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Delirium risk of histamine-2 receptor antagonists and proton pump inhibitors: A study based on the adverse drug event reporting database in Japan

発表形態:
原著論文
主要業績:
主要業績
単著・共著:
共著
発表年月:
2021年
DOI:
10.1016/j.genhosppsych.2021.07.010
会議属性:
指定なし
査読:
有り
リンク情報:

日本語フィールド

著者:
Kikkawa, Nao; Sogawa, Rintaro; Monji, Akira; Sumi, Shintaro; Murakawa-Hirachi, Toru; Kubo, Toshiki; Eguchi, Yuko; Miyamoto, Yuki; Kamo, Masahiro; Tobita, Shuko; Yukawa, Misako; Uchida, Rina; Egoshi, Masayoshi; Shimanoe, Chisato
題名:
Delirium risk of histamine-2 receptor antagonists and proton pump inhibitors: A study based on the adverse drug event reporting database in Japan
発表情報:
General Hospital Psychiatry 巻: 72 ページ: 88 - 91
キーワード:
Delirium; Histamine-2 receptor antagonist; Proton pump inhibitor
概要:
Objective: Although histamine-2 receptor antagonists (H2RAs) have been shown to be more likely to cause delirium than proton pump inhibitors (PPIs), these results were not adjusted for potential confounding factors. Accordingly, we investigated whether H2RAs and PPIs are risk factors for delirium, even when adjusting for other risk factors by analyzing adverse drug event reports compiled in the post-marketing stages of drugs provided by the Japanese regulatory authorities. Method: We analyzed 577,431 reports in the Japanese Adverse Drug Event Report database from April 2004 to July 2020. Results: Of all reports analyzed, 2532 described delirium, and 574,899 described other adverse events. Delirium was associated with H2RAs (crude reporting odds ratio, ROR, 4.17; 95% CI, 3.34–5.22) but not PPIs (crude ROR 0.62; 95% CI 0.43–0.90). Even with adjustment for age, sex, history of dementia or depression, and concomitant drugs reported as risk factors for delirium, the use of H2RAs showed a significantly higher adjusted ROR than that of PPIs (H2RAs: adjusted ROR 3.99; 95% CI 3.18–5.01 and PPIs: adjusted ROR 0.58; 95%CI 0.40–0.84). Conclusions: These results suggest that, from a cognitive perspective, PPIs may be preferable to H2RAs for patients with or at risk for delirium.
抄録:

英語フィールド

Author:
Kikkawa, Nao; Sogawa, Rintaro; Monji, Akira; Sumi, Shintaro; Murakawa-Hirachi, Toru; Kubo, Toshiki; Eguchi, Yuko; Miyamoto, Yuki; Kamo, Masahiro; Tobita, Shuko; Yukawa, Misako; Uchida, Rina; Egoshi, Masayoshi; Shimanoe, Chisato
Title:
Delirium risk of histamine-2 receptor antagonists and proton pump inhibitors: A study based on the adverse drug event reporting database in Japan
Announcement information:
General Hospital Psychiatry Vol: 72 Page: 88 - 91
Keyword:
Delirium; Histamine-2 receptor antagonist; Proton pump inhibitor
An abstract:
Objective: Although histamine-2 receptor antagonists (H2RAs) have been shown to be more likely to cause delirium than proton pump inhibitors (PPIs), these results were not adjusted for potential confounding factors. Accordingly, we investigated whether H2RAs and PPIs are risk factors for delirium, even when adjusting for other risk factors by analyzing adverse drug event reports compiled in the post-marketing stages of drugs provided by the Japanese regulatory authorities. Method: We analyzed 577,431 reports in the Japanese Adverse Drug Event Report database from April 2004 to July 2020. Results: Of all reports analyzed, 2532 described delirium, and 574,899 described other adverse events. Delirium was associated with H2RAs (crude reporting odds ratio, ROR, 4.17; 95% CI, 3.34–5.22) but not PPIs (crude ROR 0.62; 95% CI 0.43–0.90). Even with adjustment for age, sex, history of dementia or depression, and concomitant drugs reported as risk factors for delirium, the use of H2RAs showed a significantly higher adjusted ROR than that of PPIs (H2RAs: adjusted ROR 3.99; 95% CI 3.18–5.01 and PPIs: adjusted ROR 0.58; 95%CI 0.40–0.84). Conclusions: These results suggest that, from a cognitive perspective, PPIs may be preferable to H2RAs for patients with or at risk for delirium.


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