Detailed Information

Research Field/Keywords for Research Field

• life science

Education

• 1984/03, Graduated

Employment Experience

• 1984/04 - 1988/09 Researcher
• 1986/09 - 1990/03
• 1988/10 - 1993/03 Researcher
• 1993/04 - 1995/07 Research Associate
• 1995/08 - 1996/03
• 1996/03 - 2001/06 Research Associate
• 2001/07 - 2003/09 Associate Professor
• 2003/10 - 2004/08 Associate Professor, Faculty of Medicine, Saga University
• 2004/09 - 2007/03 Associate Professor, Medicine, Faculty of Medicine, Saga University
• 2007/04 - 2013/06 Associate Professor, Medicine, Faculty of Medicine, Saga University
• 2013/07 - 2014/03 Associate Professor, Center for Comprehensive Community Medicine, Center for Comprehensive Community Medicine, Faculty of Medicine, Saga University
• 2014/04 - 2015/08 Associate Professor, Organization for General Education, Organization for General Education, Saga University
• 2015/09 -  *  Professor, Organization for General Education, Organization for General Education, Saga University

Field of Specialization

• Hematology, Structural biochemistry

Research Topics and Results

• Hemostatic and protein C pathway dysfunction in the pathogenesis of experimental cerebral malaria. 2022/08
• Hydrothermal processing of ﾎｲ-glucan from Aureobasidium pullulans produces a low molecular weight reagent that regulates inflammatory responses induced by TLR 2019/04
• Toll-Like Receptor 4 Agonistic Antibody Promotes Host Defense against Chronic Pseudomonas aeruginosa Lung Infection in Mice. 2016
• 水熱処理法で精製した黒酵母βグルカンによるマクロファージ活性化の抑制 2016
• Inhibition of antibody production in vivo by pre-stimulation of Toll-like receptor 4 before antigen priming is caused by defective B-cell priming and not impairment in antigen presentation 2013
• Reduced surface expression of TLR4 by a V254I point mutation accounts for the low lipopolysaccharide responder phenotype of BALB/c B cells. 2013
• Toll-like receptor 4 agonistic antibody promotes innate immunity against severe pneumonia induced by coinfection with influenza virus and Streptococcus pneumoniae 2013
• Inhibition of primary but not secondary humoral immune responses by pre-injection of an agonistic anti-TLR4/MD-2 antibody. 2011/11
• Agonistic anti-TLR4 monoclonal antibodies function as immunoadjuvants. 2010/08
• Lipopolysaccharide- bindingprotein-mediated Toll-like receptor 4 dimerization enables rapid signal transduction against lipopolysaccharide stimulation on membrane-associated CD14-expressing cells. 2010/08
• Lipopolysaccharide-binding protein-mediated Toll-like receptor 4 dimerization enables rapid signal transduction against lipopolysaccharide stimulation on membrane-associated CD14-expressing cells. 2010
• Organotypic culture of human bone marrow adipose tissue. 2010
• Blocking endothelial protein C receptor (EPCR) accelerates thrombus development in vivo. 2010
• Activated protein C utilizes the angiopoietin/Tie2 axis to promote endothelial barrier function. 2010
• Oligomerization-independent TLR4-signaling in CD14-negative cells 2007/11
• Adjuvant effects of agonistic anti-TLR4 monoclonal antibody in antibody induction 2007/11
• プロテインC受容体（EPCR) 2007/09
• Preparation of recombinant murine tumor necrosis factor-alpha in Escherichia coli: a rapid method to remove tags from fusion proteins by thrombin-cleavage and ion-exchange chromatography. 2007
• Preparation and Characterization of Agonistic Monoclonal Antibodies Against Toll-Like Receptor 4-MD-2 Complex. 2007
• The functional and structural properties of MD-2 required for lipopolysaccharide binding are absent in MD-1 2005
• Preparation and Characterization of Monoclonal Antibodies to Thrombomodulin 2005
• Comparison of Lipopolysaccharide-Binding Functions of CD14 and MD-2 2005

Books

• プロテインC受容体（EPCR);　2007/09
  ANNOUNCEMENT INFO.;　, 14, 3, 303-306
  AUTHOR;　
  
