日本語フィールド
著者：Yuki Kurihara, Hiroki Tashiro, Yoshie Konomi, Hironori Sadamatsu, Satoshi Ihara, Shinya Kimura, Naoko Sueoka-Aragane, Koichiro Takahashi題名：Thymic stromal lymphopoietin contributes to ozone-induced exacerbations of eosinophilic airway inflammation via granulocyte colony-stimulating factor in mice (in press)発表情報：Allergology International 巻: 73 号: 2 ページ: 313-322キーワード：Asthma, Eosinophilic airway inflammation,
Granulocyte colony-stimulating factor, Ozone,
Thymic stromal lymphopoietin概要：抄録：Ozone is one of the triggers of asthma however, impact for pathophysiology of asthma such as airway inflammation and airway hyperresponsiveness (AHR) is not fully understood. Thymic stromal lymphopoietin (TSLP) is increasingly focused a crucial molecule associated with severity of asthma such as corticosteroid resistance. In the present study, ozone exposure induced augmentation of eosinophilic airway inflammation and AHR in mice sensitized and challenged with house dust mite (HDM). Additionally, TSLP but not IL-33 and IL-25 was increased in lung by ozone exposure. To confirm whether TSLP signal is associated with the airway responses to ozone, administration of anti-TSLP antibody induced significantly attenuation of eosinophilic airway inflammation but not AHR. Interestingly, granulocyte colony stimulating factor (G-CSF) but not type 2 cytokines such as IL-4, IL-5 and IL-13 was regulated by TSLP signal associated with eosinophilic airway inflammation and G-CSF directory involve to extend survival and activate function of adhesion for eosinophils. Present data will contribute greater understanding of ozone induced severity mechanisms for pathophysiology of asthma related to TSLP and G-CSF.英語フィールド
Author：Yuki Kurihara, Hiroki Tashiro, Yoshie Konomi, Hironori Sadamatsu, Satoshi Ihara, Shinya Kimura, Naoko Sueoka-Aragane, Koichiro TakahashiTitle：Thymic stromal lymphopoietin contributes to ozone-induced exacerbations of eosinophilic airway inflammation via granulocyte colony-stimulating factor in mice (in press)Announcement information:Allergology International Vol: 73 Issue: 2 Page: 313-322Keyword：Asthma, Eosinophilic airway inflammation,
Granulocyte colony-stimulating factor, Ozone,
Thymic stromal lymphopoietinAn abstract：Ozone is one of the triggers of asthma however, impact for pathophysiology of asthma such as airway inflammation and airway hyperresponsiveness (AHR) is not fully understood. Thymic stromal lymphopoietin (TSLP) is increasingly focused a crucial molecule associated with severity of asthma such as corticosteroid resistance. In the present study, ozone exposure induced augmentation of eosinophilic airway inflammation and AHR in mice sensitized and challenged with house dust mite (HDM). Additionally, TSLP but not IL-33 and IL-25 was increased in lung by ozone exposure. To confirm whether TSLP signal is associated with the airway responses to ozone, administration of anti-TSLP antibody induced significantly attenuation of eosinophilic airway inflammation but not AHR. Interestingly, granulocyte colony stimulating factor (G-CSF) but not type 2 cytokines such as IL-4, IL-5 and IL-13 was regulated by TSLP signal associated with eosinophilic airway inflammation and G-CSF directory involve to extend survival and activate function of adhesion for eosinophils. Present data will contribute greater understanding of ozone induced severity mechanisms for pathophysiology of asthma related to TSLP and G-CSF.