Detailed Information

Research Field/Keywords for Research Field

• Biochemistry, Molecular Biology

Education

• 2000/03, Kyushu University, School of Agriculture, Department of Fishary, Graduated
• 2002/03, Kyushu University, Graduate Schoold of Bioresource and Bioenvironmental Sciences, Bioresource and Biotechnology Course, Master Course, Completed
• 2005/03, Nara Institute of Science and Technology, Graduate Schoold of Bioscience, Immunology course, Doctor Course, Completed

Employment Experience

• 2005/04 - 2008/03 Researcher
• 2008/04 - 2010/12 Researcher Biomedical Research Centre, University of Dundee
• 2011/08 - 2015/07 Assistant Professor
• 2015/08 - 2019/03 Lecturer, Applied Biochemistry and Food Science, Faculty of Agriculture, Saga University
• 2015/08 - 9999/99 Part-time Lecturer
• 2017/04 - 9999/99 Lecturer
• 2019/04 - 2023/03 Lecturer, Faculty of Agriculture, Division of Nature Science, Saga University
• 2020/09 - 9999/99
• 2022/10 - 2023/03 Lecturer
• 2023/04 -  *  Associate Professor, Faculty of Agriculture, Division of Nature Science, Saga University
• 2023/04 - 9999/99 Associate Professor

Field of Specialization

• Applied health science, Applied biochemistry, Applied molecular and cellular biology

Membership in Academic Societies

• The Japan Society for Bioscience, Biotechnology, and Agrochemistry (JSBBA), The Japanese Biochemical Society, Japanese Society for Host Defence Research, The Japanese Society of Polyamine Research

Awards

• 日本生化学会東北支部優秀論文賞 （2015/05）
• 東北大学医学部奨学賞（銀賞） （2015/01）
• 宮城県医師会　医学奨学賞 （2015/01）
• 第2回 JST-ERATO 環境応答国際シンポジウム ポスター賞 （2007/12）

