Detailed Information

Research Field/Keywords for Research Field

• Glycobiology

Education

• 2000/03, Graduated
• 2005/03, Doctor Course, Completed

Employment Experience

• 2005/04 - 2007/01
• 2007/02 - 2010/03 Researcher, Medicine, Faculty of Medicine, Saga University
• 2010/04 - 2013/05 Assistant Professor
• 2013/06 -  *  Assistant Professor, Medicine, Faculty of Medicine, Saga University

Field of Specialization

• Biological pharmacy, Applied biochemistry, Applied molecular and cellular biology

Research Topics and Results

• 果実におけるアレルゲンコンポーネント糖鎖の発現メカニズム 2021/07
• Involvement of the α-helical and Src homology 3 domains in the molecular assembly and enzymatic activity of human α1,6-fucosyltransferase, FUT8. 2020/07
• Characterization of MiFUT11 from Mangifera indica L.: A functional core α1,3-fucosyltransferase potentially involved in the biosynthesis of immunogenic carbohydrates in mango fruit 2019/09
• Molecular cloning and characterization of novel β1,3-galactosyltransferase genes from Mangifera indica L. 2019/03
• Properties of Lewis type α1,3/α1,4-fucosyltransferase from Mangifera indica L. 2018/09
• Molecular cloning and characterization of novel β1,2-xylosyltransferase from Mangifera indica L. 2018/03
• Molecular cloning and functional expression of Lewis type α1,3/α1,4-fucosyltransferase cDNAs from Mangifera indica L. 2017/12
• Molecular cloning and characterization of novel α1,3/α1,4-fucosyltransferases from Mangifera indica L. 2017/03
• Liver resident macrophages (Kupffer cells) share several functional antigens in common with endothelial cells. 2016
• Control of glycan assembly by enzyme competition 2015/04
• Cloning, expression and characterization of Bombyx mori α1,6-fucosyltransferase. 2014/07
• Toll-like receptor 4-dependent adjuvant activity of Kakkon-to extract exists in the high molecular weight polysaccharide fraction. 2011/01
• Cloning and characterization of a β-N-acetylglucosaminidase (BmFDL) from silkworm Bombyx mori. 2010/10
• N-Glycosylation engineering of lepidopteran insect cells by the introduction of the β1,4-N-acetylglucosaminyltransferase III gene. 2010/09
• Fucosylation of chitooligosaccharides by human alpha1,6-fucosyltransferase requires a nonreducing terminal chitotriose unit as a minimal structure. 2010/08
• Expression of N-terminally truncated forms of rat peroxiredoxin-4 in insect cells. 2010/06
• Bidirectional N-acetylglucosamine transfer mediated by beta-1,4-N-acetylglucosaminyltransferase III. 2009/04
• Glyco-remodeling of Sf21 cell line with β-1,4-N-Acetylglucosaminyltransferase III (GnT-III) 2009/03
• Molecular cloning and expression of two novel beta-N-acetylglucosaminidases from silkworm Bombyx mori. 2007/07
• Crystal structure of archaeal toxin-antitoxin RelE-RelB complex with implications for toxin activity and antitoxin effects. 2005/04
• Contribution of the second OB fold of ribosomal protein S1 from Escherichia coli to the recognition of TmRNA. 2004/11

Books

• 果実におけるアレルゲンコンポーネント糖鎖の発現メカニズム;　2021/07
  ANNOUNCEMENT INFO.;　, 83-92
  AUTHOR;　
  

Original Articles

• Involvement of the α-helical and Src homology 3 domains in the molecular assembly and enzymatic activity of human α1,6-fucosyltransferase, FUT8.;　2020/07
  ANNOUNCEMENT INFO.;　Biochim Biophys Acta Gen Subj, 1864, 7, 129596
  AUTHOR;　Ihara H, Okada T, Taniguchi N, Ikeda Y
  
