1; 2018年01月
    発表情報; Molecules, 23, 4, -
    著者; Kawaguchi, Shin ichi; Gonda, Yuhei; Yamamoto, Takuya; Sato, Yuki; Shinohara, Hiroyuki; Kobiki, Yohsuke; Ichimura, Atsuhiko; Dan, Takashi; Sonoda, Motohiro; Miyata, Toshio; Ogawa, Akiya; Tsujita, Tadayuki
  • A Benzoyl Peroxide/Diphenyl Diselenide Binary System for Functionalization of Alkynes Leading to Alkenyl and Alkynyl Selenides; 2017年12月
    発表情報; Journal of Organic Chemistry, 82, 23, 1247712484
    著者; Kodama, Shintaro; Saeki, Tomokazu; Mihara, Kei; Higashimae, Shinya; Kawaguchi, Shin Ichi; Sonoda, Motohiro; Nomoto, Akihiro; Ogawa, Akiya
  • Hydroiodination-Triggered Cascade Reaction with I2/PPh3/H2O: Metal-Free Access to 3-Substituted Phthalides from 2-Alkynylbenzoates; 2017年10月
    発表情報; European Journal of Organic Chemistry, 2017, 36, 53435346
    著者; Kawaguchi, Shin Ichi; Nakamura, Kentaro; Yamaguchi, Kotaro; Sato, Yuki; Gonda, Yuhei; Nishioka, Masaaki; Sonoda, Motohiro; Nomoto, Akihiro; Ogawa, Akiya
  • Photoinduced Coupling Reaction of Diphenyl(2,4,6-trimethylbenzoyl)phosphine Oxide with Interelement Compounds: Application to the Synthesis of Thio- or Selenophosphinates; 2017年08月
    発表情報; Synthesis (Germany), 49, 16, 35583567
    著者; Sato, Yuki; Kawaguchi, Shin Ichi; Nomoto, Akihiro; Ogawa, Akiya
  • The PMe3-catalyzed addition of enantiomerically pure (−)-MenthylO(Ph)P(O)H to electron-deficient alkenes: an efficient way for the preparation of P-stereogenic compounds; 2017年01月
    発表情報; Tetrahedron Asymmetry, 28, 1, 8489
    著者; Saga, Yuta; Saga, Yuta; Mino, Yuka; Kawaguchi, Shin ichi; Han, Daoqing; Ogawa, Akiya; Han, Li Biao
  • Copper-catalyzed tandem reaction directed toward synthesis of 2,2-disubstituted quinazolinones from vinyl halides and 2-aminobenzamides; 2017年01月
    発表情報; Tetrahedron Letters, 58, 43, 40434047
    著者; Yamaguchi, Kotaro; Kawaguchi, Shin ichi; Sonoda, Motohiro; Tanimori, Shinji; Ogawa, Akiya
  • P-Fluorous Phosphines as Electron-Poor/Fluorous Hybrid Functional Ligands for Precious Metal Catalysts: Synthesis of Rh(I), Ir(I), Pt(II), and Au(I) Complexes Bearing P-Fluorous Phosphine Ligands; 2017年01月
    発表情報; Inorganics, 5, 5
    著者; Kawaguchi, S-i.*; Saga, Y.; Sato, Y.; Minamida, Y.; Nomoto, A.; Ogawa, A.
  • Phosphinylphosphination of Alkenes with Tetraphenyldiphosphine Monoxide; 2016年01月
    発表情報; Angewandte Chemie - International Edition, 55, 33, 9700
    著者; Sato, Y.; Kawaguchi, S-i. *; Nomoto, A.; Ogawa, A.
  • A salt-free synthesis of 1,2-bisphosphorylethanes via an efficient PMe3-catalyzed addition of Z2P(O)H to vinylphosphoryl compounds; 2015年01月
    発表情報; Tetrahedron Letters, 56, 38, 5303
    著者; Saga, Y., Han, D., Kawaguchi, S-i., Ogawa, A., Han, L.-B.
  • Photoinduced Synthesis of P-Perfluoroalkylated Phosphines from Triarylphosphines and Their Application in the Copper-Free Cross-Coupling of Acid Chlorides and Terminal Alkynes; 2015年01月
    発表情報; Advanced Synthesis and Catalysis, 357, 11, 2509
    著者; Kawaguchi, S-i., Minamida, Y., Okuda, T., Sato, Y., Saeki, T., Yoshimura, A., Nomoto, A., Ogawa, A.
  • Palladium-Catalyzed Synthesis of α-Diimines from Triarylbismuthines and Isocyanides; 2015年01月
    発表情報; Organic Letters, 17, 14, 3490
    著者; Kobiki, Y., Kawaguchi, S-i., Ogawa, A.
  • Photoinduced reductive perfluoroalkylation of phosphine oxides: synthesis of P-perfluoroalkylated phosphines using TMDPO and perfluoroalkyl iodides; 2015年01月
    発表情報; Chemical Communications, 51, 52, 10385
    著者; Sato, Y., Kawaguchi, S-i., Ogawa, A.
  • Hypoxia-sensitive reporter system for high-throughput screening; 2015年01月
    発表情報; Tohoku Journal of Experimental Medicine, 235, 2, 151
    著者; Tsujita, T., Kawaguchi, S-i., Dan, T., Baird, L., Miyata, T., Yamamoto, M.
  • Discovery of an NRF1-specific inducer from a large-scale chemical library using a direct NRF1-protein monitoring system; 2015年01月
    発表情報; Genes to Cells, 20, 7, 563
    著者; Tsujita, T., Baird, L., Furusawa, Y., Katsuoka, F., Hou, Y., Gotoh, S., Kawaguchi, S-i., Yamamoto, M.
  • DNA methyltransferase 3a regulates osteoclast differentiation by coupling to an S-adenosylmethionine-producing metabolic pathway; 2015年01月
    発表情報; Nature Medicine, 21, 3, 281
    著者; Nishikawa, K., Iwamoto, Y., Kobayashi, Y., Katsuoka, F., Kawaguchi, S-i., Tsujita, T., Nakamura, T., Kato, S., Yamamoto, M., Takayanagi, H., Ishii, M.
  • Hypoxia signaling cascade for erythropoietin production in hepatocytes; 2015年01月
    発表情報; Molecular and Cellular Biology, 35, 15, 2658