Themes for Ongoing Research

• Innate immune system analysis

Research Themes in the Past

• Innate immune system analysis

Research Topics and Results

• Emerging Role of GCN1 in Disease and Homeostasis 2024/03
• The transcription factor NRF1 (NFE2L1) activates aggrephagy by inducing p62 and GABARAPL1 after proteasome inhibition to maintain proteostasis 2023/12
• Identification and mechanistic investigation of ellagitannins from Osbeckia octandra that attenuate liver fibrosis via the TGF-β/SMAD signaling pathway 2023/10
• Improving lipophilicity of 5-(1-acetyl-5-phenylpyrazolidin-3-ylidene)-1,3-dimethylbarbituric acid increases its efficacy to activate hypoxia-inducible factors 2022/09
• Erratum: Prolyl Hydroxylase Domain Protein Inhibitor Not Harboring a 2-Oxoglutarate Scaffold Protects against Hypoxic Stress (ACS Pharmacol. Transl. Sci. (2022) 5:5 (362−372) DOI: 10.1021/acsptsci.2c00002) 2022/04
• Prolyl hydroxylase domain protein inhibitor not harboring a 2-oxoglutarate scaffold protects against hypoxic stress. 2022/04
• Anti-fibrotic and anti-angiogenic activities of osbeckia octandra leaf extracts in thioacetamide-induced experimental liver cirrhosis 2021/08
• O-GlcNAcylation signal mediates proteasome inhibitor resistance in cancer cells by stabilizing NRF1 2018/09
• Nrf2 activation attenuates genetic endoplasmic reticulum stress induced by a mutation in the phosphomannomutase 2 gene in zebrafish 2018/01
• Furan- and thiophene-2-carbonyl amino acid derivatives activate hypoxia-inducible factor via inhibition of factor inhibiting hypoxia-inducible factor-1 2018/01
• A ubiquitin-proteasome inhibitor bortezomib suppresses the expression of CYP11B2, a key enzyme of aldosterone synthesis 2017/07
• Halofuginone enhances the chemo-sensitivity of cancer cells by suppressing NRF2 accumulation 2017/02
• A homeostatic shift facilitates endoplasmic reticulum proteostasis through transcriptional integration of proteostatic stress response pathways 2017/01
• Intracellular thiol contents and fatty acid metabolism pathways are regulated by the Nrf1 (NFE2L1) with its transcriptional suppressor activity 2016/12
• Hypoxia Signaling Cascade for Erythropoietin Production in Hepatocytes 2015/07
• Discovery of an NRF1‐specific inducer from a large‐scale chemical library using a direct NRF1‐protein monitoring system 2015/05
• Hypoxia-sensitive reporter system for high-throughput screening 2015/02
• DNA methyltransferase 3a regulates osteoclast differentiation by coupling to an S-adenosylmethionine-producing metabolic pathway 2015/02
• Transcription factor Nrf1 negatively regulates the cystine/glutamate transporter and lipid-metabolizing enzymes 2015/01
• 酸化ストレス認識分子基盤と創薬応用 2014/10
• Transcription factor Nrf1 negatively regulates the cystine/glutamate transporter and lipid-metabolizing enzymes 2014/09
• Loss of Nrf2 in mice evokes a congenital intrahepatic shunt that alters hepatic oxygen and protein expression gradients and toxicity. 2014/09
• Transcription factor NF-E2-related factor 1 impairs glucose metabolism in mice 2014/07
• 北から南から；20年ぶりの佐賀—佐賀大学農学部生命機能科学科生化学分野 2014/05
• 転写因子Nrf1はシステイントランスポーターおよび脂質代謝酵素群を抑制制御する 2014/02
• 低酸素応答系を調節する低分子化合物の探索と創薬研究 2013/12
• Early stage drug-screening trials at the United Centers for Advanced Research and Translational Medicine (ART) 2012/12
• Human embryonic stem cell derived astrocytes mediate non-cell-autonomous neuroprotection through endogenous and drug-induced mechanisms 2012/05
• Peptide inhibitors of the Keap1-Nrf2 protein-protein interaction 2012/01
• Tissue-restricted expression of Nrf2 and its target genes in zebrafish with gene-specific variations in the induction profiles 2011/10
• Mild oxidative stress activates Nrf2 in astrocytes, which contributes to neuroprotective ischemic preconditioning 2011/01
• Nitro-fatty acids and cyclopentenone prostaglandins share strategies to activate the Keap1-Nrf2 system: A study using green fluorescent protein transgenic zebrafish 2011/01
• Loss of Nrf2 markedly exacerbates nonalcoholic steatohepatitis 2010/01
• Teleost TLR22 recognizes RNA duplex to induce IFN and protect cells from birnaviruses 2008/09
• Modulation of double-stranded RNA recognition by the N-terminal histidine-rich region of the human toll-like receptor 3 2008/08
• Lipoteichoic acid downregulates Fcε{lunate}RI expression on human mast cells through Toll-like receptor 2 2007/08
• Lamprey TLRs with properties distinct from those of the variable lymphocyte receptors 2007/01
• Fish soluble Toll-like receptor (TLR)5 amplifies human TLR5 response via physical binding to flagellin. 2006/03
• Role of toll-like receptors in adjuvant-augmented immune therapies 2006/03
• Fish soluble Toll-like receptor 5 (TLR5S) is an acute-phase protein with integral flagellin-recognition activity. 2005/03
• Sensing bacterial flagellin by membrane and soluble orthologs of toll-like receptor 5 in rainbow trout (Onchorhynchus mikiss) 2004/11
• がん治療モデルとしての魚類の可能性の探索 2004/07
• Prediction of the prototype of the human Toll-like receptor gene family from the pufferfish, Fugu rubripes, genome 2003/01

Original Articles

• The transcription factor NRF1 (NFE2L1) activates aggrephagy by inducing p62 and GABARAPL1 after proteasome inhibition to maintain proteostasis;　2023/12
  ANNOUNCEMENT INFO.;　Scientific Reports, 13, 1, -
  AUTHOR;　Hatanaka, Atsushi; Nakada, Sota; Matsumoto, Gen; Satoh, Katsuya; Aketa, Iori; Watanabe, Akira; Hirakawa, Tomoaki; Tsujita, Tadayuki; Waku, Tsuyoshi; Kobayashi, Akira
  
• Identification and mechanistic investigation of ellagitannins from Osbeckia octandra that attenuate liver fibrosis via the TGF-β/SMAD signaling pathway;　2023/10
  ANNOUNCEMENT INFO.;　Bioscience, biotechnology, and biochemistry, 87, 11, 1295 - 1309
  AUTHOR;　Bogahawaththa, Sudarma^D; Kawamura, Tomoak^Mi; Bandaranayake, Udari; Hirakawa, Tomoaki^D; Yamada, Goki^D; Ishino, Hana^M; Hirohashi, Tsuzumi^M; Kawaguchi, Shin Ichi; Wijesundera, Kavindra K.; Wijayagunawardane, Missaka P.B.; Ishimaru, Kanji; Kodithuwakku, Suranga P.; Tsujita, Tadayuki
  
• Improving lipophilicity of 5-(1-acetyl-5-phenylpyrazolidin-3-ylidene)-1,3-dimethylbarbituric acid increases its efficacy to activate hypoxia-inducible factors;　2022/09
  ANNOUNCEMENT INFO.;　Bioorganic and Medicinal Chemistry, 73, 1, 117039
  AUTHOR;　Sonoda, Kento; Ujike, Saki; Katayama, Akito; Suzuki, Norio; Kawaguchi, Shin-ichi; Tsujita, Tadayuki
  
