2012/04 - 2015/03 Postdoctoral Fellowships of Japan Society for the Promotion of Science
2015/04 - 2016/02 Part-time researcher for university or other academic organization
2016/03 - 2019/03 Center for Education and Research in Agricultural Innovation, Faculty of Agriculture, Saga University
2019/04 - * Associate Professor, Faculty of Agriculture, Center for Education and Research in Agricultural Innovation, Saga University
2019/04 - * Associate Professor, Saga University
Field of Specialization
Organic chemistry, Drug development chemistry, Green/Environmental chemistry, Chemical pharmacy, Bioorganic chemistry
Membership in Academic Societies
American Chemical Society
Research Topics and Results
Improving lipophilicity of 5-(1-acetyl-5-phenylpyrazolidin-3-ylidene)-1,3-dimethylbarbituric acid increases its efficacy to activate hypoxia-inducible factors 2022/11
Prolyl Hydroxylase Domain Protein Inhibitor Not Harboring a 2-Oxoglutarate Scaffold Protects against Hypoxic Stress 2022/05
Synthesis of diaryl phosphates using orthophosphoric acid as a phosphorus source 2022/04
CHARACTERIZATION AND ANTITUMOR ACTIVITY OF FURAZANO[3,4-g]PTERIDINE-2,4(1H,3H)-DIONE 2022/01
The molecular mechanism of phytosphingosine binding to FFAR4/GPR120 differs from that of other fatty acids 2021/11
Transition-metal-catalyzed diarylation of isocyanides with triarylbismuthines for the selective synthesis of imine derivatives 2021/08
Highly regio- And stereoselective phosphinylphosphination of terminal alkynes with tetraphenyldiphosphine monoxide under radical conditions 2021/04
Phosphorus-recycling wittig reaction: Design and facile synthesis of a fluorous phosphine and its reusable process in the wittig reaction 2020/11
Photoinduced syntheses and reactivities of phosphorus-containing interelement compounds 2020/11
Photoinduced Cyclizations of o-Diisocyanoarenes with Organic Diselenides and Thiols that Afford Chalcogenated Quinoxalines 2020/06
Catalytic synthesis of sulfur and phosphorus compounds via atom-economic reactions 2020/03
Highly selective hydroiodination of carbon-carbon double or triple bonds 2020/01
Palladium-Catalyzed Diarylation of Isocyanides with Tetraarylleads for the Selective Synthesis of Imines and α-Diimines 2019/09
Applications of Diphosphines in Radical Reactions 2019/08
Molecular Mechanism of Cellular Oxidative Stress Sensing by Keap1 2019/07
Reductive Rearrangement of Tetraphenyldiphosphine Disulfide To Trigger the Bisthiophosphinylation of Alkenes and Alkynes 2019/05
Synthesis of Aryl Iodides from Arylhydrazines and Iodine 2018/08
Palladium-Catalyzed Cyanothiolation of Internal Alkynes Using Organic Disulfides and tert-Butyl Isocyanide 2018/05
Furan- and thiophene-2-carbonyl amino acid derivatives activate hypoxia-inducible factor via inhibition of factor inhibiting hypoxia-inducible factor-1 2018/01
A Benzoyl Peroxide/Diphenyl Diselenide Binary System for Functionalization of Alkynes Leading to Alkenyl and Alkynyl Selenides 2017/12
Hydroiodination-Triggered Cascade Reaction with I2/PPh3/H2O: Metal-Free Access to 3-Substituted Phthalides from 2-Alkynylbenzoates 2017/10
Photoinduced Coupling Reaction of Diphenyl(2,4,6-trimethylbenzoyl)phosphine Oxide with Interelement Compounds: Application to the Synthesis of Thio- or Selenophosphinates 2017/08
