Detailed Information

Research Field/Keywords for Research Field

• Histology and Molecular Cell Biology

Employment Experience

• 2016/02 -  *  Professor, Medicine, Faculty of Medicine, Saga University

Field of Specialization

• Morphological basic dentistry, Periodontology, General anatomy (including histology/embryology), Social dentistry, Pain science

Membership in Academic Societies

• International Association for Dental Research

Research Topics and Results

• Correlation Between Work Motivation and Life Events in Female Physicians 2023/07
• Involvement of skin TRPV3 in temperature detection regulated by TMEM79 in mice 2023/07
• Transient Receptor Potential Channel Vanilloid 1 Contributes to Facial Mechanical Hypersensitivity in a Mouse Model of Atopic Asthma  2023/06
• Immunohistochemical characterization of transient receptor potential vanilloid types 2 and 1 in a trinitrobenzene sulfonic acid-induced rat colitis model with visceral hypersensitivity 2023/02
• Increased GLUT1 expression and localization to Golgi apparatus of acinar cells in the parotid gland of Goto-Kakizaki diabetic rats 2023/02
• TRPV1 contribute to facial mechanical hypersensitivity in atopic asthma mouse 2022/07
• An ultrasonic osteotomy device enhanced post-osteotomy bone healing beyond that with a conventional rotary device in a rat calvarial model  2022/05
• [2P-384]Thermo-sensitive ion channel TRPV4 regulates actin dynamics in oral epithelial cells 2022
• [1P-763]Aldehyde dehydrogenase 2 deficiency affects epithelial barrier and airway hyper responsiveness in allergic asthma model mouse 2022
• Challenges and supports for female doctors with childrearing responsibilities at a regional hospital in Japan 2021/08
• The large GTPase Rab44 regulates granule exocytosis in mast cells and IgE-mediated anaphylaxis 2020/12
• Expression and localisation of Rab44 in immune-related cells change during cell differentiation and stimulation 2020/07
• Reduced Post-ischemic Brain Injury in Transient Receptor Potential Vanilloid 4 Knockout Mice 2020/05
• The TRPV4-AKT axis promotes oral squamous cell carcinoma cell proliferation via CaMKII activation. 2020/02
• Reduced post-ischemic brain tissue injury following transient focal cerebral ischemia in Transient receptor potential vanilloid 4 knockout mice. 2020/02
• Enhanced junctional epithelial permeability in TRPV4-deficient mice. 2020/01
• Impaired Junctions and Invaded Macrophages in Oral Epithelia With Oral Pain. 2019/04
• CALHM1/CALHM3 channel is intrinsically sorted to the basolateral membrane of epithelial cells including taste cells. 2019/02
• The preliminary result of motivational drive chart of Japanese female medical doctors. 2019
• Changes of TRPV4 distribution in labial mucosa of Xerostomia patients with unpleasant burning sensation. 2019
• A novel autoantibody against Plexin D1 in patients with neuropathic pain. 2018
• Warm sensitive TRP channels and oral mucosal barrier. 2018
• Warm activated TRPV4 enhanced oral epitherial cell-cell adhesion and suppresses migration 2018
• Effects of deficiency of Kelch-like ECH-associated protein 1 on skeletal organization: a mechanism for diminished nuclear factor of activated T cells cytoplasmic 1 during osteoclastogenesis. 2017
• Post-translational palmitoylation controls the voltage gating and lipid raft association of the CALHM1 channel. 2017
• An Anti-Plexin D1 Autoantibody Is Associated with Immunotherapy-Responsive Neuropathic Pain 2017
• Oral barrier formation via temperature-sensitive TRP channels. 2017
• Epithelial barrier disorganization and oral pain. 2017
• Temperature sensitive TRP channels in Oral Mucosa. 2017
• Warm-activated TRPV4 enhances oral epithelial cell-cell adhesion and suppresses migration. 2017
• The oral mucosal membrane and transient receptor potential channels. 2017
• Allergic inflammation leads to neuropathic pain via glial cell activation. 2016
• Oral mucosal membrane and TRP channels. 2016
• Temperature changes affect intercellular adhesion of oral epithelial cells. 2016
• Disorganization of adherens junction of labial epithelia in xerostomia patients. 2016
• Hypomaturation of dental enamel in thermosensitive TRP channel deleted mice. 2016
• The thermosensitive TRPV3 channel contributes to rapid wound healing in oral epithelia. 2015
• Milk basic protein supplementation enhances fracture healing in mice. 2015
• The role of thermosensitive TRP channel in oral wound healing. 2015
• Temperature sensitive TRP channels in Oral Epithelial Barrier. 2015
• Effect of TRPV4 gene deletion to barrier function in gingival epithelium. 2015
• Hydropic Degeneration of Labial Mucosal Epithelium and Infiltration of Macrophages in Xerostomia Patients. 2015
• Burning Sensation and Degeneration in Labial Epithelium of Xerostomia Patients. 2015

