Detailed Information

Education

• 1978/03, Graduated
• 1980/03, Master Course, Completed

Employment Experience

• 1981/07 - 1987/03 Saga Medical School
• 1987/04 - 1989/03 Department of Medicine, University of Texas Health Science Center
• 1989/04 - 1991/06 Research Associate Faculty of Dentistry, Kyushu University
• 1991/09 - 2000/07 Research Associate Deparment of Microbiology, Saga Medical School
• 2000/08 - 2003/09 Associate Professor Deparment of Microbiology, Saga Medical School
• 2003/10 - 2007/03 Associate Professor, Faculty of Medicine, Saga University
• 2007/04 - 2009/03 Associate Professor, Medicine, Faculty of Medicine, Saga University
• 2009/04 - 2021/03 Associate Professor, Medicine, Faculty of Medicine, Saga University
• 2014/04 - 2021/03 Kyushu University
• 2021/04 -  *  Professor, Faculty of Medicine, Saga University

Field of Specialization

• General medical chemistry, Functional basic dentistry, Bacteriology (including mycology)

Awards

• ふくおか「臨床医学研究賞」 （2018/02）

Research Topics and Results

• miR-92a-3p encapsulated in bone metastatic mammary tumor cell-derived extracellular vesicles modulates mature osteoclast longevity  2022/12
• A novel role of helix-loop-helix transcriptional factor Bhlhe40 in osteoclast activation 2022/10
• Leukemia/lymphoma-related factor (LRF) or osteoclast zinc finger protein (OCZF) overexpression promotes osteoclast survival by increasing Bcl-xl mRNA: A novel regulatory mechanism mediated by the RNA binding protein SAM68  2022/09
• Modulation of osteoclastogenesis through adrenomedullin receptors on osteoclast precursors: initiation of differentiation by asymmetric cell division  2021/11
• In vitro and in vivo detection of tunneling nanotubes in normal and pathological osteoclastogenesis involving osteoclast fusion  2021/09
• PMEPA1 and NEDD4 control the proton production of osteoclasts by regulating vesicular trafficking  2021/02
• IgG immune complexes with Staphylococcus aureus protein A enhance osteoclast differentiation and bone resorption by stimulating Fc receptors and TLR2 2020/02
• Deficiency of stress-associated gene Nupr1 increases bone volume by attenuating differentiation of osteoclasts and enhancing differentiation of osteoblasts.  2019/08
• Osteoblast lineage-specific cell-surface antigen (A7)regulates osteoclast recruitment and calcification during bone remodeling.  2019/06
• Prostate transmembrane protein androgen induced 1 is induced by activation of osteoclasts and regulates bone resorption. 2019/03
• Prostate　transmembrane　protein　androgen　induced-1　is　localized　to　lysosome　with　Nedd4　in　osteoclasts, and regulates bone resorption  2019
• Deficiency of stress-associated gene Nupr1/p8 increased bone volume by enhancing differentiation of osteoblasts 2019
• Pmepa1 induced by RANKL-p38 MAPK pathway has a novel role in osteoclastogenesis 2018
• IL-1β Induces Pathologically Activated Osteoclasts Bearing Extremely High Levels of Resorbing Activity: A Possible Pathological Subpopulation of Osteoclasts, Accompanied by Suppressed Expression of Kindlin-3 and Talin-1. 2018
• Novel Osteoblast-lineage Specific Cell-Surface Antigen possibly regulating Osteoclastogenesis and Calcification 2018
• IgG complex with protein A of Staphylococcus aureus enhance the differentiation and bone resorption of osteoclasts. 2018
• Deletion of the gene encoding Nupr1/p8, a regulator of autophagy, attenuates osteoclastogenesis but increases trabecular bone mass by enhancing osteoblast differentiation 2018
• Novel osteoblast-lineage specific cell-surface antigen possibly regulateing osteoclastogenesis and calcification 2018
• IgG complex with protein A of Staphylococcus aureus enhance the differentiation and bone resorption of osteoclasts. 2018
• LRF/OCZF regulates Survival of Osteoclasts via Sam68, a Splicing Regulator of Bcl-x. 2017/09
• Nupr1/p8, a key player of stress response, regulates autophagy and apoptosis of osteoclasts 2017/09
• Pmepa1 is specifically induced by bone components in osteoclasts and regulates bone resorption 2017/09
• Nedd4 adaptor protein Pmepa1 is induced by bone components and involved in bone resorption 2017/07
• Role of Nupr1/p8 in autophagy and apoptosis of osteoclasts 2017/07
• LRF/OCZF regulates survival of osteoclasts via Sam 68. a splicing regulator of BCL-X 2017/07
• Staphylococcus aureus enhance the differentiation of osteoclasts via formation of IgG complex with protein A 2017/07
• Osteoblast-derived Laminin-332 is a novel negative regulator of　osteoclastogenesis in bone microenvironments. 2017
• Osteoclast formed undrt stimulation by IL-1b posses extremely high ability to secrete protons and to resorb dentin with abnoprmal adhesiveness, imaged by pH-sensitive fluorescence probes 2017
• Generation mechanism of RANKL+ effector memory B cells: its relevance to the pathogenesis of rheumatoid arthritis. 2016
• Extremely high expression of antisense RNA for Wilms' Tumor 1 in active　osteoclasts: Suppression of Wilms' Tumor 1 protein expression during　osteoclastogenesis 2016
• Membrane Nanotube Formation in Osteoclastogenesis. 2015
• Involvement of deoxyadenosine and adenosine deaminase in the Methotrexatre-induced suppression of inflammatory bone destruction. In "Adenosine Receptors: Pharmacology, Functions and Therapeutic Aspects" Ed. Kasandra Warrick, NOVA hardcover edited collection. 2015
• Novel Role of Nedd4 adaptor protein, Pmepa1 in the differentiation and function of osteoclasts 2015
• Novel role of Nedd4 adaptor protein, Pmepa1 in the differentiation and function of osteoclasts 2015
• Regulation of osteoclastogenesis through Tim-3: possible involvement of the Tim-3/galectin-9 system in the modulation of inflammatory bone destruction. 2014
• Mesenchymal stem cells markedly suppress inflammatory bone destruction in rats with adjuvant-induced arthritis. 2014
• Mesenchymal Stem Cells Markedly Suppress Inflammatory Bone Destruction in Rats with Adjuvant-Induced Arthritis. 2014
• Identification and functional analysis of osteoclast-specific genes differentially expressed in mononuclear preosteoclasts and multinuclear osteoclasts. 2013/06
• A possible regulation of osteoclast differentiation by galectin-9. 2013/06
• Establishment of mouse macrophage reporter cell lines which express fluorescent properties under the control of cathepsin K promoter and analysis of osteoclast differentiation 2013/05
• Analysis of contigency tables based on generalized median polish with power transformations and non-additive models. 2013
• Adenosine blocks aminopterin-induced suppression of osteoclast differentiation. 2013
• Tunneling nanotube formation is essential for the regulation of osteoclastogenesis. 2013
• Infection of RANKL-primed RAW-D macrophages with Porphyromonas gingivalis promotes osteoclastogenesis in a TNF--independent manner 2012/06
• Stage-specific functions of leukemia/lymphoma-related factor (LRF) in the transcriptional control of osteoclast development. 2012
• Characterization and identification of subpopulations of mononuclearpreosteoclasts induced by TNF-a in combination with TGF-b　in rats. 2012