• Characterization of MiFUT11 from Mangifera indica L.: A functional core α1,3-fucosyltransferase potentially involved in the biosynthesis of immunogenic carbohydrates in mango fruit;　2019/09
  ANNOUNCEMENT INFO.;　Phytochemistry., 165, 112050
  AUTHOR;　Okada T, Ihara H, Ikeda Y
  
• Molecular cloning and functional expression of Lewis type α1,3/α1,4-fucosyltransferase cDNAs from Mangifera indica L.;　2017/12
  ANNOUNCEMENT INFO.;　Phytochemistry, 144, 98-105
  AUTHOR;　Okada T, Ihara H, Ito R, Ikeda Y
  
• Liver resident macrophages (Kupffer cells) share several functional antigens in common with endothelial cells.;　2016
  ANNOUNCEMENT INFO.;　Scand J Immunol., 83, 2, 139-50.
  AUTHOR;　Okada T, Kimura A, Kanki K, Nakatani S, Nagahara Y, Hiraga M, Watanabe Y
  
• 1α,25-Dihydroxyvitamin D3 enhances γ-glutamyltranspeptidase activity in porcine kidney epithelial cell line, LLC-PK1 cells.;　2014/10
  ANNOUNCEMENT INFO.;　Molecular Medicine Reports, 10, 4, 2111-2115
  AUTHOR;　Ito R, Ihara H, Okada T, Ikeda Y.
  
• Cloning, expression and characterization of Bombyx mori α1,6-fucosyltransferase.;　2014/07
  ANNOUNCEMENT INFO.;　Biochem Biophys Res Commun., 450, 2, 953-960
  AUTHOR;　Ihara H, Okada T, Ikeda Y
  
• Toll-like receptor 4-dependent adjuvant activity of Kakkon-to extract exists in the high molecular weight polysaccharide fraction.;　2011/01
  ANNOUNCEMENT INFO.;　International Journal of Immunopathology and Pharmacology, 24, 1, 43-54
  AUTHOR;　Ishijima Y , Kawamura T , Kimura A , Kohno A , Okada T , Tsuji T , Watanabe Y.
  
• Cloning and characterization of a β-N-acetylglucosaminidase (BmFDL) from silkworm Bombyx mori.;　2010/10
  ANNOUNCEMENT INFO.;　Journal of Bioscience and Bioengineering, 110, 4, 386-391
  AUTHOR;　Nomura T, Ikeda M, Ishiyama S, Mita K, Tamura T, Okada T, Fujiyama K, Usami A.
  
• N-Glycosylation engineering of lepidopteran insect cells by the introduction of the β1,4-N-acetylglucosaminyltransferase III gene.;　2010/09
  ANNOUNCEMENT INFO.;　Glycobiology, 20, 9, 1147-1159
  AUTHOR;　Okada T, Ihara H, Ito R, Nakano M, Matsumoto K, Yamaguchi Y, Taniguchi N, Ikeda Y.
  
• Fucosylation of chitooligosaccharides by human alpha1,6-fucosyltransferase requires a nonreducing terminal chitotriose unit as a minimal structure.;　2010/08
  ANNOUNCEMENT INFO.;　Glycobiology, 20, 8, 1021-1033
  AUTHOR;　Ihara H, Hanashima S, Okada T, Ito R, Yamaguchi Y, Taniguchi N, Ikeda Y.
  
• Expression of N-terminally truncated forms of rat peroxiredoxin-4 in insect cells.;　2010/06
  ANNOUNCEMENT INFO.;　Protein Expression and Purification, 72, 1, 1-7
  AUTHOR;　Ikeda Y, Ito R, Ihara H, Okada T, Fujii J.
  
• Bidirectional N-acetylglucosamine transfer mediated by beta-1,4-N-acetylglucosaminyltransferase III.;　2009/04
  ANNOUNCEMENT INFO.;　Glycobiology, 19, 4, 368-374
  AUTHOR;　Okada T, Ihara H, Ito R, Taniguchi N, Ikeda Y.
  
