Detailed Information

Research Field/Keywords for Research Field

• Food function, Biochemistry, Cell biology

Education

• 1996/03, Graduated
• 1998/03, Master Course, Completed
• 2001/03, Doctor Course, Completed

Employment Experience

• 2001/04 - 2002/03 Technical Staff
• 2002/04 - 2008/03 Assistant Professor
• 2008/04 - 2013/08
• 2013/09 - 2023/03 Associate Professor, Applied Biochemistry and Food Science, Faculty of Agriculture, Saga University
• 2015/04 - 9999/99
• 2023/04 -  *  Professor, Faculty of Agriculture, Saga University

Field of Specialization

• Applied biochemistry, Food science, Applied molecular and cellular biology, Functional biochemistry, Cell biology

Awards

• 長瀬科学振興財団研究振興賞 （2014/04）
• 第3回セラミド研究会　学術集会 Young Investigator Award 受賞 （2010/11）
• FEBS Letters Young Leaders Award 2013 （2013/07）

Research Topics and Results

• Red algae-derived isofloridoside activates the sweet taste receptor T1R2/T1R3 2022/11
• Liberation of eicosapentaenoic acid and degradation of the major cell wall polysaccharide porphyran by fermentation of nori, the dried thalli of Pyropia yezoensis, with koji 2021/10
• The molecular mechanism of phytosphingosine binding to FFAR4/GPR120 differs from that of other fatty acids 2021/10
• Teadenol A in microbial fermented tea acts as a novel ligand on GPR120 to increase GLP-1 secretion 2020/12
• Phytosphingosine is a novel ligand of GPR120/FFR4 2021/11
• Konjac Ceramide (kCer) Regulates Keratinocyte Migration by Sema3A-like Repulsion Mechanism. 2019/01
• Structure-inspired design of a sphingolipid mimic sphingosine-1-phosphate receptor agonist from a naturally occurring sphingomyelin synthase inhibitor 2018/11
• Sphingomyelin in micro domains of the plasma membrane regulates amino acid-stimulated mTOR signal activation 2018/06
• Phytosphingosine is a novel activator of GPR120 2018/06
• 細胞膜スフィンゴミエリンの代謝制御による新規細胞膜ダイナミズム 2017/02
• Synthesis of nontoxic fluorous sphingolipids as molecular probes of exogenous metabolic studies for rapid enrichment by FSPE 2017/02
• Possible roles of long-chain sphingomyelines and sphingomyelin synthase 2 in mouse macrophage inflammatory response 2017/01
• Sphingomyelin generated by sphingomyelin synthase 1 is involved in attachment and infection with Japanese encephalitis virus 2016/11
• 細胞膜脂質と食品機能 2016/09
• Chemical Analysis of the Sugar Moiety of Monohexosylceramide Contained in Koji, Japanese Traditional Rice Fermented with Aspergillus 2016/01
• Sphingomyelin synthase 2, but not sphingomyelin synthase 1, is involved in HIV-1 envelope-mediated membrane fusion. 2014/10
• Pathological roles of ceramide and its metabolites in metabolic syndrome and Alzheimer's disease 2014/05
• Decreased amyloid-β pathologies by intracerebral loading of glycosphingolipid-enriched exosomes in Alzheimer model mice. 2014
• ceramide kinase deficiency improves diet-induced obesity and insulin resistances 2013/07
• “Sphingolipids in lipid microdomains and obesity” 2013/00
• Improved high-fat diet-induced glucose intolerance by an oral administration of phytosphingosine 2013
• SMS2 is implicated as a novel regulator of lipid microdomain structure and function 2012/04
• Regulation of autophagy and its associated cell death by “sphingolipid rheostat”: reciprocal role of ceramide and sphingosine 1-phosphate in the mammalian target of rapamycin pathway 2012
• A sensitive cell-based method to screen for selective inhibitors of SMS1 or SMS2 using HPLC and a fluorescent substrate 2012
• Ceramide kinase deficiency improves diet-induced obesity and insulin resistance 2012
• Sphingolipid-modulated exosome secretion promotes clearance of amyloid-β by microglia 2012
• Regulation of cell migration by sphingomyelin synthases: sphingomyelin in lipid rafts decreases responsiveness to signaling by the CXCL12/CXCR4 pathway 2012
• Dynamic modification of sphingomyelin in lipid microdomains controls development of obesity, fatty liver, and type 2 diabetes 2011
• Qualitative and quantitative cellular glycomics of glycosphingolipids based on rhodococcal endoglycosylceramidase-assisted glycan cleavage, glycoblotting-assisted sample preparation, and matrix-assisted laser desorption ionization tandem time-of-flight mass spectrometry analysis 2011
• ELOVL1 production of C24 acyl-CoAs is linked to C24 sphingolipid synthesis 2010
• ABCA12 dysfunction causes a disorder in glucosylceramide accumulation during keratinocyte differentiation 2010
• Ceramide kinase is not essential but might act as an Ca2+-sensor for mast cell activation 2010
• The generation and behavioral analysis of ceramide kinase-null mice, indicating a function in cerebellar Purkinje cells 2007
• Transbilayer movement of ceramide in the plasma membrane of live cells 2007
• Calmodulin is involved in the Ca2+-dependent activation of ceramide kinase as a calcium sensor 2005
• Ceramide kinase is a mediator of calcium-dependent degranulation in mast cells 2004
• Molecular cloning and characterization of sphingolipid ceramide N-deacylase from a marine bacterium, Shewanella alga G8 2002
• Purification, characterization, molecular cloning, and subcellular distribution of neutral ceramidase of rat kidney 2001
• Enzymatic synthesis of 14C-glycosphingolipids by reverse hydrolysis reaction of sphingolipid ceramide N-deacylase: detection of endoglycoceramidase activity in a seaflower 1998
• [14C]Ceramide synthesis by sphingolipid ceramide N-deacylase: new assay for ceramidase activity detection 1997