• Erratum: Prolyl Hydroxylase Domain Protein Inhibitor Not Harboring a 2-Oxoglutarate Scaffold Protects against Hypoxic Stress (ACS Pharmacol. Transl. Sci. (2022) 5:5 (362−372) DOI: 10.1021/acsptsci.2c00002);　2022/04
  ANNOUNCEMENT INFO.;　ACS Pharmacology and Translational Science, 5, 7, -
  AUTHOR;　Sonoda, Kento; Bogahawaththa, Sudarma; Katayama, Akito; Ujike, Saki; Kuroki, Sae; Kitagawa, Naho; Hirotsuru, Kohichi; Suzuki, Norio; Miyata, Toshio; Kawaguchi, Shin Ichi; Tsujita, Tadayuki
  
• Prolyl hydroxylase domain protein inhibitor not harboring a 2-oxoglutarate scaffold protects against hypoxic stress.;　2022/04
  ANNOUNCEMENT INFO.;　ACS Pharmacology & Translational Science, 5, 5, 362-372
  AUTHOR;　Sonoda, Kento; Bogahawaththa, Sudarma; Katayama, Akito; Ujike, Saki; Kuroki, Sae; Kitagawa, Naho; Hirotsuru, Kohichi; Suzuki, Norio; Miyata, Toshio; Kawaguchi, Shin-ichi; Tsujita, Tadayuki
  
• Anti-fibrotic and anti-angiogenic activities of osbeckia octandra leaf extracts in thioacetamide-induced experimental liver cirrhosis;　2021/08
  ANNOUNCEMENT INFO.;　Molecules, 26, 16, 4836
  AUTHOR;　Bogahawaththa, Sudarma; Kodithuwakku, Suranga P.; Wijesundera, Kavindra K.; Siriweera, Eranga H.; Jayasinghe, Lalith; Dissanayaka, Waruna L.; Rajapakse, Jayanthe; Herath, Chandana B.; Tsujita, Tadayuki; Wijayagunawardane, Missaka P.B.
  
• O-GlcNAcylation signal mediates proteasome inhibitor resistance in cancer cells by stabilizing NRF1;　2018/09
  ANNOUNCEMENT INFO.;　Molecular and Cellular Biology, 38, 17, e00252-18
  AUTHOR;　Sekine, Hiroki; Okazaki, Keito; Kato, Koichiro; Morshedul Alam, M.; Shima, Hiroki; Katsuoka, Fumiki; Tsujita, Tadayuki; Suzuki, Norio; Kobayashi, Akira; Igarashi, Kazuhiko; Yamamoto, Masayuki; Motohashi, Hozumi
  
• Nrf2 activation attenuates genetic endoplasmic reticulum stress induced by a mutation in the phosphomannomutase 2 gene in zebrafish;　2018/01
  ANNOUNCEMENT INFO.;　Proceedings of the National Academy of Sciences of the United States of America, 115, 11, 2758 - 2763
  AUTHOR;　Mukaigasa, Katsuki; Tsujita, Tadayuki; Nguyen, Vu Thanh; Li, Li; Yagi, Hirokazu; Fuse, Yuji; Nakajima-Takagi, Yaeko; Kato, Koichi; Yamamoto, Masayuki; Kobayashi, Makoto
  
• Furan- and thiophene-2-carbonyl amino acid derivatives activate hypoxia-inducible factor via inhibition of factor inhibiting hypoxia-inducible factor-1;　2018/01
  ANNOUNCEMENT INFO.;　Molecules, 23, 4, 885
  AUTHOR;　Kawaguchi, Shin ichi; Gonda, Yuhei; Yamamoto, Takuya; Sato, Yuki; Shinohara, Hiroyuki; Kobiki, Yohsuke; Ichimura, Atsuhiko; Dan, Takashi; Sonoda, Motohiro; Miyata, Toshio; Ogawa, Akiya; Tsujita, Tadayuki
  
• Induction of erythropoietin gene expression in epithelial cells by chemicals identified in GATA inhibitor screenings;　2017/10
  ANNOUNCEMENT INFO.;　Genes to Cells, 22, 11, 939 - 952
  AUTHOR;　Kaneko, Hiroshi; Katoh, Takehide; Hirano, Ikuo; Hasegawa, Atsushi; Tsujita, Tadayuki; Yamamoto, Masayuki; Shimizu, Ritsuko
  
