日本語フィールド
著者：Yuichiro Nishida; Tsuyoshi Hachiya; Megumi Hara; Chisato Shimanoe; Keitaro Tanaka; Yoichi Sutoh; Atsushi Shimizu; Asahi Hishida; Mineko Tsukamoto; Yuka Kadomatsu; Isao Oze; Yuriko N. Koyanagi; Nagato Kuriyama; Teruhide Koyama; Rie Ibusuki; Toshiro Takezaki; Hiroaki Ikezaki; Norihiro Furusyo; Naoyuki Takashima; Aya Kadota; Hirokazu Uemura; Sakurako Katsuura-Kamano; Sadao Suzuki; Hiroko Nakagawa-Senda; Kiyonori Kuriki; Haruo Mikami; Yohko Nakamura; Yukihide Momozawa; Michiaki Kubo; Masahiro Nakatochi; Mariko Naito; Kenji Wakai題名：The interaction between ABCA1 polymorphism and physical activity on the HDL-cholesterol levels in a Japanese population発表情報：Journal of Lipid Research 巻: 61 号: 1 ページ: 86-94キーワード：概要：Few studies have investigated the interactions between HDL-C-related SNPs identified by genome-wide association (GWA) study and physical activity (PA) on HDL-C. First, we conducted a sex-stratified GWA study in a discovery sample (2,231 men and 2,431 women) and replication sample (2,599 men and 3,109 women) to identify SNPs influencing log-transformed HDL-C in Japanese participants in the baseline survey of the Japan Multi-Institutional Collaborative Cohort Study. We also replicated previously reported HDL-C-related SNPs in a combined (discovery plus replication) sample (4,830 men and 5,540 women). We then analyzed the interactions of the HDL-C-related SNPs with PA on HDL-C. The sex-stratified GWA analyses identified 11 and 10 HDL-C-related SNPs in men and women as targets for an interaction analysis. Among these, only one interaction of ABCA1 rs1883025 with PA was statistically significant in men, after Bonferroni correction [P-interaction = 0.001 (α = 0.05/21 = 0.002)]. The per-major-allele (C allele) increase in log-transformed HDL-C was lost in men with low PA (β = 0.008) compared with those with medium (β = 0.032) or high PA (β = 0.034). These findings suggest that the benefit of carrying a C allele of ABCA1 rs1883025 on enhancing HDL-C may be attenuated in inactive men.抄録：英語フィールド
Author：Yuichiro Nishida; Tsuyoshi Hachiya; Megumi Hara; Chisato Shimanoe; Keitaro Tanaka; Yoichi Sutoh; Atsushi Shimizu; Asahi Hishida; Mineko Tsukamoto; Yuka Kadomatsu; Isao Oze; Yuriko N. Koyanagi; Nagato Kuriyama; Teruhide Koyama; Rie Ibusuki; Toshiro Takezaki; Hiroaki Ikezaki; Norihiro Furusyo; Naoyuki Takashima; Aya Kadota; Hirokazu Uemura; Sakurako Katsuura-Kamano; Sadao Suzuki; Hiroko Nakagawa-Senda; Kiyonori Kuriki; Haruo Mikami; Yohko Nakamura; Yukihide Momozawa; Michiaki Kubo; Masahiro Nakatochi; Mariko Naito; Kenji WakaiTitle：The interaction between ABCA1 polymorphism and physical activity on the HDL-cholesterol levels in a Japanese populationAnnouncement information:Journal of Lipid Research Vol: 61 Issue: 1 Page: 86-94An abstract：Few studies have investigated the interactions between HDL-C-related SNPs identified by genome-wide association (GWA) study and physical activity (PA) on HDL-C. First, we conducted a sex-stratified GWA study in a discovery sample (2,231 men and 2,431 women) and replication sample (2,599 men and 3,109 women) to identify SNPs influencing log-transformed HDL-C in Japanese participants in the baseline survey of the Japan Multi-Institutional Collaborative Cohort Study. We also replicated previously reported HDL-C-related SNPs in a combined (discovery plus replication) sample (4,830 men and 5,540 women). We then analyzed the interactions of the HDL-C-related SNPs with PA on HDL-C. The sex-stratified GWA analyses identified 11 and 10 HDL-C-related SNPs in men and women as targets for an interaction analysis. Among these, only one interaction of ABCA1 rs1883025 with PA was statistically significant in men, after Bonferroni correction [P-interaction = 0.001 (α = 0.05/21 = 0.002)]. The per-major-allele (C allele) increase in log-transformed HDL-C was lost in men with low PA (β = 0.008) compared with those with medium (β = 0.032) or high PA (β = 0.034). These findings suggest that the benefit of carrying a C allele of ABCA1 rs1883025 on enhancing HDL-C may be attenuated in inactive men.