• 血管内皮プロテインＣレセプター;　2005
  ANNOUNCEMENT INFO.;　, 473-478
  AUTHOR;　
  

Original Articles

• Hemostatic and protein C pathway dysfunction in the pathogenesis of experimental cerebral malaria.;　2022/08
  ANNOUNCEMENT INFO.;　, 107, 8, 1950-1954
  AUTHOR;　O'Regan N, Gegenbauer K, Gleeson EM, Fukudome K, O'Sullivan JM, Drakeford C, Dalton N, Chion A, Brophy TM, Smith OP, Preston RJS, O'Donnell JS.
  
• Hydrothermal processing of ﾎｲ-glucan from Aureobasidium pullulans produces a low molecular weight reagent that regulates inflammatory responses induced by TLR;　2019/04
  ANNOUNCEMENT INFO.;　Biochem Biophys Res Commun., 511, 2, 318-322
  AUTHOR;　Hayashi N, Shoubayashi Y, Kondo N, Fukudome K.
  
• Toll-Like Receptor 4 Agonistic Antibody Promotes Host Defense against Chronic Pseudomonas aeruginosa Lung Infection in Mice.;　2016
  ANNOUNCEMENT INFO.;　Infection and Immunity, 84, 7, 1986-93
  AUTHOR;　Nakamura S, Iwanaga N, Seki M, Fukudome K, Oshima K, Miyazaki T, Izumikawa K, Yanagihara K, Miyazaki Y, Mukae H, Kohno S
  
• Inhibition of antibody production in vivo by pre-stimulation of Toll-like receptor 4 before antigen priming is caused by defective B-cell priming and not impairment in antigen presentation;　2013
  ANNOUNCEMENT INFO.;　Int Immunol. 2013 Feb;25(2):117-28., 25, 2, 117-128
  AUTHOR;　Rachmawati NM, Fukudome K, Tsuneyoshi N, Bahrun U, Tsukamoto H, Yanagibashi T, Nagai Y, Takatsu K, Ohta S, Kimoto M.
  
• Reduced surface expression of TLR4 by a V254I point mutation accounts for the low lipopolysaccharide responder phenotype of BALB/c B cells.;　2013
  ANNOUNCEMENT INFO.;　J Immunol., 190, 1, 195-204
  AUTHOR;　Tsukamoto H, Fukudome K, Takao S, Tsuneyoshi N, Ohta S, Nagai Y, Ihara H, Miyake K, Ikeda Y, Kimoto M.
  
• Toll-like receptor 4 agonistic antibody promotes innate immunity against severe pneumonia induced by coinfection with influenza virus and Streptococcus pneumoniae;　2013
  ANNOUNCEMENT INFO.;　Clin Vaccine Immunol., 20, 7, 977-985
  AUTHOR;　Tanaka A, Nakamura S, Seki M, Fukudome K, Iwanaga N, Imamura Y, Miyazaki T, Izumikawa K, Kakeya H, Yanagihara K, Kohno S.
  
• Lipopolysaccharide-binding protein-mediated Toll-like receptor 4 dimerization enables rapid signal transduction against lipopolysaccharide stimulation on membrane-associated CD14-expressing cells.;　2010
  ANNOUNCEMENT INFO.;　Int Immunol., 22, 4, 271-280
  AUTHOR;　Tsukamoto H, Fukudome K, Takao S, Tsuneyoshi N, Kimoto M
  
• Organotypic culture of human bone marrow adipose tissue.;　2010
  ANNOUNCEMENT INFO.;　Pathol Int., 60, 4, 259-267
  AUTHOR;　Uchihashi K, Aoki S, Shigematsu M, Kamochi N, Sonoda E, Soejima H, Fukudome K, Sugihara H, Hotokebuchi T, Toda S.
  
• Blocking endothelial protein C receptor (EPCR) accelerates thrombus development in vivo.;　2010
  ANNOUNCEMENT INFO.;　Thromb Haemostasis. 103(6):1239-44., 103, 6, 1239-1244
  AUTHOR;　Centelles MN, Puy C, L�pez-Sagaseta J, Fukudome K, Montes R, Hermida J.
  
