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Copper-catalyzed tandem reaction directed toward synthesis of 2,2-disubstituted quinazolinones from vinyl halides and 2-aminobenzamides

発表形態:
原著論文
主要業績:
主要業績
単著・共著:
共著
発表年月:
2017年01月
DOI:
10.1016/j.tetlet.2017.09.001
会議属性:
指定なし
査読:
有り
リンク情報:

日本語フィールド

著者:
Yamaguchi, Kotaro; Kawaguchi, Shin ichi; Sonoda, Motohiro; Tanimori, Shinji; Ogawa, Akiya
題名:
Copper-catalyzed tandem reaction directed toward synthesis of 2,2-disubstituted quinazolinones from vinyl halides and 2-aminobenzamides
発表情報:
Tetrahedron Letters 巻: 58 号: 43 ページ: 40434047
キーワード:
概要:
© 2017 Elsevier Ltd A copper-catalyzed tandem reaction with vinyl halides and 2-aminobenzamides has been developed. In this synthetic route, cross-coupling reaction of the amide moiety with vinyl halides initially progresses, followed by hydroamination, to provide 2,2-disubstituted quinazolinone derivatives. Moreover, the tandem reaction is used in a one-pot synthesis beginning with alkyne hydroiodination by PPh 3 , I 2 , and H 2 O.
抄録:

英語フィールド

Author:
Yamaguchi, Kotaro; Kawaguchi, Shin ichi; Sonoda, Motohiro; Tanimori, Shinji; Ogawa, Akiya
Title:
Copper-catalyzed tandem reaction directed toward synthesis of 2,2-disubstituted quinazolinones from vinyl halides and 2-aminobenzamides
Announcement information:
Tetrahedron Letters Vol: 58 Issue: 43 Page: 40434047
An abstract:
© 2017 Elsevier Ltd A copper-catalyzed tandem reaction with vinyl halides and 2-aminobenzamides has been developed. In this synthetic route, cross-coupling reaction of the amide moiety with vinyl halides initially progresses, followed by hydroamination, to provide 2,2-disubstituted quinazolinone derivatives. Moreover, the tandem reaction is used in a one-pot synthesis beginning with alkyne hydroiodination by PPh 3 , I 2 , and H 2 O.


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