日本語フィールド
著者：*Muneto Tatsumoto, Ritsuko Matsumura, Takuyuki Endo, Isao T Tokuda, Koichi Node, Makoto Akashi題名：Potential negative effect of total parenteral nutrition on the human circadian clock 発表情報：Genes Cells 巻: 27 号: 10 ページ: 613-620キーワード：circadian clock; clock gene; hair follicle; total parenteral nutrition概要：When patients cannot eat on their own, total parenteral nutrition (TPN) is a clinically beneficial method of maintaining nutrition. However, many animal studies have demonstrated that circadian rhythms are strongly affected by feeding time, raising the concern that continuous TPN around the clock may have an unexpected negative impact on the circadian clock of patients. To investigate this concern, we compared clock gene expression of aged subjects with or without TPN using hair follicle cells and found that while none of the non-TPN subjects showed any obvious defects in circadian rhythms of peripheral clock gene expression, a portion of aged subjects receiving continuous TPN showed abnormal circadian rhythms in peripheral clocks. Continuous TPN around the clock may therefore potentially perturb peripheral circadian rhythms, giving rise to the proposal that TPN needs to be administered with consideration to time factors. 抄録：英語フィールド
Author：*Muneto Tatsumoto, Ritsuko Matsumura, Takuyuki Endo, Isao T Tokuda, Koichi Node, Makoto AkashiTitle：Potential negative effect of total parenteral nutrition on the human circadian clock Announcement information:Genes Cells Vol: 27 Issue: 10 Page: 613-620Keyword：circadian clock; clock gene; hair follicle; total parenteral nutritionAn abstract：When patients cannot eat on their own, total parenteral nutrition (TPN) is a clinically beneficial method of maintaining nutrition. However, many animal studies have demonstrated that circadian rhythms are strongly affected by feeding time, raising the concern that continuous TPN around the clock may have an unexpected negative impact on the circadian clock of patients. To investigate this concern, we compared clock gene expression of aged subjects with or without TPN using hair follicle cells and found that while none of the non-TPN subjects showed any obvious defects in circadian rhythms of peripheral clock gene expression, a portion of aged subjects receiving continuous TPN showed abnormal circadian rhythms in peripheral clocks. Continuous TPN around the clock may therefore potentially perturb peripheral circadian rhythms, giving rise to the proposal that TPN needs to be administered with consideration to time factors. 