• A ubiquitin-proteasome inhibitor bortezomib suppresses the expression of CYP11B2, a key enzyme of aldosterone synthesis;　2017/07
  ANNOUNCEMENT INFO.;　Biochemical and Biophysical Research Communications, 489, 1, 21 - 28
  AUTHOR;　Ito, Ryo; Sato, Ikuko; Tsujita, Tadayuki; Yokoyama, Atsushi; Sugawara, Akira
  
• Halofuginone enhances the chemo-sensitivity of cancer cells by suppressing NRF2 accumulation;　2017/02
  ANNOUNCEMENT INFO.;　Free Radical Biology and Medicine, 103, 236 - 247
  AUTHOR;　Tsuchida, Kouhei; Tsujita, Tadayuki; Tsujita, Tadayuki; Hayashi, Makiko; Ojima, Asaka; Keleku-Lukwete, Nadine; Katsuoka, Fumiki; Otsuki, Akihito; Kikuchi, Haruhisa; Oshima, Yoshiteru; Suzuki, Mikiko; Yamamoto, Masayuki; Yamamoto, Masayuki
  
• A homeostatic shift facilitates endoplasmic reticulum proteostasis through transcriptional integration of proteostatic stress response pathways;　2017/01
  ANNOUNCEMENT INFO.;　Molecular and Cellular Biology, 37, 4, e00439-16
  AUTHOR;　Baird, Liam; Tsujita, Tadayuki; Kobayashi, Eri H.; Funayama, Ryo; Nagashima, Takeshi; Nakayama, Keiko; Yamamoto, Masayuki; Yamamoto, Masayuki
  
• Time-resolved fluorescent detection for glucose using a complex of luminescent layered titanates and enzymes;　2017/01
  ANNOUNCEMENT INFO.;　Analytical Sciences, 33, 9, 989-991
  AUTHOR;　Sakaguchi, Yuki; Minamikawa, Tomoka; Yamamuro, Mayuko; Tsujita, Tadayuki; Ueda, Toshihisa; Kamada, Kai; Soh, Nobuaki
  
• Hypoxia Signaling Cascade for Erythropoietin Production in Hepatocytes;　2015/07
  ANNOUNCEMENT INFO.;　Molecular and Cellular Biology, 35, 15, 2658-2672
  AUTHOR;　Tojo, Yutaka; Sekine, Hiroki; Hirano, Ikuo; Pan, Xiaoqing; Souma, Tomokazu; Tsujita, Tadayuki; Kawaguchi, Shin-ichi; Takeda, Norihiko; Takeda, Kotaro; Fong, Guo-Hua; Dan, Takashi; Ichinose, Masakazu; Miyata, Toshio; Yamamoto, Masayuki; Suzuki, Norio
  
• Discovery of an NRF1‐specific inducer from a large‐scale chemical library using a direct NRF1‐protein monitoring system;　2015/05
  ANNOUNCEMENT INFO.;　Genes to Cells, 20, 7, 563-577
  AUTHOR;　Tsujita, Tadayuki; Baird, Liam; Furusawa, Yuki; Katsuoka, Fumiki; Hou, Yoshika; Gotoh, Satomi; Kawaguchi, Shin‐ichi; Yamamoto, Masayuki;
  
• Hypoxia-sensitive reporter system for high-throughput screening;　2015/02
  ANNOUNCEMENT INFO.;　Tohoku Journal of Experimental Medicine, 235, 2, 151-159
  AUTHOR;　Tsujita, Tadayuki; Tsujita, Tadayuki; Kawaguchi, Shin Ichi; Dan, Takashi; Baird, Liam; Miyata, Toshio; Yamamoto, Masayuki
  
• DNA methyltransferase 3a regulates osteoclast differentiation by coupling to an S-adenosylmethionine-producing metabolic pathway;　2015/02
  ANNOUNCEMENT INFO.;　Nature Medicine, 21, 3, 281-287
  AUTHOR;　Nishikawa, Keizo; Iwamoto, Yoriko; Kobayashi, Yasuhiro; Katsuoka, Fumiki; Kawaguchi, Shin-ichi; Tsujita, Tadayuki; Nakamura, Takashi; Kato, Shigeaki; Yamamoto, Masayuki; Takayanagi, Hiroshi;
  
• Transcription factor Nrf1 negatively regulates the cystine/glutamate transporter and lipid-metabolizing enzymes;　2014/09
  ANNOUNCEMENT INFO.;　Molecular and Cellular Biology, 34, 20, 3800-3816
  AUTHOR;　Tsujita, Tadayuki; Peirce, Vivian; Baird, Liam; Matsuyama, Yuka; Takaku, Misaki; Walsh, Shawn V; Griffin, Julian L; Uruno, Akira; Yamamoto, Masayuki; Hayes, John D;
  
• Loss of Nrf2 in mice evokes a congenital intrahepatic shunt that alters hepatic oxygen and protein expression gradients and toxicity.;　2014/09
  ANNOUNCEMENT INFO.;　Toxicological Sciences, 141, 1, 112-119
  AUTHOR;　Skoko, John J.; Wakabayashi, Nobunao; Noda, Kentaro; Kimura, Shoko; Tobita, Kimimasa; Shigemura, Norihisa; Tsujita, Tadayuki; Yamamoto, Masayuki; Kensler, Thomas W.
  
