日本語フィールド
著者：〇Tokumaru S, Uno T, Kaneyasu Y, Kazumoto T, Harima Y, Noda S, Niibe Y, Shimanoe C, Toita T題名：Outcomes of postoperative radiotherapy for pelvic lymph node-positive uterine cervical cancer: A multi-institutional survey in Japan発表情報：第28回日本放射線腫瘍学会学術大会, 2015/11/19-21キーワード：概要：Objective: To clarify the clinical outcomes of postoperative radiotherapy for pelvic lymph node (LN)-positive uterine cervical cancer.
Materials/Methods: The cases of 137 patients who were treated with postoperative radiotherapy for cervical cancer with pelvic LN-positivity proved pathologically between Jan. 2000 and Dec. 2009 at nine institutions in Japan were retrospectively analyzed. The median age was 48 years (range: 26–76 years). The numbers of patients at pathological T stages 1a, 1b1, 1b2, 2a, 2b, and 3a or higher were 1, 42, 17, 20, 54, and 3, respectively. The number of LNs was revealed in 125 patients (91%) (median: 2, range: 1–18). Regarding the histological type, squamous cell carcinoma and others were observed in 105 and 32 patients, respectively. All 137 patients were treated with pelvic external beam radiotherapy (median dose: 50 Gy). Sixty-five patients (48%) underwent intracavitary brachytherapy. Seventy-four patients (55%) were treated with chemotherapy.
Results: The median follow-up was 71 months. The 5-year overall survival rate, disease-free survival rate, and pelvic recurrence-free survival rate were 78.8%, 60.8%, and 90.1%, respectively. Multiple number of LNs and higher pathological T stage (≥ 2b) were shown to be risk factors for the recurrence of cervical cancer (p=0.004 and p=0.036, Cox hazard test). No patient deaths were associated with postoperative (chemo) radiotherapy. Grade 1–4 and 3–4 late adverse events were seen in 55 (40%) and 11 patients (8%), respectively. Grade 4 events were seen in three patients at the small intestine, one patient at the bladder, and one patient at the colon. Leg edema was seen in 36 patients (27%), and higher age (≥ 51 years) was thought to be a risk factor for the leg edema (odds ratio=3.5, 95% confidence interval=1.5-8.4; p=0.004).
Conclusion: Our findings indicate that postoperative radiotherapy for cervical cancer with positive pelvic LNs is quite effective. Cervical cancer patients who have multiple pelvic LNs or are at higher than T2b stage should be monitored closely for recurrence.抄録：抄録集英語フィールド
Author：〇Tokumaru S, Uno T, Kaneyasu Y, Kazumoto T, Harima Y, Noda S, Niibe Y, Shimanoe C, Toita TTitle：Outcomes of postoperative radiotherapy for pelvic lymph node-positive uterine cervical cancer: A multi-institutional survey in JapanAnnouncement information:The 28th Annual Meeting of the Japanese Society for Radiation Oncology, 2015/11/19-21An abstract：Objective: To clarify the clinical outcomes of postoperative radiotherapy for pelvic lymph node (LN)-positive uterine cervical cancer.
Materials/Methods: The cases of 137 patients who were treated with postoperative radiotherapy for cervical cancer with pelvic LN-positivity proved pathologically between Jan. 2000 and Dec. 2009 at nine institutions in Japan were retrospectively analyzed. The median age was 48 years (range: 26–76 years). The numbers of patients at pathological T stages 1a, 1b1, 1b2, 2a, 2b, and 3a or higher were 1, 42, 17, 20, 54, and 3, respectively. The number of LNs was revealed in 125 patients (91%) (median: 2, range: 1–18). Regarding the histological type, squamous cell carcinoma and others were observed in 105 and 32 patients, respectively. All 137 patients were treated with pelvic external beam radiotherapy (median dose: 50 Gy). Sixty-five patients (48%) underwent intracavitary brachytherapy. Seventy-four patients (55%) were treated with chemotherapy.
Results: The median follow-up was 71 months. The 5-year overall survival rate, disease-free survival rate, and pelvic recurrence-free survival rate were 78.8%, 60.8%, and 90.1%, respectively. Multiple number of LNs and higher pathological T stage (≥ 2b) were shown to be risk factors for the recurrence of cervical cancer (p=0.004 and p=0.036, Cox hazard test). No patient deaths were associated with postoperative (chemo) radiotherapy. Grade 1–4 and 3–4 late adverse events were seen in 55 (40%) and 11 patients (8%), respectively. Grade 4 events were seen in three patients at the small intestine, one patient at the bladder, and one patient at the colon. Leg edema was seen in 36 patients (27%), and higher age (≥ 51 years) was thought to be a risk factor for the leg edema (odds ratio=3.5, 95% confidence interval=1.5-8.4; p=0.004).
Conclusion: Our findings indicate that postoperative radiotherapy for cervical cancer with positive pelvic LNs is quite effective. Cervical cancer patients who have multiple pelvic LNs or are at higher than T2b stage should be monitored closely for recurrence.An abstract：abstract