• Activated protein C utilizes the angiopoietin/Tie2 axis to promote endothelial barrier function.;　2010
  ANNOUNCEMENT INFO.;　FASEB J., 24, 3, 873-881
  AUTHOR;　Minhas N, Xue M, Fukudome K, Jackson CJ.
  
• Microparticle-associated endothelial protein C receptor and the induction of cytoprotective and anti-inflammatory effects.;　2009
  ANNOUNCEMENT INFO.;　Haematologica, 94, 3, 387-94, 94, 3, 387-394
  AUTHOR;　*P�rez-Casal M, Downey C, Cutillas-Moreno B, Zuzel M, Fukudome K, Toh CH.
  
• Effect of disease activity and corticosteroids on serum levels of soluble endothelial cell protein C receptor in patients with systemic lupus erythematosus.;　2009
  ANNOUNCEMENT INFO.;　Mod Rteumatol.19.2.173-9, 19, 2, 173-179
  AUTHOR;　○Koarada S, Tsuneyoshi N, Haruta Y, Tada Y, Mitamura M, Inoue H, Ohta A, Fukudome K, Nagasawa K.
  
• Penta-acylated lipopolisaccharide binds to murine MD-2 but does not induce the oligomelization of TLR4 required for signal transduction.;　2007
  ANNOUNCEMENT INFO.;　Cellular Immunology , 244, 1, 57-64
  AUTHOR;　Tsuneyoshi N, Kohara J, Bahrun U, Saitoh S-I, Akashi S, Gauchat J-F, Kimoto M, Fukudome K
  
• Preparation of recombinant murine tumor necrosis factor-alpha in Escherichia coli: a rapid method to remove tags from fusion proteins by thrombin-cleavage and ion-exchange chromatography.;　2007
  ANNOUNCEMENT INFO.;　Protein Expr Purif.(Academic Press), 56, 1, 138-144
  AUTHOR;　Tsukamoto H, Fukudome K, Kohara J, Nakatake H, Kimoto M
  
• Preparation and Characterization of Agonistic Monoclonal Antibodies Against Toll-Like Receptor 4-MD-2 Complex.;　2007
  ANNOUNCEMENT INFO.;　Hybridoma(Mary Ann Liebert, Inc.), 26, 6, 393-399
  AUTHOR;　Bahrun U, Kimoto M, Tsukamoto H, Tsuneyoshi N, Kohara J, Fukudome K
  
• Expression of CD180, a Toll-like receptor homologue, is up-regulated in children with Kawasaki disease.;　2006
  ANNOUNCEMENT INFO.;　J. Mol. Med., 84, 2, 168-174
  AUTHOR;　Imayoshi M, Yamamoto S, Watanabe M, Nishimura S, Tashiro K, Zaitsu M, Takaski H, Kimoto M, Hamasaki Y, Ishii E
  
• Preparation and characterization of truncated human lipopolysaccharide-binding protein in Escherichia coli.;　2006
  ANNOUNCEMENT INFO.;　Protein Expr Purif. , 49, 2, 276-283
  AUTHOR;　Kohara J, Tsuneyoshi N, Gauchat JF, Kimoto M, Fukudome K
  
• Recombinant human activated protein C upregulates the release of soluble fractalkine from human endothelial cells.;　2006
  ANNOUNCEMENT INFO.;　Br J Haematol. , 133, 5, 550-557
  AUTHOR;　Brueckmann M, Nahrup AS, Lang S, Bertsch T, Fukudome K, Liebe V, Kaden JJ, Hoffmann U, Borggrefe M, Huhle G
  
• Induction of long-term lipopolysacchride tolerance by an agonistic monoclonal antibody to the Toll-like receptor 4/MD-2 complex.;　2006
  ANNOUNCEMENT INFO.;　Clin Vaccine Immunol., 13, 10, 1131-1136
  AUTHOR;　Ohta S, Bahrun U, Shimazu R, Matsushita H, Fukudome K, Kimoto M
  
