Japanese Association of Laboratory Animal Scinece, The Japanese Society of Veterinary Science, Japan Rabbit Bioscience Association, Japan Atherosclerosis Society, Kyushu Experimental Animal Research Association
Research Topics and Results
Strategies for highly efficient rabbit sperm cryopreservation 2021/04
Transgenic rabbit models: Now and the future. 2020/10
Cryopreservation of rabbit sperm 2016/08
Rabbit models for the study of human atherosclerosis: From pathophysiological mechanisms to translational medicine 2015/10
Motility and fertility of rabbit sperm cryopreserved using soybean lecithin as an alternative to egg yolk 2015/09
Delaying embryo development by storing at 4˚C for synchronization to recipients in microinjection technique in rabbits 2013
Effect of the primary cooling rate on the motility and fertility of the frozen-thawed rabbit spermatozoa 2012
Age is an important factor influence on the number of recovered eggs in superovulated rabbits: Analysis of our past 5 years data of 509 rabbits superovulated by FSH or PMSG. 2011
Technology suitable for rabbit semen conservation 2009/06
Expression of human apoAII in transgenic rabbits leads to dyslipidemia: a new model for combined hyperlipidemia 2009
Human C-reactive protein does not promote atherosclerosis in transgenic rabbits 2009
Transgenic rabbits with increased VEGF expression developed hemangiomas in the liver: A new model for the Kasabach-Merritt syndrome 2005
Overexpression of lipoprotein lipase improves insulin resistance induced by a high-fat diet in transgenic rabbits. 2004
Transgenic Rabbits: Production and Application for Human Disease Models. 2003
Books
Strategies for highly efficient rabbit sperm cryopreservation.; 2022/07 ANNOUNCEMENT INFO.; Challenges and new strategies on rabbit breeding. Garcıa-Garcı, R.-M. and Alvarez, M.-A. (edit), 19-32 AUTHOR; Nishijima, K., Kitajima, S., Matsuhisa, F., Niimi, M., Wang, C-C., Fan, J.
Improvement of rabbit production; 2009 ANNOUNCEMENT INFO.; Rabbit Biotechnology: rabbit genomics, transgenesis, cloning and models, 3-12 AUTHOR; Kitajima, S
Rabbit transgenesis; 2009 ANNOUNCEMENT INFO.; Rabbit Biotechnology: rabbit genomics, transgenesis, cloning and models, 37-48 AUTHOR; Kitajima, S., Liu, E. and Fan, J.
Collagen vitrigel membrane-coated nylon line prevents stenosis after conization of the uterine cervix.; 2021/04 ANNOUNCEMENT INFO.; Tissue Engineering Part A, 27, 23-24, pp.1480-1489 AUTHOR; Hashiguchi, M., Takezawa, T., Nagase, K., Tayama-Abe, M., Matsuhisa, F., Kitajima, S., Morito, S., Yamaji, K., Futamata, M., Sakata, Y., Akutagawa, T., Yokoyama, M., Toda, S., Aoki, S.
Endothelial lipase exerts its anti-atherogenic effect through increased catabolism of b-VLDLs; 2021/00 ANNOUNCEMENT INFO.; J. Atheroscler. Thromb., 28, 157-168 AUTHOR; Yan, H., Niimi, M., Chuan Wang, C., Chen, Y., Zhou, H., Matsuhisa, F., Nishijima, K., Kitajima, S., Zhang, B., Yokomichi, H., Zhang, J., Chen, Y. E., Fan, J.
PMEPA1 and NEDD4 control proton production of osteoclasts through regulating vesicular trafficking; 2021/00 ANNOUNCEMENT INFO.; FASEB Journal, 35, 2, e21281 AUTHOR; Hirata, H., Xu, X., Nishioka, K., Matsuhisa, F., Kitajima, S., Kukita, T., Murayama, M., Urano, Y., Miyamoto, H., Mawatari, M., Kukita, A.
Whole‑body insulin resistance and energy expenditure indices, serum lipids, and skeletal muscle metabolome in a state of lipoprotein lipase overexpression; 2021/00 ANNOUNCEMENT INFO.; Metabolomics, 17, 26 AUTHOR; Nishida, Y., Nishijima, K., Yamada, Y., Tanaka, H., Matsumoto, A., Fan, J., Uda, Y., Tomatsu, H., Yamamoto, H., Kami, K., Kitajima, S., and Tanaka, K.