• Molecular cloning and expression of two novel beta-N-acetylglucosaminidases from silkworm Bombyx mori.;　2007/07
  ANNOUNCEMENT INFO.;　Bioscience, Biotechnology, and Biochemistry, 71, 7, 1626-1635
  AUTHOR;　Okada T, Ishiyama S, Sezutsu H, Usami A, Tamura T, Mita K, Fujiyama K, Seki T.
  
• Crystal structure of archaeal toxin-antitoxin RelE-RelB complex with implications for toxin activity and antitoxin effects.;　2005/04
  ANNOUNCEMENT INFO.;　Nature Structural & Molecular Biology, 12, 4, 327-331
  AUTHOR;　Takagi H, Kakuta Y, Okada T, Yao M, Tanaka I, Kimura M.
  
• Contribution of the second OB fold of ribosomal protein S1 from Escherichia coli to the recognition of TmRNA.;　2004/11
  ANNOUNCEMENT INFO.;　Bioscience, Biotechnology, and Biochemistry, 68, 11, 2319-2325
  AUTHOR;　Okada T, Wower IK, Wower J, Zwieb CW, Kimura M.
  

General Lectures

• Molecular cloning and characterization of novel β1,3-galactosyltransferase genes from Mangifera indica L.;　2019/03
  ANNOUNCEMENT INFO.;　The Annual Meeting of Japan Society for Bioscience, Biotechnology, and Agrochemistry
  AUTHOR;　Takahiro OKADA, Yoshitaka IKEDA
  
• Properties of Lewis type α1,3/α1,4-fucosyltransferase from Mangifera indica L.;　2018/09
  ANNOUNCEMENT INFO.;　The 91st Annual Meeting of the Japanese Biochemical Society
  AUTHOR;　Takahiro OKADA, Hideyuki IHARA, Ritsu ITO, Yoshitaka IKEDA
  
• Molecular cloning and characterization of novel β1,2-xylosyltransferase from Mangifera indica L.;　2018/03
  ANNOUNCEMENT INFO.;　The Annual Meeting of Japan Society for Bioscience, Biotechnology, and Agrochemistry
  AUTHOR;　Takahiro OKADA, Yoshitaka IKEDA
  
• Molecular cloning and characterization of novel α1,3/α1,4-fucosyltransferases from Mangifera indica L.;　2017/03
  ANNOUNCEMENT INFO.;　
  AUTHOR;　Takahiro Okada, Yoshitaka Ikeda
  
• Glyco-remodeling of Sf21 cell line with β-1,4-N-Acetylglucosaminyltransferase III (GnT-III);　2009/03
  ANNOUNCEMENT INFO.;　Clinical and Translational Research on Cancer:Glycomics Applications The 2nd Seminar on Functional Glycomics for Young Investigators HGPI-Human Disease Glycomics/Proteome Initiative
  AUTHOR;　Okada T, Ihara H, Ito R, Taniguchi N, Ikeda Y.
  
• Functional analysis of SH3 domain on alpha1,6-fucosyltransferase, FUT8.;　2008/12
  ANNOUNCEMENT INFO.;　第31回日本分子生物学会年会・第81回日本生化学会大会　合同大会
  AUTHOR;　
  
• Development of ELISA for measurement of peroxiredoxin-4 and quantification in rat tissues.;　2007/12
  ANNOUNCEMENT INFO.;　第30回日本分子生物学会年会・第80回日本生化学会大会 合同大会
  AUTHOR;　
  
• Site-directed and functional analysis of SH3 domain of α 1,6-fucosyltransferase, FUT8.;　2007/12
  ANNOUNCEMENT INFO.;　第30回日本分子生物学会年会・第80回日本生化学会大会 合同大会
  AUTHOR;　
  

Review Articles

• Control of glycan assembly by enzyme competition;　2015/04
  ANNOUNCEMENT INFO.;　Glycoscience: Biology and Medicine, Springer Japan. 東京, 1-8
  AUTHOR;　Okada T, Ihara H, Ikeda Y