• Median Polish with Power Transformations as an Alternative for the Analysis of Contingency Tables with Patient Data 2012
• Median Polish with Power Transformations as an Alternative for the Analysis of Contingency Tables with Patient Data 2012
• P. gingivalis infection promotes osteoclastogenesis from RANKL-stimulated macrophages 2011/09
• Involvement and regulatory role of membrane nanotubes in fusion of osteoclast precursors: a possible migration and penetration of DC-STAMP protein into osteoclast precursors through inter-cellular bridge 2011/09
• Mesenchymal stem cells markedly suppressed inflammatory bone destruction in rats with adjuvant-induce arthritis. 2011/09
• Adenosine abolishes MTX-induced suppression of osteoclastogenesis and　inflammatory bone destruction in adjuvant-induced arthritis. 2011
• The transcription factor FBI-1/OCZF/LRF is expressed in osteoclasts and regulates RANKL-induced osteoclast formation in vitro and in vivo. 2011
• Development of a novel PCR method to comprehensively analyze salivary bacterial flora and its application to patients with odontogenic infections. 2010
• A possible suppressive role of galectin-3 in upregulated osteoclastogenesis accompanying adjuvant-induced arthritis in rats.　 2009/01
• Regulation of osteoclastogenesis by ganoderic acid DM isolated from Ganoderma lucidum.　 2009/01
• Ganoderic acid DM: anti-androgenic osteoclastogenesis inhibitor. 2009
• Mature and activated osteoclasts exist in the synovium of rapidly destructive coxarthrosis 2007/05
• Mature osteoclasts　involved　in　joint　destruction　are　present　in　the　synovium　from　patients　with　rapidly　destructive coxarthrosis.　 2007
• Inhibition of hitone deacetylase suppresses osteoclastogenesis and bone destruction by inducing IFNbeta production. 2005
• RANKL-induced DC-STAMP is essential for osteoclastogenesis. 2004
• Possible involvement of MIP-1alpha in the recruitment of osteoclast progenitors to the distal tibia in rats with adjuvant-induced arthritis. 2004
• Two histone deacetylase inhibitors, trichostatin A and sodium butyrate, suppress differentiation into osteodasts but not into macrophages. 2003
• Fibroblasts from the inner granulation tissue of the pseudocapsule in hips at revision artheoplasty induce osteoclast fidderentiation, as do stromal cells. 2002
• Balance of Th1/Th2 cytokines associated with the preventive effect of incomplete Freund’s adjuvant on the development of adjuvant arthritis in LEW rats 2001
• Tumor necrosis factor- cooperates with receptor of nuclear factorB ligand in generation of osteoclasts in stromal cell-depleted rat bone marrow cell culture. 2001
• Osteoclast differentiation antigen, distinct from receptor activator of nuclear factor kappa B, is involved in osteoclastogenesis under calcitonin-regulatef aciditions. 2001
• Kat1-antigen a reliable immunological marker for identifying osteoclast precursors of ratdetection of subpopulation among precursors and initiation of osteoclastogenesis. 2001
• The new aspect of calcitonin escape phenomenon:a possible involvement of osteoclast differentiation antigen in the regulation of osteoclastogenesis and function of calcitonin receptor. 2001
• New induction of leukotriene A4 hydrolase by interleukin-4 and interleukin-13 in human polymorphonuclear leukocytes. 1999
• Osteoclast-derived zinc finger (OCZF) protein with POZ domain, a possible transcriptional repressor, is involved in osteoclastogenesis. 1999
• A novel role of IL-15 in the development of osteoclasts: inability to replace its activity with IL-2 1999
• Involvement of lymphocyte function-associated antigen-1 and intercellular adhesion molecule-1 in osteoclastogenesis:a possible role in direct interaction between osteoclast precursors. 1998
• Succesful detection of active osteoclasts in situ by systemic administration of an osteoclast-specific monoclonal antibody. 1998
• Laminin, a major basement membrane component of the blood vessel, as a negative regulator of osteoclastogenesis 1998
• Regulation of osteoclastogenesis by antisense oligodeoxy- nucleotides specific to zinc finger nuclear transcription factor Egr-1 and WT1 in rat bone marrow culture system 1997
• Macrophage inflammatory protein-1 alpha (LD78)expressed in human bone marrow: its role in regulation of hematopoiesis and osteoclast recruitment 1997
• Osteoclast differentiation antigen 1996
• Interleukin-10 selectively inhibits osteoclastogenesis by inhibiting differentiation of osteoclast progenitors into preosteoclast-like cells in rat bone marrow culture system 1995
• In vitro differentiation of the murine macriohage cell line BDM-1 into osteoclast-like cells. 1995
• Intracellular multiplication of Legionella pneumophila in HL-60 cells finctionally differentiated in response to 22-oxacalcitriol. 1995
• Novel cell-surface Ag expressed on rat osteoclasts regulating the function of the calcitonin receptor. 1994
• Localization of osteopontin in resorption lacnae formed by osteoclast-like cells:a study by a novel monoclonal antibody which recognizes rat osteopontin. 1994
• A novel monoclonal antibody recognizing a unique antigen of rat osteoclasts induced by the calcified matrices. 1994
• Induction of mononuclear precursor cells with osteoclastic phenotypes in a rat bone marrow culture system depleted of stromal cells. 1993
• Heat-treated osteoblastic cell (ROS17/2.8)-conditioned medium induces the formation of osteoclast-like cells 1993
• Recombinant LD78 protein,a member of the small cytokine family, enhances osteoclast differentiation in rat bone marrow culture system. 1992
• Primary and secondary culture of rat ameloblasts in serum-free medium. 1992
• 12-o-tetradecanoylphorbol-13-acetate inhibits osteoclast- like cell differentiation in rat bone marrow cultures by inducing macrophage polykaryons. 1992
• Interleukin 6. A potential autocrine/paracrine factor in Paget’s disease of bone. 1992
• Trypsinized osteoclast-like multinucleated cells formed in rat bone marrow cultures efficiently form resorption lacmae on dentine 1992
• Immunohistochemical demonstration of amelogenin penetration toward the dental pulp in the early stages of ameloblast development in rat molar tooth germs. 1991
• Inhibitory effects of the bone-derived growth factors osteoinductive factor and transforming growth factor-beta on isolated osteoclasts. 1990
• Osteoinductive factor inhibits formation of human osteoclast-like cells. 1990
• Atypical multinucleated cells form in long-term marrow cultures from patients with Paget’s disease 1990
• The structure of brain-specific rat aldolase C mRNA and the evolution of aldolase isozyme genes. 1987
• Molecular gene mapping of human aldolase A (ALDOA) gene to chromosome 16. 1987

Books

• Involvement of deoxyadenosine and adenosine deaminase in the Methotrexatre-induced suppression of inflammatory bone destruction. In "Adenosine Receptors: Pharmacology, Functions and Therapeutic Aspects" Ed. Kasandra Warrick, NOVA hardcover edited collection.;　2015
  ANNOUNCEMENT INFO.;　NOVA Science Publisher, N.Y. USA, p143‐164
  AUTHOR;　Qu P-F., Kukita A. Li Y-J., Moriyama K., Lei L., Kukita T.
  