    著者; Tojo, Y., Sekine, H., Hirano, I., Pan, X., Souma, T., Tsujit, T., Kawaguchi, S-i., Takeda, N., Takeda, K., Fong, G.-H., Dan, T., Ichinose, M., Miyata, T., Yamamoto, M., Suzuki, N.
  • A convenient hydroiodination of alkynes using I2/PPh3/H2O and its application to the one-pot synthesis of trisubstituted alkenes via iodoalkenes using Pd-catalyzed cross-coupling reactions; 2014年01月
    発表情報; Tetrahedron Letters, 55, 50, 6779
    著者; Kawaguchi, S-i., Gonda, Y., Masuno, H., Vu, H.T., Yamaguchi, K., Shinohara, H., Sonoda, M., Ogawa, A.
  • Highly regioselective hydroselenation of inactivated terminal alkynes using diselenide-Ph2P(O)H mixed systems under visible-light irradiation; 2013年01月
    発表情報; Tetrahedron Letters, 54, 40, 5453
    著者; Kobiki, Y., Kawaguchi, S-i., Ogawa, A.
  • Photoinduced synthesis of unsymmetrical diaryl selenides from triarylbismuthines and diaryl diselenides; 2013年01月
    発表情報; Beilstein Journal of Organic Chemistry, 9, 1141
    著者; Kobiki, Y., Kawaguchi, S-i., Ohe, T., Ogawa, A.
  • Synthesis and properties of perfluoroalkyl phosphine ligands: Photoinduced reaction of diphosphines with perfluoroalkyl iodides; 2013年01月
    発表情報; Angewandte Chemie - International Edition, 52, 6, 1748
    著者; Kawaguchi, S-i., Minamida, Y., Ohe, T., Nomoto, A., Sonoda, M., Ogawa, A.
  • Highly regioselective hydroiodination of terminal alkynes and silylalkynes with iodine and phosphorus reagents leading to internal iodoalkenes; 2012年01月
    発表情報; Tetrahedron, 68, 47, 9818
    著者; Kawaguchi, S-i., Masuno, H., Sonoda, M., Nomoto, A., Ogawa, A.
  • Rhodium-catalyzed highly stereoselective hydroselenation of internal alkynes bearing an electron-withdrawing group; 2011年01月
    発表情報; Organometallics, 30, 24, 6766
    著者; Kawaguchi, S-i., Kotani, M., Atobe, S., Nomoto, A., Sonoda, M., Ogawa, A.
  • Palladium-catalyzed Sonogashira cross-coupling of organic tellurides with alkynes; 2011年01月
    発表情報; Tetrahedron Letters, 52, 32, 4120
    著者; Kawaguchi, S-i., Srivastava, P., Engman, L.
  • Highly selective hydroiodation of alkynes using an iodine-hydrophosphine binary system; 2010年01月
    発表情報; Organic Letters, 12, 9, 1893
    著者; Kawaguchi, S-i., Ogawa, A.
  • Rhodium-catalyzed anti-markovnikov-type hydrophosphination of terminal alkynes with diphosphines and hydrosilanes in the presence of oxygen; 2010年01月
    発表情報; Phosphorus, Sulfur and Silicon and the Related Elements, 185, 1090
    著者; Kawaguchi, S-i., Kotani, M., Ohe, T., Nagata, S., Nomoto, A., Sonoda, M., Ogawa, A.
  • Highly selective phosphinotelluration of terminal alkynes using a (Ph 2P)2-(PhTe)2 mixed system upon visible light irradiation: Straightforward access to 1-phosphino-2-telluro-alkenes; 2010年01月
    発表情報; Organometallics, 29, 2, 312
    著者; Kawaguchi, S-i., Ohe, T., Shirai, T., Nomoto, A., Sonoda, M., Ogawa, A.
  • Highly regioselective simultaneous introduction of phosphino and seleno groups into unsaturated bonds by the novel combination of (Ph2P) 2 and (PhSe)2 upon photoirradiation; 2009年01月
    発表情報; Journal of Organic Chemistry, 74, 4, 1751
    著者; Kawaguchi, S-i., Shirai, T., Ohe, T., Nomoto, A., Sonoda, M., Ogawa, A.
  • Photoinduced hydrophosphinylation of alkenes with diphenylphosphine oxide; 2009年01月
    発表情報; Tetrahedron Letters, 50, 6, 624
    著者; Kawaguchi S-i., Nomoto, A., Sonoda, M., Ogawa, A.
  • A highly regioselective palladium-catalyzed hydrophosphination of alkynes using a diphosphine-hydrosilane binary system; 2008年01月
    発表情報; Journal of Organic Chemistry, 73, 20, 7928
    著者; Kawaguchi, S-i., Nagata, S., Nomoto, A., Sonoda, M., Ogawa, A.
  • Photoinduced highly selective thiophosphination of alkynes using a (PhS)2/(Ph2P)2 binary system; 2008年01月
    発表情報; Tetrahedron Letters, 49, 25, 4043
    著者; Shirai, T., Kawaguchi, S-i., Nomoto, A., Ogawa, A.
  • A highly regioselective hydrophosphination of terminal alkynes with tetraphenyldiphosphine in the presence of palladium catalyst; 2007年01月
    発表情報; Tetrahedron Letters, 48, 38, 6637
    著者; Nagata, S., Kawaguchi, S-i., Matsumoto, M., Kamiya, I., Nomoto, A., Sonoda, M., Ogawa, A.
  • Highly selective double chalcogenation of isocyanides with disulfide-diselenide mixed systems; 2007年01月
    発表情報; Journal of Organic Chemistry, 72, 2, 415
    著者; Tsuchii, K., Tsuboi, Y., Kawaguchi, S-i, Takahashi, J., Sonoda, N., Nomoto, A., Ogawa, A.
  • Photochemical behaviors of tetraphenyldiphosphine in the presence of alkynes; 2006年01月
    発表情報; Tetrahedron Letters, 47, 23, 3919
    著者; Kawaguchi, S.-i., Nagata, S., Shirai, T., Tsuchii, K., Nomoto, A., Ogawa, A.