Books

• “Sphingolipids in lipid microdomains and obesity”;　2013/00
  ANNOUNCEMENT INFO.;　Vitamins & Hormones "Obesity", 91, 271-284
  AUTHOR;　S. Mitsutake, and Y. Igarashi
  

Original Articles

• Red algae-derived isofloridoside activates the sweet taste receptor T1R2/T1R3;　2022/11
  ANNOUNCEMENT INFO.;　Food Bioscience, 50, 102186
  AUTHOR;　Miku Akishino, Yuko Aoki, Hajime Baba, Makio Asakawa, Yoichiro Hama, Susumu Mitsutake
  
• Liberation of eicosapentaenoic acid and degradation of the major cell wall polysaccharide porphyran by fermentation of nori, the dried thalli of Pyropia yezoensis, with koji;　2021/10
  ANNOUNCEMENT INFO.;　Journal of Applied Phycology, 33, 4105
  AUTHOR;　Yoichiro Hama, Emi Yamagata, Noriko Takahama, Yuka Yoshimura, Rin Yanagida, Susumu Mitsutake
  
• The molecular mechanism of phytosphingosine binding to FFAR4/GPR120 differs from that of other fatty acids;　2021/10
  ANNOUNCEMENT INFO.;　FEBS Open Bio, 11, 3081-3089
  AUTHOR;　Tomotaka Nagasawa, Masaki Horitani, Shin-ichi Kawaguchi, Shigeki Higashiyama, Yoichiro Hama, Susumu Mitsutake
  
• Teadenol A in microbial fermented tea acts as a novel ligand on GPR120 to increase GLP-1 secretion;　2020/12
  ANNOUNCEMENT INFO.;　Food & Function, 11, 12, 10534
  AUTHOR;　Nagasawa T, Ishimaru K, Higashiyama S, Hama Y, Mitsutake S
  
• Relationship Between the Limonoid Content in Different Parts of the Sour Orange (Citrus aurantium L.) and the Ligand Activity of a Bile Acid Receptor, TGR5;　2020/08
  ANNOUNCEMENT INFO.;　The Horticulture Journal, 89, 4, 384-393
  AUTHOR;　Fatema Tuz Zohra, Yuri Tominaga, Yomi Matsumoto, Naoko Taguchi, Ai Okubo, Susumu Mitsutake, Nobuhiro Kotoda
  