Original Articles

• miR-92a-3p encapsulated in bone metastatic mammary tumor cell-derived extracellular vesicles modulates mature osteoclast longevity ;　2022/12
  ANNOUNCEMENT INFO.;　Cancer Sci, 113, 12, 4219-4229
  AUTHOR;　*Norihisa Uehara, Yukari Kyumoto-Nakamura, Yoshikazu Mikami, Manabu Hayatsu, Soichiro Sonoda, Takayoshi Yamaza, Akiko Kukita, Toshio Kukita
  
• A novel role of helix-loop-helix transcriptional factor Bhlhe40 in osteoclast activation;　2022/10
  ANNOUNCEMENT INFO.;　J Cell Physiol, 237, 10, 3912-3926
  AUTHOR;　Hirohito Hirata, Asana Kamohara, Masatoshi Murayama, Kenichi Nishioka, Hiroaki Honda, Yasuteru Urano, Hidenobu Soejima, Shinya Oki, Toshio Kukita, Shunsuke Kawano, Masaaki Mawatari, Akiko Kukita
  
• Leukemia/lymphoma-related factor (LRF) or osteoclast zinc finger protein (OCZF) overexpression promotes osteoclast survival by increasing Bcl-xl mRNA: A novel regulatory mechanism mediated by the RNA binding protein SAM68 ;　2022/09
  ANNOUNCEMENT INFO.;　Lab Invest, 102, 9, 1000-1010
  AUTHOR;　*Xianghe Xu, Takeo Shobuike, Makoto Shiraki, Asana Kamohara, Hirohito Hirata, Masatoshi Murayama, Daisuke Mawatari, Masaya Ueno, Tadatsugu Morimoto, Toshio Kukita, Masaaki Mawatari, Akiko Kukita
  
• Modulation of osteoclastogenesis through adrenomedullin receptors on osteoclast precursors: initiation of differentiation by asymmetric cell division ;　2021/11
  ANNOUNCEMENT INFO.;　Lab Invest, 101, 11, 1449-1457
  AUTHOR;　*Toshio Kukita, Hidenobu Hiura, Jiong-Yan Gu, Jing-Qi Zhang, Yukari Kyumoto-Nakamura, Norihisa Uehara, Sara Murata, Soichiro Sonoda, Takayoshi Yamaza, Ichiro Takahashi, Akiko Kukita
  
• In vitro and in vivo detection of tunneling nanotubes in normal and pathological osteoclastogenesis involving osteoclast fusion ;　2021/09
  ANNOUNCEMENT INFO.;　Lab Invest
  AUTHOR;　*Jing-Qi Zhang, Akira Takahashi, Jiong-Yan Gu, Xiaoxu Zhang, Yukari Kyumoto-Nakamura, Akiko Kukita, Norihisa Uehara, Hidenobu Hiura, Takayoshi Yamaza, Toshio Kukita
  
• PMEPA1 and NEDD4 control the proton production of osteoclasts by regulating vesicular trafficking ;　2021/02
  ANNOUNCEMENT INFO.;　FASEB J, 35, 2, e21281
  AUTHOR;　Hirohito Hirata, Xianghe Xu, Kenichi Nishioka, Fumikazu Matsuhisa, Shuji Kitajima, Toshio Kukita, Masatoshi Murayama, Yasuteru Urano, Hiroshi Miyamoto, Masaaki Mawatari, Akiko Kukita
  
• IgG immune complexes with Staphylococcus aureus protein A enhance osteoclast differentiation and bone resorption by stimulating Fc receptors and TLR2;　2020/02
  ANNOUNCEMENT INFO.;　Int Immunol, 32, 2, 89-104
  AUTHOR;　Asana Kamohara, Hirohito Hirata, Xianghe Xu, Makoto Shiraki, Sakuo Yamada, Jing-Qi Zhang, Toshio Kukita, Kenji Toyonaga, Hiromitsu Hara, Yasuteru Urano, Yoshio Yamashita , Hiroshi Miyamoto, Akiko Kukita
  
• Deficiency of stress-associated gene Nupr1 increases bone volume by attenuating differentiation of osteoclasts and enhancing differentiation of osteoblasts. ;　2019/08
  ANNOUNCEMENT INFO.;　FASEB J. , 33, 8, 8836-8852
  AUTHOR;　Shiraki M, Xu X, Iovanna JL, Kukita T, Hirata H, Kamohara A, Kubota Y, Miyamoto H, Mawatari M, Kukita A.
  
• Osteoblast lineage-specific cell-surface antigen (A7)regulates osteoclast recruitment and calcification during bone remodeling. ;　2019/06
  ANNOUNCEMENT INFO.;　Lab Invest. , 99, 6, 866-884
  AUTHOR;　*Badawy T, Kyumoto-Nakamura Y, Uehara N, Zhang J, Sonoda S, Hiura H, Yamaza T, Kukita A, Kukita T.
  
• Prostate transmembrane protein androgen induced 1 is induced by activation of osteoclasts and regulates bone resorption.;　2019/03
  ANNOUNCEMENT INFO.;　FASEB J. , 33, 3, 4365-4375
  AUTHOR;　Xu X, Hirata H, Shiraki M, Kamohara A, Nishioka K, Miyamoto H, Kukita T, Kukita A.
  
• Pmepa1 induced by RANKL-p38 MAPK pathway has a novel role in osteoclastogenesis;　2018
  ANNOUNCEMENT INFO.;　J Cell Physiol. , 233, 4, 3105-3118
  AUTHOR;　*Funakubo N, Xu X, Kukita T, Nakamura S, Miyamoto H, Kukita A
  
• IL-1β Induces Pathologically Activated Osteoclasts Bearing Extremely High Levels of Resorbing Activity: A Possible Pathological Subpopulation of Osteoclasts, Accompanied by Suppressed Expression of Kindlin-3 and Talin-1.;　2018
  ANNOUNCEMENT INFO.;　J Immunol. , 200, 1, 218-228
  AUTHOR;　*Shiratori T, Kyumoto-Nakamura Y, Kukita A, Uehara N, Zhang J, Koda K, Kamiya M, Badawy T, Tomoda E, Xu X, Yamaza T, Urano Y, Koyano K, Kukita T.
  
• Osteoblast-derived Laminin-332 is a novel negative regulator of　osteoclastogenesis in bone microenvironments.;　2017
  ANNOUNCEMENT INFO.;　Lab Invest. , 97, 10, 1235-1244
  AUTHOR;　*Uehara N, Kukita A, Kyumoto-Nakamura Y, Yamaza T, Yasuda H, Kukita T
  
• Generation mechanism of RANKL+ effector memory B cells: its relevance to the pathogenesis of rheumatoid arthritis.;　2016
  ANNOUNCEMENT INFO.;　Arthritis Reseach & Therapy, 18, 67
  AUTHOR;　*Ota Y., Niiro H., Ota S., Ueki N., Tsuzuki H., Nakayama T., Mishima K., Higashioka K., Jabbarzadeh-Tabrizi S., Mitoma H., Akahoshi M., Arinobu Y., Kukita A., Yamada H., Tsukamoto H., Akashi K.
  
