Detailed Information

Research Topics and Results

• Pathogenic and Compensatory Mechanisms in Epidermis of Sphingomyelin Synthase 2-Deficient Mice 2021/09
• Induction of coenzyme A-dependent transacylation activity in rat liver microsomes by administration of clofibrate 1994/03

Original Articles

• Pathogenic and Compensatory Mechanisms in Epidermis of Sphingomyelin Synthase 2-Deficient Mice;　2021/09
  ANNOUNCEMENT INFO.;　Skin Pharmacology and Physiology, 34, 5, 246 - 252
  AUTHOR;　Sakai, Shota; Makino, Asami; Nishi, Akihito; Ichikawa, Takeshi; Yamashita, Tadashi; Taniguchi, Makoto; Tokudome, Yoshihiro; Hirabayashi, Yoshio; Akiyama, Masashi; Crumrine, Debra; Uchida, Yoshikazu; Elias, Peter M.; Tsuchida, Tetsuya; Hamanaka, Sumiko
  
• Effect of Lactic Fermentation Products on Human Epidermal Cell Differentiation, Ceramide Content, and Amino Acid Production;　2021/04
  ANNOUNCEMENT INFO.;　Skin Pharmacology and Physiology, 34, 2, 103 - 114
  AUTHOR;　Otsuka, Moe; Tamane, Tsuyoshi; Tokudome, Yoshihiro
  
• Enhancement of cornified envelope-related gene and protein expression by Carba cyclic phosphatidic acid in normal human epidermal keratinocytes;　2021/03
  ANNOUNCEMENT INFO.;　Biological and Pharmaceutical Bulletin, 44, 3, 453 - 457
  AUTHOR;　Saito, Erika; Kage, Madoka; Tokudome, Yoshihiro
  
• Nanoparticulation of hyaluronic acid: A new skin penetration enhancing polyion complex formulation: Mechanism and future potential;　2020/12
  ANNOUNCEMENT INFO.;　Materialia, 14, -
  AUTHOR;　Shigefuji, Miki; Tokudome, Yoshihiro
  
• Synthesis of resorcinol derivatives and their effects on melanin production;　2020/09
  ANNOUNCEMENT INFO.;　Cosmetics, 7, 3, -
  AUTHOR;　Tokudome, Yoshihiro; Hoshi, Tsuyoshi; Mori, Sayaka; Hijikuro, Ichiro
  
• Improvement of the skin barrier function with physiologically active substances;　2019/01
  ANNOUNCEMENT INFO.;　Yakugaku Zasshi, 139, 12, 1549 - 1551
  AUTHOR;　Tokudome, Yoshihiro
  
• Influence of oral administration of lactic acid bacteria metabolites on skin barrier function and water content in a murine model of atopic dermatitis;　2018/12
  ANNOUNCEMENT INFO.;　Nutrients, 10, 12, -
  AUTHOR;　Tokudome, Yoshihiro
  
• A new strategy for the passive skin delivery of nanoparticulate, high molecular weight hyaluronic acid prepared by a polyion complex method;　2018/12
  ANNOUNCEMENT INFO.;　Scientific Reports, 8, 1, -
  AUTHOR;　Tokudome, Yoshihiro; Komi, Tatsuya; Omata, Ami; Sekita, Marie
  
• Epidermal permeability barrier function and sphingolipid content in the skin of sphingomyelin synthase 2 deficient mice;　2018/08
  ANNOUNCEMENT INFO.;　Experimental Dermatology, 27, 8, 827 - 832
  AUTHOR;　Nomoto, Koji; Itaya, Yurina; Watanabe, Ken; Yamashita, Tadashi; Okazaki, Toshiro; Tokudome, Yoshihiro
  
• Chimyl alcohol suppresses PGE2 synthesis by human epidermal keratinocytes through the activation of PPAR-γ;　2018/01
  ANNOUNCEMENT INFO.;　Journal of Oleo Science, 67, 4, 455 - 462
  AUTHOR;　Yokota, Mariko; Yahagi, Shoichi; Tokudome, Yoshihiro; Masaki, Hitoshi
  
• Related topic: Liposomes-recent advances and future perspective;　2017/11
  ANNOUNCEMENT INFO.;　Skin Permeation and Disposition of Therapeutic and Cosmeceutical Compounds, 137 - 142
  AUTHOR;　Yokota, Mami; Tokudome, Yoshihiro
  