• Thrombus and encapsulated hematoma in cerebral cavernous malformations;　2005
  ANNOUNCEMENT INFO.;　ACTA NEUROPATHOLOGICA, 109, 5, 503-509
  AUTHOR;　Abe, M / Fukudome, K / Sugita, Y / Oishi, T / Tabuchi, K / Kawano, T
  
• Activated protein C induces the release of microparticle-associated endothelial protein C receptor;　2005
  ANNOUNCEMENT INFO.;　BLOOD, 105, 4, 1515-1522
  AUTHOR;　Perez-Casal, M / Downey, C / Fukudome, K / Marx, G / Toh, C. HToh
  
• The functional and structural properties of MD-2 required for lipopolysaccharide binding are absent in MD-1;　2005
  ANNOUNCEMENT INFO.;　JOURNAL OF IMMUNOLOGY, 174, 1, 340-344
  AUTHOR;　Tsuneyoshi, N / Fukudome, K / Kohara, J / Tomimasu, R / Gauchat, J.-F / Nakatake, H / Kimoto, M
  
• Recombinant human activated protein C upregulates cyclooxygenase-2 expression in endothelial cells via binding to endothelial cell protein C receptor and activation of protease-activated receptor-1;　2005
  ANNOUNCEMENT INFO.;　Thromb Haemost, 93, 743-750
  AUTHOR;　Brueckmann, M., S. Horn, S. Lang, K. Fukudome, A. Schulze Nahrup, U. Hoffmann, J.J. Kaden, M. Borggrefe, K.K. Haase, and G. Huhle
  
• Preparation and Characterization of Monoclonal Antibodies to Thrombomodulin;　2005
  ANNOUNCEMENT INFO.;　HYBRIDOMA AND HYBRIDOMICS, 24, 4, 189-196
  AUTHOR;　Tsuneyoshi, N / Fukudome, K / Higuchi, K / Kimoto, M
  
• Anti-inflammatory effect of activated protein C in gastric epithelial cells;　2005
  ANNOUNCEMENT INFO.;　JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 3, 12, 2721-2729
  AUTHOR;　NAKAMURA, M / GABAZZA, E. C / IMOTO, I / YANO, Y / TAGUCHI, O / HORIKI, N / Fukudome, K / SUZUKI, K / ADACHI, Y.
  
• Comparison of Lipopolysaccharide-Binding Functions of CD14 and MD-2;　2005
  ANNOUNCEMENT INFO.;　CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY, 12, 11, 1292-1297
  AUTHOR;　Koraha, J / Tsuneyoshi, N / Kimoto, M / Gauchat, J.-F / Nakatake, H / Fukudome, K
  
• Endothelial Protein C Receptor and Protease-Activated Receptor-1 Mediate Induction of a Wound-Healing Phenotype in Human Keratinocytes by Activated Protein C;　2005
  ANNOUNCEMENT INFO.;　JOURNAL OF INVESTIGATIVE DERMATOLOGY, 125, 6, 1279-1285
  AUTHOR;　Xue, M / Campbell, D / Sambrook, P. N / Fukudome, K / Jackson, C. J
  
• プロテインＣとその受容体;　2005
  ANNOUNCEMENT INFO.;　, 6, 245-252
  AUTHOR;　
  
• Autoantibodies against EPCR are found in antiphospholipid syndrome and are a risk factor for fetal death;　2004
  ANNOUNCEMENT INFO.;　BLOOD, 104, 5, 1369-1374
  AUTHOR;　Hurtado, V / Montes, R / Gris, J.-C / Bertolaccini, M. L / Alonso, A / Martinez-Gonzalez, M. A / Khamashta, M. A / Fukudome, K / Lane, D. A. / Hermida, J.
  
• Activated Protein C Induces Endothelial Cell Proliferation by Mitogen-Activated Protein Kinase Activation In Vitro and Angiogenesis In Vivo;　2004
  ANNOUNCEMENT INFO.;　CIRCULATION RESEARCH, 95, 1, 34-41
  AUTHOR;　Uchiba, M / Okajima, K / Oike, Y / Ito, Y / Fukudome, K / Isobe, H / Suda, T
  
• Activated protein C inhibits bronchial hyperresponsiveness and Th2 cytokine expression in mice.;　2004
  ANNOUNCEMENT INFO.;　Blood, 103, 2196-2204
  AUTHOR;　Yuda H,Adachi Y,Taguchi O,Gabazza EC,Hataji O,Fujimoto H,Tamaki S,Nishikubo K,Fukudome K,D'Alessandro-Gabazza CN,Maruyama J,Izumizaki M,Iwase M,Homma I,Inoue R,Kamada H,Hayashi T,Kasper M,Lambrecht BN,Bames PJ,SuzukiK.
  
