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Osteochondral Regeneration Using Adipose TissueDerived Mesenchymal Stem Cells

発表形態:
原著論文
主要業績:
主要業績
単著・共著:
共著
発表年月:
2020年05月
DOI:
10.3390/ijms21103589
会議属性:
指定なし
査読:
有り
リンク情報:

日本語フィールド

著者:
Murata D, Fujimoto R, Nakayama K
題名:
Osteochondral Regeneration Using Adipose TissueDerived Mesenchymal Stem Cells
発表情報:
Int J Mol Sci 巻: 21 号: 10 ページ: E3589
キーワード:
概要:
Osteoarthritis (OA) is a major joint disease that promotes locomotor deficiency during the middle- to old-age, with the associated disability potentially decreasing quality of life. Recently, surgical strategies to reconstruct both articular cartilage and subchondral bone for OA have been diligently investigated for restoring joint structure and function. Adipose tissue-derived mesenchymal stem cells (AT-MSCs), which maintain pluripotency and self-proliferation ability, have recently received attention as a useful tool to regenerate osteocartilage for OA. In this review, several studies were described related to AT-MSC spheroids, with scaffold and scaffold-free three-dimensional (3D) constructs produced using "mold" or "Kenzan" methods for osteochondral regeneration. First, several examples of articular cartilage regeneration using AT-MSCs were introduced. Second, studies of osteochondral regeneration (not only cartilage but also subchondral bone) using AT-MSCs were described. Third, examples were presented wherein spheroids were produced using AT-MSCs for cartilage regeneration. Fourth, osteochondral regeneration following autologous implantation of AT-MSC scaffold-free 3D constructs, fabricated using the "mold" or "Kenzan" method, was considered. Finally, prospects of osteochondral regeneration by scaffold-free 3D constructs using AT-MSC spheroids were discussed.
抄録:

英語フィールド

Author:
Murata D, Fujimoto R, Nakayama K
Title:
Osteochondral Regeneration Using Adipose TissueDerived Mesenchymal Stem Cells
Announcement information:
Int J Mol Sci Vol: 21 Issue: 10 Page: E3589
An abstract:
Osteoarthritis (OA) is a major joint disease that promotes locomotor deficiency during the middle- to old-age, with the associated disability potentially decreasing quality of life. Recently, surgical strategies to reconstruct both articular cartilage and subchondral bone for OA have been diligently investigated for restoring joint structure and function. Adipose tissue-derived mesenchymal stem cells (AT-MSCs), which maintain pluripotency and self-proliferation ability, have recently received attention as a useful tool to regenerate osteocartilage for OA. In this review, several studies were described related to AT-MSC spheroids, with scaffold and scaffold-free three-dimensional (3D) constructs produced using "mold" or "Kenzan" methods for osteochondral regeneration. First, several examples of articular cartilage regeneration using AT-MSCs were introduced. Second, studies of osteochondral regeneration (not only cartilage but also subchondral bone) using AT-MSCs were described. Third, examples were presented wherein spheroids were produced using AT-MSCs for cartilage regeneration. Fourth, osteochondral regeneration following autologous implantation of AT-MSC scaffold-free 3D constructs, fabricated using the "mold" or "Kenzan" method, was considered. Finally, prospects of osteochondral regeneration by scaffold-free 3D constructs using AT-MSC spheroids were discussed.


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