• Recovery effects of oral administration of glucosylceramide and beet extract on skin barrier destruction by UVB in hairless mice;　2017/11
  ANNOUNCEMENT INFO.;　Nutrients, 9, 11, -
  AUTHOR;　Tokudome, Yoshihiro; Masutani, Noriomi; Uchino, Shohei; Fukai, Hisano
  
• Glyceraldehyde-derived advanced glycation end products accumulate faster than Nϵ-(Carboxymethyl) Lysine;　2017/08
  ANNOUNCEMENT INFO.;　Annals of Dermatology, 29, 4, 508 - 511
  AUTHOR;　Yokota, Mami; Sekita, Marie; Okano, Yuri; Masaki, Hitoshi; Takeuchi, Masayoshi; Tokudome, Yoshihiro
  
• Effects of peach (Prunus persica)-derived glucosylceramide on the human skin;　2017/04
  ANNOUNCEMENT INFO.;　Immunology, Endocrine and Metabolic Agents in Medicinal Chemistry, 17, 1, 56 - 70
  AUTHOR;　Koikeda, Takashi; Tokudome, Yoshihiro; Okayasu, Musashi; Kobayashi, Yuki; Kuroda, Kohei; Yamakawa, Junko; Niu, Kiyosato; Masuda, Kou; Saito, Masami
  
• The Effect of Glycation on Epidermal Lipid Content, Its Metabolism and Change in Barrier Function;　2016/12
  ANNOUNCEMENT INFO.;　Skin Pharmacology and Physiology, 29, 5, 231 - 242
  AUTHOR;　Yokota, Mami; Tokudome, Yoshihiro
  
• Upregulation of gene expression levels of ceramide metabolic enzymes after application of sphingomyelin-based liposomes to a three-dimensional cultured human epidermis model;　2016/04
  ANNOUNCEMENT INFO.;　Biochemical and Biophysical Research Communications, 473, 1, 114 - 117
  AUTHOR;　Itaya, Yurina; Tokudome, Yoshihiro
  
• Hyaluronan tetrasaccharides stimulate ceramide production through upregulated mRNA expression of ceramide synthesis-associated enzymes;　2016/03
  ANNOUNCEMENT INFO.;　Archives of Dermatological Research, 308, 2, 95 - 101
  AUTHOR;　Kage, Madoka; Tokudome, Yoshihiro
  
• Examination of the physicochemical properties of caffeic acid complexed with γ-cyclodextrin;　2015/12
  ANNOUNCEMENT INFO.;　Journal of Inclusion Phenomena and Macrocyclic Chemistry, 83, 3-4, 289 - 298
  AUTHOR;　Inoue, Yutaka; Suzuki, Kengo; Ezawa, Toshinari; Murata, Isamu; Yokota, Mami; Tokudome, Yoshihiro; Kanamoto, Ikuo
  
• Permeation of hydrophilic molecules across glycated skin is differentially regulated by the stratum corneum and epidermis-dermis;　2015/09
  ANNOUNCEMENT INFO.;　Biological and Pharmaceutical Bulletin, 38, 9, 1383 - 1388
  AUTHOR;　Yokota, Mami; Tokudome, Yoshihiro
  
• Enhancement of skin penetration of hydrophilic and lipophilic compounds by pH-sensitive liposomes;　2015/07
  ANNOUNCEMENT INFO.;　Journal of Pharmacy and Pharmaceutical Sciences, 18, 3, 249 - 257
  AUTHOR;　Tokudome, Yoshihiro; Nakamura, Kaoru; Itaya, Yurina; Hashimoto, Fumie
  
• Esterase activity and intracellular localization in reconstructed human epidermal cultured skin models;　2015/01
  ANNOUNCEMENT INFO.;　Annals of Dermatology, 27, 3, 269 - 274
  AUTHOR;　Tokudome, Yoshihiro; Katayanagi, Mishina; Hashimoto, Fumie
  
• Effect of liquid crystals with cyclodextrin on the bioavailability of a poorly water-soluble compound, diosgenin, after its oral administration to rats;　2014/09
  ANNOUNCEMENT INFO.;　International Journal of Pharmaceutics, 472, 1-2, 257 - 261
  AUTHOR;　Okawara, Masaki; Hashimoto, Fumie; Todo, Hiroaki; Sugibayashi, Kenji; Tokudome, Yoshihiro
  
• Effects of low molecular weight soybean peptide on mRNA and protein expression levels of differentiation markers in normal human epidermal keratinocytes;　2014/01
  ANNOUNCEMENT INFO.;　Bioscience, Biotechnology and Biochemistry, 78, 6, 1018 - 1021
  AUTHOR;　Tokudome, Yoshihiro; Nakamura, Kyosuke; Hashimoto, Fumie
  
• Effect of hyaluronan tetrasaccharides on epidermal differentiation in normal human epidermal keratinocytes;　2014/01
  ANNOUNCEMENT INFO.;　International Journal of Cosmetic Science, 36, 1, 109 - 115
  AUTHOR;　Kage, M.; Tokudome, Y.; Matsunaga, Y.; Hariya, T.; Hashimoto, F.
  