• Extremely high expression of antisense RNA for Wilms' Tumor 1 in active　osteoclasts: Suppression of Wilms' Tumor 1 protein expression during　osteoclastogenesis;　2016
  ANNOUNCEMENT INFO.;　Am J Pathol., 186, 9, 2317-25
  AUTHOR;　*Li YJ, Kukita A, Kyumoto-Nakamura Y, Kukita T.
  
• Membrane Nanotube Formation in Osteoclastogenesis.;　2015
  ANNOUNCEMENT INFO.;　Methods. Mol. Biol., 1313, p193-202
  AUTHOR;　Kukita T., Takahashi A., Zhang J-Q., Kukita A.
  
• Regulation of osteoclastogenesis through Tim-3: possible involvement of the Tim-3/galectin-9 system in the modulation of inflammatory bone destruction.;　2014
  ANNOUNCEMENT INFO.;　Lab. Invest, 94, 11, 1200-11
  AUTHOR;　*K. Moriyama, A. Kukita, Y-J. Li, N. Uehara, J-Q Zhang, I. Takahashi, T. Kukita
  
• Mesenchymal stem cells markedly suppress inflammatory bone destruction in rats with adjuvant-induced arthritis.;　2014
  ANNOUNCEMENT INFO.;　Lab. Invest. , 94, 3, 286-96
  AUTHOR;　*T. Takano, Y-J Li, A. Kukita, T. Yamaza, Y. Ayukawa, K. Moriyama, N. Uehara, H. Nomiyama, K. Koyano, T. Kukita
  
• Mesenchymal Stem Cells Markedly Suppress Inflammatory Bone Destruction in Rats with Adjuvant-Induced Arthritis.;　2014
  ANNOUNCEMENT INFO.;　Lab Invest., 94, 3, 286-296
  AUTHOR;　Takano T., Li Y-J., Kukita A., Yamaza T., Ayukawa Y., Nomiyama H., Koyano K.Kukita T.
  
• Analysis of contigency tables based on generalized median polish with power transformations and non-additive models.;　2013
  ANNOUNCEMENT INFO.;　Health Information Science and Systems, 1, 11, 30
  AUTHOR;　*Klawonn, F., Jayaram B., Crull K., Kukita A., Pessler F.
  
• Adenosine blocks aminopterin-induced suppression of osteoclast differentiation.;　2013
  ANNOUNCEMENT INFO.;　J. Bone Miner. Metab., 31, 1, 64-70
  AUTHOR;　Teramachi J., Kukita A., Qu P-F., Wada N., Li Y-J., Kukita T.
  
• Tunneling nanotube formation is essential for the regulation of osteoclastogenesis.;　2013
  ANNOUNCEMENT INFO.;　J Cell Biochem.
  AUTHOR;　Takahashi A., Kukita A. , Li Y-J., Zhang JQ, Nomiyama H., Yamaza T., Ayuyama Y., Koyano K., Kukita T
  
• Infection of RANKL-primed RAW-D macrophages with Porphyromonas gingivalis promotes osteoclastogenesis in a TNF--independent manner;　2012/06
  ANNOUNCEMENT INFO.;　Plos One
  AUTHOR;　Akiko Kukita, Yuka Ichigi, Ippei Takigawa, Toshiyuki Watanabe, Toshio Kukita, and Hiroshi Miyamoto
  
• Stage-specific functions of leukemia/lymphoma-related factor (LRF) in the transcriptional control of osteoclast development.;　2012
  ANNOUNCEMENT INFO.;　Proc Natl Acad Sci U S A., 109, 7, 2561-2566
  AUTHOR;　*Tsuji-Takechi K, Negishi-Koga T, Sumiya E, Kukita A, Kato S, Maeda T, Pandolfi PP, Moriyama K, Takayanagi H.
  
• The human apoptosis inhibitor NAIP induces pyroptosis in macrophages infected with Legionella pneumophila.;　2012
  ANNOUNCEMENT INFO.;　Microbes Infect.
  AUTHOR;　Katagiri N, Shobuike T, Chang B, Kukita A, Miyamoto H.
  
• Characterization and identification of subpopulations of mononuclearpreosteoclasts induced by TNF-a in combination with TGF-b　in rats.;　2012
  ANNOUNCEMENT INFO.;　PloS One
  AUTHOR;　Matsubara R., Kukita T., Ichig Y., Takigawa I., Qu P-F., Funakubo N., Miyamoto H., Nonaka K., Kukita A.
  
• Nordihydroguaiaretic acid inhibition of NFATc1 suppresses osteoclastogenesis and arthritis bone destruction in rats.;　2012
  ANNOUNCEMENT INFO.;　Lab. Invest.　, 92, 12, 1777-87
  AUTHOR;　*Li Y-J., Kukita A., Watanabe T., Takano., Qu P-F., Sanematsu K., Ninomiya Y., Kukita T.
  
• Median Polish with Power Transformations as an Alternative for the Analysis of Contingency Tables with Patient Data;　2012
  ANNOUNCEMENT INFO.;　Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), 7231, 25-35
  AUTHOR;　*Klawonn F, Crull K, Kukita A, Pessler F
  
• Corticosteroid-induced spinal epidural lipomatosis in the pediatric age group:report of a new case and updated analysis of the literature.;　2011
  ANNOUNCEMENT INFO.;　Pediatr Rheumatol Online J., 9, 1, 5
  AUTHOR;　Möller JC, Cron RQ, Young DW, Girschick HJ, Levy DM, Sherry DD, Kukita A, Saijo　K, Pessler F.
  
• Adenosine abolishes MTX-induced suppression of osteoclastogenesis and　inflammatory bone destruction in adjuvant-induced arthritis.;　2011
  ANNOUNCEMENT INFO.;　Lab Invest., 9, 5, 719-721
  AUTHOR;　Teramachi J, Kukita A, Li YJ, Ushijima Y, Ohkuma H, Wada N, Watanabe T, Nakamura S, Kukita T
  
• The transcription factor FBI-1/OCZF/LRF is expressed in osteoclasts and regulates RANKL-induced osteoclast formation in vitro and in vivo.;　2011
  ANNOUNCEMENT INFO.;　Arthritis Rheum, 63, 9, 2744-2754
  AUTHOR;　A. Kukta, T. Kukita, K. Nagata, J. Teramachi, Y-J. Li, H. Yoshida, H. Miyamoto, S. Gay, F. Pessler, T. Shobuike
  
• Development of a novel PCR method to comprehensively analyze salivary bacterial flora and its application to patients with odontogenic infections.;　2010
  ANNOUNCEMENT INFO.;　Oral Surg Oral Med Oral Pathol Oral Radiol Endod., 109, 5, 669-676
  AUTHOR;　Akiyama T, Miyamoto H, Fukuda K, Sano N, Katagiri N, Shobuike T, Kukita A, Yamashita Y, Taniguchi H, Goto M.
  