• MAb PS7 against human protein S;　2004
  ANNOUNCEMENT INFO.;　Hybridoma and Hybridomics 23:389, 2004
  AUTHOR;　Tsuneyoshi N,Fukudome K,Kimoto M
  
• Current Topics of EPCR;　2003/12
  ANNOUNCEMENT INFO.;　, 14, 6, 511-513
  AUTHOR;　
  
• Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective;　2003
  ANNOUNCEMENT INFO.;　NATURE MEDICINE, 9, 3, 338-342
  AUTHOR;　Cheng, T / Liu, D / Griffin, J. H / Fernandez, J. A / Castellino, F / Rosen, E. D / Fukudome, K / Zlokovic, B. V
  
• Activated protein C alters cytosolic calcium flux in human brain endothelium via binding to endothelial protein C receptor and activation of protease activated receptor-1;　2003
  ANNOUNCEMENT INFO.;　BLOOD, 101, 12, 4797-4801
  AUTHOR;　Domotor, E / Benzakour, O / Griffin, J. H / Yule, D / Fukudome, K / Zlokovic, B. V
  
• Activated protein C inhibits the expression of platelet-derived growth fador in the lung.;　2003
  ANNOUNCEMENT INFO.;　Am. J. Respir. Crit. Care Med., 167, 10, 1416-1426
  AUTHOR;　Shimizu S,Gabazza EC,Taguchi O,Yasui H,Taguchi Y,Hayashi T,Ido M,Shimizu T,Nakagaki T,Kobayashi H,Fukudome K,Tsuneyoshi N,D'Alessandro-Gabazza CN,Izumizaki, Iwase M,Homma I,Adachi Y,Suzuki K.
  
• Expression and function of the endothelial protein C receptor in human neutrophils;　2003
  ANNOUNCEMENT INFO.;　BLOOD, 102, 4, 1499-1505
  AUTHOR;　Sturn, D / H. Kaneider, N. C / Feistritzer, C / Djanani, A / Fukudome, K / Wiedermann, C. J.
  
• Characterization of protein C receptor expression in monocytes.;　2001
  ANNOUNCEMENT INFO.;　Br. J. Haematol. , 115, 408-414
  AUTHOR;　Galligan L, Livingstone W, Volkov Y, Hokamp K, Murphy C, Lawler M, Fukudome K and Smith O
  
• Expression and anticoagulant function of the endothelial cell protein C receptor (EPCR) in cancer cell lines.;　2001
  ANNOUNCEMENT INFO.;　Thromb. Haemost. , 895, 356-361
  AUTHOR;　Tsuneyoshi N, Fukudome K, Horiguchi S, Ye X, Matsuzaki M, Toi M, Suzuki K and Kimoto M
  
• Regulatory roles for CD14 and phosphatidylinositol in the signaling via toll-like receptor 4-MD-2.;　2000
  ANNOUNCEMENT INFO.;　Biochem. Biophys. Res. Commu., 268, 172-177
  AUTHOR;　Akashi S, Ogata H, Kirikae F, Kirikae T, Kawasaki K, Nishijima M, Shimazu R, Nagai Y, Fukudome K, Kimoto M and Miyake K
  
• 血管内皮細胞における抗血栓性―プロテインC受容体-トロンボモジュリン―;　2000
  ANNOUNCEMENT INFO.;　, 55, 2, 168-176
  AUTHOR;　
  
• Anti-adhesive function of CD43 130 kDa glycoform expressed in CD4 T lymphocyte clones and in transfectant cell lines.;　2000
  ANNOUNCEMENT INFO.;　Blood , 96, 4267-4275
  AUTHOR;　Fukuoka M, Fukudome K, Yamashita Y, Tokushima M, Miyake K and Kimoto M
  