• Transcription factor NF-E2-related factor 1 impairs glucose metabolism in mice;　2014/07
  ANNOUNCEMENT INFO.;　Genes to Cells, 19, 8, 650-665
  AUTHOR;　Hirotsu, Yosuke; Higashi, Chika; Fukutomi, Toshiaki; Katsuoka, Fumiki; Tsujita, Tadayuki; Yagishita, Yoko; Matsuyama, Yuka; Motohashi, Hozumi; Uruno, Akira; Yamamoto, Masayuki;
  
• Human embryonic stem cell derived astrocytes mediate non-cell-autonomous neuroprotection through endogenous and drug-induced mechanisms;　2012/05
  ANNOUNCEMENT INFO.;　Cell Death and Differentiation, 19, 5, 779-787
  AUTHOR;　Gupta, K.; Patani, R.; Baxter, P.; Serio, A.; Story, D.; Tsujita, T.; Hayes, J. D.; Pedersen, R. A.; Hardingham, G. E.; Chandran, S.;
  
• Peptide inhibitors of the Keap1-Nrf2 protein-protein interaction;　2012/01
  ANNOUNCEMENT INFO.;　Free Radical Biology and Medicine, 52, 2, 444-451
  AUTHOR;　Hancock, Rowena; Bertrand, Hélène C.; Tsujita, Tadayuki; Naz, Shama; El-Bakry, Ayman; Laoruchupong, Jitnueng; Hayes, John D.; Wells, Geoff
  
• Tissue-restricted expression of Nrf2 and its target genes in zebrafish with gene-specific variations in the induction profiles;　2011/10
  ANNOUNCEMENT INFO.;　PLoS ONE, 6, 10, e26884
  AUTHOR;　Nakajima, Hitomi; Nakajima-Takagi, Yaeko; Tsujita, Tadayuki; Tsujita, Tadayuki; Akiyama, Shin Ichi; Wakasa, Takeshi; Mukaigasa, Katsuki; Kaneko, Hiroshi; Kaneko, Hiroshi; Tamaru, Yutaka; Yamamoto, Masayuki; Yamamoto, Masayuki; Kobayashi, Makoto; Kobayashi, Makoto
  
• Mild oxidative stress activates Nrf2 in astrocytes, which contributes to neuroprotective ischemic preconditioning;　2011/01
  ANNOUNCEMENT INFO.;　Proceedings of the National Academy of Sciences of the United States of America, 108, 1, E1-2
  AUTHOR;　Bell, Karen F.; Al-Mubarak, Bashayer; Fowler, Jill H.; Baxter, Paul S.; Gupta, Kunal; Tsujita, Tadayuki; Chowdhry, Sudhir; Patani, Rickie; Chandran, Siddharthan; Horsburgh, Karen; Hayes, John D.; Hardingham, Giles E.
  
• Nitro-fatty acids and cyclopentenone prostaglandins share strategies to activate the Keap1-Nrf2 system: A study using green fluorescent protein transgenic zebrafish;　2011/01
  ANNOUNCEMENT INFO.;　Genes to Cells, 16, 1, 46-57
  AUTHOR;　Tsujita, Tadayuki; Li, Li; Nakajima, Hitomi; Iwamoto, Noriko; Nakajima-Takagi, Yaeko; Ohashi, Ken; Kawakami, Koichi; Kumagai, Yoshito; Freeman, Bruce A.; Yamamoto, Masayuki; Kobayashi, Makoto
  
• Loss of Nrf2 markedly exacerbates nonalcoholic steatohepatitis;　2010/01
  ANNOUNCEMENT INFO.;　Free Radical Biology and Medicine, 48, 2, 357-371
  AUTHOR;　Chowdhry, Sudhir; Nazmy, Maiiada H.; Meakin, Paul J.; Dinkova-Kostova, Albena T.; Dinkova-Kostova, Albena T.; Walsh, Shaun V.; Tsujita, Tadayuki; Dillon, John F.; Ashford, Michael L J; Hayes, John D.
  