• A possible suppressive role of galectin-3 in upregulated osteoclastogenesis accompanying adjuvant-induced arthritis in rats.　;　2009/01
  ANNOUNCEMENT INFO.;　Lab Invest., 89, 1, 26-37
  AUTHOR;　 Li YJ, Kukita A, Teramachi J, Nagata K, Wu Z, Akamine A, Kukita T.
  
• Regulation of osteoclastogenesis by ganoderic acid DM isolated from Ganoderma lucidum.　;　2009/01
  ANNOUNCEMENT INFO.;　Eur J Pharmacol., 5, 602, 1-7
  AUTHOR;　Miyamoto I, Liu J, Shimizu K, Sato M, Kukita A, Kukita T, Kondo R.
  
• Ganoderic acid DM: anti-androgenic osteoclastogenesis inhibitor.;　2009
  ANNOUNCEMENT INFO.;　Bioorg Med Chem Lett., 15, 19, 2154-2157
  AUTHOR;　Liu J, Shiono J, Shimizu K, Kukita A, Kukita T, Kondo R.
  
• Mature and activated osteoclasts exist in the synovium of rapidly destructive coxarthrosis;　2007/05
  ANNOUNCEMENT INFO.;　
  AUTHOR;　Ogawa K. Maeatari M., Komine M., Shigematsu M., Kitajima, M., Kukita A., Hotokebuchi T.
  
• FGF23 induces expression of two isoforms of NAB2, which are corepressors of Egr-1.;　2007/01
  ANNOUNCEMENT INFO.;　Biochem. Biophys. Res. Comm., 353, 1, 147-151
  AUTHOR;　T.Fukuda, K. Kanomata, J. Nojima, I. Urakawa, T. Suzawa, M. Imada, A. Kukita, R. Kamijo, T. Yamashita, T. Katagiri
  
• Mature osteoclasts　involved　in　joint　destruction　are　present　in　the　synovium　from　patients　with　rapidly　destructive coxarthrosis.　;　2007
  ANNOUNCEMENT INFO.;　J.　of　Bone　and Mineral Metabolism, 25, 354-360
  AUTHOR;　K. Ogawa,　M.　Mawatari,　M.　Komine,　M.　Shigematsu,　M.　Kitajima,　A.　Kukita,　 T.　Hotokebuchi　
  
• Regulation of osteoclastogenesis by Simon extracts composed of caffeic acid and related compounds:successful supression of bone destruction accompanied with ajuvant-induced arthritis in rats.;　2006
  ANNOUNCEMENT INFO.;　Histochem. Cell Biol., 125, 3, 215-225
  AUTHOR;　Tang Q,Kukita T, Ushijima Y, Kukita A, Nagata K, Sandra F,Watanabe T, Toh K, Okuma Y, Kawasaki S, Rasubala L,Teramachi J,Miyamoto I, Wu Z, Iijima T
  
• Inhibition of hitone deacetylase suppresses osteoclastogenesis and bone destruction by inducing IFNbeta production.;　2005
  ANNOUNCEMENT INFO.;　J. Immunology, 175, 9, 5809-5816
  AUTHOR;　Nakamura T,Kukita T, Shoubuike T. Nagata K, Wu Z, Ogawa T, Hotokebuchi T, Kohashi O,Kukita A
  
• RANKL-induced DC-STAMP is essential for osteoclastogenesis.;　2004
  ANNOUNCEMENT INFO.;　J. Exp. Med., 200, 4, 941-946
  AUTHOR;　Kukita T,Wada N,Kukita A,Kakimoto T,Sandra F,Toh K,Nagata K,Iijima T,Horiuchi M,Matsusaki H,Hieshima K,Yoshie O,Nomiyama H
  
• Possible involvement of MIP-1alpha in the recruitment of osteoclast progenitors to the distal tibia in rats with adjuvant-induced arthritis.;　2004
  ANNOUNCEMENT INFO.;　Lab. Invest., 84, 9, 1092-1102
  AUTHOR;　Toh K,Kukita T,Wu Z,Kukita A,Sandra F,Tang QY,Nomiyama H,Iijima T
  
• Direct stimulation of osteoclastogenesis by MIP-1alpha: evidence obtained from studies using RAW264 cell clone highly responsive to RANKL;　2004
  ANNOUNCEMENT INFO.;　J. Endocrinol., 180, 1, 193-201
  AUTHOR;　Watanabe T,Kukita T,Kukita A,Wada N,Toh K,Nagata K,Nomiyama H,Iijima T
  
• Extremely high expression of beta-actin mRNA in osteodasts resorbing alveolar bone located at the distal area of the developing molar tooth germ in newbom rats.;　2003
  ANNOUNCEMENT INFO.;　J. Electron Microsc., 52, 6, 545-550
  AUTHOR;　Kukita T,Kukita A,Xu L,Toh K,Tang Q,Nomiyama H,Iijima T
  
• Two histone deacetylase inhibitors, trichostatin A and sodium butyrate, suppress differentiation into osteodasts but not into macrophages.;　2003
  ANNOUNCEMENT INFO.;　Blood., 101, 9, 3451-3459
  AUTHOR;　Rahman MM,Kukita A,Kukita T,Shobuike T,Nakamura T,Kohashi O
  
• Complete Freund's adjuvant promotes the increases of IFN-gamma and nitric oxide in suppressing chronic arthritis induced by pristane.;　2003
  ANNOUNCEMENT INFO.;　Inflammation., 27, 4, 247-255
  AUTHOR;　Zheng CL,Ohki K,Hossain MA,Kukita A,Satoh T,Kohashi O
  
• Fibroblasts from the inner granulation tissue of the pseudocapsule in hips at revision artheoplasty induce osteoclast fidderentiation, as do stromal cells.;　2002
  ANNOUNCEMENT INFO.;　Ann. Rheum. Dis., 61, 2, 103-109
  AUTHOR;　Sakai H, Jingushi S, Shuto T, Urabe T, Ikenoue T, Okzaki K, Kukita T, Kukita A, Iwamoto Y.
  
• Balance of Th1/Th2 cytokines associated with the preventive effect of incomplete Freund’s adjuvant on the development of adjuvant arthritis in LEW rats;　2001
  ANNOUNCEMENT INFO.;　J. Autoimmun., 17, 4, 189-195
  AUTHOR;　 Hossain A, Zheng CL, Kukita A, Kohashi O.
  
• Tumor necrosis factor- cooperates with receptor of nuclear factorB ligand in generation of osteoclasts in stromal cell-depleted rat bone marrow cell culture.;　2001
  ANNOUNCEMENT INFO.;　Bone, 28, 5, 474-483
  AUTHOR;　Komine M, Kukita A, Kukita T, Ogata Y, Hotokebuti T Kohashi O.
  
• Osteoclast differentiation antigen, distinct from receptor activator of nuclear factor kappa B, is involved in osteoclastogenesis under calcitonin-regulatef aciditions.;　2001
  ANNOUNCEMENT INFO.;　J. Endocrinology, 170, 1, 175- 183
  AUTHOR;　 Kukita T, Kukita A, Watanabe T, Iijima T.
  
• Kat1-antigen a reliable immunological marker for identifying osteoclast precursors of ratdetection of subpopulation among precursors and initiation of osteoclastogenesis.;　2001
  ANNOUNCEMENT INFO.;　Histochem Cell Biol., 115, 3, 215-222
  AUTHOR;　Kukita T, Kukita A, Xu T, Watanabe T, Iijima T.
  