• Koji glycosylceramide commonly contained in Japanese traditional fermented foods alters cholesterol metabolism in obese mice.;　2019/08
  ANNOUNCEMENT INFO.;　Bioscience, Biotechnology, and Biochemistry, 83, 1514-1522
  AUTHOR;　H. Hamajima, M. Tanaka, M. Miyagawa, M. Sakamoto, T. Nakamura, T. Yanagita, S. Mitsutake, J. Wakayama, K. Nagao, H. Kitagaki
  
• Konjac Ceramide (kCer) Regulates Keratinocyte Migration by Sema3A-like Repulsion Mechanism.;　2019/01
  ANNOUNCEMENT INFO.;　Biochemistry and Biophysics Reports, 17, 132-138
  AUTHOR;　Usuki S., Tamura N., Tamura T., Higashiyama S., Tanji K., Mitsutake S., Inoue A., Aoki J., Mukai K., Igarashi Y.
  
• Structure-inspired design of a sphingolipid mimic sphingosine-1-phosphate receptor agonist from a naturally occurring sphingomyelin synthase inhibitor;　2018/11
  ANNOUNCEMENT INFO.;　Chemical Communications, 54, 12758-12761
  AUTHOR;　M.M.M. Swamy, Y Murai, Y Ohno, K Jojima, A Kihara, S Mitsutake, Y Igarashi, J Yu, M Yao, Y Suga, M Anetai and K Monde
  
• Multiple roles of SMS2 in white and brown adipose tissues form diet-induced obese mice;　2018/08
  ANNOUNCEMENT INFO.;　J. Metabolic Syndrome, 7, 241
  AUTHOR;　H. Hamamatsu, S. Mitsutake, S. Sakai, T. Okazaki, K. Watanabe, Y. Igarashi, K. Yuyama
  
• Sphingomyelin in micro domains of the plasma membrane regulates amino acid-stimulated mTOR signal activation;　2018/06
  ANNOUNCEMENT INFO.;　Cell. Biol. Inter., 42, 7, 823-831
  AUTHOR;　K Zama, S Mitsutake*, T Okazaki, Y Igarashi
  
• Phytosphingosine is a novel activator of GPR120;　2018/06
  ANNOUNCEMENT INFO.;　J. Biochemistry, 164, 1, 27-32
  AUTHOR;　T Nagasawa, H Nakamichi, Y Hama, S Higashiyama, I Yasuyuki, S. Mitsutake
  
• The fungal 9-methylsphingadiene is a novel ligand for both PPARg and GPR120;　2018/06
  ANNOUNCEMENT INFO.;　J. Food Biochem., e12624
  AUTHOR;　S. Esaki, T. Nagasawa, H. Tanaka, A. Tominaga, D. Mikami, S. Usuki, H. Hamajima, S. Sakai, Y. Hama, Y. Igarashi, H. Kitagaki, S. Mitsutake*
  
• Synthesis of nontoxic fluorous sphingolipids as molecular probes of exogenous metabolic studies for rapid enrichment by FSPE;　2017/02
  ANNOUNCEMENT INFO.;　European Journal of Organic Chemistry, 2017, 1045
  AUTHOR;　Saito S., Murai Y., Usuki S.,Yoshida M., Hammam M., Mitsutake S., Yuyama K., Igarashi Y., Monde K.
  
• Possible roles of long-chain sphingomyelines and sphingomyelin synthase 2 in mouse macrophage inflammatory response;　2017/01
  ANNOUNCEMENT INFO.;　Biochemical and Biophysical Research Communications, 482, 2, 202
  AUTHOR;　Sakamoto H., Yoshida T., Sanaki T., Morita H., Oyama M., Mitsui M., Tanaka Y., Nakano T., Mitsutake S., Igarashi Y., Takemoto H.
  
• Sphingomyelin generated by sphingomyelin synthase 1 is involved in attachment and infection with Japanese encephalitis virus;　2016/11
  ANNOUNCEMENT INFO.;　Scientific Reports, 6, 37829
  AUTHOR;　Taniguchi M., Tasaki T., Ninomiya H., Ueda Y., Kuremoto KI., Mitsutake S., Igarashi Y., Okazaki T., Takegami T.
  
