NameTokudome Yoshihiro
DepartmentInstitute of Ocean Energy
Job TitleProfessor Degree Obtained
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Detailed Information

Research Topics and Results

  • Pathogenic and Compensatory Mechanisms in Epidermis of Sphingomyelin Synthase 2-Deficient Mice 2021/09
  • Induction of coenzyme A-dependent transacylation activity in rat liver microsomes by administration of clofibrate 1994/03

Original Articles

  • Pathogenic and Compensatory Mechanisms in Epidermis of Sphingomyelin Synthase 2-Deficient Mice; 2021/09
    ANNOUNCEMENT INFO.; Skin Pharmacology and Physiology, 34, 5, 246 - 252
    AUTHOR; Sakai, Shota; Makino, Asami; Nishi, Akihito; Ichikawa, Takeshi; Yamashita, Tadashi; Taniguchi, Makoto; Tokudome, Yoshihiro; Hirabayashi, Yoshio; Akiyama, Masashi; Crumrine, Debra; Uchida, Yoshikazu; Elias, Peter M.; Tsuchida, Tetsuya; Hamanaka, Sumiko
  • Effect of Lactic Fermentation Products on Human Epidermal Cell Differentiation, Ceramide Content, and Amino Acid Production; 2021/04
    ANNOUNCEMENT INFO.; Skin Pharmacology and Physiology, 34, 2, 103 - 114
    AUTHOR; Otsuka, Moe; Tamane, Tsuyoshi; Tokudome, Yoshihiro
  • Enhancement of cornified envelope-related gene and protein expression by Carba cyclic phosphatidic acid in normal human epidermal keratinocytes; 2021/03
    ANNOUNCEMENT INFO.; Biological and Pharmaceutical Bulletin, 44, 3, 453 - 457
    AUTHOR; Saito, Erika; Kage, Madoka; Tokudome, Yoshihiro
  • Nanoparticulation of hyaluronic acid: A new skin penetration enhancing polyion complex formulation: Mechanism and future potential; 2020/12
    ANNOUNCEMENT INFO.; Materialia, 14, -
    AUTHOR; Shigefuji, Miki; Tokudome, Yoshihiro
  • Synthesis of resorcinol derivatives and their effects on melanin production; 2020/09
    ANNOUNCEMENT INFO.; Cosmetics, 7, 3, -
    AUTHOR; Tokudome, Yoshihiro; Hoshi, Tsuyoshi; Mori, Sayaka; Hijikuro, Ichiro
  • Improvement of the skin barrier function with physiologically active substances; 2019/01
    ANNOUNCEMENT INFO.; Yakugaku Zasshi, 139, 12, 1549 - 1551
    AUTHOR; Tokudome, Yoshihiro
  • Influence of oral administration of lactic acid bacteria metabolites on skin barrier function and water content in a murine model of atopic dermatitis; 2018/12
    ANNOUNCEMENT INFO.; Nutrients, 10, 12, -
    AUTHOR; Tokudome, Yoshihiro
  • A new strategy for the passive skin delivery of nanoparticulate, high molecular weight hyaluronic acid prepared by a polyion complex method; 2018/12
    ANNOUNCEMENT INFO.; Scientific Reports, 8, 1, -
    AUTHOR; Tokudome, Yoshihiro; Komi, Tatsuya; Omata, Ami; Sekita, Marie
  • Epidermal permeability barrier function and sphingolipid content in the skin of sphingomyelin synthase 2 deficient mice; 2018/08
    ANNOUNCEMENT INFO.; Experimental Dermatology, 27, 8, 827 - 832
    AUTHOR; Nomoto, Koji; Itaya, Yurina; Watanabe, Ken; Yamashita, Tadashi; Okazaki, Toshiro; Tokudome, Yoshihiro
  • Chimyl alcohol suppresses PGE2 synthesis by human epidermal keratinocytes through the activation of PPAR-γ; 2018/01
    ANNOUNCEMENT INFO.; Journal of Oleo Science, 67, 4, 455 - 462
    AUTHOR; Yokota, Mariko; Yahagi, Shoichi; Tokudome, Yoshihiro; Masaki, Hitoshi
  • Related topic: Liposomes-recent advances and future perspective; 2017/11
    ANNOUNCEMENT INFO.; Skin Permeation and Disposition of Therapeutic and Cosmeceutical Compounds, 137 - 142
    AUTHOR; Yokota, Mami; Tokudome, Yoshihiro
  • Recovery effects of oral administration of glucosylceramide and beet extract on skin barrier destruction by UVB in hairless mice; 2017/11
    ANNOUNCEMENT INFO.; Nutrients, 9, 11, -