• New induction of leukotriene A4 hydrolase by interleukin-4 and interleukin-13 in human polymorphonuclear leukocytes.;　1999
  ANNOUNCEMENT INFO.;　Blood, 96, 2, 601-609
  AUTHOR;　M Zaitsu, Y Hamasaki, MMatsuo, A Kukita, K Tsuji, M Miyazaki, R Hayasaki, E Muro, S Yamamoto, I Kobayashi, T Ichimaru, O Kohashi, and S Miyazaki
  
• Osteoclast-derived zinc finger (OCZF) protein with POZ domain, a possible transcriptional repressor, is involved in osteoclastogenesis.;　1999
  ANNOUNCEMENT INFO.;　Blood, 94, 6, 1987-1997
  AUTHOR;　Kukita A, Kukita T, Ouchida M, Maeda H, Yatsuki H, Kohashi O
  
• A novel role of IL-15 in the development of osteoclasts: inability to replace its activity with IL-2;　1999
  ANNOUNCEMENT INFO.;　J. Immunology, 162, 5, 2754-2760
  AUTHOR;　Ogata Y, Kukita A, Kukita T, Komine M, Miyahara A, S. Miyazaki, O. Kohashi
  
• Involvement of lymphocyte function-associated antigen-1 and intercellular adhesion molecule-1 in osteoclastogenesis:a possible role in direct interaction between osteoclast precursors.;　1998
  ANNOUNCEMENT INFO.;　Endocrinology, 139, 9, 3967-3975
  AUTHOR;　Harada H, Kukita T, Kukita A, Iwamoto Y, Iijima T.
  
• Succesful detection of active osteoclasts in situ by systemic administration of an osteoclast-specific monoclonal antibody.;　1998
  ANNOUNCEMENT INFO.;　Calcif. Tissue Int., 63, 2, 148- 153
  AUTHOR;　Kukita T, Kukita A, Xu L, Maeda H, Iijima T.
  
• Laminin, a major basement membrane component of the blood vessel, as a negative regulator of osteoclastogenesis;　1998
  ANNOUNCEMENT INFO.;　Calcif. Tissue. Int., 63, 2, 140 -142
  AUTHOR;　Kukita T, Hata K, Kukita A, Iijima T.
  
• Regulation of osteoclastogenesis by antisense oligodeoxy- nucleotides specific to zinc finger nuclear transcription factor Egr-1 and WT1 in rat bone marrow culture system;　1997
  ANNOUNCEMENT INFO.;　Endocrinology, 138, 10, 4384- 4389
  AUTHOR;　Kukita T, Kukita A, Harada H, Iijima T.
  
• Macrophage inflammatory protein-1 alpha (LD78)expressed in human bone marrow: its role in regulation of hematopoiesis and osteoclast recruitment;　1997
  ANNOUNCEMENT INFO.;　Lab. Invest., 76, 3, 399-406
  AUTHOR;　Kukita T, Nomiyama H, Ohmoto Y, Kukita A, Shuto T, Hotokebuti T.Sugioka Y.Miura R. Iijima T.
  
• Interleukin-10 selectively inhibits osteoclastogenesis by inhibiting differentiation of osteoclast progenitors into preosteoclast-like cells in rat bone marrow culture system;　1995
  ANNOUNCEMENT INFO.;　J. Cell Physiol., 165, 3, 624-629
  AUTHOR;　Xu LX, Kukita T, Kukita A, Otsuka T, Niho Y, Iijima T.
  
• In vitro differentiation of the murine macriohage cell line BDM-1 into osteoclast-like cells.;　1995
  ANNOUNCEMENT INFO.;　Endocrinology, 136, 10, 4285-4292
  AUTHOR;　Shin JH, Kukita A, Ohki K, Katsuki T, Kohashi O
  
• Intracellular multiplication of Legionella pneumophila in HL-60 cells finctionally differentiated in response to 22-oxacalcitriol.;　1995
  ANNOUNCEMENT INFO.;　J. Leukoc. Biol., 57, 4, 574-580
  AUTHOR;　Matsuzaki M, Shimamoto Y,Watanabe M, Kukita A, Yoshida S、Tadano J.
  
• Novel cell-surface Ag expressed on rat osteoclasts regulating the function of the calcitonin receptor.;　1994
  ANNOUNCEMENT INFO.;　J. Immunol., 153, 11, 5265-5273
  AUTHOR;　Kukita T, Kukita A, Nagata K, Maeda H, Kurisu K, Watanabe T、Iijima T.
  
• Localization of osteopontin in resorption lacnae formed by osteoclast-like cells:a study by a novel monoclonal antibody which recognizes rat osteopontin.;　1994
  ANNOUNCEMENT INFO.;　Histochemistry, 102, 4, 247-254
  AUTHOR;　Maeda H, Kukita T, Akamine A, Kukita A, Iijima T.
  
• A novel monoclonal antibody recognizing a unique antigen of rat osteoclasts induced by the calcified matrices.;　1994
  ANNOUNCEMENT INFO.;　Histochemistry, 101, 5, 347-354
  AUTHOR;　Hata K, Kukita T, Akamine A, Kukita A, Kurisu K, Iijima T
  
• Induction of mononuclear precursor cells with osteoclastic phenotypes in a rat bone marrow culture system depleted of stromal cells.;　1993
  ANNOUNCEMENT INFO.;　Biochem. Biophys. Res. Commun, 196, 3, 1383-1389
  AUTHOR;　Kukita A, Kukita T, Shin JH, Kohashi O.
  
• Heat-treated osteoblastic cell (ROS17/2.8)-conditioned medium induces the formation of osteoclast-like cells;　1993
  ANNOUNCEMENT INFO.;　Bone Mine, 23, 2, 113-127
  AUTHOR;　Kukita A, Kukita T, Hata K, Kurisu K, Kohashi O
  
• Recombinant LD78 protein,a member of the small cytokine family, enhances osteoclast differentiation in rat bone marrow culture system.;　1992
  ANNOUNCEMENT INFO.;　Bone Miner., 19, 3, 215-223
  AUTHOR;　Kukita T, Nakao J, Hamada F, Kukita A, Inai T, Kurisu K, Nomiyama H.
  
• Primary and secondary culture of rat ameloblasts in serum-free medium.;　1992
  ANNOUNCEMENT INFO.;　Calcif. Tissue Int, 51, 5, 393- 398.
  AUTHOR;　Kukita A, Harada H, Kukita T, Inai T, Matsuhashi S.Kurisu K.
  
• 12-o-tetradecanoylphorbol-13-acetate inhibits osteoclast- like cell differentiation in rat bone marrow cultures by inducing macrophage polykaryons.;　1992
  ANNOUNCEMENT INFO.;　Endocrinology, 130, 2, 577-584.
  AUTHOR;　Kukita T, Kukita A, Hata K, Kurisu K.
  
