日本語フィールド
著者：Chisato Shimanoe, Yasuki Higaki, Yuichiro Nishida, Megumi Hara, Hinako Nanri, Kazuyo Nakamura, Takeshi Imaizumi, Tatsuhiko Sakamoto, Naoto Taguchi, Mikako Horita, Koichi Shinchi, Keitaro Tanaka, J-MICC Study Group題名：Significant interaction between ADIPOQ gene and higher BMI on HbA1c levels in a Japanese general population発表情報：第25回日本疫学会学術総会 2015,1,21-23キーワード：概要：Background: The ADIPOQ 45T>G, 276G>T and —11377C>G single nucleotide polymorphisms have been associated with the risk of diabetes mellitus and obesity. However, these associations have been heterogeneous by ethnicity, and relevant population-based data in Japanese remain limited.
Objectives: To examine the association of the above ADIPOQ polymorphisms with glycated hemoglobin (HbA1c) in a Japanese general population and to explore possible interactions between those polymorphisms and lifestyle factors including body mass index (BMI) on HbA1c.
Methods: In this cross-sectional study, we used the baseline survey data from 2618 participants aged 40-69 years in the Japan Multi-Institutional Collaborateive Cohort Study. Genotyping was performed using polymerase chain reaction-based invader assay. Multivariate analyses with linear regression and logistic regression were conducted to control for potential confounders (age, sex, area, BMI, energy intake, alcohol, smoking, physical activity, stress, and family history of diabetes) and to examine the above interactions.
Results: After full adjustment, 45GG genotype compared with TT genotype was significantly associated with high HbA1c levels of ≥6.5% (OR=2.1, 95%CI=1.1-4.2) although —11377C>G and 276G>T polymorphisms showed no significant associations. A significant interaction between 45T>G polymorphism and BMI on HbA1c levels was observed (Pinteraction=0.004); in overweight/obese subjects (BMI≥25kg/m2), increasing G allele was significantly associated with higher HbA1c (Ptrend=0.011), but not in subjects with BMI<25kg/m2 (Ptrend=0.77). Conversely, increasing -11377G allele was associated with lower HbA1c in overweight/obese subjects only (Ptrend=0.019), albeit the corresponding interaction was not significant.
Conclusion: The 45T>G and, possibly, —11377C>G polymorphisms of ADIPOQ gene may confer different susceptibility for hyperglycemia, particularly in overweight/obese individuals of the Japanese general population.抄録：J. Epidemiol. (Suppl.) 25, 1, 61英語フィールド
Author：Chisato Shimanoe, Yasuki Higaki, Yuichiro Nishida, Megumi Hara, Hinako Nanri, Kazuyo Nakamura, Takeshi Imaizumi, Tatsuhiko Sakamoto, Naoto Taguchi, Mikako Horita, Koichi Shinchi, Keitaro Tanaka, J-MICC Study GroupTitle：Significant interaction between ADIPOQ gene and higher BMI on HbA1c levels in a Japanese general populationAnnouncement information:An abstract：Background: The ADIPOQ 45T>G, 276G>T and —11377C>G single nucleotide polymorphisms have been associated with the risk of diabetes mellitus and obesity. However, these associations have been heterogeneous by ethnicity, and relevant population-based data in Japanese remain limited.
Objectives: To examine the association of the above ADIPOQ polymorphisms with glycated hemoglobin (HbA1c) in a Japanese general population and to explore possible interactions between those polymorphisms and lifestyle factors including body mass index (BMI) on HbA1c.
Methods: In this cross-sectional study, we used the baseline survey data from 2618 participants aged 40-69 years in the Japan Multi-Institutional Collaborateive Cohort Study. Genotyping was performed using polymerase chain reaction-based invader assay. Multivariate analyses with linear regression and logistic regression were conducted to control for potential confounders (age, sex, area, BMI, energy intake, alcohol, smoking, physical activity, stress, and family history of diabetes) and to examine the above interactions.
Results: After full adjustment, 45GG genotype compared with TT genotype was significantly associated with high HbA1c levels of ≥6.5% (OR=2.1, 95%CI=1.1-4.2) although —11377C>G and 276G>T polymorphisms showed no significant associations. A significant interaction between 45T>G polymorphism and BMI on HbA1c levels was observed (Pinteraction=0.004); in overweight/obese subjects (BMI≥25kg/m2), increasing G allele was significantly associated with higher HbA1c (Ptrend=0.011), but not in subjects with BMI<25kg/m2 (Ptrend=0.77). Conversely, increasing -11377G allele was associated with lower HbA1c in overweight/obese subjects only (Ptrend=0.019), albeit the corresponding interaction was not significant.
Conclusion: The 45T>G and, possibly, —11377C>G polymorphisms of ADIPOQ gene may confer different susceptibility for hyperglycemia, particularly in overweight/obese individuals of the Japanese general population.An abstract：J. Epidemiol. (Suppl.) 25, 1, 61