Apolipoprotein CIII deficiency protects against atherosclerosis in knock-out rabbits.; 2020 ANNOUNCEMENT INFO.; Arterioscler. Thromb. Vasc. Biol., 40, 9, 2095-2107 AUTHOR; Yan, H., Niimi, M., Kitajima, S., Zhou, H., Chen, Y., Wang, C., Matsuhisa, F., Yang, X., Yao, J., Yang, D., Zhang, J., Murakami, M., Nakajima, K., Wang, Y., Liu, E., Chen, Y. , Liang, J. and Fan J.
Macrophage-derived MMP-9 enhances the vascular calcification and progression of atherosclerotic lesions in transgenic rabbits.; 2020 ANNOUNCEMENT INFO.; J. Cell. Mol. Med., 24, 7, 4261-4274 AUTHOR; Chen, Y., Waqar, A.B., Nishijima, K., Ning, B., Kitajima, S., Matsuhisa, F., Chen, L., Liu, E., Zhang, J., Chen, Y.E., Liang, J., Fan, J.
Sex hormones affect endothelial lipase-mediated lipid metabolism and atherosclerosis; 2019/12 ANNOUNCEMENT INFO.; Lipids in Health and Disease, 18, 229 AUTHOR; Wang, C., Niimi, M., Kitajima, S., Matsuhisa, F., Yan, H., Dong, S., Liang, J., Fan, J.
Macrophage-derived matrix metalloproteinase-1 enhances aortic aneurysm formation in transgenic rabbits.; 2019/07 ANNOUNCEMENT INFO.; J. Biomed. Res., 33, 5, 271-275 AUTHOR; Niimi, M., Nishijima, K., Kitajima, S., Matsuhisa, F., Satoh, K., Yamazaki, H., Zhang, J., Chen, Y.E., Fan, J.
Growing oocyte specific transcription-dependent de novo DNA methylation at the imprinted Zrsr1-DMR; 2018/04 ANNOUNCEMENT INFO.; Epigenetics & Chromatin, 11, 28 AUTHOR; Joh, K., Matsuhisa, F., Kitajima, S., Nishioka, K., Higashimoto, K., Yatsuki, H., Kono, T., Koseki, H., Soejima, H.
Increased hepatic expression of endothelial lipase inhibits cholesterol diet–induced hypercholesterolemia and atherosclerosis in transgenic rabbits; 2017/05 ANNOUNCEMENT INFO.; Arterioscler. Thromb. Vasc. Biol., 37, 7, 1282-1289 AUTHOR; Wang, C., Nishijima, K., Kitajima, S., Niimi, M., Yan, H., Chen, Y., Ning, B., Matsuhisa, F., Liu, E., Zhang, J., Chen, Y. E., Fan. J.
ApoE knockout rabbits: a novel model for the study of human hyperlipidemia; 2016/04 ANNOUNCEMENT INFO.; Atherosclerosis, 245, 187-193 AUTHOR; Niimi, M., Yang, D., Kitajima, S., Ning, B., Wang, C., Li, S., Liu, E., Zhang, J., Chen, Y.E., and Fan, J.
Motility and fertility of rabbit sperm cryopreserved using soybean lecithin as an alternative to egg yolk; 2015/09 ANNOUNCEMENT INFO.; Theriogenology, 84, 1172-1175 AUTHOR; Nishijima, K., Kitajima, S., Koshimoto, C., Morimoto, M., Watanabe, T., Fan, J., Matsuda, Y.
Effects of type III antifreeze protein on sperm and embryo cryopreservation in rabbit; 2014/05 ANNOUNCEMENT INFO.; Cryobiology, 69, 22-25 AUTHOR; Nishijima, K., Tanaka, M., Sakai, Y., Koshimoto, C., Morimoto, M., Watanabe, T., Fan, J., Kitajima, S.
Effects of cholesterol-loaded cyclodextrins on the rate and the quality of motility in frozen and thawed rabbit sperm; 2014/04 ANNOUNCEMENT INFO.; Exp. Anim., 63, (2), 149-154 AUTHOR; Nishijima, K., Yamaguchi, S., Tanaka, M., Sakai, Y., Koshimoto, C., Morimoto, M., Watanabe, T., Fan, J., Kitajima, S.
Human apolipoprotein AII protects against diet-induced atherosclerosis in transgenic rabbits; 2013 ANNOUNCEMENT INFO.; Arterioscler. Thromb. Vasc. Biol., 33, 224-231 AUTHOR; Wang, Y., Niimi, M., Nishijima, K., Yu, Y., Koike, T., Kitajima, S., Inoue, T., Waqar, A.B., Liu, E., Kohashi, M., Keyamura, Y., Yoshigawa, T., Zhang, J., Ma, L., Zha, X., Watanabe, T., Asada, A., Y. Chen, E. and Fan, J.