• Characterization and regulation of the 5'-flanking region of the murine endothelial protein C receptor gene.;　2000
  ANNOUNCEMENT INFO.;　J. Biol. Chem. , 275, 12481-12488
  AUTHOR;　Gu JM, Fukudome K and Esmon CT
  
• Activated protein C suppresses tissue factor expression on U937 cells in the endothelial protein C receptor-dependent manner.;　2000
  ANNOUNCEMENT INFO.;　FEBS Lett. , 477, 3, 208-212
  AUTHOR;　Shua F, Kobayashia H, Fukudome K, Tsuneyoshi N, Kimoto M and Terao T
  
• Inflammation, sepsis and coagulation.;　1999
  ANNOUNCEMENT INFO.;　Haematologica , 84, 3, 254-259
  AUTHOR;　Esmon CT, Fukudome K, Mather T, Bode W, Rega LM, Stearns-Kurosawa DJ and Kurosawa S
  
• プロテインC活性化機構におけるプロテインCレセプターの役割;　1999
  ANNOUNCEMENT INFO.;　, 10, 6, 469-473
  AUTHOR;　
  
• MD-2, a molecule that confers lipopolysaccharide responsiveness on toll-like receptor 4.;　1999
  ANNOUNCEMENT INFO.;　J. Exp. Med. , 189, 1777-1782
  AUTHOR;　Shimazu R, Akashi S, Ogata H, Nagai Y, Fukudome K, Miyake K and Kimoto M
  
• Fibroblasts, glial, and neuronal cells are involved in extravascular prothrombin activation.;　1999
  ANNOUNCEMENT INFO.;　J Biochem , 126, 4, 655-661
  AUTHOR;　Yamazaki Y, Shikamoto Y, Fukudome K, Kimoto M, Morita T
  
• The endothelial cell protein C receptor (EPCR) functions as a primary receptor for protein C activation on endothelial cells in arteries, veins, and capillaries.;　1999
  ANNOUNCEMENT INFO.;　Biochem Biophys Res Commun. , 259, 3, 671-677
  AUTHOR;　Ye X, Fukudome K, Tsuneyoshi N, Satoh T, Tokunaga O, Sugawara K, Mizokami H, Kimoto M
  
• Activation mechanism of anticoagulant protein C in large blodd vessels involving the endothelial cell protein C receptor.;　1998
  ANNOUNCEMENT INFO.;　J. Exp. Med. , 187, 1029-1035
  AUTHOR;　2. Fukudome K, Ye X, Tsuneyoshi N, Tokunaga O, Sugawara K, Mizokami H and Kimoto M
  
• プロテインＣ受容体;　1997
  ANNOUNCEMENT INFO.;　, 6, 4, 399-406
  AUTHOR;　
  
• プロテインＣレセプター;　1996
  ANNOUNCEMENT INFO.;　, 33, 2, 146-155
  AUTHOR;　
  
• The endothelial cell protein C receptor: Cell Surface expression and direct ligand binding by the solubule receptor;　1996
  ANNOUNCEMENT INFO.;　J. Biol. Chem., 271, 17491-17498
  AUTHOR;　Fukudome K, Kurosawa S, Stearns-Kurosawa DJ, He X, Rezaie AR, Esmon CT
  
• The endothelial cell protein C receptor: Inhibition of activated protein C antiacoagulant functiiion without modulation of reaction with protease inhibitors.;　1996
  ANNOUNCEMENT INFO.;　J. BIol. Chem, 271, 17499-17503
  AUTHOR;　Regan LM, Sterns-Kurosawa DJ, Kurosawa S, Molica J, Fukudome K Esmon CT
  

General Lectures

• 水熱処理法で精製した黒酵母βグルカンによるマクロファージ活性化の抑制;　2016
  ANNOUNCEMENT INFO.;　
  AUTHOR;　
  
• Inhibition of primary but not secondary humoral immune responses by pre-injection of an agonistic anti-TLR4/MD-2 antibody.;　2011/11
  ANNOUNCEMENT INFO.;　
  AUTHOR;　Rachmawati NM, Fukudome K, Tsuneyoshi N, Uleng B, Ohta S, Kimoto M
  
