日本語フィールド
著者：Yuichiro Nishida, Takeshi Matsubara, Takuro Tobina, Munehiro Shindo, Kumpei Tokuyama, Keitaro Tanaka, and Hiroaki Tanaka題名：Effect of low-intensity aerobic exercise on insulin-like growth factor-I and insulin-like growth factor-binding proteins in healthy men発表情報：International Journal of Endocrinology 巻: doi:10.1155/2010/452820キーワード：IGF-I, IGFBP-1, insulin sensitivity, mild training exercise概要：抄録：Increased concentrations of circulating insulin-like growth factor-I (IGF-I) or IGF-I relative to IGF-binding proteins (IGFBPs) are associated with increased risk of developing several forms of cancer. Conversely, exercise is linked with reduced risk. This study aims to investigate the effect of a low-intensity exercise program on circulating levels of IGF-I, IGFBP-1, and IGFBP-3, in previously sedentary males. Fourteen healthy men participated in cycle ergometer training at lactate threshold intensity for 60 min/day, 5 days/week for 6 weeks. After aerobic training, insulin sensitivity improved by 20%, while fasting insulin levels decreased by 13%. Simultaneously, low-intensity aerobic training decreased circulating levels of IGF-I by 9%, while IGFBP-1 levels increased by 16%. An interesting finding was that higher pre-training level of IGF-I was associated with greater decline in IGF-I with training. Insulin-sensitizing low-intensity aerobic exercise is thus considered to be an effective method for down-regulating IGF-I and up-regulating IGFBP-1 levels.英語フィールド
Author：Yuichiro Nishida, Takeshi Matsubara, Takuro Tobina, Munehiro Shindo, Kumpei Tokuyama, Keitaro Tanaka, and Hiroaki TanakaTitle：Effect of low-intensity aerobic exercise on insulin-like growth factor-I and insulin-like growth factor-binding proteins in healthy menAnnouncement information:International Journal of Endocrinology Vol: doi:10.1155/2010/452820Keyword：IGF-I, IGFBP-1, insulin sensitivity, mild training exerciseAn abstract：Increased concentrations of circulating insulin-like growth factor-I (IGF-I) or IGF-I relative to IGF-binding proteins (IGFBPs) are associated with increased risk of developing several forms of cancer. Conversely, exercise is linked with reduced risk. This study aims to investigate the effect of a low-intensity exercise program on circulating levels of IGF-I, IGFBP-1, and IGFBP-3, in previously sedentary males. Fourteen healthy men participated in cycle ergometer training at lactate threshold intensity for 60 min/day, 5 days/week for 6 weeks. After aerobic training, insulin sensitivity improved by 20%, while fasting insulin levels decreased by 13%. Simultaneously, low-intensity aerobic training decreased circulating levels of IGF-I by 9%, while IGFBP-1 levels increased by 16%. An interesting finding was that higher pre-training level of IGF-I was associated with greater decline in IGF-I with training. Insulin-sensitizing low-intensity aerobic exercise is thus considered to be an effective method for down-regulating IGF-I and up-regulating IGFBP-1 levels.