• Japanese traditional dietary fungus Koji Aspergillus oryzae funtions as a prebiotic for Blautia coccoides through glycosylceramide;　2016/08
  ANNOUNCEMENT INFO.;　Springerplus, 5, 1, 1321
  AUTHOR;　
  
• Chemical Analysis of the Sugar Moiety of Monohexosylceramide Contained in Koji, Japanese Traditional Rice Fermented with Aspergillus;　2016/01
  ANNOUNCEMENT INFO.;　Fermentation, 2, 1, 2
  AUTHOR;　Hiroshi Hamajima 1, Ayami Fujikawa, Mikako Yamashiro, Takatoshi Ogami, Seiichi Kitamura , Masahito Tsubata, Sei Tan, Haruka Matsunaga, Kazutaka Sawada, Satoshi Kumagai, Nobuyuki Hayashi, Koji Nagao, Teruyoshi Yanagita, Takuji Oka, Susumu Mitsutake and Hiroshi Kitagak
  
• Glucosylceramide Contained in Koji Mold-Cultured Cereal Confers Membrane and Flavor Modification and Stress Tolerance to Saccharomyces cerevisiae during Coculture Fermentation.;　2015/07
  ANNOUNCEMENT INFO.;　Appl Environ Microbiol., 81, 11, 3688
  AUTHOR;　Sawada K, Sato T, Hamajima H, Jayakody LN, Hirata M, Yamashiro M, Tajima M, Mitsutake S, Nagao K, Tsuge K, Abe F, Hanada K, Kitagaki H.
  
• Sphingomyelin synthase 2, but not sphingomyelin synthase 1, is involved in HIV-1 envelope-mediated membrane fusion.;　2014/10
  ANNOUNCEMENT INFO.;　J Biol Chem., 289, 44, 30842
  AUTHOR;　Hayashi Y, Nemoto-Sasaki Y, Tanikawa T, Oka S, Tsuchiya K, Zama K, Mitsutake S, Sugiura T, Yamashita A.
  
• Altered levels of serum sphingomyelin and ceramide containing distinct acyl chains in young obese adults.;　2014/00
  ANNOUNCEMENT INFO.;　Nutrition & Diabetes, 4, e141
  AUTHOR;　H. Hanamatsu, S. Ohnishi, S. Sakai, K. Yuyama, S. Mitsutake, H. Takeda, Y. Igarashi
  
• Decreased amyloid-β pathologies by intracerebral loading of glycosphingolipid-enriched exosomes in Alzheimer model mice.;　2014
  ANNOUNCEMENT INFO.;　
  AUTHOR;　K. Yuyama, H. Sun, S. Sakai, S. Mitsutake, M. Okada, H. Tahara, J. Furukawa, N. Fujitani, Y. Shinohara, Y. Igarashi
  
• Improved high-fat diet-induced glucose intolerance by an oral administration of phytosphingosine;　2013
  ANNOUNCEMENT INFO.;　Bioscience, Biotechnology, and Biochemistry, 77, 194-197
  AUTHOR;　I. Murakami, S. Mitsutake*, N. Kobayashi, J. Matsuda, A. Suzuki, T. Shigyo, Y. Igarashi
  
• Regulation of autophagy and its associated cell death by “sphingolipid rheostat”: reciprocal role of ceramide and sphingosine 1-phosphate in the mammalian target of rapamycin pathway;　2012
  ANNOUNCEMENT INFO.;　Journal of Biological Chemistry, 287, 398987-39910
  AUTHOR;　M. Taniguchi, K. Kitatani, T. Kondo, M. Hashimoto-Nishimura, S. Asano, A. Hayashi, S. Mitsutake, Y. Igarashi, H. Umehara, H. Takeya, J. Kigawa, T. Okazaki
  
• A sensitive cell-based method to screen for selective inhibitors of SMS1 or SMS2 using HPLC and a fluorescent substrate;　2012
  ANNOUNCEMENT INFO.;　Chemistry and Physics of Lipids, 165, 760-768
  AUTHOR;　K. Zama, S. Mitsutake*, K. Watanabe, T. Okazaki, Y. Igarashi
  
• Ceramide kinase deficiency improves diet-induced obesity and insulin resistance;　2012
  ANNOUNCEMENT INFO.;　FEBS Letters, 586, 1300-1305
  AUTHOR;　S. Mitsutake*, T. Date, H. Yokota, M. Sugiura, T. Kohama, Y. Igarashi
  