The PMe3-catalyzed addition of enantiomerically pure (−)-MenthylO(Ph)P(O)H to electron-deficient alkenes: an efficient way for the preparation of P-stereogenic compounds 2017/01
Copper-catalyzed tandem reaction directed toward synthesis of 2,2-disubstituted quinazolinones from vinyl halides and 2-aminobenzamides 2017/01
P-Fluorous Phosphines as Electron-Poor/Fluorous Hybrid Functional Ligands for Precious Metal Catalysts: Synthesis of Rh(I), Ir(I), Pt(II), and Au(I) Complexes Bearing P-Fluorous Phosphine Ligands 2017/01
Phosphinylphosphination of Alkenes with Tetraphenyldiphosphine Monoxide 2016/01
A salt-free synthesis of 1,2-bisphosphorylethanes via an efficient PMe3-catalyzed addition of Z2P(O)H to vinylphosphoryl compounds 2015/01
Photoinduced Synthesis of P-Perfluoroalkylated Phosphines from Triarylphosphines and Their Application in the Copper-Free Cross-Coupling of Acid Chlorides and Terminal Alkynes 2015/01
Palladium-Catalyzed Synthesis of α-Diimines from Triarylbismuthines and Isocyanides 2015/01
Photoinduced reductive perfluoroalkylation of phosphine oxides: synthesis of P-perfluoroalkylated phosphines using TMDPO and perfluoroalkyl iodides 2015/01
Hypoxia-sensitive reporter system for high-throughput screening 2015/01
Discovery of an NRF1-specific inducer from a large-scale chemical library using a direct NRF1-protein monitoring system 2015/01
DNA methyltransferase 3a regulates osteoclast differentiation by coupling to an S-adenosylmethionine-producing metabolic pathway 2015/01
Hypoxia signaling cascade for erythropoietin production in hepatocytes 2015/01
A convenient hydroiodination of alkynes using I2/PPh3/H2O and its application to the one-pot synthesis of trisubstituted alkenes via iodoalkenes using Pd-catalyzed cross-coupling reactions 2014/01
Highly selective addition of phosphorus-containing interelement compounds to alkynes 2013/01
Highly regioselective hydroselenation of inactivated terminal alkynes using diselenide-Ph2P(O)H mixed systems under visible-light irradiation 2013/01
Photoinduced synthesis of unsymmetrical diaryl selenides from triarylbismuthines and diaryl diselenides 2013/01
Synthesis and properties of perfluoroalkyl phosphine ligands: Photoinduced reaction of diphosphines with perfluoroalkyl iodides 2013/01
Highly regioselective hydroiodination of terminal alkynes and silylalkynes with iodine and phosphorus reagents leading to internal iodoalkenes 2012/01
Rhodium-catalyzed highly stereoselective hydroselenation of internal alkynes bearing an electron-withdrawing group 2011/01
Palladium-catalyzed Sonogashira cross-coupling of organic tellurides with alkynes 2011/01
The development of highly selective addition reactions of tetraphenyldiphosphine to carbon-carbon unsaturated bonds 2010/01
Highly selective hydroiodation of alkynes using an iodine-hydrophosphine binary system 2010/01
Rhodium-catalyzed anti-markovnikov-type hydrophosphination of terminal alkynes with diphosphines and hydrosilanes in the presence of oxygen 2010/01
Highly selective phosphinotelluration of terminal alkynes using a (Ph 2P)2-(PhTe)2 mixed system upon visible light irradiation: Straightforward access to 1-phosphino-2-telluro-alkenes 2010/01
Highly regioselective simultaneous introduction of phosphino and seleno groups into unsaturated bonds by the novel combination of (Ph2P) 2 and (PhSe)2 upon photoirradiation 2009/01
Photoinduced hydrophosphinylation of alkenes with diphenylphosphine oxide 2009/01
