日本語フィールド
著者：*Hidehiro Kaneko, Yuta Suzuki, Kensuke Ueno, Akira Okada, Katsuhito Fujiu, Satoshi Matsuoka, Nobuaki Michihata, Taisuke Jo, Norifumi Takeda, Hiroyuki Morita, Kentaro Kamiya, Koichi Node, Hideo Yasunaga, Issei Komuro題名：Association of Life's Simple 7 with incident cardiovascular disease in 52,956 patients with cancer 発表情報：Eur J Prev Cardiol 巻: 29 号: 18 ページ: 2324-2332キーワード：Cancer Survivors; Cardiovascular Risk; Life’s Simple 7 Cardiovascular Health Metrics; Onco-Cardiology; Prevention概要：Aims: Cancer survivors have a greater risk of cardiovascular disease (CVD). Although Life's Simple 7 is used for CVD risk stratification in a general population, its utility in cancer survivors remains unknown. We aimed to clarify the association of Life's Simple 7 with incident CVD among cancer survivors. Furthermore, we analyzed the relationship between the change in Life's Simple 7 and the subsequent CVD risk.
Methods: This retrospective observational study was conducted using the JMDC Claims Database, and we analyzed 53,974 patients with a prior history of breast, colorectal, or stomach cancer, which is a common cancer site in the Japanese population. The median age was 54 years, and 37.8% were men. We modified the original definition of Life's Simple 7 and identified the following (modified) ideal Life's Simple 7 cardiovascular health metrics: nonsmoking, body mass index < 25 kg/m2, physical activity at goal, optimal dietary habits, untreated fasting plasma glucose < 100 mg/dL, untreated blood pressure < 120/80 mmHg, and untreated total cholesterol < 200 mg/dL. The primary endpoint was composite CVD outcome, including myocardial infarction, angina pectoris, stroke, and heart failure.
Results: Over a mean follow-up period of 975 ± 794 days, 3,150 composite CVD outcomes were recorded. The risk of CVD events increased with a greater number of non-ideal Life's Simple 7. The hazard ratio per 1-point increase in non-ideal Life's Simple 7 was 1.15 (95% CI:1.12-1.18). Furthermore, a 1-point increase in non-ideal Life's Simple 7 over one year was associated with subsequent CVD risk (Hazard ratio 1.12, 95% CI:1.06-1.19).
Conclusions: Life's Simple 7 could be applicable for CVD risk stratification even among cancer survivors. Optimizing Life's Simple 7 may prevent the development of CVD in cancer survivors.抄録：英語フィールド
Author：*Hidehiro Kaneko, Yuta Suzuki, Kensuke Ueno, Akira Okada, Katsuhito Fujiu, Satoshi Matsuoka, Nobuaki Michihata, Taisuke Jo, Norifumi Takeda, Hiroyuki Morita, Kentaro Kamiya, Koichi Node, Hideo Yasunaga, Issei KomuroTitle：Association of Life's Simple 7 with incident cardiovascular disease in 52,956 patients with cancer Announcement information:Eur J Prev Cardiol Vol: 29 Issue: 18 Page: 2324-2332Keyword：Cancer Survivors; Cardiovascular Risk; Life’s Simple 7 Cardiovascular Health Metrics; Onco-Cardiology; PreventionAn abstract：Aims: Cancer survivors have a greater risk of cardiovascular disease (CVD). Although Life's Simple 7 is used for CVD risk stratification in a general population, its utility in cancer survivors remains unknown. We aimed to clarify the association of Life's Simple 7 with incident CVD among cancer survivors. Furthermore, we analyzed the relationship between the change in Life's Simple 7 and the subsequent CVD risk.
Methods: This retrospective observational study was conducted using the JMDC Claims Database, and we analyzed 53,974 patients with a prior history of breast, colorectal, or stomach cancer, which is a common cancer site in the Japanese population. The median age was 54 years, and 37.8% were men. We modified the original definition of Life's Simple 7 and identified the following (modified) ideal Life's Simple 7 cardiovascular health metrics: nonsmoking, body mass index < 25 kg/m2, physical activity at goal, optimal dietary habits, untreated fasting plasma glucose < 100 mg/dL, untreated blood pressure < 120/80 mmHg, and untreated total cholesterol < 200 mg/dL. The primary endpoint was composite CVD outcome, including myocardial infarction, angina pectoris, stroke, and heart failure.
Results: Over a mean follow-up period of 975 ± 794 days, 3,150 composite CVD outcomes were recorded. The risk of CVD events increased with a greater number of non-ideal Life's Simple 7. The hazard ratio per 1-point increase in non-ideal Life's Simple 7 was 1.15 (95% CI:1.12-1.18). Furthermore, a 1-point increase in non-ideal Life's Simple 7 over one year was associated with subsequent CVD risk (Hazard ratio 1.12, 95% CI:1.06-1.19).
Conclusions: Life's Simple 7 could be applicable for CVD risk stratification even among cancer survivors. Optimizing Life's Simple 7 may prevent the development of CVD in cancer survivors.