MF研究者総覧

教員活動データベース

One-Pot Preparation of Collagen Tubes Using Diffusing Gelation

発表形態:
原著論文
主要業績:
主要業績
単著・共著:
共著
発表年月:
2022年06月
DOI:
10.1021/acsomega.2c02623
会議属性:
指定なし
査読:
有り
リンク情報:

日本語フィールド

著者:
○Yui Iwamoto, Ryota Haraguchi, Ryosuke Nakao, Shigehisa Aoki, Yushi Oishi, Takayuki Narita
題名:
One-Pot Preparation of Collagen Tubes Using Diffusing Gelation
発表情報:
ACS Omega 巻: 7 号: 26 ページ: 22872-22878
キーワード:
概要:
One-pot gelation in capillary glass tubes with carbonate-based buffer solution allows the formation of hollow collagen gels (collagen tubes) with an outer diameter of 1 mm or less. The preparation conditions of collagen concentration, buffer concentration, and capillary diameter impacted the ratio and size of the hollow gel and allowed for morphological control of the cavity. The morphology of the hollows suggests that their vacancies are the result of macroscopic phase separation and pinning due to gelation. Mechanical strength measurements of the dried collagen gel tubes demonstrated that the collagen concentration determines their Young's modulus and maximum stress and that the material is strong enough for practical use. In vitro seeding studies of vascular endothelial cells demonstrated the possible formation of endothelial cells in layers in the gel lumen.
抄録:

英語フィールド

Author:
○Yui Iwamoto, Ryota Haraguchi, Ryosuke Nakao, Shigehisa Aoki, Yushi Oishi, Takayuki Narita
Title:
One-Pot Preparation of Collagen Tubes Using Diffusing Gelation
Announcement information:
ACS Omega Vol: 7 Issue: 26 Page: 22872-22878
An abstract:
One-pot gelation in capillary glass tubes with carbonate-based buffer solution allows the formation of hollow collagen gels (collagen tubes) with an outer diameter of 1 mm or less. The preparation conditions of collagen concentration, buffer concentration, and capillary diameter impacted the ratio and size of the hollow gel and allowed for morphological control of the cavity. The morphology of the hollows suggests that their vacancies are the result of macroscopic phase separation and pinning due to gelation. Mechanical strength measurements of the dried collagen gel tubes demonstrated that the collagen concentration determines their Young's modulus and maximum stress and that the material is strong enough for practical use. In vitro seeding studies of vascular endothelial cells demonstrated the possible formation of endothelial cells in layers in the gel lumen.


Copyright © MEDIA FUSION Co.,Ltd. All rights reserved.