• Agonistic anti-TLR4 monoclonal antibodies function as immunoadjuvants.;　2010/08
  ANNOUNCEMENT INFO.;　14th International Congress of Immunology 2010, 8, 22-27
  AUTHOR;　Rachmawati NM, Uleng B, Fukudome K, Kimoto M
  
• Lipopolysaccharide- bindingprotein-mediated Toll-like receptor 4 dimerization enables rapid signal transduction against lipopolysaccharide stimulation on membrane-associated CD14-expressing cells.;　2010/08
  ANNOUNCEMENT INFO.;　14th International Congress of Immunology 2010, 8, 22-27
  AUTHOR;　Tsukamoto H, Fukudome K, Takao S, Tsuneyoshi N, Kimoto M.
  
• 機能抑制型ヒトTLR4抗体;　2008
  ANNOUNCEMENT INFO.;　, 38, 169
  AUTHOR;　
  
• Oligomerization-independent TLR4-signaling in CD14-negative cells;　2007/11
  ANNOUNCEMENT INFO.;　
  AUTHOR;　
  
• Adjuvant effects of agonistic anti-TLR4 monoclonal antibody in antibody induction;　2007/11
  ANNOUNCEMENT INFO.;　
  AUTHOR;　Fukudome K, Kohara J, Tsukamoto H,Tsuneyoshi N, Kimoto M
  
• Charaterization of agonistic monoclonal antibodies against murine TLR4/MD-2.;　2006/12
  ANNOUNCEMENT INFO.;　第36回日本免疫学会総会　大阪市, 36, 43
  AUTHOR;　Bahrun U, Fukudome, K, Tsuneyoshi N, Tsukamoto H, Kimoto M
  
• Oligomelization- independent signal transduction in innate immunity by agonistic anti-TLR4/MD-2 monoclonal antibodies.;　2006/12
  ANNOUNCEMENT INFO.;　第36回日本免疫学会総会　大阪市, 36, 43
  AUTHOR;　Kohara J, Tsukamoto H, Bahrun U, Tsuneyoshi N, Fukudome, K, Kimoto M
  
• Murine B cell proliferation induced by agonistic anti-TLR4/MD-2 monoclonal antibodies.;　2006/12
  ANNOUNCEMENT INFO.;　第36回日本免疫学会総会　大阪市, 36, 223
  AUTHOR;　Tsukamoto H, Fukudome K, Bahrun U, Kohara J , Kimoto M
  
• CD14ロイシンリッチリピート１－３の機能解析;　2005/12
  ANNOUNCEMENT INFO.;　, 35, 44
  AUTHOR;　
  
• LPS結合蛋白(LBP)の大腸菌での発現と機能解析;　2005/12
  ANNOUNCEMENT INFO.;　, 35, 44
  AUTHOR;　
  
• 大腸菌によるCD14の発現と機能解析;　2004/12
  ANNOUNCEMENT INFO.;　, 34, 53
  AUTHOR;　
  
• MD-2のLPS結合におけるヒトとマウスの違い;　2004/12
  ANNOUNCEMENT INFO.;　, 34, 48
  AUTHOR;　
  
• Binding characteristics of MD proteins to lpopolysaccharide.;　2004/07
  ANNOUNCEMENT INFO.;　12th International Congress of Immunology 2004,7,21. Online Abstracts (http://www.immuno2004.org/onlineabstracts/allposters/1684.html)
  AUTHOR;　Fukudome K, Tsuneyoshi N, Tomimasu R, Kohara J, Gauchat F, Kimoto M
  
• 脳星細胞系腫瘍の血管内皮細胞におけるEPCR およびTM 発現の免疫組織化学的検討;　2004/06
  ANNOUNCEMENT INFO.;　
  AUTHOR;　
  
• A novel isoform of MD-2 that regulates LPS signaling.;　2004/02
  ANNOUNCEMENT INFO.;　10th International Conference on Lymphocyte Activation and Immune Regulation 2004,2,6. Abstracts, 3
  AUTHOR;　Ohta S, Bahrun U, Fukudome K, Kimoto M
  