• Interleukin 6. A potential autocrine/paracrine factor in Paget’s disease of bone.;　1992
  ANNOUNCEMENT INFO.;　J. Clin. Invest., 89, 1, 46-52
  AUTHOR;　Roodman GD, Kurihara N, Ohsaki Y, Kukita A, Hosking D, Demulder　A, Smith JF Singer RF
  
• Trypsinized osteoclast-like multinucleated cells formed in rat bone marrow cultures efficiently form resorption lacmae on dentine;　1992
  ANNOUNCEMENT INFO.;　Bone, 13, 2, 139-146
  AUTHOR;　Hata K, Kukita T, Akamine A, Kukita A, Kurisu K.
  
• Immunohistochemical demonstration of amelogenin penetration toward the dental pulp in the early stages of ameloblast development in rat molar tooth germs.;　1991
  ANNOUNCEMENT INFO.;　Anat. Rec, 229, 2, 259-270
  AUTHOR;　Inai T, Kukita T, Ohsaki Y, Nagata K, Kukita A, Kurisu K.
  
• Inhibitory effects of the bone-derived growth factors osteoinductive factor and transforming growth factor-beta on isolated osteoclasts.;　1990
  ANNOUNCEMENT INFO.;　Endocrinology, 126, 6, 3069-3075
  AUTHOR;　Oreffo RO, Bonewald L, Kukita A, Garrett IR, Seyedin SM, Rosen D, Mundy GR.
  
• Osteoinductive factor inhibits formation of human osteoclast-like cells.;　1990
  ANNOUNCEMENT INFO.;　Proc. Natl. Acad. Sci. USA, 89, 8, 3023-302
  AUTHOR;　Kukita A, Bonewald L, Rosen D, Seyedin S, Mundy GR, Roodman GD
  
• Atypical multinucleated cells form in long-term marrow cultures from patients with Paget’s disease;　1990
  ANNOUNCEMENT INFO.;　J. Clin. Invest, 85, 4, 1280-1286
  AUTHOR;　Kukita A, Chenu C, McManus LM, Mundy GR, Roodman GD
  
• The structure of brain-specific rat aldolase C mRNA and the evolution of aldolase isozyme genes.;　1987
  ANNOUNCEMENT INFO.;　Eur. J. Biochem., 171, 3, 471-478
  AUTHOR;　Kukita A, Mukai T, Miyata T, Hori K
  
• Molecular gene mapping of human aldolase A (ALDOA) gene to chromosome 16.;　1987
  ANNOUNCEMENT INFO.;　Hum. Genet., 76, 1, 20-26
  AUTHOR;　Kukita A, Yoshida MC, Fukushige S, Sakakibara M, Joh K, Mukai T, Hori K.
  

General Lectures

• Prostate　transmembrane　protein　androgen　induced-1　is　localized　to　lysosome　with　Nedd4　in　osteoclasts, and regulates bone resorption ;　2019
  ANNOUNCEMENT INFO.;　
  AUTHOR;　
  
• Deficiency of stress-associated gene Nupr1/p8 increased bone volume by enhancing differentiation of osteoblasts;　2019
  ANNOUNCEMENT INFO.;　
  AUTHOR;　
  
• Novel Osteoblast-lineage Specific Cell-Surface Antigen possibly regulating Osteoclastogenesis and Calcification;　2018
  ANNOUNCEMENT INFO.;　ASBMR 2018 Annual Meeting, 2018, 9, 28‐10.1
  AUTHOR;　*Tamer Abdelhadi Badawy, Yukari Kyumoto-Nakamura, Norihisa Uehara, Jingqi Zhang, Hidenobu Hiura, Akiko Kukita, Toshio Kukita
  
• IgG complex with protein A of Staphylococcus aureus enhance the differentiation and bone resorption of osteoclasts.;　2018
  ANNOUNCEMENT INFO.;　ASBMR 2018 Annual Meeting, 2018, 9, 28‐10.1
  AUTHOR;　Asana Kamohara, Xianghe Xu, Makoto Shiraki, Hiroto Hirata, Toshio Kukita, Akiko Kukita
  
• Deletion of the gene encoding Nupr1/p8, a regulator of autophagy, attenuates osteoclastogenesis but increases trabecular bone mass by enhancing osteoblast differentiation;　2018
  ANNOUNCEMENT INFO.;　ASBMR 2018 Annual Meeting, 2018, 9, 28‐10.1
  AUTHOR;　Makoto Shiraki, Hiroto Hirata, Asana Kamohara, Juan Iovanna, Toshio Kukita, Masaaki Mawatari, Akiko Kukita
  
• Novel osteoblast-lineage specific cell-surface antigen possibly regulateing osteoclastogenesis and calcification;　2018
  ANNOUNCEMENT INFO.;　
  AUTHOR;　
  
• IgG complex with protein A of Staphylococcus aureus enhance the differentiation and bone resorption of osteoclasts.;　2018
  ANNOUNCEMENT INFO.;　
  AUTHOR;　
  
• LRF/OCZF regulates Survival of Osteoclasts via Sam68, a Splicing Regulator of Bcl-x.;　2017/09
  ANNOUNCEMENT INFO.;　ASBMR 2017 Annual Meeting, 2017.9.8‐11
  AUTHOR;　Xianghe Xu, Makoto Shiraki, Asana Kamohara, Takeo Shobuike, Toshio Kukita, Akiko Kukita
  
• Nupr1/p8, a key player of stress response, regulates autophagy and apoptosis of osteoclasts;　2017/09
  ANNOUNCEMENT INFO.;　ASBMR 2017 Annual Meeting, 2017.9.8‐11
  AUTHOR;　Makoto Shiraki, Xianghe Xu, Asana Kamohara, Juan Iovanna, Yasushi Kubota, Toshio Kukita Masaaki Mawatari, Akiko Kukita
  
• Pmepa1 is specifically induced by bone components in osteoclasts and regulates bone resorption;　2017/09
  ANNOUNCEMENT INFO.;　ASBMR 2017 Annual Meeting, 2017.9.8‐11
  AUTHOR;　Xu X., Shiraki M., Kamohara A., Nishioka K., Matsuhisa F., Kitajima S., Kukita T., Kukita A
  
• Nedd4 adaptor protein Pmepa1 is induced by bone components and involved in bone resorption;　2017/07
  ANNOUNCEMENT INFO.;　
  AUTHOR;　Xianghe Xu, Makoto Shiraki, Asana Kamohara, Toshio Kukita, Akiko Kukita
  
• Role of Nupr1/p8 in autophagy and apoptosis of osteoclasts;　2017/07
  ANNOUNCEMENT INFO.;　
  AUTHOR;　Makoto Shiraki、Xianghe Xu、Asana Kamohara,　Masaaki Mawatari、Akiko Kuita
  
• LRF/OCZF regulates survival of osteoclasts via Sam 68. a splicing regulator of BCL-X;　2017/07
  ANNOUNCEMENT INFO.;　
  AUTHOR;　Xianghe Xu , Makoto Shiraki , Asana Kamohara, Takeo Shobuike , Toshio Kukita , Akiko Kukita
  
• Staphylococcus aureus enhance the differentiation of osteoclasts via formation of IgG complex with protein A;　2017/07
  ANNOUNCEMENT INFO.;　
  AUTHOR;　Asana Kamohara, Xianghe Xu, Makoto Shuraki, Akiko Kukita
  
• Osteoclast formed undrt stimulation by IL-1b posses extremely high ability to secrete protons and to resorb dentin with abnoprmal adhesiveness, imaged by pH-sensitive fluorescence probes;　2017
  ANNOUNCEMENT INFO.;　ASBMR 2017 Annual Meeting, 2017.9.8‐11
  AUTHOR;　* Shiratori T., Kukita A., Kyumoto-Nakamura Y., Uehara N., Zhang J., Koda K., Kamiya M., Badawy T., Xu X., Yamaza T., Urano Y., Koyano K., Kukita T.
  
