日本語フィールド
著者：*Fujii, Ryosuke; Hishida, Asahi; Nakatochi, Masahiro; Furusyo, Norihiro; Murata, Masayuki; Tanaka, Keitaro; Shimanoe, Chisato; Suzuki, Sadao; Watanabe, Miki; Kuriyama, Nagato; Koyama, Teruhide; Takezaki, Toshiro; Shimoshikiryo, Ippei; Arisawa, Kokichi; Katsuura-Kamano, Sakurako; Takashima, Naoyuki; Turin, Tanvir C.; Kuriki, Kiyonori; Endoh, Kaori; Mikami, Haruo; Nakamura, Yohko; Oze, Isao; Ito, Hidemi; Kubo, Michiaki; Momozawa, Yukihide; Kondo, Takaaki; Naito, Mariko; Wakai, Kenji題名：Association of genetic risk score and chronic kidney disease in a Japanese population発表情報：Nephrology 巻: 24 号: 6 ページ: 670 - 673キーワード：概要：© 2018 Asian Pacific Society of Nephrology Chronic kidney disease (CKD) is a public health problem worldwide including Japan. Recent genome-wide association studies have discovered CKD susceptibility variants. We developed a genetic risk score (GRS) based on CKD-associated variants and assessed a possibility that the GRS can improve the discrimination capability for the prevalence of CKD in a Japanese population. The present study consists of 11 283 participants randomly selected from 12 Japan Multi-Institutional Collaborative Cohort Study sites. Individual GRS was constructed combining 18 single-nucleotide polymorphisms identified in a Japanese population. Participants with eGFR <60 mL/min per 1.73 m 2 was defined as case (stage 3 CKD or higher) in this study. Logistic regression analysis was used to examine the association between the GRS and CKD risk with adjustment for sex, age, hypertension and type 2 diabetes mellitus. The frequency of individuals with CKD was 8.3%, which was relatively low compared with those previously reported in a Japanese population. The odds ratio of having CKD was 1.120 (95% confidence interval: 1.042–1.203) per 10 GRS increment in the fully adjusted model (P = 0.002). The C-statistic was significantly increased in the model with the GRS, comparing with the model without the GRS (0.720 vs 0.719, P difference = 0.008). Increment of the GRS was associated with increased risk of CKD. Additionally, the GRS significantly improved the discriminatory ability of CKD prevalence in a Japanese population; however, the improvement of discriminatory ability brought about by the GRS seemed to be small compared with that of non-genetic CKD risk factors.抄録：英語フィールド
Author：*Fujii, Ryosuke; Hishida, Asahi; Nakatochi, Masahiro; Furusyo, Norihiro; Murata, Masayuki; Tanaka, Keitaro; Shimanoe, Chisato; Suzuki, Sadao; Watanabe, Miki; Kuriyama, Nagato; Koyama, Teruhide; Takezaki, Toshiro; Shimoshikiryo, Ippei; Arisawa, Kokichi; Katsuura-Kamano, Sakurako; Takashima, Naoyuki; Turin, Tanvir C.; Kuriki, Kiyonori; Endoh, Kaori; Mikami, Haruo; Nakamura, Yohko; Oze, Isao; Ito, Hidemi; Kubo, Michiaki; Momozawa, Yukihide; Kondo, Takaaki; Naito, Mariko; Wakai, KenjiTitle：Association of genetic risk score and chronic kidney disease in a Japanese populationAnnouncement information:Nephrology Vol: 24 Issue: 6 Page: 670 - 673An abstract：© 2018 Asian Pacific Society of Nephrology Chronic kidney disease (CKD) is a public health problem worldwide including Japan. Recent genome-wide association studies have discovered CKD susceptibility variants. We developed a genetic risk score (GRS) based on CKD-associated variants and assessed a possibility that the GRS can improve the discrimination capability for the prevalence of CKD in a Japanese population. The present study consists of 11 283 participants randomly selected from 12 Japan Multi-Institutional Collaborative Cohort Study sites. Individual GRS was constructed combining 18 single-nucleotide polymorphisms identified in a Japanese population. Participants with eGFR <60 mL/min per 1.73 m 2 was defined as case (stage 3 CKD or higher) in this study. Logistic regression analysis was used to examine the association between the GRS and CKD risk with adjustment for sex, age, hypertension and type 2 diabetes mellitus. The frequency of individuals with CKD was 8.3%, which was relatively low compared with those previously reported in a Japanese population. The odds ratio of having CKD was 1.120 (95% confidence interval: 1.042–1.203) per 10 GRS increment in the fully adjusted model (P = 0.002). The C-statistic was significantly increased in the model with the GRS, comparing with the model without the GRS (0.720 vs 0.719, P difference = 0.008). Increment of the GRS was associated with increased risk of CKD. Additionally, the GRS significantly improved the discriminatory ability of CKD prevalence in a Japanese population; however, the improvement of discriminatory ability brought about by the GRS seemed to be small compared with that of non-genetic CKD risk factors.