    AUTHOR; Tokudome, Yoshihiro; Masutani, Noriomi; Uchino, Shohei; Fukai, Hisano
  • Glyceraldehyde-derived advanced glycation end products accumulate faster than Nϵ-(Carboxymethyl) Lysine; 2017/08
    ANNOUNCEMENT INFO.; Annals of Dermatology, 29, 4, 508 - 511
    AUTHOR; Yokota, Mami; Sekita, Marie; Okano, Yuri; Masaki, Hitoshi; Takeuchi, Masayoshi; Tokudome, Yoshihiro
  • Effects of peach (Prunus persica)-derived glucosylceramide on the human skin; 2017/04
    ANNOUNCEMENT INFO.; Immunology, Endocrine and Metabolic Agents in Medicinal Chemistry, 17, 1, 56 - 70
    AUTHOR; Koikeda, Takashi; Tokudome, Yoshihiro; Okayasu, Musashi; Kobayashi, Yuki; Kuroda, Kohei; Yamakawa, Junko; Niu, Kiyosato; Masuda, Kou; Saito, Masami
  • The Effect of Glycation on Epidermal Lipid Content, Its Metabolism and Change in Barrier Function; 2016/12
    ANNOUNCEMENT INFO.; Skin Pharmacology and Physiology, 29, 5, 231 - 242
    AUTHOR; Yokota, Mami; Tokudome, Yoshihiro
  • Upregulation of gene expression levels of ceramide metabolic enzymes after application of sphingomyelin-based liposomes to a three-dimensional cultured human epidermis model; 2016/04
    ANNOUNCEMENT INFO.; Biochemical and Biophysical Research Communications, 473, 1, 114 - 117
    AUTHOR; Itaya, Yurina; Tokudome, Yoshihiro
  • Hyaluronan tetrasaccharides stimulate ceramide production through upregulated mRNA expression of ceramide synthesis-associated enzymes; 2016/03
    ANNOUNCEMENT INFO.; Archives of Dermatological Research, 308, 2, 95 - 101
    AUTHOR; Kage, Madoka; Tokudome, Yoshihiro
  • Examination of the physicochemical properties of caffeic acid complexed with γ-cyclodextrin; 2015/12
    ANNOUNCEMENT INFO.; Journal of Inclusion Phenomena and Macrocyclic Chemistry, 83, 3-4, 289 - 298
    AUTHOR; Inoue, Yutaka; Suzuki, Kengo; Ezawa, Toshinari; Murata, Isamu; Yokota, Mami; Tokudome, Yoshihiro; Kanamoto, Ikuo
  • Permeation of hydrophilic molecules across glycated skin is differentially regulated by the stratum corneum and epidermis-dermis; 2015/09
    ANNOUNCEMENT INFO.; Biological and Pharmaceutical Bulletin, 38, 9, 1383 - 1388
    AUTHOR; Yokota, Mami; Tokudome, Yoshihiro
  • Enhancement of skin penetration of hydrophilic and lipophilic compounds by pH-sensitive liposomes; 2015/07
    ANNOUNCEMENT INFO.; Journal of Pharmacy and Pharmaceutical Sciences, 18, 3, 249 - 257
    AUTHOR; Tokudome, Yoshihiro; Nakamura, Kaoru; Itaya, Yurina; Hashimoto, Fumie
  • Esterase activity and intracellular localization in reconstructed human epidermal cultured skin models; 2015/01
    ANNOUNCEMENT INFO.; Annals of Dermatology, 27, 3, 269 - 274
    AUTHOR; Tokudome, Yoshihiro; Katayanagi, Mishina; Hashimoto, Fumie
  • Effect of liquid crystals with cyclodextrin on the bioavailability of a poorly water-soluble compound, diosgenin, after its oral administration to rats; 2014/09
    ANNOUNCEMENT INFO.; International Journal of Pharmaceutics, 472, 1-2, 257 - 261
    AUTHOR; Okawara, Masaki; Hashimoto, Fumie; Todo, Hiroaki; Sugibayashi, Kenji; Tokudome, Yoshihiro
  • Effects of low molecular weight soybean peptide on mRNA and protein expression levels of differentiation markers in normal human epidermal keratinocytes; 2014/01
    ANNOUNCEMENT INFO.; Bioscience, Biotechnology and Biochemistry, 78, 6, 1018 - 1021
    AUTHOR; Tokudome, Yoshihiro; Nakamura, Kyosuke; Hashimoto, Fumie
  • Effect of hyaluronan tetrasaccharides on epidermal differentiation in normal human epidermal keratinocytes; 2014/01
    ANNOUNCEMENT INFO.; International Journal of Cosmetic Science, 36, 1, 109 - 115
    AUTHOR; Kage, M.; Tokudome, Y.; Matsunaga, Y.; Hariya, T.; Hashimoto, F.