• Teleost TLR22 recognizes RNA duplex to induce IFN and protect cells from birnaviruses;　2008/09
  ANNOUNCEMENT INFO.;　Journal of Immunology, 181, 5, 3474-3485
  AUTHOR;　Matsuo, Aya; Oshiumi, Hiroyuki; Tsujita, Tadayuki; Tsujita, Tadayuki; Mitani, Hiroshi; Kasai, Hisae; Yoshimizu, Mamoru; Matsumoto, Misako; Seya, Tsukasa
  
• Modulation of double-stranded RNA recognition by the N-terminal histidine-rich region of the human toll-like receptor 3;　2008/08
  ANNOUNCEMENT INFO.;　Journal of Biological Chemistry, 283, 33, 22787-22794
  AUTHOR;　Fukuda, Kotaro; Watanabe, Tomoya; Tokisue, Takashi; Tsujita, Tadayuki; Nishikawa, Satoshi; Hasegawa, Tsunemi; Seya, Tsukasa; Matsumoto, Misako
  
• Lipoteichoic acid downregulates Fcε{lunate}RI expression on human mast cells through Toll-like receptor 2;　2007/08
  ANNOUNCEMENT INFO.;　Journal of Allergy and Clinical Immunology, 120, 2, 452-461
  AUTHOR;　Yoshioka, Mino; Fukuishi, Nobuyuki; Iriguchi, Sayuri; Ohsaki, Kanae; Yamanobe, Hiroyuki; Inukai, Asumi; Kurihara, Daisuke; Imajo, Naoki; Yasui, Yumiko; Matsui, Nobuaki; Tsujita, Tadayuki; Ishii, Akihiro; Seya, Tsukasa; Takahama, Makoto; Akagi, Masaaki
  
• Lamprey TLRs with properties distinct from those of the variable lymphocyte receptors;　2007/01
  ANNOUNCEMENT INFO.;　Journal of Immunology, 178, 1, 397-406
  AUTHOR;　Ishii, Akihiro; Matsuo, Aya; Sawa, Hirofumi; Tsujita, Tadayuki; Tsujita, Tadayuki; Shida, Kyoko; Matsumoto, Misako; Matsumoto, Misako; Seya, Tsukasa; Seya, Tsukasa; Seya, Tsukasa
  
• Fish soluble Toll-like receptor (TLR)5 amplifies human TLR5 response via physical binding to flagellin.;　2006/03
  ANNOUNCEMENT INFO.;　Vaccine, 24, 12, 2193-2199
  AUTHOR;　Tsujita, Tadayuki; Ishii, Akihiro; Tsukada, Hironobu; Matsumoto, Misako; Che, Fang-Sik; Seya, Tsukasa;
  
• Fish soluble Toll-like receptor 5 (TLR5S) is an acute-phase protein with integral flagellin-recognition activity.;　2005/03
  ANNOUNCEMENT INFO.;　International Journal of Molecular Medicine, 15, 3, 519-525
  AUTHOR;　Tsukada, Hironobu; Fukui, Aya; Tsujita, Tadayuki; Matsumoto, Misako; Iida, Takaji; Seya, Tsukasa
  
• Sensing bacterial flagellin by membrane and soluble orthologs of toll-like receptor 5 in rainbow trout (Onchorhynchus mikiss);　2004/11
  ANNOUNCEMENT INFO.;　Journal of Biological Chemistry, 279, 47, 48588-48597
  AUTHOR;　Tsujita, Tadayuki; Tsukada, Hironobu; Nakao, Miki; Oshiumi, Hiroyuki; Matsumoto, Misako; Seya, Tsukasa
  
• Prediction of the prototype of the human Toll-like receptor gene family from the pufferfish, Fugu rubripes, genome;　2003/01
  ANNOUNCEMENT INFO.;　Immunogenetics, 54, 11, 791-800
  AUTHOR;　Oshiumi, Hiroyuki; Tsujita, Tadayuki; Shida, Kyoko; Matsumoto, Misako; Ikeo, Kazuho; Seya, Tsukasa;
  

Material, Commentary, Editorials, Research Report, A Comprehensive Journal Articles

• Emerging Role of GCN1 in Disease and Homeostasis;　2024/03
  ANNOUNCEMENT INFO.;　International Journal of Molecular Sciences, 25, 5, -
  AUTHOR;　Tatara, Yota; Kasai, Shuya; Kokubu, Daichi; Tsujita, Tadayuki; Mimura, Junsei; Itoh, Ken
  
• 酸化ストレス認識分子基盤と創薬応用;　2014/10
  ANNOUNCEMENT INFO.;　, 10章, 63−70
  AUTHOR;　
  

General Lectures

• Accumulation of the acrolein conjugated protein in Nrf1 knockout mice and cellular model.;　2019/09
  ANNOUNCEMENT INFO.;　The Environmental response V
  AUTHOR;　
  