• Application of glucosylceramide-based liposomes increased the ceramide content in a three-dimensional cultured skin epidermis;　2013/08
  ANNOUNCEMENT INFO.;　Skin Pharmacology and Physiology, 27, 1, 18 - 24
  AUTHOR;　Tokudome, Y.; Endo, M.; Hashimoto, F.
  
• Enhancement of diosgenin distribution in the skin by cyclodextrin complexation following oral administration;　2013/01
  ANNOUNCEMENT INFO.;　Biological and Pharmaceutical Bulletin, 36, 1, 36 - 40
  AUTHOR;　Okawara, Masaki; Tokudome, Yoshihiro; Todo, Hiroaki; Sugibayashi, Kenji; Hashimoto, Fumie
  
• Permeation of hyaluronan tetrasaccharides through hairless mouse skin: An in vitro and in vivo study;　2013/01
  ANNOUNCEMENT INFO.;　Archives of Dermatological Research, 305, 1, 69 - 77
  AUTHOR;　Kage, Madoka; Tokudome, Yoshihiro; Hashimoto, Fumie
  
• Therapeutic effect of lipophilic and/or hydrophilic zinc related compound injections on alveolar bone mass in zinc-deficient osteoporosis rats;　2013/01
  ANNOUNCEMENT INFO.;　Key Engineering Materials, 529-530, 1, 457 - 460
  AUTHOR;　Otsuka, Makoto; Tokudome, Yoshihiro; Otsuka, Kuniko; Ito, Atsuo
  
• Effects of soybean peptide and collagen peptide on collagen synthesis in normal human dermal fibroblasts;　2012/09
  ANNOUNCEMENT INFO.;　International Journal of Food Sciences and Nutrition, 63, 6, 689 - 695
  AUTHOR;　Tokudome, Yoshihiro; Nakamura, Kyosuke; Kage, Madoka; Todo, Hiroaki; Sugibayashi, Kenji; Hashimoto, Fumie
  
• Possibility of alveolar bone promoting enhancement by using lipophilic and/or hydrophilic zinc related compounds in zinc-deficient osteoporosis rats;　2012/01
  ANNOUNCEMENT INFO.;　Biological and Pharmaceutical Bulletin, 35, 9, 1496 - 1501
  AUTHOR;　Tokudome, Yoshihiro; Otsuka, Makoto
  
• Effect of zinc-containing β-tricalcium phosphate nano particles injection on jawbone mineral density and mechanical strength of osteoporosis model rats;　2011/08
  ANNOUNCEMENT INFO.;　Biological and Pharmaceutical Bulletin, 34, 8, 1215 - 1218
  AUTHOR;　Tokudome, Yoshihiro; Ito, Atsuo; Otsuka, Makoto
  
• Increase in ceramide level after application of various sizes of sphingomyelin liposomes to a cultured human skin model;　2011/05
  ANNOUNCEMENT INFO.;　Skin Pharmacology and Physiology, 24, 4, 218 - 223
  AUTHOR;　Tokudome, Y.; Jinno, M.; Todo, H.; Kon, T.; Sugibayashi, K.; Hashimoto, F.
  
• Preparation and evaluation of liquid-crystal formulations with skin-permeation-enhancing abilities for entrapped drugs;　2011/01
  ANNOUNCEMENT INFO.;　Journal of Oleo Science, 60, 1, 31 - 40
  AUTHOR;　Yamada, Keisuke; Yamashita, Jun; Todo, Hiroaki; Miyamoto, Keiko; Hashimoto, Satoru; Tokudome, Yoshihiro; Hashimoto, Fumie; Sugibayashi, Kenji
  
• Permeation pathway of macromolecules and nanospheres through skin;　2010/09
  ANNOUNCEMENT INFO.;　Biological and Pharmaceutical Bulletin, 33, 8, 1394 - 1399
  AUTHOR;　Todo, Hiroaki; Kimura, Eriko; Yasuno, Hirotaka; Tokudome, Yoshihiro; Hashimoto, Fumie; Ikarashi, Yoshiaki; Sugibayashi, Kenji
  
