日本語フィールド
著者：*Keisuke Kidoguchi, Yasushi Kubota, Shun Fujimoto, Yasuhisa Sakata, Haruna Kizuka-Sano, Kyosuke Yamaguchi, Hiroshi Ureshino, Hiroo Katsuya, Toshihiko Ando, Motohiro Esaki, Shinya Kimura題名：Aplastic Anemia in a Patient with Cronkhite-Canada Syndrome 発表情報：Intern Med 巻: 60 号: 10 ページ: 1601-1605キーワード：Cronkhite-Canada syndrome; aplastic anemia; autoimmune disorder; human leukocyte antigen; paroxysmal nocturnal hemoglobinuria概要：Cronkhite-Canada syndrome (CCS) is a rare polyposis disorder accompanied by alopecia and onychodystrophy. A 63-year-old man with a history of CCS and repeated embolism developed progressive thrombocytopenia and mild anemia. Laboratory testing, a bone marrow examination, and magnetic resonance imaging of the spine resulted in a diagnosis of concurrent aplastic anemia (AA). Paroxysmal nocturnal hemoglobinuria (PNH)-type cells were detected in a peripheral blood specimen. In addition, human leukocyte antigen (HLA) included DRB1*15:01 and DRB1*15:02. Mesalazine was discontinued in consideration of possible drug-induced pancytopenia. Immunosuppressive therapy ameliorated both the gastrointestinal symptoms of CCS and pancytopenia. A common autoimmune abnormality might underlie both CCS and AA. 抄録：英語フィールド
Author：*Keisuke Kidoguchi, Yasushi Kubota, Shun Fujimoto, Yasuhisa Sakata, Haruna Kizuka-Sano, Kyosuke Yamaguchi, Hiroshi Ureshino, Hiroo Katsuya, Toshihiko Ando, Motohiro Esaki, Shinya KimuraTitle：Aplastic Anemia in a Patient with Cronkhite-Canada Syndrome Announcement information:Intern Med Vol: 60 Issue: 10 Page: 1601-1605Keyword：Cronkhite-Canada syndrome; aplastic anemia; autoimmune disorder; human leukocyte antigen; paroxysmal nocturnal hemoglobinuriaAn abstract：Cronkhite-Canada syndrome (CCS) is a rare polyposis disorder accompanied by alopecia and onychodystrophy. A 63-year-old man with a history of CCS and repeated embolism developed progressive thrombocytopenia and mild anemia. Laboratory testing, a bone marrow examination, and magnetic resonance imaging of the spine resulted in a diagnosis of concurrent aplastic anemia (AA). Paroxysmal nocturnal hemoglobinuria (PNH)-type cells were detected in a peripheral blood specimen. In addition, human leukocyte antigen (HLA) included DRB1*15:01 and DRB1*15:02. Mesalazine was discontinued in consideration of possible drug-induced pancytopenia. Immunosuppressive therapy ameliorated both the gastrointestinal symptoms of CCS and pancytopenia. A common autoimmune abnormality might underlie both CCS and AA. 