日本語フィールド
著者：○Yuichiro Nishida, Megumi Hara, Yasuki Higaki, Naoto Taguchi, Kazuyo Nakamura, Hinako Nanri, Takeshi Imaizumi, Tatsuhiko Sakamoto, Chisato Shimanoe, Mikako Horita, Koichi Shinchi, Keitaro Tanaka題名：Sedentary time, physical activity, and serum SPARC in a middle-aged population 発表情報：Eur J Sport Sci 巻: 22 号: 11 ページ: 1786-1794キーワード：Behavior; endocrinology; exercise; kinesiology; obesity概要：The influence of habitual physical activity (PA) on the circulating levels of secreted protein acidic and rich in cysteine (SPARC) remains unclear. The purpose of the current study was to clarify the effects of sedentary time, light-intensity PA (LPA), and moderate- to vigorous-intensity PA (MVPA) on the serum SPARC in a general middle-aged population. The current study is a cross-sectional study of 4,000 men and 6,040 women (40 to 69 years). Sedentary time, LPA, and MVPA were objectively measured by an accelerometer. The serum SPARC concentration was measured by enzyme-linked immunosorbent assay. Using an isotemporal substitution model, cross-sectional associations of replacing sedentary time with either LPA or MVPA on serum SPARC levels were analyzed according to sex. Interactions with subject characteristics, such as the body mass index (BMI), smoking, and alcohol consumption, were also examined. In men, replacing 60 min of sedentary time with 60 min of MVPA was significantly associated with 23 ng/mL lower serum SPARC levels (confidence interval: -43, -2) after adjusting for confounders, including the BMI (P = 0.028). A significant interaction between replacing sedentary behavior with LPA and the BMI on SPARC was detected in women (P = 0.029), although the stratified associations for each BMI level (<25 or ?25 kg/m2) did not reach significance. The current study suggests that replacing sedentary time with MVPA is associated with reduced serum SPARC levels in middle-aged men, but not in women. In addition, a potential interaction between LPA and the BMI on SPARC was also found in women. 抄録：英語フィールド
Author：○Yuichiro Nishida, Megumi Hara, Yasuki Higaki, Naoto Taguchi, Kazuyo Nakamura, Hinako Nanri, Takeshi Imaizumi, Tatsuhiko Sakamoto, Chisato Shimanoe, Mikako Horita, Koichi Shinchi, Keitaro TanakaTitle：Sedentary time, physical activity, and serum SPARC in a middle-aged population Announcement information:Eur J Sport Sci Vol: 22 Issue: 11 Page: 1786-1794Keyword：Behavior; endocrinology; exercise; kinesiology; obesityAn abstract：The influence of habitual physical activity (PA) on the circulating levels of secreted protein acidic and rich in cysteine (SPARC) remains unclear. The purpose of the current study was to clarify the effects of sedentary time, light-intensity PA (LPA), and moderate- to vigorous-intensity PA (MVPA) on the serum SPARC in a general middle-aged population. The current study is a cross-sectional study of 4,000 men and 6,040 women (40 to 69 years). Sedentary time, LPA, and MVPA were objectively measured by an accelerometer. The serum SPARC concentration was measured by enzyme-linked immunosorbent assay. Using an isotemporal substitution model, cross-sectional associations of replacing sedentary time with either LPA or MVPA on serum SPARC levels were analyzed according to sex. Interactions with subject characteristics, such as the body mass index (BMI), smoking, and alcohol consumption, were also examined. In men, replacing 60 min of sedentary time with 60 min of MVPA was significantly associated with 23 ng/mL lower serum SPARC levels (confidence interval: -43, -2) after adjusting for confounders, including the BMI (P = 0.028). A significant interaction between replacing sedentary behavior with LPA and the BMI on SPARC was detected in women (P = 0.029), although the stratified associations for each BMI level (<25 or ?25 kg/m2) did not reach significance. The current study suggests that replacing sedentary time with MVPA is associated with reduced serum SPARC levels in middle-aged men, but not in women. In addition, a potential interaction between LPA and the BMI on SPARC was also found in women. 