• 4, 8-Sphingadienine and 4-hydroxy-8-sphingenine activate ceramide production in the skin;　2012
  ANNOUNCEMENT INFO.;　Lipids in Health and Disease, 11, 108
  AUTHOR;　Y. Shirakura, K. Kikuchi, K. Matsumura, K. Mukai, S. Mitsutake, Y. Igarashi
  
• Sphingolipid-modulated exosome secretion promotes clearance of amyloid-β by microglia;　2012
  ANNOUNCEMENT INFO.;　 Journal of Biological Chemistry, 287, 10977-10989
  AUTHOR;　K. Yuyama, H. Sun, S. Mitsutake, Y. Igarashi
  
• Regulation of cell migration by sphingomyelin synthases: sphingomyelin in lipid rafts decreases responsiveness to signaling by the CXCL12/CXCR4 pathway;　2012
  ANNOUNCEMENT INFO.;　Molecular and Cellular Biology, 32, 3242-3252
  AUTHOR;　S. Asano, K. Kitatani, M. Taniguchi, M. Hashimoto, K. Zama, S. Mitsutake, Y. Igarashi, H. Takeya, J. Kigawa, A. Hayashi, H. Umehara, T. Okazaki
  
• Dynamic modification of sphingomyelin in lipid microdomains controls development of obesity, fatty liver, and type 2 diabetes;　2011
  ANNOUNCEMENT INFO.;　 Journal of Biological Chemistry, 286, 28544-28555
  AUTHOR;　S. Mitsutake*, K. Zama, H. Yokota, T. Yoshida, M. Tanaka, M. Mitsui, M. Ikawa, M. Okabe, Y. Tanaka, T. Yamashita, H. Takemoto, T. Okazaki, K. Watanabe, Y. Igarashi
  
• Qualitative and quantitative cellular glycomics of glycosphingolipids based on rhodococcal endoglycosylceramidase-assisted glycan cleavage, glycoblotting-assisted sample preparation, and matrix-assisted laser desorption ionization tandem time-of-flight mass spectrometry analysis;　2011
  ANNOUNCEMENT INFO.;　Journal of Biological Chemistry, 286, 41669-41679
  AUTHOR;　N. Fujitani, Y. Takegawa, Y. Ishibashi, K. Araki, J. Furukawa, S. Mitsutake, Y. Igarashi, M. Ito, Y. Shinohara
  
• Phytoceramide and sphingoid bases derived from brewer's yeast Saccharomyces pastorianus activate peroxisome proliferator-activated receptors;　2011
  ANNOUNCEMENT INFO.;　Lipids in Health and Disease, 10, 150
  AUTHOR;　I. Murakami, Y. Wakasa, S. Yamashita, T. Kurihara, K. Zama, N. Kobayashi, Y. Mizutani, S. Mitsutake, T. Shigyo, Y. Igarashi
  
• ELOVL1 production of C24 acyl-CoAs is linked to C24 sphingolipid synthesis;　2010
  ANNOUNCEMENT INFO.;　Proceedings of the National Academy of Sciences of the United States of America, 107, 18439-18444
  AUTHOR;　Y. Ohno, S. Suto, M. Yamanaka, Y. Mizutani, S. Mitsutake, Y. Igarashi, T. Sassa, A. Kihara
  
• ABCA12 dysfunction causes a disorder in glucosylceramide accumulation during keratinocyte differentiation;　2010
  ANNOUNCEMENT INFO.;　Journal of Dermatological Science, 60, 128-129
  AUTHOR;　S. Mitsutake, C. Suzuki, M. Akiyama, K. Tsuji, T. Yanagi, H. Shimizu, Y. Igarashi
  
• Ceramide kinase is not essential but might act as an Ca2+-sensor for mast cell activation;　2010
  ANNOUNCEMENT INFO.;　Prostaglandins and Other Lipid Mediators, 93, 109-112
  AUTHOR;　S. Mitsutake, H. Kumada, M. Soga, Y. Hurue, F. Asanuma, M. Nagira, M. Deguchi, T. Date, U. Yokose, Y. Inagaki, M. Sugiura, T. Kohama, Y. Igarashi
  