• Novel Role of Nedd4 adaptor protein, Pmepa1 in the differentiation and function of osteoclasts;　2015
  ANNOUNCEMENT INFO.;　
  AUTHOR;　Xu　Xianghe, Noboru Funakubo, Makoto Shiraki, Toshio Kukita, Akiko Kukita
  
• Novel role of Nedd4 adaptor protein, Pmepa1 in the differentiation and function of osteoclasts;　2015
  ANNOUNCEMENT INFO.;　
  AUTHOR;　Xu Xianghe, Makoto Shiraki, Asana Kamohara, Toshio Kukita, Akiko Kukita
  
• Identification and functional analysis of osteoclast-specific genes differentially expressed in mononuclear preosteoclasts and multinuclear osteoclasts.;　2013/06
  ANNOUNCEMENT INFO.;　Joint meeting of the international Bone and Mineral Research and the Japanese Society for Bone and Mineral Research
  AUTHOR;　FunakuboN., Kukita T., Nakamura S., Kukita A.
  
• A possible regulation of osteoclast differentiation by galectin-9.;　2013/06
  ANNOUNCEMENT INFO.;　Joint meeting of the international Bone and Mineral Research and the Japanese Society for Bone and Mineral Research
  AUTHOR;　Moriyama K., Kukita A., Li Y-J., Qu P-F., Takahashi I., Kukita T.
  
• Establishment of mouse macrophage reporter cell lines which express fluorescent properties under the control of cathepsin K promoter and analysis of osteoclast differentiation;　2013/05
  ANNOUNCEMENT INFO.;　Joint meeting of the international Bone and Mineral Research and the Japanese Society for Bone and Mineral Research
  AUTHOR;　Kukita A., Funakubo N,m Shobuike N., Kukita T.
  
• Median Polish with Power Transformations as an Alternative for the Analysis of Contingency Tables with Patient Data;　2012
  ANNOUNCEMENT INFO.;　the proceedings of The 1st International Conference on Health Information Science (HIS 2012)
  AUTHOR;　*Frank Klawonn, Katja Crull, Akiko Kukita Frank Pessler
  
• P. gingivalis infection promotes osteoclastogenesis from RANKL-stimulated macrophages;　2011/09
  ANNOUNCEMENT INFO.;　13th International Union of Microbiological Sciences 2011 Congress　2011,9,6-10
  AUTHOR;　Yuka Ichigi, Ippei Takigawa, Toshio Kukita, Hiroshi Miyamoto, Akiko Kukita
  
• Involvement and regulatory role of membrane nanotubes in fusion of osteoclast precursors: a possible migration and penetration of DC-STAMP protein into osteoclast precursors through inter-cellular bridge;　2011/09
  ANNOUNCEMENT INFO.;　33th　Annual Meeting of The American Society for Bone and Mineral　2011,9,16-20
  AUTHOR;　Akira Takahashi, Akiko Kukita, Yin-ji Li, Hisayuki Nomiyama, Yasunori Ayukawa, Kiyoshi Koyano, Toshio Kukita
  
• Mesenchymal stem cells markedly suppressed inflammatory bone destruction in rats with adjuvant-induce arthritis.;　2011/09
  ANNOUNCEMENT INFO.;　The American Society for Bone and Mineral Research 2011 Annual Meeting　2011,9,16-20
  AUTHOR;　Toshio Takano, Yin-ji Li, Akiko Kukita, Takayoshi Yamaza, Yasunori Ayukawa, Kiyoshi Koyano, Toshio Kukita
  
• POZ-Zn transcriptional regulator, OCZF/LRF is induced by RANKL and increases c-Fos expression in osteoclastogenesis;　2007/09
  ANNOUNCEMENT INFO.;　American Sciety for Bone and Mineral Research
  AUTHOR;　A. Kukita et al.
  
• Expression of OCZF Directed by the Cathepsin K Promoter Affects Bone Mass and Osteoclast Formation in Transgenic Mice.;　2007/09
  ANNOUNCEMENT INFO.;　American Sciety for Bone and Mineral Research
  AUTHOR;　T. Shobuike et al.
  
• A possible suppressive role of galectin-3 in osteoclastic bone destruction accompanying adjuvant-induced arthritis in rats.;　2007/09
  ANNOUNCEMENT INFO.;　American Sciety for Bone and Mineral Research
  AUTHOR;　Y. Li et al.
  
• A possible sregulatory role of Galectin-3 (Mac-2 antigen) in osteoclastogenesis;　2006/09
  ANNOUNCEMENT INFO.;　
  AUTHOR;　
  
• Inhibitory effects of nitric oxide on prevention of adjuvant arthritis and pristine-induced arthritis.;　2003/08
  ANNOUNCEMENT INFO.;　6th World Congress on Inflammation. Vancouver, Canada 2003, 8, 2-6. Abstract. No.11. 3 (Poster)
  AUTHOR;　Kohashi O, Hossain M, Zheng C, Kukita A, Ohki K
  
• A histone deacetylase inhibitor, FR901228, suppresses differatiation osteoclasts but not into macrophages International.Bone and Mineral Sosiety-Japanese Bone and Mineral Society.;　2003/06
  ANNOUNCEMENT INFO.;　2003, 6, 3-7. IBMS-JSBMR 2003Japan day Program and Abstract. JP-22.
  AUTHOR;　Nakamura T,Kukita A,Kukita T, Shobuike T,Kohashi O
  
• Butyrate and trichostatin A inhibit osteoclast differentiation in a macrophage cell line(英語);　2003/04
  ANNOUNCEMENT INFO.;　
  AUTHOR;　
  

Review Articles

• Multifunctional properties of RANKL/RANK in cell differentiation, proliferation and metastasis.;　2013/09
  ANNOUNCEMENT INFO.;　
  AUTHOR;　Kukita A*, Kukita T.
  
• The new aspect of calcitonin escape phenomenon:a possible involvement of osteoclast differentiation antigen in the regulation of osteoclastogenesis and function of calcitonin receptor.;　2001
  ANNOUNCEMENT INFO.;　Recent Res. Devel. Endocrinol, 2, 347-355
  AUTHOR;　Kukita T, Kukita A.
  
• Osteoclast differentiation antigen;　1996
  ANNOUNCEMENT INFO.;　Histol.Histopatho, 11, 3, 821-830
  AUTHOR;　Kukita T, Kukita A.
  

Invited Lecture, Special Lecture

• A possible suppressive role of galectin-3 in osteoclastic bone destruction accompanying adjuvant-induced arthritis in rats.A possible suppressive role of galectin-3 in osteoclastic bone destruction accompanying adjuvant-induced arthritis in rats.;　2007/01
  ANNOUNCEMENT INFO.;　
  AUTHOR;