資料・解説・論説・研究報告・総合雑誌の論文

  • Catalytic synthesis of sulfur and phosphorus compounds via atom-economic reactions; 2020年03月
    発表情報; Mendeleev Communications, 30, 2, 129 - 138
    著者; Kawaguchi, Shin ichi; Yamamoto, Yuki; Ogawa, Akiya
  • Highly selective hydroiodination of carbon-carbon double or triple bonds; 2020年01月
    発表情報; Current Organic Chemistry, 24, 18, 2153 - 2168
    著者; Yamamoto, Yuki; Kawaguchi, Shin Ichi; Kodama, Shintaro; Nomoto, Akihiro; Ogawa, Akiya
  • Applications of Diphosphines in Radical Reactions; 2019年08月
    発表情報; Asian Journal of Organic Chemistry, 8, 8, 1164 - 1173
    著者; Kawaguchi, Shin ichi; Ogawa, Akiya
  • 酸素センサーPHDを標的とした低分子阻害薬の開発; 2013年01月
    発表情報; 細胞(特集 低酸素ストレス応答の疾患生物学), 45, 9, 427
    著者; 川口真一、小川昭弥、宮田敏男
  • The development of highly selective addition reactions of tetraphenyldiphosphine to carbon-carbon unsaturated bonds; 2010年01月
    発表情報; Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry, 68, 7, 705
    著者; Kawaguchi, S-i., Ogawa, A.

総説

  • Highly selective addition of phosphorus-containing interelement compounds to alkynes; 2013年01月
    発表情報; Synlett, 24, 17, 2199
    著者; Kawaguchi, S-i., Ogawa, A.


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