日本語フィールド
著者：Kawaguchi, Shin Ichi; Nakamura, Kentaro; Yamaguchi, Kotaro; Sato, Yuki; Gonda, Yuhei; Nishioka, Masaaki; Sonoda, Motohiro; Nomoto, Akihiro; Ogawa, Akiya題名：Hydroiodination-Triggered Cascade Reaction with I2/PPh3/H2O: Metal-Free Access to 3-Substituted Phthalides from 2-Alkynylbenzoates発表情報：European Journal of Organic Chemistry 巻: 2017 号: 36 ページ: 53435346キーワード：概要：© 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Phthalide is an important scaffold found in several biologically active compounds. Therefore, effective methods for the synthesis of phthalides are strongly desired. Herein, we describe the metal-free synthesis of 3-substituted phthalides by the reductive hydroiodination of 2-alkynylbenzoates through an I 2 /PPh 3 /H 2 O-triggered cascade reaction. A variety of 3-substituted phthalides were synthesized in excellent yields by a one-pot reaction involving four processes: desilylation, hydroiodination, cyclization, and reduction.抄録：英語フィールド
Author：Kawaguchi, Shin Ichi; Nakamura, Kentaro; Yamaguchi, Kotaro; Sato, Yuki; Gonda, Yuhei; Nishioka, Masaaki; Sonoda, Motohiro; Nomoto, Akihiro; Ogawa, AkiyaTitle：Hydroiodination-Triggered Cascade Reaction with I2/PPh3/H2O: Metal-Free Access to 3-Substituted Phthalides from 2-AlkynylbenzoatesAnnouncement information:European Journal of Organic Chemistry Vol: 2017 Issue: 36 Page: 53435346An abstract：© 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Phthalide is an important scaffold found in several biologically active compounds. Therefore, effective methods for the synthesis of phthalides are strongly desired. Herein, we describe the metal-free synthesis of 3-substituted phthalides by the reductive hydroiodination of 2-alkynylbenzoates through an I 2 /PPh 3 /H 2 O-triggered cascade reaction. A variety of 3-substituted phthalides were synthesized in excellent yields by a one-pot reaction involving four processes: desilylation, hydroiodination, cyclization, and reduction.