• Possibility and effectiveness of drug delivery to skin by needle-free injector;　2010/05
  ANNOUNCEMENT INFO.;　International Journal of Pharmaceutics, 391, 1-2, 65 - 72
  AUTHOR;　Inoue, Naoko; Todo, Hiroaki; Iidaka, Dai; Tokudome, Yoshihiro; Hashimoto, Fumie; Kishino, Tohru; Sugibayashi, Kenji
  
• Infrared spectroscopic study of lipid interaction in stratum corneum treated with transdermal absorption enhancers;　2010/04
  ANNOUNCEMENT INFO.;　International Journal of Pharmaceutics, 389, 1-2, 18 - 23
  AUTHOR;　Obata, Yasuko; Utsumi, Shunichi; Watanabe, Hiroshi; Suda, Masafumi; Tokudome, Yoshihiro; Otsuka, Makoto; Takayama, Kozo
  
• Effect of topically applied sphingomyelin-based liposomes on the ceramide level in a three-dimensional cultured human skin model;　2010/01
  ANNOUNCEMENT INFO.;　Journal of Liposome Research, 20, 1, 49 - 54
  AUTHOR;　Tokudome, Yoshihiro; Uchida, Raina; Yokote, Takeshi; Todo, Hiroaki; Hada, Nobuko; Kon, Tatsuhiko; Yasuda, Junko; Hayashi, Hidenori; Hashimoto, Fumie; Sugibayashi, Kenji
  
• Non-invasive and rapid analysis for observation of internal structure of press-coated tablet using X-ray computed tomography Internal structure of press-coated tablet using X-ray CT;　2009/11
  ANNOUNCEMENT INFO.;　Drug Development and Industrial Pharmacy, 35, 6, 678 - 682
  AUTHOR;　Tokudome, Yoshihiro; Ohshima, Hiroyuki; Otsuka, Makoto
  
• Nano- and macro-geometrical structural change of caffeine and theophylline anhydrate tablets during hydration process by using X-ray computed tomography;　2009/10
  ANNOUNCEMENT INFO.;　Colloids and Surfaces B: Biointerfaces, 73, 2, 351 - 359
  AUTHOR;　Otsuka, Makoto; Ibe, Koyuki; Tokudome, Yoshihiro; Ohshima, Hiroyuki
  
• Preparation and characterization of ceramide-based liposomes with high fusion activity and high membrane fluidity;　2009/10
  ANNOUNCEMENT INFO.;　Colloids and Surfaces B: Biointerfaces, 73, 1, 92 - 96
  AUTHOR;　Tokudome, Yoshihiro; Saito, Yuko; Sato, Fumihiko; Kikuchi, Maki; Hinokitani, Toshihiro; Goto, Kenichi
  
• Long-term therapeutic effect of novel calcium phosphate-based compounds injected in ovariectomized rats;　2009/01
  ANNOUNCEMENT INFO.;　Journal of Biomedical Materials Research - Part B Applied Biomaterials, 90 B, 1, 229 - 237
  AUTHOR;　Tokudome, Yoshihiro; Otsuka, Makoto; Ito, Atsuo; LeGeros, Racquel Z.
  
• Efficacy of the injectable calcium phosphate ceramics suspensions containing magnesium, zinc and fluoride on the bone mineral deficiency in ovariectomized rats;　2008/01
  ANNOUNCEMENT INFO.;　Journal of Pharmaceutical Sciences, 97, 1, 421 - 432
  AUTHOR;　Otsuka, Makoto; Oshinbe, Ayako; Legeros, Racquel Z.; Tokudome, Yoshihiro; Ito, Atsuo; Otsuka, Kuniko; Higuchi, William I.
  
• Effects of solid-state reaction between paracetamol and cloperastine hydrochloride on the pharmaceutical properties of their preparations;　2007/04
  ANNOUNCEMENT INFO.;　International Journal of Pharmaceutics, 335, 1-2, 12 - 19
  AUTHOR;　Sakata, Yukoh; Tanabe, Eishi; Sumikawa, Toshiharu; Shiraishi, Sumihiro; Tokudome, Yoshihiro; Otsuka, Makoto
  
• Mechanism of the synergic effects of calcium chloride and electroporation on the in vitro enhanced skin permeation of drugs;　2004/03
  ANNOUNCEMENT INFO.;　Journal of Controlled Release, 95, 2, 267 - 274
  AUTHOR;　Tokudome, Yoshihiro; Sugibayashi, Kenji
  