  • Application of glucosylceramide-based liposomes increased the ceramide content in a three-dimensional cultured skin epidermis; 2013/08
    ANNOUNCEMENT INFO.; Skin Pharmacology and Physiology, 27, 1, 18 - 24
    AUTHOR; Tokudome, Y.; Endo, M.; Hashimoto, F.
  • Enhancement of diosgenin distribution in the skin by cyclodextrin complexation following oral administration; 2013/01
    ANNOUNCEMENT INFO.; Biological and Pharmaceutical Bulletin, 36, 1, 36 - 40
    AUTHOR; Okawara, Masaki; Tokudome, Yoshihiro; Todo, Hiroaki; Sugibayashi, Kenji; Hashimoto, Fumie
  • Permeation of hyaluronan tetrasaccharides through hairless mouse skin: An in vitro and in vivo study; 2013/01
    ANNOUNCEMENT INFO.; Archives of Dermatological Research, 305, 1, 69 - 77
    AUTHOR; Kage, Madoka; Tokudome, Yoshihiro; Hashimoto, Fumie
  • Therapeutic effect of lipophilic and/or hydrophilic zinc related compound injections on alveolar bone mass in zinc-deficient osteoporosis rats; 2013/01
    ANNOUNCEMENT INFO.; Key Engineering Materials, 529-530, 1, 457 - 460
    AUTHOR; Otsuka, Makoto; Tokudome, Yoshihiro; Otsuka, Kuniko; Ito, Atsuo
  • Effects of soybean peptide and collagen peptide on collagen synthesis in normal human dermal fibroblasts; 2012/09
    ANNOUNCEMENT INFO.; International Journal of Food Sciences and Nutrition, 63, 6, 689 - 695
    AUTHOR; Tokudome, Yoshihiro; Nakamura, Kyosuke; Kage, Madoka; Todo, Hiroaki; Sugibayashi, Kenji; Hashimoto, Fumie
  • Possibility of alveolar bone promoting enhancement by using lipophilic and/or hydrophilic zinc related compounds in zinc-deficient osteoporosis rats; 2012/01
    ANNOUNCEMENT INFO.; Biological and Pharmaceutical Bulletin, 35, 9, 1496 - 1501
    AUTHOR; Tokudome, Yoshihiro; Otsuka, Makoto
  • Effect of zinc-containing β-tricalcium phosphate nano particles injection on jawbone mineral density and mechanical strength of osteoporosis model rats; 2011/08
    ANNOUNCEMENT INFO.; Biological and Pharmaceutical Bulletin, 34, 8, 1215 - 1218
    AUTHOR; Tokudome, Yoshihiro; Ito, Atsuo; Otsuka, Makoto
  • Increase in ceramide level after application of various sizes of sphingomyelin liposomes to a cultured human skin model; 2011/05
    ANNOUNCEMENT INFO.; Skin Pharmacology and Physiology, 24, 4, 218 - 223
    AUTHOR; Tokudome, Y.; Jinno, M.; Todo, H.; Kon, T.; Sugibayashi, K.; Hashimoto, F.
