日本語フィールド
著者：○Katsuya H, Nakamura H, Maeda A, Ishii K, Nagaie T, Sano H, Sano H, Itamura H, Okamoto S, Ando T, Watanabe T, Uchimaru K, Satou Y, Sueoka E, Kimura S題名：HTLV-1 cell-free DNA in plasma as a potential biomarker in HTLV-1 carriers and adult T-cell leukemia-lymphoma発表情報：EJHaem 巻: 4 号: 3 ページ: 733-737キーワード：ATL; HTLV‐I; lymphoid malignancies; quantitative PCR概要：Viral cell-free DNA (cfDNA) in plasma has been widely evaluated for detecting cancer and monitoring disease in virus-associated tumors. We investigated whether the amount of cfDNA of human T-cell leukemia virus type 1 (HTLV-1) correlates with disease state in adult T-cell leukemia-lymphoma (ATL). HTLV-1 cfDNA in aggressive ATL was significantly higher than that in indolent ATL and asymptomatic carriers. Notably, patients with lymphoma type represented higher HTLV-1 cfDNA amount than chronic and smoldering subtypes, though they had no abnormal lymphocytes in the peripheral blood. HTLV-1 cfDNA can be a universal biomarker that reflects the expansion of ATL clones. 抄録：英語フィールド
Author：○Katsuya H, Nakamura H, Maeda A, Ishii K, Nagaie T, Sano H, Sano H, Itamura H, Okamoto S, Ando T, Watanabe T, Uchimaru K, Satou Y, Sueoka E, Kimura STitle：HTLV-1 cell-free DNA in plasma as a potential biomarker in HTLV-1 carriers and adult T-cell leukemia-lymphomaAnnouncement information:EJHaem Vol: 4 Issue: 3 Page: 733-737Keyword：ATL; HTLV‐I; lymphoid malignancies; quantitative PCRAn abstract：Viral cell-free DNA (cfDNA) in plasma has been widely evaluated for detecting cancer and monitoring disease in virus-associated tumors. We investigated whether the amount of cfDNA of human T-cell leukemia virus type 1 (HTLV-1) correlates with disease state in adult T-cell leukemia-lymphoma (ATL). HTLV-1 cfDNA in aggressive ATL was significantly higher than that in indolent ATL and asymptomatic carriers. Notably, patients with lymphoma type represented higher HTLV-1 cfDNA amount than chronic and smoldering subtypes, though they had no abnormal lymphocytes in the peripheral blood. HTLV-1 cfDNA can be a universal biomarker that reflects the expansion of ATL clones. 