Original Articles

• Correlation Between Work Motivation and Life Events in Female Physicians;　2023/07
  ANNOUNCEMENT INFO.;　Kurume Med J, 68, 2, 69-74
  AUTHOR;　*Moriya F, Kakuma T, Obara H, Mori M, Hara M, Masuoka M, Torimura T, Kido M, Yano H
  
• Involvement of skin TRPV3 in temperature detection regulated by TMEM79 in mice;　2023/07
  ANNOUNCEMENT INFO.;　Nat Commun, 14, 1, 4104
  AUTHOR;　*Lei J, Yoshimoto RU, Matsui T, Amagai M, Kido MA, Tominaga M
  
• Transient Receptor Potential Channel Vanilloid 1 Contributes to Facial Mechanical Hypersensitivity in a Mouse Model of Atopic Asthma ;　2023/06
  ANNOUNCEMENT INFO.;　Lab Invest, 103, 6, 100149
  AUTHOR;　Cao A, Gao W, Sawada T, Yoshimoto RU, Aijima R, Ohsaki Y, Kido MA
  
• Immunohistochemical characterization of transient receptor potential vanilloid types 2 and 1 in a trinitrobenzene sulfonic acid-induced rat colitis model with visceral hypersensitivity;　2023/02
  ANNOUNCEMENT INFO.;　Cell Tissue Res, 391, 2, 287-303
  AUTHOR;　*Matsumoto K, Sugimoto F, Mizuno T, Hayashi T, Okamura R, Nishioka T, Yasuda H, Horie S, Kido MA, Kato S
  
• Increased GLUT1 expression and localization to Golgi apparatus of acinar cells in the parotid gland of Goto-Kakizaki diabetic rats;　2023/02
  ANNOUNCEMENT INFO.;　Arch Oral Biol, 146, 105601
  AUTHOR;　Maruo K, Nishiyama M, Honda Y, Cao AL, Gao WQ, Shibata K, Murata Y, Kido MA
  
• An ultrasonic osteotomy device enhanced post-osteotomy bone healing beyond that with a conventional rotary device in a rat calvarial model ;　2022/05
  ANNOUNCEMENT INFO.;　J Oral Maxillofac Surg Med Pathol , 34, 3, 243-251
  AUTHOR;　○Danjo A, Aijima R, Yoshimoto RU, Tanaka S, Iwamoto S, Katsuki T, Aoki S, Kido MA, Yamashita Y
  
• The large GTPase Rab44 regulates granule exocytosis in mast cells and IgE-mediated anaphylaxis;　2020/12
  ANNOUNCEMENT INFO.;　Cell Mol Immunol, 17, 12, 1287-1289
  AUTHOR;　*Tomoko Kadowaki, Yu Yamaguchi, Mizuho A Kido, Takaya Abe, Kohei Ogawa, Mitsuko Tokuhisa, Weiqi Gao, Kuniaki Okamoto, Hiroshi Kiyonari, Takayuki Tsukuba
  
• Expression and localisation of Rab44 in immune-related cells change during cell differentiation and stimulation;　2020/07
  ANNOUNCEMENT INFO.;　Sci Rep, 10, 1, 10728
  AUTHOR;　*Mitsuko Tokuhisa, Tomoko Kadowaki, Kohei Ogawa, Yu Yamaguchi, Mizuho A Kido, Weiqi Gao, Masahiro Umeda, Takayuki Tsukuba
  
• Reduced Post-ischemic Brain Injury in Transient Receptor Potential Vanilloid 4 Knockout Mice;　2020/05
  ANNOUNCEMENT INFO.;　Front Neurosci, 14, 453
  AUTHOR;　*Koji Tanaka, Shoji Matsumoto, Takeshi Yamada, Ryo Yamasaki, Makoto Suzuki, Mizuho A Kido, Jun-Ichi Kira
  
• The TRPV4-AKT axis promotes oral squamous cell carcinoma cell proliferation via CaMKII activation.;　2020/02
  ANNOUNCEMENT INFO.;　Lab Invest. , 100, 2, 311-323
  AUTHOR;　*Fujii S, Tajiri Y, Hasegawa K, Matsumoto S, Yoshimoto RU, Wada H, Kishida S, Kido MA, Yoshikawa H, Ozeki S, Kiyoshima T
  