• Evaluation of synthetic sphingolipid analogs as ligands for peroxisome proliferator-activated receptors;　2009
  ANNOUNCEMENT INFO.;　Bioorganic & Medicinal Chemistry Letters, 19, 1643-1646
  AUTHOR;　K. Tsuji, S. Satoh, S. Mitsutake, I. Murakami, J.-J. Park, Q. Li, Y.-T. Chang, S.-K. Chung, Y. Igarashi
  
• Role of ceramide kinase in peroxisome proliferator-activated receptor beta-induced cell survival of mouse keratinocytes;　2008
  ANNOUNCEMENT INFO.;　FEBS Journal, 275, 3815-3826
  AUTHOR;　K. Tsuji, S. Mitsutake, U. Yokose, M. Sugiura, T. Kohama, Y. Igarashi
  
• The generation and behavioral analysis of ceramide kinase-null mice, indicating a function in cerebellar Purkinje cells;　2007
  ANNOUNCEMENT INFO.;　Biochemical and Biophysical Research Communications, 363, 519-524
  AUTHOR;　S. Mitsutake, U. Yokose, M. Kato, I. Matsuoka, J.-M. Yoo, T.-J. Kim, H.-S. Yoo, K. Fujimoto, Y. Ando, M. Sugiura, T. Kohama, Y. Igarashi
  
• Transbilayer movement of ceramide in the plasma membrane of live cells;　2007
  ANNOUNCEMENT INFO.;　Biochemical and Biophysical Research Communications, 359, 622-627
  AUTHOR;　S. Mitsutake, Y. Igarashi
  
• Kinetics of the ceramide kinase inhibitor K1, a suppressor of mast-cell activation;　2007
  ANNOUNCEMENT INFO.;　Bioscience, Biotechnology, and Biochemistry, 71, 2581-2584
  AUTHOR;　H. Kumada, S. Mitsutake, Y. Inagaki, S. Mitsunaga, H. Tsuchikawa, S. Katsumura, Y. Igarashi
  
• Ceramide kinase expression is altered during macrophage-like cell differentiation of the leukemia cell line HL-60;　2007
  ANNOUNCEMENT INFO.;　In Vitro Cellular & Developmental Biology-Animal, 43, 321-323
  AUTHOR;　T. Date, S. Mitsutake, Y. Igarashi
  
• Dietary glucosylceramide improves skin barrier function in hairless mice;　2006
  ANNOUNCEMENT INFO.;　Journal of Dermatological Science, 44, 101-107
  AUTHOR;　K. Tsuji, S. Mitsutake, J. Ishikawa, Y. Takagi, M. Akiyama, H. Shimizu, T. Tomiyama, Y. Igarashi
  
• Apoptosis occurs via the ceramide recycling pathway in human HaCaT keratinocytes;　2006
  ANNOUNCEMENT INFO.;　Journal of Biochemistry, 139, 255-262
  AUTHOR;　S. Takeda, S. Mitsutake, K. Tsuji, Y. Igarashi
  
• Identification of a nuclear localization signal in the retinitis pigmentosa-mutated RP26 protein, ceramide kinase-like protein;　2006
  ANNOUNCEMENT INFO.;　Biochemical and Biophysical Research Communications,, 343, 982-987
  AUTHOR;　Y. Inagaki, S. Mitsutake, Y. Igarashi
  
• The interaction between the pleckstrin homology domain of ceramide kinase and phosphatidylinositol 4,5-bisphosphate regulates the plasma membrane targeting and ceramide 1-phosphate levels;　2006
  ANNOUNCEMENT INFO.;　Biochemical and Biophysical Research Communications, 342, 611-617
  AUTHOR;　T.-J. Kim, S. Mitsutake, Y. Igarashi
  
• Calmodulin is involved in the Ca2+-dependent activation of ceramide kinase as a calcium sensor;　2005
  ANNOUNCEMENT INFO.;　Journal of Biological Chemistry, 280, 40436-40441
  AUTHOR;　S. Mitsutake, Y. Igarashi
  
• The leucine 10 residue in the pleckstrin homology domain of ceramide kinase is crucial for its catalytic activity;　2005
  ANNOUNCEMENT INFO.;　FEBS Letters, 579, 4383-4388
  AUTHOR;　T.-J. Kim, S. Mitsutake, M. Kato, Y. Igarashi
  