• Functional analysis and newly generated chemical activator for Nrf1, and anti-aging approach.;　2016/12
  ANNOUNCEMENT INFO.;　Third Myanmar – Japan International Symposium
  AUTHOR;　
  
• Use of a newly established screening system to identify activators of transcription factor Nrf1/NFE2L1, and their use to correct lipid and thiol metabolomic disorders.;　2014/07
  ANNOUNCEMENT INFO.;　The Gordon Research Conference on Thiol-Based Redox Regulation & Signaling
  AUTHOR;　
  
• Transcription factor Nrf1 negatively regulates the cystine transporter and lipid metabolic enzymes to prevent over-nutrition in hepatocytes.;　2014/03
  ANNOUNCEMENT INFO.;　17th Biennial Meeting of Society for Free Radical Research International (SFRRI2014)
  AUTHOR;　
  
• Transcription factor Nrf1 negatively regulates the cystine/glutamate transporter and lipid-metabolizing enzymes;　2014/02
  ANNOUNCEMENT INFO.;　The Environmental Response IV
  AUTHOR;　
  
• New therapy for hypoxia by a prolyl hydroxylase inhibitor;　2013/05
  ANNOUNCEMENT INFO.;　NIH-Tohoku University-JSPS Symposium
  AUTHOR;　
  
• Development of an inducible liver-specific Nrf1 knockout mouse that has allowed a metabolomic analysis of the development of non-alcoholic steato hepatitis (NASH) in adult animals.;　2012/06
  ANNOUNCEMENT INFO.;　The 33rd Naito conference on oxygen biology; hypoxia, oxidative stress and diseases
  AUTHOR;　
  
• Pharmacological suppression of plasminogen activator inhibitor-1 (PAI-1) ameliorates the injury of glomerular podocyte in the experimental glomerulonephritis.;　2012/05
  ANNOUNCEMENT INFO.;　49th ERA-EDTA Congress
  AUTHOR;　
  
• A physiological study of ER stress using zebrafish mutants.;　2009/12
  ANNOUNCEMENT INFO.;　JSPS-DST Asian academic seminar
  AUTHOR;　
  
• Nrf2 activation by genetically induced endoplasmic reticulum stress in zebrafish;　2009/02
  ANNOUNCEMENT INFO.;　International symposium on “Molecular mechanism of environmental response to food and oxygen III”
  AUTHOR;　
  
• A zebrafish model for endoplasmic reticulum stress;　2009/01
  ANNOUNCEMENT INFO.;　3rd Strategic conference of zebrafish investigators
  AUTHOR;　
  
• A Pmm2 mutation in zebrafish: a model for human congenital disorders of glycosylation.;　2008/06
  ANNOUNCEMENT INFO.;　8th International meeting of zebrafish developmental and genetics
  AUTHOR;　
  
• A DNA helicase mutation in zebrafish reduces Nrf2-mediated gene induction;　2007/12
  ANNOUNCEMENT INFO.;　The 2nd JST-ERATO Yamamoto environmental response project international symposium
  AUTHOR;　
  
• A spontaneous ER stress in zebrafish mutant it768 induces a constitutive activation of Nrf2-mediated gene expression.;　2007/12
  ANNOUNCEMENT INFO.;　The 2nd JST-ERATO Yamamoto environmental response project international symposium
  AUTHOR;　
  
• N-terminal binding site in the human Toll-like receptor 3 ectodomain;　2007/11
  ANNOUNCEMENT INFO.;　The fifth symposium on nucleic acids chemistry
  AUTHOR;　
  
• A genetic screen for mutations affecting induction of cancer preventive phase 2 enzymes in zebrafish.;　2007/02
  ANNOUNCEMENT INFO.;　2nd Strategic conference of zebrafish investigators
  AUTHOR;　
  
• Biochemical analysis of human Toll-like receptor 3 ectodomain.;　2006/06
  ANNOUNCEMENT INFO.;　20th IUBMB International congress of biochemistry and molecular biology
  AUTHOR;　
  
• Identification of two zebrafish Keap1 with similar activities in Nrf2 degradation and distinct responses to electrophiles.;　2006/06
  ANNOUNCEMENT INFO.;　20th IUBMB International congress of biochemistry and molecular biology
  AUTHOR;　
  
• Monitoring of electrophile-induced gene expression in GFP transgenic zebrafish generated using the gstp1 promoter and Tol2 transposable element.;　2006/06
  ANNOUNCEMENT INFO.;　7th International meeting of zebrafish developmental and genetics
  AUTHOR;　
  
• Mechanism of amplifiable response of Toll-like receptor 5 in the fish: Toll-like receptor 5-mediated NF-kappaB activation is enhanced by flagellin-inducible soluble Toll-like receptor 5.;　2004/07
  ANNOUNCEMENT INFO.;　12th International congress of immunology and 4th Annual Conference of FOCIS
  AUTHOR;　
  

