日本語フィールド
著者：*Risa Kudo, Masayuki Sekine, Manako Yamaguchi, Megumi Hara, Sharon J B Hanley, Megumi Kurosawa, Sosuke Adachi, Yutaka Ueda, Etsuko Miyagi, Sayaka Ikeda, Asami Yagi, Takayuki Enomoto題名：Effectiveness of human papillomavirus vaccine against cervical precancer in Japan: Multivariate analyses adjusted for sexual activity発表情報：Cancer Sci 巻: 113 号: 9 ページ: 3211-3220キーワード：HPV infection; HPV vaccine; cervical cancer; cytological abnormality; sexual activity概要：Japanese girls aged 12-16 years are offered free HPV vaccination and cervical cancer screening is conducted with cytology and not HPV testing from the age of 20 years. So far, no study has analyzed the effect of HPV vaccination against cervical precancers considering HPV infection status and sexual activity. We aimed to analyze the vaccine effectiveness (VE) against HPV infection and cytological abnormalities, adjusted for sexual activity. This study was comprised of women aged 20-26 years who underwent cervical screening in Niigata. We obtained HPV vaccination status from municipal records and a questionnaire along with information concerning sexual activity. Of 5,194 women registered for this study, final analyses included 3,167 women in the vaccinated group (2,821 vaccinated women prior to sexual debut) and 1,386 women in the unvaccinated group. HPV 16/18 (0.2% vs 3.5%), 31/45/52 (3.4% vs 6.6%) and 31/33/45/52/58 (5.0% vs 9.3%) positive rates were significantly lower in the vaccinated group (p < 0.001). No women vaccinated before sexual debut had HPV 16/18 related cytological abnormalities. VE for HPV 16/18 infection and high-grade cytological abnormalities in women vaccinated prior to sexual debut were 95.8% (95% CI 81.9-99.0%; p < 0.001) and 78.3% (95% CI 11.3-94.7%; p = 0.033), respectively, in multivariate analyses adjusted for age and the number of sexual partners. However, analyses of all vaccinated women did not show significant effectiveness against cytological abnormalities. Our results showed the effectiveness of HPV vaccine against high-grade cervical cytological abnormalities and the importance of the vaccination before sexual debut.抄録：英語フィールド
Author：*Risa Kudo, Masayuki Sekine, Manako Yamaguchi, Megumi Hara, Sharon J B Hanley, Megumi Kurosawa, Sosuke Adachi, Yutaka Ueda, Etsuko Miyagi, Sayaka Ikeda, Asami Yagi, Takayuki EnomotoTitle：Effectiveness of human papillomavirus vaccine against cervical precancer in Japan: Multivariate analyses adjusted for sexual activityAnnouncement information:Cancer Sci Vol: 113 Issue: 9 Page: 3211-3220Keyword：HPV infection; HPV vaccine; cervical cancer; cytological abnormality; sexual activityAn abstract：Japanese girls aged 12-16 years are offered free HPV vaccination and cervical cancer screening is conducted with cytology and not HPV testing from the age of 20 years. So far, no study has analyzed the effect of HPV vaccination against cervical precancers considering HPV infection status and sexual activity. We aimed to analyze the vaccine effectiveness (VE) against HPV infection and cytological abnormalities, adjusted for sexual activity. This study was comprised of women aged 20-26 years who underwent cervical screening in Niigata. We obtained HPV vaccination status from municipal records and a questionnaire along with information concerning sexual activity. Of 5,194 women registered for this study, final analyses included 3,167 women in the vaccinated group (2,821 vaccinated women prior to sexual debut) and 1,386 women in the unvaccinated group. HPV 16/18 (0.2% vs 3.5%), 31/45/52 (3.4% vs 6.6%) and 31/33/45/52/58 (5.0% vs 9.3%) positive rates were significantly lower in the vaccinated group (p < 0.001). No women vaccinated before sexual debut had HPV 16/18 related cytological abnormalities. VE for HPV 16/18 infection and high-grade cytological abnormalities in women vaccinated prior to sexual debut were 95.8% (95% CI 81.9-99.0%; p < 0.001) and 78.3% (95% CI 11.3-94.7%; p = 0.033), respectively, in multivariate analyses adjusted for age and the number of sexual partners. However, analyses of all vaccinated women did not show significant effectiveness against cytological abnormalities. Our results showed the effectiveness of HPV vaccine against high-grade cervical cytological abnormalities and the importance of the vaccination before sexual debut.