Delaying embryo development by storing at 4˚C for synchronization to recipients in microinjection technique in rabbits; 2013 ANNOUNCEMENT INFO.; Lab. Anim., 47, 53-57 AUTHOR; Nishijima, K., Liu, E., Yamaguchi, S., Tanaka, M., Morimoto, M., Watanabe, T., Fan, J. and Kitajima, S.
Endothelial lipase mediates HDL levels in normal and hyperlipidemic rabbits; 2012 ANNOUNCEMENT INFO.; J. Atheros. Thromb., 19, 3, 213-226 AUTHOR; Zhang, J., Ying Yu, Y., Nakamura, K., Tomonari Koike, T., Waqar, A. B., Zhang, X., Liu, E., Nishijima, K., Kitajima, S., Shiomi, M., Qi, Z., Yu, J., Graham, M. J., Crooke, R. M., Ishida, T., Hirata, K., Hurt-Camejo, E., Chen, Y. E., Fan, J.
Effect of the primary cooling rate on the motility and fertility of the frozen-thawed rabbit spermatozoa; 2012 ANNOUNCEMENT INFO.; World Rabbit Sci., 20, 65-70 AUTHOR; Maeda, T., Liu, E., Nishijima, K., Tanaka, M., Yamaguchi, S., Morimoto, M., Watanabe, T., Fan, J. and Kitajima, S.
Human C-reactive protein enhances thrombus formation after neointimal balloon injury in transgenic rabbits.; 2011 ANNOUNCEMENT INFO.; J. Thromb. Haemost., 9, 201-208 AUTHOR; Matsuda, S., Yamashita, A., Sato, Y., Kitajima, S., Koike, T., Sugita, C., Moriguchi-Goto, S., Hatakeyama, K., Takahashi, M., Koshimoto, C., Matsuura, Y., Iwakiri, T., Chen, Y.E., Fan, J. and Asada. Y.
Age is an important factor influence on the number of recovered eggs in superovulated rabbits: Analysis of our past 5 years data of 509 rabbits superovulated by FSH or PMSG.; 2011 ANNOUNCEMENT INFO.; Scand. J. Lab. Anim. Sci., 38, 3, 169-174 AUTHOR; Kitajima, S., Maeda, T., Liu, E., Nishijima, K., Morimoto, M., Watanabe, T. and Fan, J.
Overexpression of peroxiredoxin 4 protects against high-dose streptozotocin-induced diabetes by suppressing oxidative stress and cytokines in transgenic mice.; 2010 ANNOUNCEMENT INFO.; Antioxid. Redox Signal, 13, 10, 1477-1490 AUTHOR; Ding, Y., Yamada, S., Wang, K.Y., Shimajiri, S., Guo, X., Tanimoto, A., Murata, Y., Kitajima, S., Watanabe, T., Izumi, H., Kohno, K., Sasaguri, Y.
Expression of human apoAII in transgenic rabbits leads to dyslipidemia: a new model for combined hyperlipidemia; 2009 ANNOUNCEMENT INFO.; Arterioscler. Thromb. Vasc. Biol., 29, 2047-2053 AUTHOR; Koike,T.*, Kitajima, S.*, Yu, Y., Li, Y., Nishijima, K., Liu, E., Sun, H., Ahmed Bilal Waqar, A.B., Shibata, N., Inoue, T., Wang, Y., Zhang, B, Kobayashi, J, Morimoto, M., Saku, K., Watanabe, T., Fan, J.(*equally contributed)
Human C-reactive protein does not promote atherosclerosis in transgenic rabbits; 2009 ANNOUNCEMENT INFO.; Circulation, 120, 2088-2094 AUTHOR; Koike, T.*, Kitajima, S.*, Yu, Y., Nishijima, K., Zhang, J., Ozaki, Y., Morimoto, M., Watanabe, T., Bhakdi, S., Asada, Y., Chen, Y.E., Fan, J.(*equally contributed)
Matrix metalloproteinase 12 is a factor that accelerates the initiation of atherosclerosis and stimulates the progression of fatty streaks to fibrous plaques in transgenic rabbits; 2008 ANNOUNCEMENT INFO.; Am J Pathol, 172, 1419-1429 AUTHOR; Yamada, S., Wang, K-Y., Tanimoto, A., Fan, J., Shimajiri, S., Kitajima, S., Morimoto, M., Tsutsui, M., Watanabe, T., Yasumoto, K., and Sasaguri, Y.
