Detailed Information

Research Topics and Results

• Clinical effects of a selective urate reabsorption inhibitor dotinurad in patients with hyperuricemia and treated hypertension: a multicenter, prospective, exploratory study (DIANA)  2023/07
• Linagliptin exacerbates heart failure due to energy deficiency via downregulation of glucose utilization and absorption in a mouse model 2023/06
• A Novel Soluble Epoxide Hydrolase Vaccine Protects Murine Cardiac Muscle Against Myocardial Infarction 2022/10
• Empagliflozin improves cardiac mitochondrial function and survival through energy regulation in a murine model of heart failure  2022/09
• The DPP4 inhibitor linagliptin exacerbated heart failure due to energy deficiency via downregulation of glucose absorption and utilization in mice 2022/08
• Author Correction: A novel soluble epoxide hydrolase vaccine protects murine cardiac muscle against myocardial infarction  2022/05
• A novel soluble epoxide hydrolase vaccine protects murine cardiac muscle against myocardial infarction 2022/04
• Simple risk-score model for in-hospital major bleeding based on multiple blood variables in patients with acute myocardial infarction  2022/01
• A Novel Soluble Epoxide Hydrolase Peptide Vaccine Attenuates Cardiac Remodeling After Myocardial Infarction Through Angiogenesis 2021/11
• Empagliflozin improves prognosis and energetic properties through modulating mitochondrial function in failing murine hearts 2021/08
• Does cilnidipine, a dual L- and N-type Ca 2+ blocker, shows promise in drug repositioning approaches? 2020/07
• GLP-1 analog liraglutide-induced cardiac dysfunction due to energetic starvation in heart failure with non-diabetic dilated cardiomyopathy.  2019/11
• COA-Cl (2-Cl-C.OXT-A) can promote coronary collateral development following acute myocardial infarction in mice.  2019
• Cardiac Dysfunction Induced by Incretin-Related Drugs Due to Energetic Starvation in Non-Diabetic Failing Heart 2019
• Efficacy and safety of sitagliptin in elderly patients with type 2 diabetes mellitus. 2018
• Azelnidipine Inhibits the Differentiation and Activation of THP-1 Macrophages through the L-Type Calcium Channel. 2018
• Losing body weight is a strong independent predictor of rehospitalization and prognosis in patients with heart failure. 2018
• EGCG attenuate cardiac hypertrophy in the hypertensive Dahl rats. 2018
• EGCG, a green tea catechin, attenuates the progression of heart failure induced by the heart/muscle-specific deletion of MnSOD in mice 2017/02

Original Articles

• Clinical effects of a selective urate reabsorption inhibitor dotinurad in patients with hyperuricemia and treated hypertension: a multicenter, prospective, exploratory study (DIANA) ;　2023/07
  ANNOUNCEMENT INFO.;　Eur J Med Res, 28, 1, 238
  AUTHOR;　Tanaka A, Taguchi I, Hisauchi I, Yoshida H, Shimabukuro M, Hongo H, Ishikawa T, Kadokami T, Yagi S, Sata M, Node K; DIANA study investigators(Tetsuya Kaneko, Kohei Kaneta, Masahiro Natsuaki, Aya Shiraki, Shinjo Sonoda, Ayumu Yajima, Kensuke Yokoi, Goro Yoshioka et al.)
  
• Linagliptin exacerbates heart failure due to energy deficiency via downregulation of glucose utilization and absorption in a mouse model;　2023/06
  ANNOUNCEMENT INFO.;　Eur J Pharmacol, 948, 175673
  AUTHOR;　Shiraki A, Oyama JI, Shimizu T, Node K
  
• Empagliflozin improves cardiac mitochondrial function and survival through energy regulation in a murine model of heart failure ;　2022/09
  ANNOUNCEMENT INFO.;　Eur J Pharmacol, 931, 175194
  AUTHOR;　Aya Shiraki, Jun-Ichi Oyama, Takahiko Shimizu, Takayuki Nakajima, Takashi Yokota, Koichi Node
  
• Author Correction: A novel soluble epoxide hydrolase vaccine protects murine cardiac muscle against myocardial infarction ;　2022/05
  ANNOUNCEMENT INFO.;　Sci Rep, 12, 1, 7737
  AUTHOR;　*Takahiro Kitsuka, Aya Shiraki, Jun-Ichi Oyama, Hironori Nakagami, Atsushi Tanaka, Koichi Node
  
• A novel soluble epoxide hydrolase vaccine protects murine cardiac muscle against myocardial infarction;　2022/04
  ANNOUNCEMENT INFO.;　Sci Rep, 12, 1, 6923
  AUTHOR;　*Takahiro Kitsuka, Aya Shiraki, Jun-Ichi Oyama, Hironori Nakagami, Atsushi Tanaka, Koichi Node
  
• Simple risk-score model for in-hospital major bleeding based on multiple blood variables in patients with acute myocardial infarction ;　2022/01
  ANNOUNCEMENT INFO.;　Int J Cardiol, 346, 1-7
  AUTHOR;　○Yuhei Goriki, Goro Yoshioka, Masahiro Natsuaki, Kodai Shinzato, Kensaku Nishihira, Nehiro Kuriyama, Mitsuhiro Shimomura, Yohei Inoue, Toshiyuki Nishikido, Tetsuya Kaneko, Kensuke Yokoi, Ayumu Yajima, Yoshiko Sakamoto, Motoko Tago, Atsushi Kawaguchi, Fumi Yamamoto, Atsushi Tanaka, Takanori Yamaguchi, Aya Shiraki, Machiko Asaka, Norihiko Kotooka, Shinjo Sonoda, Yutaka Hikichi, Yoshisato Shibata, Koichi Node
  