• MD-2蛋白の大腸菌での発現;　2003/12
  ANNOUNCEMENT INFO.;　, 33, 126
  AUTHOR;　
  
• MD-2アイソフォームによるLPSシグナル制御;　2003/12
  ANNOUNCEMENT INFO.;　, 33, 121
  AUTHOR;　
  
• CHO細胞でのMD-1の発現とその構造解析;　2003/12
  ANNOUNCEMENT INFO.;　, 33, 124
  AUTHOR;　
  
• Expression of MD-1 protein in CHO cells.;　2003
  ANNOUNCEMENT INFO.;　第76回生化学会大会　2003,10,16. 生化学, 75, 873
  AUTHOR;　Tsuneyoshi N, Tomimasu R, Fukudome K, Kimoto M
  
• 血管内皮プロテインCレセプター（EPCR）とトロンボモジュリン（TM）の会合;　2002/10
  ANNOUNCEMENT INFO.;　, 74, 215
  AUTHOR;　
  
• 血管内皮細胞上でのプロテインC活性化機構;　2001/11
  ANNOUNCEMENT INFO.;　, 67
  AUTHOR;　
  
• 血管内皮プロテインCレセプター（EPCR）とトロンボモジュリン（TM）の会合;　2001/10
  ANNOUNCEMENT INFO.;　, 73, 787
  AUTHOR;　
  
• Anti-adhesive function of CD43 130-kDa glycoform.;　2001
  ANNOUNCEMENT INFO.;　11th International Congress of Immunology 2001,7,27. Program , 28
  AUTHOR;　Kimoto M, Fukudome K, Yamashita Y, Tokushima M, Miyake K, Fukuoka M
  
• プロテインCのGlaドメインを介した結合様式の解析;　2000/10
  ANNOUNCEMENT INFO.;　, 72, 8, 780
  AUTHOR;　
  
• 血管内皮細胞上におけるプロテインC活性化機構;　2000/07
  ANNOUNCEMENT INFO.;　, 35
  AUTHOR;　
  
• Activation mechanism of anticoagulant protein C in large blood vessels involving the endothelial cell protein C receptor.;　2000/06
  ANNOUNCEMENT INFO.;　15th International Congress of Fibrinolysis and Proteolysis 2000,6,29. Program , 51
  AUTHOR;　Fukudome K
  
• プロテインCの軽鎖を認識するモノクローナル抗体はEPCRへの結合を阻害する;　1999/10
  ANNOUNCEMENT INFO.;　, 71, 8, 92
  AUTHOR;　
  
• マウス EPCRに対するモノクローナル抗体の作製と解析;　1999/10
  ANNOUNCEMENT INFO.;　, 71, 8, 91
  AUTHOR;　
  
• Molecular mechanism for protein C activation.;　1999
  ANNOUNCEMENT INFO.;　The first Aso International Meeting 1999,11.19. Abstract, 8-9
  AUTHOR;　Fukudome K
  
• 白血病及び神経膠芽腫由来細胞株におけるプロテインCレセプター(EPCR)の発現;　1998/10
  ANNOUNCEMENT INFO.;　, 70, 8, 748
  AUTHOR;　
  
• プロテインCレセプター(EPCR)に対するモノクローナル抗体の作製と機能解析;　1998/10
  ANNOUNCEMENT INFO.;　, 70, 8, 1013
  AUTHOR;　
  
• プロテインＣレセプター;　1997/03
  ANNOUNCEMENT INFO.;　, 65, 34
  AUTHOR;　
  
• プロテインＣ受容体;　1996/12
  ANNOUNCEMENT INFO.;　, 68, 1679
  AUTHOR;　
  
• B/WF1マウス非病原性Ｔ細胞クローンに発現する新しいCD43分子アイソフォーム．;　1996/11
  ANNOUNCEMENT INFO.;　, 26, 341
  AUTHOR;　
  
• プロテインＣレセプター;　1996/07
  ANNOUNCEMENT INFO.;　, 83
  AUTHOR;　
  
• プロテインＣレセプター(PCR)の構造と機能;　1996
  ANNOUNCEMENT INFO.;　, 68, 589
  AUTHOR;