Temporal and quantitative analysis of expression of metalloproteinase (MMPs) and their endogenous inhibitors in atherosclerotic lesions; 2008 ANNOUNCEMENT INFO.; Histol. Histopathol., 23, 1503-1516 AUTHOR; Yu, Y., Koike, T., Kitajima, S., Liu, E., Morimoto, M., Shiomi, M., Hatakeyama, K., Asada, Y., Wang, K-Y., Sasaguri, Y., Watanabe, T., and Fan, J.
Increased expression of vascular endothelial growth factor in kidney leads to progressive impairment of glomerular functions; 2007 ANNOUNCEMENT INFO.; J Am Soc Nephrol, 18, 2094-2104 AUTHOR; Liu, E., Morimoto, M., Kitajima, S., Yu, Y., Koike, T., Shiiki, H., Nagata, M., Watanabe, T., Fan, J.
Lp(a) enhances coronary atherosclerosis in transgenic Watanabe heritable hyperlipidemic rabbits; 2007 ANNOUNCEMENT INFO.; Atherosclerosis, 193, 269-276 AUTHOR; Kitajima, S., Jin, Y., Koike, T., Yu, Y., Liu, E., Morimoto, M., Shiomi, M., Marcovina, S., Watanabe, N. and Fan, J.
Re-establishment of Complement C6-deficeint Rabbit Colony by Cryopreserved Sperm Transported from Abroad; 2007 ANNOUNCEMENT INFO.; Exp Anim, 55, 2, 167-171 AUTHOR; Liu, E., Kitajima, S., Wiese, E., Reifenberg, K., Morimoto, M., Watanabe, T. and Fan, J.
Numbers of publications related to laboratory animals; 2007 ANNOUNCEMENT INFO.; Scand. J Lab. Anim. Sci., 34, 81-86 AUTHOR; Zhao, S., Liu, E., Chu, Y., Zheng, H., Kitajima, S., and Morimoto, M.
Macrophage elastase (MMP-12) accelerates the progression of atherosclerosis in transgenic rabbits; 2006 ANNOUNCEMENT INFO.; Circulation, 13, 1993-2001 AUTHOR; Liang J., Liu E., Yu Y., Kitajima S., Koike T., Jin Y., Morimoto M., Watanabe T., Hatakeyama K., Asada Y., Sasaguri Y., Watanabe S., Fan J.
High lipoprotein lipase activity increases insulin sensitivity in transgenic rabbits; 2005 ANNOUNCEMENT INFO.; Metabolism, 54, 132-138 AUTHOR; Liu. E., Kitajima, S., Higaki, Y., Morimoto, M., Sun, H., Yamada, N., and Fan, J
Macrophage-derived lipoprotein lipase increases aortic atherosclerosis in cholesterol-fed transgenic rabbits; 2005 ANNOUNCEMENT INFO.; Atherosclerosis, 179, 87-95 AUTHOR; Ichikawa, T., Liang, J., Kitajima, S., Koike, T., Wang,X., Sun, H., Morimoto, M., Shikama, H., Watanabe, T., Yamada, N. and Fan, J.
Establishment of a SPF colony of human apo(a) transgenic rabbits by frozen-thawed embryo transfer; 2005 ANNOUNCEMENT INFO.; Exp. Anim., 54, 353-357 AUTHOR; Watanabe, N., Nakagawa, H., Kitajima, S., Liu, E., Morimoto, M, Watanabe, T and Fan, J.
C-reactive protein in atherosclerotic lesions: its origin and pathophysiological significance; 2005 ANNOUNCEMENT INFO.; Am. J. Pathol., 167, 1139-1148 AUTHOR; Sun, H., Koike, T., Ichikawa, T., Hatakeyama, K., Shiomi, M., Zhang, B., Kitajima, S., Morimoto, M., Watanabe, T., Asada, Y., Chen, YE., Fan, J.
Transgenic rabbits with increased VEGF expression developed hemangiomas in the liver: A new model for the Kasabach-Merritt syndrome; 2005 ANNOUNCEMENT INFO.; Lab. Invest., 85, 12, 1517-1527 AUTHOR; Kitajima S., Liu E., Morimoto M., Koike T., Koike Y., Watanabe T., Imagawa S., Fan, J.
