MF研究者総覧

教員活動データベース

Outcomes of postoperative radiotherapy for pelvic lymph node-positive uterine cervical cancer: A multi-institutional survey in Japan

発表形態:
一般講演(学術講演を含む)
主要業績:
主要業績
単著・共著:
共著
発表年月:
2015年11月
DOI:
会議属性:
国内会議
査読:
有り
リンク情報:

日本語フィールド

著者:
〇Tokumaru S, Uno T, Kaneyasu Y, Kazumoto T, Harima Y, Noda S, Niibe Y, Shimanoe C, Toita T
題名:
Outcomes of postoperative radiotherapy for pelvic lymph node-positive uterine cervical cancer: A multi-institutional survey in Japan
発表情報:
第28回日本放射線腫瘍学会学術大会, 2015/11/19-21
キーワード:
概要:
Objective: To clarify the clinical outcomes of postoperative radiotherapy for pelvic lymph node (LN)-positive uterine cervical cancer. Materials/Methods: The cases of 137 patients who were treated with postoperative radiotherapy for cervical cancer with pelvic LN-positivity proved pathologically between Jan. 2000 and Dec. 2009 at nine institutions in Japan were retrospectively analyzed. The median age was 48 years (range: 26–76 years). The numbers of patients at pathological T stages 1a, 1b1, 1b2, 2a, 2b, and 3a or higher were 1, 42, 17, 20, 54, and 3, respectively. The number of LNs was revealed in 125 patients (91%) (median: 2, range: 1–18). Regarding the histological type, squamous cell carcinoma and others were observed in 105 and 32 patients, respectively. All 137 patients were treated with pelvic external beam radiotherapy (median dose: 50 Gy). Sixty-five patients (48%) underwent intracavitary brachytherapy. Seventy-four patients (55%) were treated with chemotherapy. Results: The median follow-up was 71 months. The 5-year overall survival rate, disease-free survival rate, and pelvic recurrence-free survival rate were 78.8%, 60.8%, and 90.1%, respectively. Multiple number of LNs and higher pathological T stage (≥ 2b) were shown to be risk factors for the recurrence of cervical cancer (p=0.004 and p=0.036, Cox hazard test). No patient deaths were associated with postoperative (chemo) radiotherapy. Grade 1–4 and 3–4 late adverse events were seen in 55 (40%) and 11 patients (8%), respectively. Grade 4 events were seen in three patients at the small intestine, one patient at the bladder, and one patient at the colon. Leg edema was seen in 36 patients (27%), and higher age (≥ 51 years) was thought to be a risk factor for the leg edema (odds ratio=3.5, 95% confidence interval=1.5-8.4; p=0.004). Conclusion: Our findings indicate that postoperative radiotherapy for cervical cancer with positive pelvic LNs is quite effective. Cervical cancer patients who have multiple pelvic LNs or are at higher than T2b stage should be monitored closely for recurrence.
抄録:
抄録集

英語フィールド

Author:
〇Tokumaru S, Uno T, Kaneyasu Y, Kazumoto T, Harima Y, Noda S, Niibe Y, Shimanoe C, Toita T
Title:
Outcomes of postoperative radiotherapy for pelvic lymph node-positive uterine cervical cancer: A multi-institutional survey in Japan
Announcement information:
The 28th Annual Meeting of the Japanese Society for Radiation Oncology, 2015/11/19-21
An abstract:
Objective: To clarify the clinical outcomes of postoperative radiotherapy for pelvic lymph node (LN)-positive uterine cervical cancer. Materials/Methods: The cases of 137 patients who were treated with postoperative radiotherapy for cervical cancer with pelvic LN-positivity proved pathologically between Jan. 2000 and Dec. 2009 at nine institutions in Japan were retrospectively analyzed. The median age was 48 years (range: 26–76 years). The numbers of patients at pathological T stages 1a, 1b1, 1b2, 2a, 2b, and 3a or higher were 1, 42, 17, 20, 54, and 3, respectively. The number of LNs was revealed in 125 patients (91%) (median: 2, range: 1–18). Regarding the histological type, squamous cell carcinoma and others were observed in 105 and 32 patients, respectively. All 137 patients were treated with pelvic external beam radiotherapy (median dose: 50 Gy). Sixty-five patients (48%) underwent intracavitary brachytherapy. Seventy-four patients (55%) were treated with chemotherapy. Results: The median follow-up was 71 months. The 5-year overall survival rate, disease-free survival rate, and pelvic recurrence-free survival rate were 78.8%, 60.8%, and 90.1%, respectively. Multiple number of LNs and higher pathological T stage (≥ 2b) were shown to be risk factors for the recurrence of cervical cancer (p=0.004 and p=0.036, Cox hazard test). No patient deaths were associated with postoperative (chemo) radiotherapy. Grade 1–4 and 3–4 late adverse events were seen in 55 (40%) and 11 patients (8%), respectively. Grade 4 events were seen in three patients at the small intestine, one patient at the bladder, and one patient at the colon. Leg edema was seen in 36 patients (27%), and higher age (≥ 51 years) was thought to be a risk factor for the leg edema (odds ratio=3.5, 95% confidence interval=1.5-8.4; p=0.004). Conclusion: Our findings indicate that postoperative radiotherapy for cervical cancer with positive pelvic LNs is quite effective. Cervical cancer patients who have multiple pelvic LNs or are at higher than T2b stage should be monitored closely for recurrence.
An abstract:
abstract


Copyright © MEDIA FUSION Co.,Ltd. All rights reserved.