• Enhanced junctional epithelial permeability in TRPV4-deficient mice.;　2020/01
  ANNOUNCEMENT INFO.;　J Periodontal Res, 55, 1, 51-60
  AUTHOR;　*Kitsuki T, Yoshimoto RU, Aijima R, Hatakeyama J, Cao AL, Zhang JQ, Ohsaki Y, Mori Y, Kido MA
  
• Impaired Junctions and Invaded Macrophages in Oral Epithelia With Oral Pain.;　2019/04
  ANNOUNCEMENT INFO.;　J Histochem Cytochem.
  AUTHOR;　Yoshimoto RU, Aijima R, Ohyama Y, Yoshizumi J, Kitsuki T, Ohsaki Y, Cao AL, Danjo A, Yamashita Y, Kiyoshima T, Kido MA
  
• CALHM1/CALHM3 channel is intrinsically sorted to the basolateral membrane of epithelial cells including taste cells.;　2019/02
  ANNOUNCEMENT INFO.;　Sci Rep, 9, 1, 2681
  AUTHOR;　＊Kashio M, GaoWQ, OhsakiY, Kido MA, Taruno A
  
• A novel autoantibody against Plexin D1 in patients with neuropathic pain.;　2018
  ANNOUNCEMENT INFO.;　Ann Neurol. , 84, 2, 208-224
  AUTHOR;　＊Fujii T, Yamasaki R, Iinuma K, Tsuchimoto D, Hayashi Y, Saitoh B, Matsushita T, Kido MA, Aishima S, Nakanishi H, Nakabeppu Y, Kira J
  
• Effects of deficiency of Kelch-like ECH-associated protein 1 on skeletal organization: a mechanism for diminished nuclear factor of activated T cells cytoplasmic 1 during osteoclastogenesis.;　2017
  ANNOUNCEMENT INFO.;　FASEB J. , 31, 9, 4011-4022
  AUTHOR;　*Sakai E, Morita M, Ohuchi M, Kido MA, Fukuma Y, Nishishita K, Okamoto K, Itoh K, Yamamoto M, Tsukub T
  
• Post-translational palmitoylation controls the voltage gating and lipid raft association of the CALHM1 channel.;　2017
  ANNOUNCEMENT INFO.;　J Physiol. , 595, 18, 6121-6145
  AUTHOR;　*Taruno A, Sun H, Nakajo K, Murakami T, Ohsaki Y, Kido MA, Ono F, Marunaka Y
  
• The oral mucosal membrane and transient receptor potential channels.;　2017
  ANNOUNCEMENT INFO.;　J Oral Sci., 59, 2, 189-193
  AUTHOR;　Kido MA, Yoshimoto RU, Aijima R, Cao AL, Gao WQ.
  
• Allergic inflammation leads to neuropathic pain via glial cell activation.;　2016
  ANNOUNCEMENT INFO.;　J Neurosci., 36, 47, 11929-11945
  AUTHOR;　＊Yamasaki R, Fujii T, Wang B, Masaki K, Kido MA, Yoshida M, Matsushita T, Kira J.
  
• The thermosensitive TRPV3 channel contributes to rapid wound healing in oral epithelia.;　2015
  ANNOUNCEMENT INFO.;　FASEB J., 29, 1, 182–192
  AUTHOR;　Aijima R, Wang B, Takao T, Mihara H, Kashio M, Ohsaki Y, Zhang JQ, Mizuno A, Suzuki M, Yamashita Y, Masuko S, Goto M, Tominaga M, Kido MA
  
• Milk basic protein supplementation enhances fracture healing in mice.;　2015
  ANNOUNCEMENT INFO.;　Nutrition, 31, 2, 399-405
  AUTHOR;　*Yoneme H, Hatakeyama J, Danjo A, Oida H, Yoshinari M, Aijima R, Murata N, Watanabe T, Oki Y, Kido MA
  

General Lectures

• [2P-384]Thermo-sensitive ion channel TRPV4 regulates actin dynamics in oral epithelial cells;　2022
  ANNOUNCEMENT INFO.;　MBSJ2022 Cooperated by the Biophysical Society of Japan(Hybrid event), 2022,11,30-12, 2(On-site+Online), Poster
  AUTHOR;　Reiko U. Yoshimoto, Yasuyoshi Osaki, Takeshi Sawada, Teppei Fukuyama, Ryunosuke Koga, Mizuho A. Kido
  