Others

• 北から南から；20年ぶりの佐賀—佐賀大学農学部生命機能科学科生化学分野;　2014/05
  ANNOUNCEMENT INFO.;　, 88, 537
  AUTHOR;　
  

Review Articles

• Intracellular thiol contents and fatty acid metabolism pathways are regulated by the Nrf1 (NFE2L1) with its transcriptional suppressor activity;　2016/12
  ANNOUNCEMENT INFO.;　, 88, 6, 776-781
  AUTHOR;　
  
• Role of toll-like receptors in adjuvant-augmented immune therapies;　2006/03
  ANNOUNCEMENT INFO.;　Evidence-based Complementary and Alternative Medicine, 3, 1, 31-38
  AUTHOR;　Seya, Tsukasa; Akazawa, Takashi; Tsujita, Tadayuki; Matsumoto, Misako
  
• がん治療モデルとしての魚類の可能性の探索;　2004/07
  ANNOUNCEMENT INFO.;　, 44, 11-12
  AUTHOR;　
  

Invited Lecture, Special Lecture

• 内因性ストレス制御を目指したポリアミン代謝機能調節の試み;　2023/11
  ANNOUNCEMENT INFO.;　
  AUTHOR;　
  
• 含硫化合物が起点となる細胞内ストレス耐性機構の調節;　2021/11
  ANNOUNCEMENT INFO.;　
  AUTHOR;　
  
• ポリアミン代謝の不均衡による内因性アクロレインの発生と肝疾患;　2019/12
  ANNOUNCEMENT INFO.;　
  AUTHOR;　
  
• ストレス応答性転写因子Nrf1によるアミノ酸の取込および感知機構の制御;　2019/12
  ANNOUNCEMENT INFO.;　
  AUTHOR;　
  
• Discovering the sunny and dark side of Nrf1 transcriptional factor and its utilization;　2019/11
  ANNOUNCEMENT INFO.;　
  AUTHOR;　Tadayuki TSUJITA
  
• 転写因子Nrf1による生体恒常性維持機構の解明;　2018/07
  ANNOUNCEMENT INFO.;　
  AUTHOR;　
  
• 唐津地産抽出物ライブラリーに含まれる有効成分の培養細胞による評価抗酸化活性を評価できるモニター細胞の創出とその応用;　2018/03
  ANNOUNCEMENT INFO.;　
  AUTHOR;　
  
• Functional analysis and advanced application for drug discovery with environmental response transcriptional factors;　2017/09
  ANNOUNCEMENT INFO.;　
  AUTHOR;　
  
• Possible link and future direction between stress transcriptional factor Nrf1/2 and NGLY1;　2017/07
  ANNOUNCEMENT INFO.;　4th Global NGLY1 Conference
  AUTHOR;　Tadayuki TSUJITA
  
• 環境転写因子Nrf1の機能探索と創薬応用研究;　2017/06
  ANNOUNCEMENT INFO.;　
  AUTHOR;　
  
• 抗酸化活性を評価できるモニター細胞の創出とその応用;　2017/03
  ANNOUNCEMENT INFO.;　
  AUTHOR;　
  
• 環境応答転写因子Nrf1のde-orphaning化研究;　2015/09
  ANNOUNCEMENT INFO.;　
  AUTHOR;　
  
• 転写因子NRF1による細胞内チオール量及び脂質代謝経路の調節;　2015/05
  ANNOUNCEMENT INFO.;　
  AUTHOR;　
  
• Transcription factor Nrf1 negatively regulates the cystine/glutamate transporter and lipid-metabolizing enzymes;　2015/01
  ANNOUNCEMENT INFO.;　
  AUTHOR;　
  
• 転写因子群の協調作用による細胞内環境調節機構の解析;　2015/01
  ANNOUNCEMENT INFO.;　
  AUTHOR;　
  
• 転写因子を標的とする創薬とその費用対効果 あるアカデミア創薬の現場から;　2014/11
  ANNOUNCEMENT INFO.;　
  AUTHOR;　
  
• 転写因子Nrf1はシステイントランスポーターおよび脂質代謝酵素群を抑制制御する;　2014/02
  ANNOUNCEMENT INFO.;　
  AUTHOR;　
  
• 低酸素応答系を調節する低分子化合物の探索と創薬研究;　2013/12
  ANNOUNCEMENT INFO.;　
  AUTHOR;　
  
• Early stage drug-screening trials at the United Centers for Advanced Research and Translational Medicine (ART);　2012/12
  ANNOUNCEMENT INFO.;　The First Japan-Russia Medical Forum
  AUTHOR;