• Synthesis and evaluation of sphingoid analogs as inhibitors of sphingosine kinases;　2005
  ANNOUNCEMENT INFO.;　Bioorganic & Medicinal Chemistry, 13, 3475-3485
  AUTHOR;　J.-W. Kim, Y.-W. Kim, Y. Inagaki, Y.-A. Hwang, S. Mitsutake, Y.-W. Ryu, W. K. Lee, H.-J. Ha, C.-S. Park, Y. Igarashi
  
• Suppression of mast cell degranulation by a novel ceramide kinase inhibitor, the F-12509A olefin isomer K1;　2005
  ANNOUNCEMENT INFO.;　Biochimica et Biophysica Acta, 1738, 82-90
  AUTHOR;　J.-W. Kim, Y. Inagaki, S. Mitsutake, N. Maezawa, S. Katsumura, Y.-W. Ryu, C.-S. Park, M. Taniguchi, Y. Igarashi
  
• Asp177 in C4 domain of mouse sphingosine kinase 1a is important for the sphingosine recognition;　2004
  ANNOUNCEMENT INFO.;　FEBS Letters, 578, 106-110
  AUTHOR;　S. Yokota, Y. Taniguchi, A. Kihara, S. Mitsutake, Y. Igarashi
  
• Ceramide kinase is a mediator of calcium-dependent degranulation in mast cells;　2004
  ANNOUNCEMENT INFO.;　Journal of Biological Chemistry, 279, 17570-17577
  AUTHOR;　S. Mitsutake, T.-J. Kim, Y. Inagaki, M. Kato, T. Yamashita, Y. Igarashi
  
• Identification of functional nuclear export sequences in human sphingosine kinase 1;　2003
  ANNOUNCEMENT INFO.;　Biochemical and Biophysical Research Communications, 311, 168-173
  AUTHOR;　Y. Inagaki, P.-Y. Li, A. Wada, S. Mitsutake, Y. Igarashi
  
• Molecular cloning and characterization of sphingolipid ceramide N-deacylase from a marine bacterium, Shewanella alga G8;　2002
  ANNOUNCEMENT INFO.;　Journal of Biological Chemistry, 277, 17300-17307
  AUTHOR;　M. Furusato, N. Sueyoshi, S. Mitsutake, K. Sakaguchi, K. Kita, N. Okino, S. Ichinose, A. Omori, M. Ito
  
• Localization of neutral ceramidase in caveolin-enriched light membranes of murine endothelial cells;　2001
  ANNOUNCEMENT INFO.;　FEBS Letters, 506, 163-168
  AUTHOR;　E. Romiti, E. Meacci, G. Tanzi, L. Becciolini, S. Mitsutake, M. Farnararo, M. Ito, P. Bruni
  
• Purification, characterization, molecular cloning, and subcellular distribution of neutral ceramidase of rat kidney;　2001
  ANNOUNCEMENT INFO.;　Journal of Biological Chemistry, 276, 26249-26259
  AUTHOR;　S. Mitsutake, M. Tani, N. Okino, K. Mori, S. Ichinose, A. Omori, H. Iida, T. Nakamura, M. Ito
  
• Purification and characterization of a neutral ceramidase from mouse liver: a single protein catalyzes the reversible reaction in which ceramide is both hydrolyzed and synthesized;　2000
  ANNOUNCEMENT INFO.;　Journal of Biological Chemistry, 275, 3462-3468
  AUTHOR;　M. Tani, N. Okino, S. Mitsutake, T. Tanigawa, H. Izu, M. Ito
  
• Specific and sensitive assay for alkaline and neutral ceramidases involving C12-NBD-ceramide;　1999
  ANNOUNCEMENT INFO.;　Journal of Biochemistry, 125, 746-749
  AUTHOR;　M. Tani, N. Okino, S. Mitsutake, M. Ito
  
• Enzymatic synthesis of 14C-glycosphingolipids by reverse hydrolysis reaction of sphingolipid ceramide N-deacylase: detection of endoglycoceramidase activity in a seaflower;　1998
  ANNOUNCEMENT INFO.;　Journal of Biochemistry, 123, 859-863
  AUTHOR;　S. Mitsutake, K. Kita, T. Nakagawa, M. Ito
  
