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Perceived stress, depressive symptoms, and cortisol-to-cortisone ratio in spot urine in 6878 older adults

発表形態:
原著論文
主要業績:
主要業績
単著・共著:
共著
発表年月:
2021年03月
DOI:
10.1016/j.psyneuen.2020.105125
会議属性:
指定なし
査読:
有り
リンク情報:

日本語フィールド

著者:
○Chisato Shimanoe, Akiko Matsumoto, Megumi Hara, Chiho Akao, Yuichiro Nishida, Mikako Horita, Hinako Nanri, Yasuki Higaki, Keitaro Tanaka
題名:
Perceived stress, depressive symptoms, and cortisol-to-cortisone ratio in spot urine in 6878 older adults
発表情報:
Psychoneuroendocrinology 巻: 125 ページ: 105125
キーワード:
11β-HSD; Cortisol; Cortisone; Depressive symptoms; Perceived stress; Spot urine
概要:
Background: Late life depression and perceived stress could influence disease pathways via reduced 11β-HSD2 activity, particularly given suggestions that reduced 11β-HSD2 activity, which is reflected in the cortisol-to-cortisone ratio, is a risk factor of disease. To date, however, examination of the relationship between the cortisol-to-cortisone ratio and perceived stress or depressive symptoms is insufficient. Methods: We examined the cross-sectional association of the cortisol-to-cortisone ratio with perceived stress and depressive symptoms, and analyzed whether cortisol levels modify this association, in 6878 participants aged 45-74 years. Cortisol and cortisone in spot urine were measured using liquid chromatography-mass spectrometry. Perceived stress during the past year was measured using a self-reported questionnaire. Depressive symptoms were evaluated using the Zung Self-Rating Depression Scale. Analyses were performed with adjustment for age, sex, lifestyle factors (smoking habit, alcohol consumption, physical activity, and sleeping hours), and physical health factors (body mass index [kg/m2] and medical history [diabetes, hypertension, and medication for hyperlipidemia or corticosteroids]). Results: Cortisol-to-cortisone ratio and cortisol were positively associated with perceived stress (% change: 2.33, Ptrend = 0.003; and 4.74, Ptrend = 0.001, respectively), but were not significantly associated with depressive symptoms. Further, the relationship between cortisol-to-cortisone ratio and perceived stress was modified by cortisol level and sex: the positive association between perceived stress and the cortisol-to-cortisone ratio was more evident in subjects with lower cortisol levels (Pinteraction = 0.009) and in men (Pinteraction = 0.026). Conclusions: These findings suggest that the cortisol-to-cortisone ratio in spot urine may be a useful marker for non-acute perceived stress in daily life against a possible background of reduced 11β-HSD2 in older adults.
抄録:

英語フィールド

Author:
○Chisato Shimanoe, Akiko Matsumoto, Megumi Hara, Chiho Akao, Yuichiro Nishida, Mikako Horita, Hinako Nanri, Yasuki Higaki, Keitaro Tanaka
Title:
Perceived stress, depressive symptoms, and cortisol-to-cortisone ratio in spot urine in 6878 older adults
Announcement information:
Psychoneuroendocrinology Vol: 125 Page: 105125
Keyword:
11β-HSD; Cortisol; Cortisone; Depressive symptoms; Perceived stress; Spot urine
An abstract:
Background: Late life depression and perceived stress could influence disease pathways via reduced 11β-HSD2 activity, particularly given suggestions that reduced 11β-HSD2 activity, which is reflected in the cortisol-to-cortisone ratio, is a risk factor of disease. To date, however, examination of the relationship between the cortisol-to-cortisone ratio and perceived stress or depressive symptoms is insufficient. Methods: We examined the cross-sectional association of the cortisol-to-cortisone ratio with perceived stress and depressive symptoms, and analyzed whether cortisol levels modify this association, in 6878 participants aged 45-74 years. Cortisol and cortisone in spot urine were measured using liquid chromatography-mass spectrometry. Perceived stress during the past year was measured using a self-reported questionnaire. Depressive symptoms were evaluated using the Zung Self-Rating Depression Scale. Analyses were performed with adjustment for age, sex, lifestyle factors (smoking habit, alcohol consumption, physical activity, and sleeping hours), and physical health factors (body mass index [kg/m2] and medical history [diabetes, hypertension, and medication for hyperlipidemia or corticosteroids]). Results: Cortisol-to-cortisone ratio and cortisol were positively associated with perceived stress (% change: 2.33, Ptrend = 0.003; and 4.74, Ptrend = 0.001, respectively), but were not significantly associated with depressive symptoms. Further, the relationship between cortisol-to-cortisone ratio and perceived stress was modified by cortisol level and sex: the positive association between perceived stress and the cortisol-to-cortisone ratio was more evident in subjects with lower cortisol levels (Pinteraction = 0.009) and in men (Pinteraction = 0.026). Conclusions: These findings suggest that the cortisol-to-cortisone ratio in spot urine may be a useful marker for non-acute perceived stress in daily life against a possible background of reduced 11β-HSD2 in older adults.


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