  • Preparation and evaluation of liquid-crystal formulations with skin-permeation-enhancing abilities for entrapped drugs; 2011/01
    ANNOUNCEMENT INFO.; Journal of Oleo Science, 60, 1, 31 - 40
    AUTHOR; Yamada, Keisuke; Yamashita, Jun; Todo, Hiroaki; Miyamoto, Keiko; Hashimoto, Satoru; Tokudome, Yoshihiro; Hashimoto, Fumie; Sugibayashi, Kenji
  • Permeation pathway of macromolecules and nanospheres through skin; 2010/09
    ANNOUNCEMENT INFO.; Biological and Pharmaceutical Bulletin, 33, 8, 1394 - 1399
    AUTHOR; Todo, Hiroaki; Kimura, Eriko; Yasuno, Hirotaka; Tokudome, Yoshihiro; Hashimoto, Fumie; Ikarashi, Yoshiaki; Sugibayashi, Kenji
  • Possibility and effectiveness of drug delivery to skin by needle-free injector; 2010/05
    ANNOUNCEMENT INFO.; International Journal of Pharmaceutics, 391, 1-2, 65 - 72
    AUTHOR; Inoue, Naoko; Todo, Hiroaki; Iidaka, Dai; Tokudome, Yoshihiro; Hashimoto, Fumie; Kishino, Tohru; Sugibayashi, Kenji
  • Infrared spectroscopic study of lipid interaction in stratum corneum treated with transdermal absorption enhancers; 2010/04
    ANNOUNCEMENT INFO.; International Journal of Pharmaceutics, 389, 1-2, 18 - 23
    AUTHOR; Obata, Yasuko; Utsumi, Shunichi; Watanabe, Hiroshi; Suda, Masafumi; Tokudome, Yoshihiro; Otsuka, Makoto; Takayama, Kozo
  • Effect of topically applied sphingomyelin-based liposomes on the ceramide level in a three-dimensional cultured human skin model; 2010/01
    ANNOUNCEMENT INFO.; Journal of Liposome Research, 20, 1, 49 - 54
    AUTHOR; Tokudome, Yoshihiro; Uchida, Raina; Yokote, Takeshi; Todo, Hiroaki; Hada, Nobuko; Kon, Tatsuhiko; Yasuda, Junko; Hayashi, Hidenori; Hashimoto, Fumie; Sugibayashi, Kenji
  • Non-invasive and rapid analysis for observation of internal structure of press-coated tablet using X-ray computed tomography Internal structure of press-coated tablet using X-ray CT; 2009/11
    ANNOUNCEMENT INFO.; Drug Development and Industrial Pharmacy, 35, 6, 678 - 682
    AUTHOR; Tokudome, Yoshihiro; Ohshima, Hiroyuki; Otsuka, Makoto
  • Nano- and macro-geometrical structural change of caffeine and theophylline anhydrate tablets during hydration process by using X-ray computed tomography; 2009/10
    ANNOUNCEMENT INFO.; Colloids and Surfaces B: Biointerfaces, 73, 2, 351 - 359
    AUTHOR; Otsuka, Makoto; Ibe, Koyuki; Tokudome, Yoshihiro; Ohshima, Hiroyuki
  • Preparation and characterization of ceramide-based liposomes with high fusion activity and high membrane fluidity; 2009/10
    ANNOUNCEMENT INFO.; Colloids and Surfaces B: Biointerfaces, 73, 1, 92 - 96
    AUTHOR; Tokudome, Yoshihiro; Saito, Yuko; Sato, Fumihiko; Kikuchi, Maki; Hinokitani, Toshihiro; Goto, Kenichi
  • Long-term therapeutic effect of novel calcium phosphate-based compounds injected in ovariectomized rats; 2009/01
    ANNOUNCEMENT INFO.; Journal of Biomedical Materials Research - Part B Applied Biomaterials, 90 B, 1, 229 - 237
    AUTHOR; Tokudome, Yoshihiro; Otsuka, Makoto; Ito, Atsuo; LeGeros, Racquel Z.
  • Efficacy of the injectable calcium phosphate ceramics suspensions containing magnesium, zinc and fluoride on the bone mineral deficiency in ovariectomized rats; 2008/01
    ANNOUNCEMENT INFO.; Journal of Pharmaceutical Sciences, 97, 1, 421 - 432
    AUTHOR; Otsuka, Makoto; Oshinbe, Ayako; Legeros, Racquel Z.; Tokudome, Yoshihiro; Ito, Atsuo; Otsuka, Kuniko; Higuchi, William I.