• [14C]Ceramide synthesis by sphingolipid ceramide N-deacylase: new assay for ceramidase activity detection;　1997
  ANNOUNCEMENT INFO.;　Analytical Biochemistry, 247, 52-57
  AUTHOR;　S. Mitsutake, K. Kita, N. Okino, M. Ito
  

Review Articles

• 細胞膜スフィンゴミエリンの代謝制御による新規細胞膜ダイナミズム;　2017/02
  ANNOUNCEMENT INFO.;　Journal of Japanese Biochemical Society, 89, 1, 86
  AUTHOR;　
  
• Pathological roles of ceramide and its metabolites in metabolic syndrome and Alzheimer's disease;　2014/05
  ANNOUNCEMENT INFO.;　Biochim. Biophys. Acta., 184, 5, 793-798
  AUTHOR;　K. Yuyama, S. Mitsutake*, and Y. Igarashi
  

Invited Lecture, Special Lecture

• インクレチンシグナリングを活性化させる食品分子;　2022/11
  ANNOUNCEMENT INFO.;　
  AUTHOR;　
  
• Phytosphingosine is a novel ligand of GPR120/FFR4;　2021/11
  ANNOUNCEMENT INFO.;　2021 BLIRC/KSMCB-Division of Lipid Biology Joint Symposium
  AUTHOR;　Susumu Mitsutake
  
• 有明ノリや米麹に含まれる低分子天然成分に関する最近の知見;　2019/10
  ANNOUNCEMENT INFO.;　
  AUTHOR;　
  
• Dynamic modification of sphingolipids regulate function of the plasma membrane;　2017/09
  ANNOUNCEMENT INFO.;　“New Prospectives on Bioactive lipids" the Symposium in the 2017 International Conference Korean Society for Molecular and Cellular Biology COEX, Seoul, Korea
  AUTHOR;　Susumu Mitsutake
  
• 細胞膜脂質と食品機能;　2016/09
  ANNOUNCEMENT INFO.;　
  AUTHOR;　
  
• スフィンゴ脂質合成／代謝酵素による細胞膜機能制御;　2014/09
  ANNOUNCEMENT INFO.;　第38回 蛋白質と酵素の構造と機能に関する九州シンポジウム 2014年9月11日〜13日　レイクサイドホテル久山、福岡
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• スフィンゴ脂質合成／代謝制御による細胞膜機能制御とその破綻によるメタボリックシンドローム;　2014/08
  ANNOUNCEMENT INFO.;　
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• スフィンゴ脂質研究の医薬品応用を目指して;　2014/03
  ANNOUNCEMENT INFO.;　
  AUTHOR;　
  
• スフィンゴ脂質の生理機能を応用した創薬への試み;　2013/09
  ANNOUNCEMENT INFO.;　
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• ceramide kinase deficiency improves diet-induced obesity and insulin resistances;　2013/07
  ANNOUNCEMENT INFO.;　FEBS LETTERS Award Lecture 38th FEBS congress St. Petersburg, Russia, 8 July, 2013
  AUTHOR;　Susumu Mitsutake
  
• SMS2 is implicated as a novel regulator of lipid microdomain structure and function;　2012/04
  ANNOUNCEMENT INFO.;　"Glycolipid & Sphingolipid Biology" 2012 Gordon Research Conferences Lucca, Italy, April 22 – 27, 2012 (speaker selected by organizing committee)
  AUTHOR;　S. Mitsutake, K. Zama, T. Yoshida, H. Takemoto, T. Okazaki, Y. Igarash
  
• Sphingomyelin synthase 2 is responsible for obesity and lipid droplet formation in liver and is a novel regulator of membrane microdomain;　2011/09
  ANNOUNCEMENT INFO.;　52nd International Conference on the Bioscience of Lipids Warsaw, Poland, Aug 30 – Sep 3, 2011, (speaker selected by organizing committee)
  AUTHOR;　S. Mitsutake, H. Yokota, K. Zama, T. Yoshida, T. Yamashita, T. Okazaki, K. Watanabe, Y. Igarashi