• [1P-763]Aldehyde dehydrogenase 2 deficiency affects epithelial barrier and airway hyper responsiveness in allergic asthma model mouse;　2022
  ANNOUNCEMENT INFO.;　MBSJ2022 Cooperated by the Biophysical Society of Japan(Hybrid event), 2022,11,30-12, 2(On-site+Online), Poster
  AUTHOR;　Takeshi Sawada, Reiko U. Yoshimoto, Akiko Matsumoto, Masanori Makino, Weiqi Gao, Ailin Cao, Teppei Fukuyama, Ryunosuke Koga, Muzuho A. Kido
  
• Reduced post-ischemic brain tissue injury following transient focal cerebral ischemia in Transient receptor potential vanilloid 4 knockout mice.;　2020/02
  ANNOUNCEMENT INFO.;　International Stroke Conference 2020, 2020, 2, 19-21
  AUTHOR;　*Tanaka K, Matsumoto S, Yamada T, Yamasaki R, Kido MA, Kira J
  
• The preliminary result of motivational drive chart of Japanese female medical doctors.;　2019
  ANNOUNCEMENT INFO.;　AMEE2019, 2019.8.24-28
  AUTHOR;　*Moriya F, Kakuma T, Obara H, Kido MA, Torimura T, Yano H
  
• Warm activated TRPV4 enhanced oral epitherial cell-cell adhesion and suppresses migration;　2018
  ANNOUNCEMENT INFO.;　96th General Session & Exhibition of the IADR IADR Pan European Regional Congress, 2018.7.25-28
  AUTHOR;　Yoshimoto RU, Aijima R, Ohsaki Y, Cao AL, Zhang J, Kiyoshima T, Nishimura F, Kido MA
  
• An Anti-Plexin D1 Autoantibody Is Associated with Immunotherapy-Responsive Neuropathic Pain;　2017
  ANNOUNCEMENT INFO.;　ANA Annual Meeting - 142nd Annual Meeting of the American Neurological Association, 2017.10.15-17
  AUTHOR;　*Fujii T, Yamasaki R, Iinuma K, Tsuchimoto D ,Kido MA, Aishima S , Nakabeppu Y , Kira J
  
• Epithelial barrier disorganization and oral pain.;　2017
  ANNOUNCEMENT INFO.;　Gender Summit 10 ? Satellite Conference in Okinawa, 2017.5.29-30
  AUTHOR;　*Yoshimoto RU, Aijima R, Ohyama Y, Yoshizumi J, Kiyoshima T, Kido MA
  
• Warm-activated TRPV4 enhances oral epithelial cell-cell adhesion and suppresses migration.;　2017
  ANNOUNCEMENT INFO.;　The 65th Annual Meeting of Japanese Association for Dental Research, 2017.11.18-19
  AUTHOR;　*Yoshimoto RU, Aijima R, Ohsaki Y, Zhang JQ, Kiyoshima T, Nishimura F, Kido MA
  
• Temperature changes affect intercellular adhesion of oral epithelial cells.;　2016
  ANNOUNCEMENT INFO.;　The 15th International Symposium on Molecular and Neural Mechanisms of Taste and Olfactory Perception (ISMNTOP2016fall: in conjunction with YR Umami Forum 2016, AISCRIB 2016), 2016, 12, 3-4
  AUTHOR;　＊Reiko U. Yoshimoto, Reona Aijima, Yasuyoshi Ohsaki, Jing-Qi Zhang, Ailin Cao, Tamotsu Kiyoshima, Mizuho A. Kido
  
• Disorganization of adherens junction of labial epithelia in xerostomia patients.;　2016
  ANNOUNCEMENT INFO.;　9th Korea-Japan Conference on Cellular Signaling for Young Scientist Seoul, 2016, 7, 21-22
  AUTHOR;　＊Reiko Yoshimoto, Reona Aijima, Yukiko Ohyama, Junko Yoshizumi, Tomoko Kitsuki, Atsushi Danjo, Yoshio Yamashita, Tamotsu Kiyoshima, Mizuho A. Kido.
  
• Hypomaturation of dental enamel in thermosensitive TRP channel deleted mice.;　2016
  ANNOUNCEMENT INFO.;　12th International Conference on Tooth Morphogenesis and Differentiation (TMD 2016), Porvoo, Finland, 2016, 6, 13-18
  AUTHOR;　＊Jing-Qi Zhang, Reiko Yoshimoto, Reona Aijima, Tomoko Kitsuki, Yasuyoshi Ohsaki, Cao Ailin, Mizuho A. Kido.
  