  • Effects of solid-state reaction between paracetamol and cloperastine hydrochloride on the pharmaceutical properties of their preparations; 2007/04
    ANNOUNCEMENT INFO.; International Journal of Pharmaceutics, 335, 1-2, 12 - 19
    AUTHOR; Sakata, Yukoh; Tanabe, Eishi; Sumikawa, Toshiharu; Shiraishi, Sumihiro; Tokudome, Yoshihiro; Otsuka, Makoto
  • Mechanism of the synergic effects of calcium chloride and electroporation on the in vitro enhanced skin permeation of drugs; 2004/03
    ANNOUNCEMENT INFO.; Journal of Controlled Release, 95, 2, 267 - 274
    AUTHOR; Tokudome, Yoshihiro; Sugibayashi, Kenji
  • The effects of calcium chloride and sodium chloride on the electroporation-mediated skin permeation of fluorescein isothiocyanate (FITC)-dextrans in vitro; 2003/10
    ANNOUNCEMENT INFO.; Biological and Pharmaceutical Bulletin, 26, 10, 1508 - 1510
    AUTHOR; Tokudome, Yoshihiro; Sugibayashi, Kenji
  • The synergic effects of various electrolytes and electroporation on the in vitro skin permeation of calcein; 2003/09
    ANNOUNCEMENT INFO.; Journal of Controlled Release, 92, 1-2, 93 - 101
    AUTHOR; Tokudome, Yoshihiro; Sugibayashi, Kenji
  • Evaluation of drug targeting strategies and liposomal trafficking; 2000/01
    ANNOUNCEMENT INFO.; Current Pharmaceutical Design, 6, 16, 1669 - 1691
    AUTHOR; Oku, Naoto; Tokudome, Yoshihiro; Asai, Tomohiro; Tsukada, Hideo
  • Application of liposomes for cancer metastasis; 1997/03
    ANNOUNCEMENT INFO.; Advanced Drug Delivery Reviews, 24, 2-3, 215 - 223
    AUTHOR; Oku, Naoto; Koike, Chieko; Tokudome, Yoshihiro; Okada, Shoji; Nishikawa, Naoyuki; Tsukada, Hideo; Kiso, Makoto; Hasegawa, Akira; Fujii, Hideki; Murata, Jun; Saiki, Ikuo
  • Liposomal Arg-Gly-Asp analogs effectively inhibit metastatic B16 melanoma colonization in murine lungs; 1996/05
    ANNOUNCEMENT INFO.; Life Sciences, 58, 24, 2263 - 2270
    AUTHOR; Oku, Naoto; Tokudome, Yoshihiro; Koike, Chieko; Nishikawa, Naoyuki; Mori, Hideto; Saiki, Ikuo; Okada, Shoji
  • Effect of serum protein binding on real-time trafficking of liposomes with different charges analyzed by positron emission tomography; 1996/04
    ANNOUNCEMENT INFO.; Biochimica et Biophysica Acta - Biomembranes, 1280, 1, 149 - 154
    AUTHOR; Oku, Naoto; Tokudome, Yoshihiro; Namba, Yukihiro; Saito, Nobuko; Endo, Masae; Hasegawa, Yoko; Kawai, Mayumi; Tsukada, Hideo; Okada, Shoji
  • Antitumor activity of vincristine encapsulated in glucuronide-modified long-circulating liposomes in mice bearing Meth A sarcoma; 1996/02
    ANNOUNCEMENT INFO.; Biochimica et Biophysica Acta - Biomembranes, 1279, 1, 70 - 74
    AUTHOR; Tokudome, Yoshihiro; Oku, Naoto; Doi, Kanako; Namba, Yukihiro; Okada, Shoji
  • Liposomal trafficking in normal and tumor-bearing mice determined by use of positron emission tomography; 1996/01
    ANNOUNCEMENT INFO.; Proceedings of the Controlled Release Society, 23, 93 - 94
    AUTHOR; Oku, N.; Tokudome, Y.; Tsukada, H.; Namba, Y.; Okada, S.
  • In vivo trafficking of long-circulating liposomes in tumour-bearing mice determined by positron emission tomography; 1996/01
    ANNOUNCEMENT INFO.; Biopharmaceutics and Drug Disposition, 17, 5, 435 - 441
    AUTHOR; Oku, Naoto; Tokudome, Yoshihiro; Tsukada, Hideo; Kosugi, Tsuyoshi; Namba, Yukihiro; Okada, Shoji
  • Real-time analysis of liposomal trafficking in tumor-bearing mice by use of positron emission tomography; 1995/08
    ANNOUNCEMENT INFO.; BBA - Biomembranes, 1238, 1, 86 - 90
    AUTHOR; Oku, Naoto; Tokudome, Yoshihiro; Tsukada, Hideo; Okada, Shoji
  • Induction of coenzyme A-dependent transacylation activity in rat liver microsomes by administration of clofibrate; 1994/03
    ANNOUNCEMENT INFO.; Biochimica et Biophysica Acta (BBA)/Lipids and Lipid Metabolism, 1211, 3, 263 - 269
    AUTHOR; Yamashita, Atsushi; Sato, Kazuaki; Watanabe, Masanobu; Tokudome, Yoshihiro; Sugiura, Takayuki; Waku, Keizo


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