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Influence of single-nucleotide polymorphisms in PPAR-δ, PPAR-γ, and PRKAA2 on the changes in anthropometric indices and blood measurements through exercise-centered lifestyle intervention in Japanese middle-aged men

発表形態:
原著論文
主要業績:
主要業績
単著・共著:
共著
発表年月:
2018年03月
DOI:
10.3390/ijms19030703
会議属性:
指定なし
査読:
有り
リンク情報:

日本語フィールド

著者:
○Nishida Y, Iyadomi M, Tominaga H, Taniguchi H, Higaki Y, Tanaka H, Horita M, Shimanoe C, Hara M, Tanaka K
題名:
Influence of single-nucleotide polymorphisms in PPAR-δ, PPAR-γ, and PRKAA2 on the changes in anthropometric indices and blood measurements through exercise-centered lifestyle intervention in Japanese middle-aged men
発表情報:
International Journal of Molecular Sciences 巻: 19 号: 3 ページ: -
キーワード:
概要:
© 2018 by the authors. Licensee MDPI, Basel, Switzerland. The purpose of the current study was to examine the influence of single-nucleotide polymorphisms (SNPs) in the peroxisome proliferator-activated receptor-δ (PPAR-δ), PPAR-γ, and α2 isoforms of the catalytic subunit of AMP-activated protein kinase (PRKAA2) on the extent of changes in anthropometric indices and blood measurements through exercise-centered lifestyle intervention in middle-aged men. A total of 109 Japanese middle-aged male subjects (47.0 ± 0.4 years) participated in the baseline health checkup, 6-month exercise-centered lifestyle intervention, and second checkup conducted several months after the subject completed the intervention. The body mass index (BMI), waist circumference, and clinical measurements, including hemoglobin Alc (HbA1c), triglyceride (TG), alanine aminotransferase (ALT), and γ-glutamyl-transpeptidase (γ-GTP), were measured at the baseline and second checkup. The three SNPs of PPAR-δ A/G (rs2267668), PPAR-γ C/G (rs1801282), and PRKAA2 A/G (rs1418442) were determined. Blunted responses in the reduction in the BMI and waist circumference were observed in A/A carriers of PPAR-δ SNP compared with G allele carriers (all p < 0.05). The A/A carriers also displayed less-marked improvements in HbA1c, TG, ALT, and γ-GTP (all p < 0.05). The current results suggest that A/A carriers of PPAR-δ SNP (rs2267668) may enjoy fewer beneficial effects of exercise-centered lifestyle intervention on anthropometric indices and blood measurements.
抄録:

英語フィールド

Author:
○Nishida Y, Iyadomi M, Tominaga H, Taniguchi H, Higaki Y, Tanaka H, Horita M, Shimanoe C, Hara M, Tanaka K
Title:
Influence of single-nucleotide polymorphisms in PPAR-δ, PPAR-γ, and PRKAA2 on the changes in anthropometric indices and blood measurements through exercise-centered lifestyle intervention in Japanese middle-aged men
Announcement information:
International Journal of Molecular Sciences Vol: 19 Issue: 3 Page: -
An abstract:
© 2018 by the authors. Licensee MDPI, Basel, Switzerland. The purpose of the current study was to examine the influence of single-nucleotide polymorphisms (SNPs) in the peroxisome proliferator-activated receptor-δ (PPAR-δ), PPAR-γ, and α2 isoforms of the catalytic subunit of AMP-activated protein kinase (PRKAA2) on the extent of changes in anthropometric indices and blood measurements through exercise-centered lifestyle intervention in middle-aged men. A total of 109 Japanese middle-aged male subjects (47.0 ± 0.4 years) participated in the baseline health checkup, 6-month exercise-centered lifestyle intervention, and second checkup conducted several months after the subject completed the intervention. The body mass index (BMI), waist circumference, and clinical measurements, including hemoglobin Alc (HbA1c), triglyceride (TG), alanine aminotransferase (ALT), and γ-glutamyl-transpeptidase (γ-GTP), were measured at the baseline and second checkup. The three SNPs of PPAR-δ A/G (rs2267668), PPAR-γ C/G (rs1801282), and PRKAA2 A/G (rs1418442) were determined. Blunted responses in the reduction in the BMI and waist circumference were observed in A/A carriers of PPAR-δ SNP compared with G allele carriers (all p < 0.05). The A/A carriers also displayed less-marked improvements in HbA1c, TG, ALT, and γ-GTP (all p < 0.05). The current results suggest that A/A carriers of PPAR-δ SNP (rs2267668) may enjoy fewer beneficial effects of exercise-centered lifestyle intervention on anthropometric indices and blood measurements.


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