A highly regioselective palladium-catalyzed hydrophosphination of alkynes using a diphosphine-hydrosilane binary system 2008/01
Photoinduced highly selective thiophosphination of alkynes using a (PhS)2/(Ph2P)2 binary system 2008/01
A highly regioselective hydrophosphination of terminal alkynes with tetraphenyldiphosphine in the presence of palladium catalyst 2007/01
Highly selective double chalcogenation of isocyanides with disulfide-diselenide mixed systems 2007/01
Photochemical behaviors of tetraphenyldiphosphine in the presence of alkynes 2006/01
Original Articles
Improving lipophilicity of 5-(1-acetyl-5-phenylpyrazolidin-3-ylidene)-1,3-dimethylbarbituric acid increases its efficacy to activate hypoxia-inducible factors; 2022/11 ANNOUNCEMENT INFO.; Bioorganic and Medicinal Chemistry, 73, - AUTHOR; Sonoda, Kento; Ujike, Saki; Katayama, Akito; Suzuki, Norio; Kawaguchi, Shin ichi; Tsujita, Tadayuki
The molecular mechanism of phytosphingosine binding to FFAR4/GPR120 differs from that of other fatty acids; 2021/11 ANNOUNCEMENT INFO.; FEBS Open Bio, 11, 11, 3081 - 3089 AUTHOR; Nagasawa, Tomotaka; Horitani, Masaki; Kawaguchi, Shin ichi; Higashiyama, Shigeki; Hama, Yoichiro; Mitsutake, Susumu
Transition-metal-catalyzed diarylation of isocyanides with triarylbismuthines for the selective synthesis of imine derivatives; 2021/08 ANNOUNCEMENT INFO.; Materials, 14, 15, - AUTHOR; Kodama, Shintaro; Yamamoto, Yuki; Kobiki, Yohsuke; Matsubara, Hitomi; Tran, Cong Chi; Kawaguchi, Shin Ichi; Nomoto, Akihiro; Ogawa, Akiya
Photoinduced selective hydrophosphinylation of allylic compounds with diphenylphosphine oxide leading to γ-functionalized P-ligand precursors; 2021/07 ANNOUNCEMENT INFO.; Research on Chemical Intermediates, 47, 7, 3067 - 3078 AUTHOR; Tran, Dat Phuc; Sato, Yuki; Yamamoto, Yuki; Kawaguchi, Shin ichi; Kodama, Shintaro; Nomoto, Akihiro; Ogawa, Akiya
Highly regio- And stereoselective phosphinylphosphination of terminal alkynes with tetraphenyldiphosphine monoxide under radical conditions; 2021/04 ANNOUNCEMENT INFO.; Beilstein Journal of Organic Chemistry, 17, 866 - 872 AUTHOR; Tran, Dat Phuc; Sato, Yuki; Yamamoto, Yuki; Kawaguchi, Shin Ichi; Kodama, Shintaro; Nomoto, Akihiro; Ogawa, Akiya
Photoinduced selective hydrophosphinylation of allylic compounds with diphenylphosphine oxide leading to γ-functionalized P-ligand precursors; 2021/01 ANNOUNCEMENT INFO.; Research on Chemical Intermediates, - AUTHOR; Tran, Dat Phuc; Sato, Yuki; Yamamoto, Yuki; Kawaguchi, Shin ichi; Kodama, Shintaro; Nomoto, Akihiro; Ogawa, Akiya
Phosphorus-recycling wittig reaction: Design and facile synthesis of a fluorous phosphine and its reusable process in the wittig reaction; 2020/11 ANNOUNCEMENT INFO.; Journal of Organic Chemistry, 85, 22, 14684 - 14696 AUTHOR; Yamamoto, Yuki; Kawaguchi, Shin Ichi; Nishimura, Misaki; Sato, Yuki; Shimada, Yoshihisa; Tabuchi, Akihiro; Nomoto, Akihiro; Ogawa, Akiya
A Benzoyl Peroxide/Diphenyl Diselenide Binary System for Functionalization of Alkynes Leading to Alkenyl and Alkynyl Selenides; 2017/12 ANNOUNCEMENT INFO.; Journal of Organic Chemistry, 82, 23, 1247712484 AUTHOR; Kodama, Shintaro; Saeki, Tomokazu; Mihara, Kei; Higashimae, Shinya; Kawaguchi, Shin Ichi; Sonoda, Motohiro; Nomoto, Akihiro; Ogawa, Akiya
