日本語フィールド
著者：○Nishida, Yuichiro; Hachiya, Tsuyoshi; Hara, Megumi; Shimanoe, Chisato; Tanaka, Keitaro; Sutoh, Yoichi; Shimizu, Atsushi; Hishida, Asahi; Tsukamoto, Mineko; Kadomatsu, Yuka; Oze, Isao; Koyanagi, Yuriko N.; Kuriyama, Nagato; Koyama, Teruhide; Ibusuki, Rie; Takezaki, Toshiro; Ikezaki, Hiroaki; Furusyo, Norihiro; Takashima, Naoyuki; Kadota, Aya; Uemura, Hirokazu; Katsuura-Kamano, Sakurako; Suzuki, Sadao; Nakagawa-Senda, Hiroko; Kuriki, Kiyonori; Mikami, Haruo; Nakamura, Yohko; Momozawa, Yukihide; Kubo, Michiaki; Nakatochi, Masahiro; Naito, Mariko; Wakai, Kenji題名：The interaction between ABCA1 polymorphism and physical activity on the HDL-cholesterol levels in a Japanese population発表情報：Journal of Lipid Research 巻: 61 号: 1 ページ: 86 - 94キーワード：概要：© 2020 American Society for Biochemistry and Molecular Biology Inc.. All rights reserved. Few studies have investigated the interactions between HDL-C-related SNPs identified by genome-wide association (GWA) study and physical activity (PA) on HDL-C. First, we conducted a sex-stratified GWA study in a discovery sample (2,231 men and 2,431 women) and replication sample (2,599 men and 3,109 women) to identify SNPs influencing log-transformed HDL-C in Japanese participants in the baseline survey of the Japan Multi-Institutional Collaborative Cohort Study. We also replicated previously reported HDLC- related SNPs in a combined (discovery plus replication) sample (4,830 men and 5,540 women). We then analyzed the interactions of the HDL-C-related SNPs with PA on HDL-C. The sex-stratified GWA analyses identified 11 and 10 HDL-Crelated SNPs in men and women as targets for an interaction analysis. Among these, only one interaction of ABCA1 rs1883025 with PA was statistically significant in men, after Bonferroni correction [P-interaction = 0.001 (α = 0.05/21 = 0.002)]. The per-major-allele (C allele) increase in log-transformed HDL-C was lost in men with low PA (β = 0.008) compared with those with medium (β= 0.032) or high PA (β= 0.034). These findings suggest that the benefit of carrying a C allele of ABCA1 rs1883025 on enhancing HDL-C may be attenuated in inactive men.抄録：英語フィールド
Author：○Nishida, Yuichiro; Hachiya, Tsuyoshi; Hara, Megumi; Shimanoe, Chisato; Tanaka, Keitaro; Sutoh, Yoichi; Shimizu, Atsushi; Hishida, Asahi; Tsukamoto, Mineko; Kadomatsu, Yuka; Oze, Isao; Koyanagi, Yuriko N.; Kuriyama, Nagato; Koyama, Teruhide; Ibusuki, Rie; Takezaki, Toshiro; Ikezaki, Hiroaki; Furusyo, Norihiro; Takashima, Naoyuki; Kadota, Aya; Uemura, Hirokazu; Katsuura-Kamano, Sakurako; Suzuki, Sadao; Nakagawa-Senda, Hiroko; Kuriki, Kiyonori; Mikami, Haruo; Nakamura, Yohko; Momozawa, Yukihide; Kubo, Michiaki; Nakatochi, Masahiro; Naito, Mariko; Wakai, KenjiTitle：The interaction between ABCA1 polymorphism and physical activity on the HDL-cholesterol levels in a Japanese populationAnnouncement information:Journal of Lipid Research Vol: 61 Issue: 1 Page: 86 - 94An abstract：© 2020 American Society for Biochemistry and Molecular Biology Inc.. All rights reserved. Few studies have investigated the interactions between HDL-C-related SNPs identified by genome-wide association (GWA) study and physical activity (PA) on HDL-C. First, we conducted a sex-stratified GWA study in a discovery sample (2,231 men and 2,431 women) and replication sample (2,599 men and 3,109 women) to identify SNPs influencing log-transformed HDL-C in Japanese participants in the baseline survey of the Japan Multi-Institutional Collaborative Cohort Study. We also replicated previously reported HDLC- related SNPs in a combined (discovery plus replication) sample (4,830 men and 5,540 women). We then analyzed the interactions of the HDL-C-related SNPs with PA on HDL-C. The sex-stratified GWA analyses identified 11 and 10 HDL-Crelated SNPs in men and women as targets for an interaction analysis. Among these, only one interaction of ABCA1 rs1883025 with PA was statistically significant in men, after Bonferroni correction [P-interaction = 0.001 (α = 0.05/21 = 0.002)]. The per-major-allele (C allele) increase in log-transformed HDL-C was lost in men with low PA (β = 0.008) compared with those with medium (β= 0.032) or high PA (β= 0.034). These findings suggest that the benefit of carrying a C allele of ABCA1 rs1883025 on enhancing HDL-C may be attenuated in inactive men.