Overexpression of lipoprotein lipase in transgenic rabbits leads to increased small dense LDL in plasma and promotes atherosderosis.; 2004 ANNOUNCEMENT INFO.; Lab. Invest., 84, 715-726 AUTHOR; Ichikawa T, Kitajima S, Liang J, Koike T, Wang X, Sun H, Okazaki M, Morimoto M, Shikama, H., Watanabe, T., and Fan, J.
Overexpression of lipoprotein lipase improves insulin resistance induced by a high-fat diet in transgenic rabbits.; 2004 ANNOUNCEMENT INFO.; Diabetologia, 47, 1202-1209 AUTHOR; Kitajima S, Morimoto M, Liu E, Koike T, Higaki Y, Taura Y, Mamba K, Itamoto K, Tsutsumi K. , Yamada N, Watanabe T, and Fan J
Overexpression of Lipoprotein lipase in transgenic Watanabe heritable hyperlipidemic rabbits improves hyperlipidemia and obesity.; 2004 ANNOUNCEMENT INFO.; J. Biol. Chem., 279, 7521-7529 AUTHOR; Koike T, Liang J, Wang X, Ichikawa T, Shiomi M, Liu G, Sun H, Kitajima S, Morimoto M, Watanabe T, Yamada N, and Fan J
Overexpression of human matrix metalloproteinase-12 enhances the development of inflammatory arthritis in transgenic rabbits.; 2004 ANNOUNCEMENT INFO.; Am. J. Pathol., 165, 1375-1383 AUTHOR; Wang X, Liang J, Koike T, Sun H, Ichikawa T, Kitajima S, Morimoto M, Shikama H, Watanabe T, Sasaguri Y, and Fan J
General Lectures
The Glucose tolerance test in lipoprotein lipase transgenic rabbit; 2003/05 ANNOUNCEMENT INFO.; The 50th annual meeting of the Japanese association for laboratory
animal science. 2003. 5. 29-31. Exp. Anim. 52(3):suppl., S75. AUTHOR; Kitajima S, Morimoto M, Liu E, Koike T, Fan J
Review Articles
Strategies for highly efficient rabbit sperm cryopreservation; 2021/04 ANNOUNCEMENT INFO.; Animals, 11, 5, 1220 AUTHOR; Nishijima, K., Kitajima, S., Matsuhisa, F., Niimi, M., Wang, C-C., Fan, J.
Transgenic rabbit models: Now and the future.; 2020/10 ANNOUNCEMENT INFO.; Appl. Sci., 10, 21, 7416 AUTHOR; Matsuhisa, F., Kitajima, S., Nishijima, K., Akiyoshi, T., Morimoto, M., Fan, J.
Rabbit models for the study of human atherosclerosis: From pathophysiological mechanisms to translational medicine; 2015/10 ANNOUNCEMENT INFO.; Pharmacology & Therapeutics, 146, 104-119 AUTHOR; Fan, J., Kitajima, S., Watanabe, T., Xuc, J., Zhang, J., Liu, E., Chen, Y.E.
Transgenic Rabbits: Production and Application for Human Disease Models.; 2003 ANNOUNCEMENT INFO.; Recent Res. Devel. Biophys. Biochem., 3, 179-194 AUTHOR; Kitajima S, Morimoto M,Watanabe T, Fan J
Invited Lecture, Special Lecture
Cryopreservation of rabbit models for human disease as a bioresource; 2023/07 ANNOUNCEMENT INFO.; The International Conference on Animal Models for Cardiovascular Disease (ICAMCD 2023) AUTHOR; Fumikazu Matsuhisa, Toshiaki Akiyoshi and Shuji Kitajima
Cryopreservation of rabbit sperm; 2016/08 ANNOUNCEMENT INFO.; The 3rd Japan China Joint Rabbit Biotechnology Forum AUTHOR; Shuji Kitajima, Kazutoshi Nishijima, Enqi Liu, Tatsuhiro Maeda, Fumikazu Matsuhisa, Kan Matsuo, Toshiaki Akiyoshi, Masatoshi Morimoto, Jianglin Fan
Technology suitable for rabbit semen conservation; 2009/06 ANNOUNCEMENT INFO.; 3rd International Meeting on Rabbit Biotechnology AUTHOR; Kitajima, S., Maeda, T., Liu, E., Nishijima, K., Morimoto, M. and Watanabe, T.
Rabbit semen conservation; 2007/06 ANNOUNCEMENT INFO.; 2nd International Meeting on Rabbit Biotechnology (invited speaker) AUTHOR; Kitajima, S.