Hydroiodination-Triggered Cascade Reaction with I2/PPh3/H2O: Metal-Free Access to 3-Substituted Phthalides from 2-Alkynylbenzoates; 2017/10 ANNOUNCEMENT INFO.; European Journal of Organic Chemistry, 2017, 36, 53435346 AUTHOR; Kawaguchi, Shin Ichi; Nakamura, Kentaro; Yamaguchi, Kotaro; Sato, Yuki; Gonda, Yuhei; Nishioka, Masaaki; Sonoda, Motohiro; Nomoto, Akihiro; Ogawa, Akiya
Photoinduced Coupling Reaction of Diphenyl(2,4,6-trimethylbenzoyl)phosphine Oxide with Interelement Compounds: Application to the Synthesis of Thio- or Selenophosphinates; 2017/08 ANNOUNCEMENT INFO.; Synthesis (Germany), 49, 16, 35583567 AUTHOR; Sato, Yuki; Kawaguchi, Shin Ichi; Nomoto, Akihiro; Ogawa, Akiya
The PMe3-catalyzed addition of enantiomerically pure (−)-MenthylO(Ph)P(O)H to electron-deficient alkenes: an efficient way for the preparation of P-stereogenic compounds; 2017/01 ANNOUNCEMENT INFO.; Tetrahedron Asymmetry, 28, 1, 8489 AUTHOR; Saga, Yuta; Saga, Yuta; Mino, Yuka; Kawaguchi, Shin ichi; Han, Daoqing; Ogawa, Akiya; Han, Li Biao
Copper-catalyzed tandem reaction directed toward synthesis of 2,2-disubstituted quinazolinones from vinyl halides and 2-aminobenzamides; 2017/01 ANNOUNCEMENT INFO.; Tetrahedron Letters, 58, 43, 40434047 AUTHOR; Yamaguchi, Kotaro; Kawaguchi, Shin ichi; Sonoda, Motohiro; Tanimori, Shinji; Ogawa, Akiya
P-Fluorous Phosphines as Electron-Poor/Fluorous Hybrid Functional Ligands for Precious Metal Catalysts: Synthesis of Rh(I), Ir(I), Pt(II), and Au(I) Complexes Bearing P-Fluorous Phosphine Ligands; 2017/01 ANNOUNCEMENT INFO.; Inorganics, 5, 5 AUTHOR; Kawaguchi, S-i.*; Saga, Y.; Sato, Y.; Minamida, Y.; Nomoto, A.; Ogawa, A.
Phosphinylphosphination of Alkenes with Tetraphenyldiphosphine Monoxide; 2016/01 ANNOUNCEMENT INFO.; Angewandte Chemie - International Edition, 55, 33, 9700 AUTHOR; Sato, Y.; Kawaguchi, S-i. *; Nomoto, A.; Ogawa, A.
A salt-free synthesis of 1,2-bisphosphorylethanes via an efficient PMe3-catalyzed addition of Z2P(O)H to vinylphosphoryl compounds; 2015/01 ANNOUNCEMENT INFO.; Tetrahedron Letters, 56, 38, 5303 AUTHOR; Saga, Y., Han, D., Kawaguchi, S-i., Ogawa, A., Han, L.-B.
Photoinduced Synthesis of P-Perfluoroalkylated Phosphines from Triarylphosphines and Their Application in the Copper-Free Cross-Coupling of Acid Chlorides and Terminal Alkynes; 2015/01 ANNOUNCEMENT INFO.; Advanced Synthesis and Catalysis, 357, 11, 2509 AUTHOR; Kawaguchi, S-i., Minamida, Y., Okuda, T., Sato, Y., Saeki, T., Yoshimura, A., Nomoto, A., Ogawa, A.
Palladium-Catalyzed Synthesis of α-Diimines from Triarylbismuthines and Isocyanides; 2015/01 ANNOUNCEMENT INFO.; Organic Letters, 17, 14, 3490 AUTHOR; Kobiki, Y., Kawaguchi, S-i., Ogawa, A.
Photoinduced reductive perfluoroalkylation of phosphine oxides: synthesis of P-perfluoroalkylated phosphines using TMDPO and perfluoroalkyl iodides; 2015/01 ANNOUNCEMENT INFO.; Chemical Communications, 51, 52, 10385 AUTHOR; Sato, Y., Kawaguchi, S-i., Ogawa, A.
Hypoxia-sensitive reporter system for high-throughput screening; 2015/01 ANNOUNCEMENT INFO.; Tohoku Journal of Experimental Medicine, 235, 2, 151 AUTHOR; Tsujita, T., Kawaguchi, S-i., Dan, T., Baird, L., Miyata, T., Yamamoto, M.
Discovery of an NRF1-specific inducer from a large-scale chemical library using a direct NRF1-protein monitoring system; 2015/01 ANNOUNCEMENT INFO.; Genes to Cells, 20, 7, 563 AUTHOR; Tsujita, T., Baird, L., Furusawa, Y., Katsuoka, F., Hou, Y., Gotoh, S., Kawaguchi, S-i., Yamamoto, M.
