日本語フィールド
著者：○C. Shimanoe; T. Hachiya; M. Hara; Y. Nishida; K. Tanaka; Y. Sutoh; A. Shimizu; A. Hishida; S. Kawai; R. Okada; T. Tamura; K. Matsuo; H. Ito; E. Ozaki; D. Matsui; R. Ibusuki; I. Shimoshikiryo; N. Takashima; A. Kadota; K. Arisawa; H. Uemura; S. Suzuki; M. Watanabe; K. Kuriki; K. Endoh; H. Mikami; Y. Nakamura; Y. Momozawa; M. Kubo; M. Nakatochi; M. Naito; K. Wakai題名：A genome-wide association study of coping behaviors suggests FBXO45 is associated with emotional expression発表情報：Genes, Brain and Behavior 巻: 18 号: 2 ページ: e12481キーワード：概要：Individuals use coping behaviors to deal with unpleasant daily events. Such behaviors can moderate or mediate the pathway between psychosocial stress and health-related outcomes. However, few studies have examined the associations between coping behaviors and genetic variants. We conducted a genome-wide association study (GWAS) on coping behaviors in 14088 participants aged 35 to 69 years as part of the Japan Multi-Institutional Collaborative Cohort Study. Five coping behaviors (emotional expression, emotional support seeking, positive reappraisal, problem solving and disengagement) were measured and analyzed. A GWAS analysis was performed using a mixed linear model adjusted for study area, age and sex. Variants with suggestive significance in the discovery phase (N = 6403) were further examined in the replication phase (N = 7685). We then combined variant-level association evidence into gene-level evidence using a gene-based analysis. The results showed a significant genetic contribution to emotional expression and disengagement, with an estimation that the 19.5% and 6.6% variance in the liability-scale was explained by common variants. In the discovery phase, 12 variants met suggestive significance (P < 1 × 10-6 ) for association with the coping behaviors and perceived stress. However, none of these associations were confirmed in the replication stage. In gene-based analysis, FBXO45, a gene with regulatory roles in synapse maturation, was significantly associated with emotional expression after multiple corrections (P < 3.1 × 10-6 ). In conclusion, our results showed the existence of up to 20% genetic contribution to coping behaviors. Moreover, our gene-based analysis using GWAS data suggests that genetic variations in FBXO45 are associated with emotional expression.抄録：英語フィールド
Author：○C. Shimanoe; T. Hachiya; M. Hara; Y. Nishida; K. Tanaka; Y. Sutoh; A. Shimizu; A. Hishida; S. Kawai; R. Okada; T. Tamura; K. Matsuo; H. Ito; E. Ozaki; D. Matsui; R. Ibusuki; I. Shimoshikiryo; N. Takashima; A. Kadota; K. Arisawa; H. Uemura; S. Suzuki; M. Watanabe; K. Kuriki; K. Endoh; H. Mikami; Y. Nakamura; Y. Momozawa; M. Kubo; M. Nakatochi; M. Naito; K. WakaiTitle：A genome-wide association study of coping behaviors suggests FBXO45 is associated with emotional expressionAnnouncement information:Genes, Brain and Behavior Vol: 18 Issue: 2 Page: e12481An abstract：Individuals use coping behaviors to deal with unpleasant daily events. Such behaviors can moderate or mediate the pathway between psychosocial stress and health-related outcomes. However, few studies have examined the associations between coping behaviors and genetic variants. We conducted a genome-wide association study (GWAS) on coping behaviors in 14088 participants aged 35 to 69 years as part of the Japan Multi-Institutional Collaborative Cohort Study. Five coping behaviors (emotional expression, emotional support seeking, positive reappraisal, problem solving and disengagement) were measured and analyzed. A GWAS analysis was performed using a mixed linear model adjusted for study area, age and sex. Variants with suggestive significance in the discovery phase (N = 6403) were further examined in the replication phase (N = 7685). We then combined variant-level association evidence into gene-level evidence using a gene-based analysis. The results showed a significant genetic contribution to emotional expression and disengagement, with an estimation that the 19.5% and 6.6% variance in the liability-scale was explained by common variants. In the discovery phase, 12 variants met suggestive significance (P < 1 × 10-6 ) for association with the coping behaviors and perceived stress. However, none of these associations were confirmed in the replication stage. In gene-based analysis, FBXO45, a gene with regulatory roles in synapse maturation, was significantly associated with emotional expression after multiple corrections (P < 3.1 × 10-6 ). In conclusion, our results showed the existence of up to 20% genetic contribution to coping behaviors. Moreover, our gene-based analysis using GWAS data suggests that genetic variations in FBXO45 are associated with emotional expression.