• The role of thermosensitive TRP channel in oral wound healing.;　2015
  ANNOUNCEMENT INFO.;　Kyudai Oral Bioscience 2015 -9th international symposium-, 2015, 2, 28
  AUTHOR;　Aijima R, Wang B, Takao T, Mihara H, Kashio M, Ohsaki Y, Zhang JQ, Masuko S, Tominaga M, Kido MA.
  
• Temperature sensitive TRP channels in Oral Epithelial Barrier.;　2015
  ANNOUNCEMENT INFO.;　The 13th International Symposium on Molecular and Neural Mechanisms of Taste and Olfactory Perception, 2015, 11, 3-4
  AUTHOR;　*Kido MA, Kitsuki T, Aijima R, Utsunomiya R, Zhang JQ, Ohsaki Y.
  
• Effect of TRPV4 gene deletion to barrier function in gingival epithelium.;　2015
  ANNOUNCEMENT INFO.;　The 63rd Annual Meeting of Japanese Association for Dental Research, 2015, 10, 30-31
  AUTHOR;　*Kitsuki T, Aijima R, Hatakeyama J, Ohsaki Y, Zhang J, Kido M.
  
• Hydropic Degeneration of Labial Mucosal Epithelium and Infiltration of Macrophages in Xerostomia Patients.;　2015
  ANNOUNCEMENT INFO.;　The 63rd Annual Meeting of Japanese Association for Dental Research, 2015, 10, 30-31
  AUTHOR;　*Yoshimoto R, Aijima R, Oyama Y, Yoshizumi J, Kitsuki T, Danjo A, Yamashita Y, Kido M.
  
• Burning Sensation and Degeneration in Labial Epithelium of Xerostomia Patients.;　2015
  ANNOUNCEMENT INFO.;　The 13th International Symposium on Molecular and Neural Mechanisms of Taste and Olfactory Perception, 2015, 11, 3-4
  AUTHOR;　*Yoshimoto RU, Aijima R, Oyama Y, Yoshizumi J, Kitsuki T, Danjo A, Yamashita Y, Kido MA.
  

Review Articles

• Oral mucosal membrane and TRP channels.;　2016
  ANNOUNCEMENT INFO.;　J. Oral Sci. in press
  AUTHOR;　Kido MA, Yoshimoto R, Aijima R, Cao AL, Gao WQ
  

Invited Lecture, Special Lecture

• TRPV1 contribute to facial mechanical hypersensitivity in atopic asthma mouse;　2022/07
  ANNOUNCEMENT INFO.;　2nd TRP conference in Wakayama, 2022, 7,30-31
  AUTHOR;　Mizuho A Kido
  
• Challenges and supports for female doctors with childrearing responsibilities at a regional hospital in Japan;　2021/08
  ANNOUNCEMENT INFO.;　EAJS Conference 2021:16th International Conference of the European Association of Japanese Studies (WEB holding), 2021, 8, 24-28
  AUTHOR;　Kido MA
  
• Changes of TRPV4 distribution in labial mucosa of Xerostomia patients with unpleasant burning sensation.;　2019
  ANNOUNCEMENT INFO.;　ISMNTOP/YRUF/AISCRIB2019, 2019.11.2-3
  AUTHOR;　Yoshimoto RU, Aijima R, Oyama Y, Yoshizumi J, Kitsuki T, Ohsaki Y, Danjo A, Yamashita Y, Kiyoshima T, Kido MA
  
• Warm sensitive TRP channels and oral mucosal barrier.;　2018
  ANNOUNCEMENT INFO.;　The 17th International Symposium on Molecular and Neural Mechanisms of Taste and Olfactory perception (ISMNTOP/YRUF/AISCRIB2018) in conjunction with Special Events celebrating the 50th Anniversary of Monell Chemical Senses Center, USA, 2018.11.30-12. 2
  AUTHOR;　Yoshimoto RU, Ohsaki Y, Gao WQ, Cao AL, Kido MA
  
• Oral barrier formation via temperature-sensitive TRP channels.;　2017
  ANNOUNCEMENT INFO.;　The 69th Annual Meeting of The Korean Physiological Society, 2017.11.2-4
  AUTHOR;　Kido MA
  
• Temperature sensitive TRP channels in Oral Mucosa.;　2017
  ANNOUNCEMENT INFO.;　9th National Congress of Romanian Society of Cellular Biology with international participation Iasi Romania, 2017.5.29-30
  AUTHOR;　Kido MA, Aijima R, Yoshimoto RU, Kitsuki T, Cao AL, Jing-Qi Z, Ohsaki Y