DNA methyltransferase 3a regulates osteoclast differentiation by coupling to an S-adenosylmethionine-producing metabolic pathway; 2015/01 ANNOUNCEMENT INFO.; Nature Medicine, 21, 3, 281 AUTHOR; Nishikawa, K., Iwamoto, Y., Kobayashi, Y., Katsuoka, F., Kawaguchi, S-i., Tsujita, T., Nakamura, T., Kato, S., Yamamoto, M., Takayanagi, H., Ishii, M.
Hypoxia signaling cascade for erythropoietin production in hepatocytes; 2015/01 ANNOUNCEMENT INFO.; Molecular and Cellular Biology, 35, 15, 2658 AUTHOR; Tojo, Y., Sekine, H., Hirano, I., Pan, X., Souma, T., Tsujit, T., Kawaguchi, S-i., Takeda, N., Takeda, K., Fong, G.-H., Dan, T., Ichinose, M., Miyata, T., Yamamoto, M., Suzuki, N.
A convenient hydroiodination of alkynes using I2/PPh3/H2O and its application to the one-pot synthesis of trisubstituted alkenes via iodoalkenes using Pd-catalyzed cross-coupling reactions; 2014/01 ANNOUNCEMENT INFO.; Tetrahedron Letters, 55, 50, 6779 AUTHOR; Kawaguchi, S-i., Gonda, Y., Masuno, H., Vu, H.T., Yamaguchi, K., Shinohara, H., Sonoda, M., Ogawa, A.
Highly regioselective hydroselenation of inactivated terminal alkynes using diselenide-Ph2P(O)H mixed systems under visible-light irradiation; 2013/01 ANNOUNCEMENT INFO.; Tetrahedron Letters, 54, 40, 5453 AUTHOR; Kobiki, Y., Kawaguchi, S-i., Ogawa, A.
Photoinduced synthesis of unsymmetrical diaryl selenides from triarylbismuthines and diaryl diselenides; 2013/01 ANNOUNCEMENT INFO.; Beilstein Journal of Organic Chemistry, 9, 1141 AUTHOR; Kobiki, Y., Kawaguchi, S-i., Ohe, T., Ogawa, A.
Synthesis and properties of perfluoroalkyl phosphine ligands: Photoinduced reaction of diphosphines with perfluoroalkyl iodides; 2013/01 ANNOUNCEMENT INFO.; Angewandte Chemie - International Edition, 52, 6, 1748 AUTHOR; Kawaguchi, S-i., Minamida, Y., Ohe, T., Nomoto, A., Sonoda, M., Ogawa, A.
Highly regioselective hydroiodination of terminal alkynes and silylalkynes with iodine and phosphorus reagents leading to internal iodoalkenes; 2012/01 ANNOUNCEMENT INFO.; Tetrahedron, 68, 47, 9818 AUTHOR; Kawaguchi, S-i., Masuno, H., Sonoda, M., Nomoto, A., Ogawa, A.
Rhodium-catalyzed highly stereoselective hydroselenation of internal alkynes bearing an electron-withdrawing group; 2011/01 ANNOUNCEMENT INFO.; Organometallics, 30, 24, 6766 AUTHOR; Kawaguchi, S-i., Kotani, M., Atobe, S., Nomoto, A., Sonoda, M., Ogawa, A.
Palladium-catalyzed Sonogashira cross-coupling of organic tellurides with alkynes; 2011/01 ANNOUNCEMENT INFO.; Tetrahedron Letters, 52, 32, 4120 AUTHOR; Kawaguchi, S-i., Srivastava, P., Engman, L.
Highly selective hydroiodation of alkynes using an iodine-hydrophosphine binary system; 2010/01 ANNOUNCEMENT INFO.; Organic Letters, 12, 9, 1893 AUTHOR; Kawaguchi, S-i., Ogawa, A.
Rhodium-catalyzed anti-markovnikov-type hydrophosphination of terminal alkynes with diphosphines and hydrosilanes in the presence of oxygen; 2010/01 ANNOUNCEMENT INFO.; Phosphorus, Sulfur and Silicon and the Related Elements, 185, 1090 AUTHOR; Kawaguchi, S-i., Kotani, M., Ohe, T., Nagata, S., Nomoto, A., Sonoda, M., Ogawa, A.
