日本語フィールド
著者：○Keitaro Ishii, Kazuharu Kamachi, Sho Okamoto, Hiroo Katsuya, Mai Fujita, Toshiaki Nagaie, Atsujiro Nishioka, Mariko Yoshimura, Hiroshi Ureshino, Yasushi Kubota, Toshihiko Ando, Tatsuro Watanabe, Mai Takeuchi, Keita Kai, Koichi Ohshima, Shinya Kimura題名：Diffuse Large B-cell Lymphoma Involving an Abundant Infiltration of T Follicular Helper Cells: A Case Report発表情報：Intern Med 巻: 62 号: 9 ページ: 1335-1340キーワード：DLBCL; T follicular helper cells; THRLBCL概要：A 76-year-old man presented with skin plaque and splenic nodules, and diffuse large B-cell lymphoma (DLBCL) with infiltration of T-cells was suspected based on the skin lesions. The disease showed indolent clinical behavior for three months, when systemic lymphadenopathy rapidly evolved. An inguinal lymph node biopsy revealed DLBCL with abundant infiltration of T follicular helper (TFH) cells. A polymerase chain reaction-based analysis of immunoglobulin variable heavy chain showed that the skin, splenic nodules, and inguinal lymph node shared the same clone. This case indicates that the dysregulated infiltration of TFH cells in the tumor microenvironment accelerates the lymphomagenesis and progression of DLBCL. 抄録：英語フィールド
Author：○Keitaro Ishii, Kazuharu Kamachi, Sho Okamoto, Hiroo Katsuya, Mai Fujita, Toshiaki Nagaie, Atsujiro Nishioka, Mariko Yoshimura, Hiroshi Ureshino, Yasushi Kubota, Toshihiko Ando, Tatsuro Watanabe, Mai Takeuchi, Keita Kai, Koichi Ohshima, Shinya KimuraTitle：Diffuse Large B-cell Lymphoma Involving an Abundant Infiltration of T Follicular Helper Cells: A Case ReportAnnouncement information:Intern Med Vol: 62 Issue: 9 Page: 1335-1340Keyword：DLBCL; T follicular helper cells; THRLBCLAn abstract：A 76-year-old man presented with skin plaque and splenic nodules, and diffuse large B-cell lymphoma (DLBCL) with infiltration of T-cells was suspected based on the skin lesions. The disease showed indolent clinical behavior for three months, when systemic lymphadenopathy rapidly evolved. An inguinal lymph node biopsy revealed DLBCL with abundant infiltration of T follicular helper (TFH) cells. A polymerase chain reaction-based analysis of immunoglobulin variable heavy chain showed that the skin, splenic nodules, and inguinal lymph node shared the same clone. This case indicates that the dysregulated infiltration of TFH cells in the tumor microenvironment accelerates the lymphomagenesis and progression of DLBCL. 