• The effects of calcium chloride and sodium chloride on the electroporation-mediated skin permeation of fluorescein isothiocyanate (FITC)-dextrans in vitro;　2003/10
  ANNOUNCEMENT INFO.;　Biological and Pharmaceutical Bulletin, 26, 10, 1508 - 1510
  AUTHOR;　Tokudome, Yoshihiro; Sugibayashi, Kenji
  
• The synergic effects of various electrolytes and electroporation on the in vitro skin permeation of calcein;　2003/09
  ANNOUNCEMENT INFO.;　Journal of Controlled Release, 92, 1-2, 93 - 101
  AUTHOR;　Tokudome, Yoshihiro; Sugibayashi, Kenji
  
• Evaluation of drug targeting strategies and liposomal trafficking;　2000/01
  ANNOUNCEMENT INFO.;　Current Pharmaceutical Design, 6, 16, 1669 - 1691
  AUTHOR;　Oku, Naoto; Tokudome, Yoshihiro; Asai, Tomohiro; Tsukada, Hideo
  
• Application of liposomes for cancer metastasis;　1997/03
  ANNOUNCEMENT INFO.;　Advanced Drug Delivery Reviews, 24, 2-3, 215 - 223
  AUTHOR;　Oku, Naoto; Koike, Chieko; Tokudome, Yoshihiro; Okada, Shoji; Nishikawa, Naoyuki; Tsukada, Hideo; Kiso, Makoto; Hasegawa, Akira; Fujii, Hideki; Murata, Jun; Saiki, Ikuo
  
• Liposomal Arg-Gly-Asp analogs effectively inhibit metastatic B16 melanoma colonization in murine lungs;　1996/05
  ANNOUNCEMENT INFO.;　Life Sciences, 58, 24, 2263 - 2270
  AUTHOR;　Oku, Naoto; Tokudome, Yoshihiro; Koike, Chieko; Nishikawa, Naoyuki; Mori, Hideto; Saiki, Ikuo; Okada, Shoji
  
• Effect of serum protein binding on real-time trafficking of liposomes with different charges analyzed by positron emission tomography;　1996/04
  ANNOUNCEMENT INFO.;　Biochimica et Biophysica Acta - Biomembranes, 1280, 1, 149 - 154
  AUTHOR;　Oku, Naoto; Tokudome, Yoshihiro; Namba, Yukihiro; Saito, Nobuko; Endo, Masae; Hasegawa, Yoko; Kawai, Mayumi; Tsukada, Hideo; Okada, Shoji
  
• Antitumor activity of vincristine encapsulated in glucuronide-modified long-circulating liposomes in mice bearing Meth A sarcoma;　1996/02
  ANNOUNCEMENT INFO.;　Biochimica et Biophysica Acta - Biomembranes, 1279, 1, 70 - 74
  AUTHOR;　Tokudome, Yoshihiro; Oku, Naoto; Doi, Kanako; Namba, Yukihiro; Okada, Shoji
  
• Liposomal trafficking in normal and tumor-bearing mice determined by use of positron emission tomography;　1996/01
  ANNOUNCEMENT INFO.;　Proceedings of the Controlled Release Society, 23, 93 - 94
  AUTHOR;　Oku, N.; Tokudome, Y.; Tsukada, H.; Namba, Y.; Okada, S.
  
• In vivo trafficking of long-circulating liposomes in tumour-bearing mice determined by positron emission tomography;　1996/01
  ANNOUNCEMENT INFO.;　Biopharmaceutics and Drug Disposition, 17, 5, 435 - 441
  AUTHOR;　Oku, Naoto; Tokudome, Yoshihiro; Tsukada, Hideo; Kosugi, Tsuyoshi; Namba, Yukihiro; Okada, Shoji
  
• Real-time analysis of liposomal trafficking in tumor-bearing mice by use of positron emission tomography;　1995/08
  ANNOUNCEMENT INFO.;　BBA - Biomembranes, 1238, 1, 86 - 90
  AUTHOR;　Oku, Naoto; Tokudome, Yoshihiro; Tsukada, Hideo; Okada, Shoji
  
• Induction of coenzyme A-dependent transacylation activity in rat liver microsomes by administration of clofibrate;　1994/03
  ANNOUNCEMENT INFO.;　Biochimica et Biophysica Acta (BBA)/Lipids and Lipid Metabolism, 1211, 3, 263 - 269
  AUTHOR;　Yamashita, Atsushi; Sato, Kazuaki; Watanabe, Masanobu; Tokudome, Yoshihiro; Sugiura, Takayuki; Waku, Keizo