Highly selective phosphinotelluration of terminal alkynes using a (Ph 2P)2-(PhTe)2 mixed system upon visible light irradiation: Straightforward access to 1-phosphino-2-telluro-alkenes; 2010/01 ANNOUNCEMENT INFO.; Organometallics, 29, 2, 312 AUTHOR; Kawaguchi, S-i., Ohe, T., Shirai, T., Nomoto, A., Sonoda, M., Ogawa, A.
Highly regioselective simultaneous introduction of phosphino and seleno groups into unsaturated bonds by the novel combination of (Ph2P) 2 and (PhSe)2 upon photoirradiation; 2009/01 ANNOUNCEMENT INFO.; Journal of Organic Chemistry, 74, 4, 1751 AUTHOR; Kawaguchi, S-i., Shirai, T., Ohe, T., Nomoto, A., Sonoda, M., Ogawa, A.
Photoinduced hydrophosphinylation of alkenes with diphenylphosphine oxide; 2009/01 ANNOUNCEMENT INFO.; Tetrahedron Letters, 50, 6, 624 AUTHOR; Kawaguchi S-i., Nomoto, A., Sonoda, M., Ogawa, A.
A highly regioselective palladium-catalyzed hydrophosphination of alkynes using a diphosphine-hydrosilane binary system; 2008/01 ANNOUNCEMENT INFO.; Journal of Organic Chemistry, 73, 20, 7928 AUTHOR; Kawaguchi, S-i., Nagata, S., Nomoto, A., Sonoda, M., Ogawa, A.
Photoinduced highly selective thiophosphination of alkynes using a (PhS)2/(Ph2P)2 binary system; 2008/01 ANNOUNCEMENT INFO.; Tetrahedron Letters, 49, 25, 4043 AUTHOR; Shirai, T., Kawaguchi, S-i., Nomoto, A., Ogawa, A.
A highly regioselective hydrophosphination of terminal alkynes with tetraphenyldiphosphine in the presence of palladium catalyst; 2007/01 ANNOUNCEMENT INFO.; Tetrahedron Letters, 48, 38, 6637 AUTHOR; Nagata, S., Kawaguchi, S-i., Matsumoto, M., Kamiya, I., Nomoto, A., Sonoda, M., Ogawa, A.
Highly selective double chalcogenation of isocyanides with disulfide-diselenide mixed systems; 2007/01 ANNOUNCEMENT INFO.; Journal of Organic Chemistry, 72, 2, 415 AUTHOR; Tsuchii, K., Tsuboi, Y., Kawaguchi, S-i, Takahashi, J., Sonoda, N., Nomoto, A., Ogawa, A.
Photochemical behaviors of tetraphenyldiphosphine in the presence of alkynes; 2006/01 ANNOUNCEMENT INFO.; Tetrahedron Letters, 47, 23, 3919 AUTHOR; Kawaguchi, S.-i., Nagata, S., Shirai, T., Tsuchii, K., Nomoto, A., Ogawa, A.
Material, Commentary, Editorials, Research Report, A Comprehensive Journal Articles
Catalytic synthesis of sulfur and phosphorus compounds via atom-economic reactions; 2020/03 ANNOUNCEMENT INFO.; Mendeleev Communications, 30, 2, 129 - 138 AUTHOR; Kawaguchi, Shin ichi; Yamamoto, Yuki; Ogawa, Akiya
Applications of Diphosphines in Radical Reactions; 2019/08 ANNOUNCEMENT INFO.; Asian Journal of Organic Chemistry, 8, 8, 1164 - 1173 AUTHOR; Kawaguchi, Shin ichi; Ogawa, Akiya
The development of highly selective addition reactions of tetraphenyldiphosphine to carbon-carbon unsaturated bonds; 2010/01 ANNOUNCEMENT INFO.; Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry, 68, 7, 705 AUTHOR; Kawaguchi, S-i., Ogawa, A.
Review Articles
Highly selective addition of phosphorus-containing interelement compounds to alkynes; 2013/01 ANNOUNCEMENT INFO.; Synlett, 24, 17, 2199 AUTHOR; Kawaguchi, S-i., Ogawa, A.