MF研究者総覧

教員活動データベース

Identification and mechanistic investigation of ellagitannins from Osbeckia octandra that attenuate liver fibrosis via the TGF-β/SMAD signaling pathway

発表形態:
原著論文
主要業績:
主要業績
単著・共著:
共著
発表年月:
2023年10月
DOI:
10.1093/bbb/zbad114
会議属性:
指定なし
査読:
有り
リンク情報:

日本語フィールド

著者:
Bogahawaththa, Sudarma; Kawamura, Tomoaki; Bandaranayake, Udari; Hirakawa, Tomoaki; Yamada, Goki; Ishino, Hana; Hirohashi, Tsuzumi; Kawaguchi, Shin Ichi; Wijesundera, Kavindra K.; Wijayagunawardane, Missaka P.B.; Ishimaru, Kanji; Kodithuwakku, Suranga P.; Tsujita, Tadayuki
題名:
Identification and mechanistic investigation of ellagitannins from Osbeckia octandra that attenuate liver fibrosis via the TGF-β/SMAD signaling pathway
発表情報:
Bioscience, biotechnology, and biochemistry 巻: 87 号: 11 ページ: 1295 - 1309
キーワード:
概要:
Fibrosis is a major problem in chronic liver disease with limited treatment options due to its complex nature. Herbal medicines are often used as an alternative. The aim of this study was to investigate the therapeutic potential of Osbeckia octandra and to identify its active compounds and regulatory pathways. The effects of crude leaf suspension and boiled leaf extract were investigated in an animal model, and the extract was found to be the more effective treatment. Three major bioactive compounds, pedunculagin, casuarinin, and gallic acid, were isolated from the extract using the hepatic stellate cell line, LX-2-based antifibrotic effect evaluation system. The results showed that all these compounds ameliorated LX-2 in fibrotic state. This inhibitory mechanism was confirmed through the TGF-β/SMAD signaling pathway. Collectively, the presence of these compounds in O. octandra suggests its potential as a treatment for liver fibrosis.
抄録:

英語フィールド

Author:
Bogahawaththa, Sudarma^D; Kawamura, Tomoak^Mi; Bandaranayake, Udari; Hirakawa, Tomoaki^D; Yamada, Goki^D; Ishino, Hana^M; Hirohashi, Tsuzumi^M; Kawaguchi, Shin Ichi; Wijesundera, Kavindra K.; Wijayagunawardane, Missaka P.B.; Ishimaru, Kanji; Kodithuwakku, Suranga P.; Tsujita, Tadayuki
Title:
Identification and mechanistic investigation of ellagitannins from Osbeckia octandra that attenuate liver fibrosis via the TGF-β/SMAD signaling pathway
Announcement information:
Bioscience, biotechnology, and biochemistry Vol: 87 Issue: 11 Page: 1295 - 1309
An abstract:
Fibrosis is a major problem in chronic liver disease with limited treatment options due to its complex nature. Herbal medicines are often used as an alternative. The aim of this study was to investigate the therapeutic potential of Osbeckia octandra and to identify its active compounds and regulatory pathways. The effects of crude leaf suspension and boiled leaf extract were investigated in an animal model, and the extract was found to be the more effective treatment. Three major bioactive compounds, pedunculagin, casuarinin, and gallic acid, were isolated from the extract using the hepatic stellate cell line, LX-2-based antifibrotic effect evaluation system. The results showed that all these compounds ameliorated LX-2 in fibrotic state. This inhibitory mechanism was confirmed through the TGF-β/SMAD signaling pathway. Collectively, the presence of these compounds in O. octandra suggests its potential as a treatment for liver fibrosis.


Copyright © MEDIA FUSION Co.,Ltd. All rights reserved.