• Does cilnidipine, a dual L- and N-type Ca 2+ blocker, shows promise in drug repositioning approaches?;　2020/07
  ANNOUNCEMENT INFO.;　Hypertens Res, 43, 7, 726-728
  AUTHOR;　Aya Shiraki, Kana Nakashima, Koichi Node
  
• GLP-1 analog liraglutide-induced cardiac dysfunction due to energetic starvation in heart failure with non-diabetic dilated cardiomyopathy. ;　2019/11
  ANNOUNCEMENT INFO.;　Cardiovasc Diabetol. , 18, 1, 164
  AUTHOR;　Shiraki A, Oyama JI, Nishikido T, Node K.
  
• COA-Cl (2-Cl-C.OXT-A) can promote coronary collateral development following acute myocardial infarction in mice. ;　2019
  ANNOUNCEMENT INFO.;　Sci Rep. , 9, 1, 2533
  AUTHOR;　○Nishikido T, Oyama JI, Shiraki A, Tsukamoto I, Igarashi J, Node K.
  
• Efficacy and safety of sitagliptin in elderly patients with type 2 diabetes mellitus.;　2018
  ANNOUNCEMENT INFO.;　Geriatr Gerontol Int. , 18, 4, 631-639
  AUTHOR;　Tago M, Oyama JI, Sakamoto Y, Shiraki A, Uchida F, Chihara A, Ikeda H, Kuroki S, Gondo S, Iwamoto T, Uchida Y, Node K.
  
• Azelnidipine Inhibits the Differentiation and Activation of THP-1 Macrophages through the L-Type Calcium Channel.;　2018
  ANNOUNCEMENT INFO.;　J Atheroscler Thromb. , 25, 8, 690-697
  AUTHOR;　*Komoda H, Shiraki A, Oyama JI, Nishikido T, Node K.
  
• EGCG, a green tea catechin, attenuates the progression of heart failure induced by the heart/muscle-specific deletion of MnSOD in mice;　2017/02
  ANNOUNCEMENT INFO.;　J Cardiol ., 69, 2, 417-427
  AUTHOR;　○Jun-Ichi Oyama, Aya Shiraki, Toshiyuki Nishikido, Toyoki Maeda, Hiroshi Komoda, Takahiko Shimizu, Naoki Makino, Koichi Node
  

General Lectures

• A Novel Soluble Epoxide Hydrolase Vaccine Protects Murine Cardiac Muscle Against Myocardial Infarction;　2022/10
  ANNOUNCEMENT INFO.;　JSH2022/ISH2022 KYOTO/APSH2022 同時開催, 2022,10,12-16
  AUTHOR;　Aya Shiraki, Takahiro Kitsuka, Junichi Oyama, Hironori Nakagami, Koichi Node
  
• The DPP4 inhibitor linagliptin exacerbated heart failure due to energy deficiency via downregulation of glucose absorption and utilization in mice;　2022/08
  ANNOUNCEMENT INFO.;　ESC Congress 2022(Hybrid format), 2022, 8,26-29(On-site+On-line)
  AUTHOR;　Aya Shiraki, Jun-ichi Oyama, T. Shimizu, Koichi Node
  
• A Novel Soluble Epoxide Hydrolase Peptide Vaccine Attenuates Cardiac Remodeling After Myocardial Infarction Through Angiogenesis;　2021/11
  ANNOUNCEMENT INFO.;　AHA Scientific Sessions 2021 (Virtual Event), 2021,11,13-15
  AUTHOR;　*Takahiro Kitsuka, Aya Shiraki, Jun-ichi Oyama, Hironori Nakagami, Atsushi Tanaka and Koichi Node
  
• Empagliflozin improves prognosis and energetic properties through modulating mitochondrial function in failing murine hearts;　2021/08
  ANNOUNCEMENT INFO.;　ESC Congress 2021 -The Digital Experience (Online Meeting), 2021, 8,27-30
  AUTHOR;　A Shiraki, J Oyama, T Shimizu, T Nakajima, T Yokota, K Node
  
• Cardiac Dysfunction Induced by Incretin-Related Drugs Due to Energetic Starvation in Non-Diabetic Failing Heart;　2019
  ANNOUNCEMENT INFO.;　AHA Scientific Sessions 2019, 2019, 11, 16-18
  AUTHOR;　Aya Shiraki, Junichi Oyama, Koichi Node
  
• Losing body weight is a strong independent predictor of rehospitalization and prognosis in patients with heart failure.;　2018
  ANNOUNCEMENT INFO.;　ESC Congress 2018, 2018.8.25-29
  AUTHOR;　Nishikido T, Oyama JI, Nagatomo D, Shiraki A, Node K.
  
• EGCG attenuate cardiac hypertrophy in the hypertensive Dahl rats.;　2018
  ANNOUNCEMENT INFO.;　ISH 2018 -The 27th Scientific Meeting of the International Society of Hypertension (Hypertension Beijing 2018), The 14th Congress of the Asian Pacific Society of Hypertension (APSH), The 20th International Symposium on Hypertension and Related Diseases, and the 2018 Chinese Hypertension Meeting (CHL), 2018.9.20-23
  AUTHOR;　Shiraki A, Oyama JI, Node K