日本語フィールド
著者：*Takashi Tamura, Nagato Kuriyama, Teruhide Koyama, Etsuko Ozaki, Daisuke Matsui, Yuka Kadomatsu, Mineko Tsukamoto, Yoko Kubo, Rieko Okada, Asahi Hishida, Tae Sasakabe, Sayo Kawai, Mariko Naito, Naoyuki Takashima, Aya Kadota, Keitaro Tanaka, Megumi Hara, Sadao Suzuki, Hiroko Nakagawa-Senda, Toshiro Takezaki, Ippei Shimoshikiryo, Hiroaki Ikezaki, Masayuki Murata, Isao Oze, Hidemi Ito, Haruo Mikami, Yohko Nakamura, Kiyonori Kuriki, Kokichi Arisawa, Hirokazu Uemura, Kenji Takeuchi, Kenji Wakai題名：Association between plasma levels of homocysteine, folate, and vitamin B 12, and dietary folate intake and hypertension in a cross-sectional study発表情報：Sci Rep 巻: 10 号: 1 ページ: 18499キーワード：概要：There are few studies examining the association between homocysteine (Hcy) level and the risk of hypertension with consideration for folate and vitamin B12 as related to Hcy level. We simultaneously examined the associations of plasma levels of Hcy, folate, and vitamin B12, and dietary folate intake with the prevalence of hypertension. Participants included 1046 men and 1033 women (mean age ± standard deviation: 56.0 ± 8.9 years) in the Japan Multi-Institutional Collaborative Cohort Study. Dietary folate intake was estimated using a validated food frequency questionnaire. Hypertension was defined based on measured blood pressure and use of antihypertensive medication. A total of 734 participants (35.3%) had hypertension. Multivariate-adjusted odds ratios of hypertension for the highest quartile group of Hcy were 2.36 (95% CI 1.41-3.96) in men and 1.86 (95% CI 1.11-3.11) in women, as compared with the lowest group (P for trend = 0.014 and 0.005, respectively). Dietary folate intake was not correlated with hypertension in both men and women (P for trend = 0.099 and 0.703, respectively). Plasma vitamin B12 was positively associated with hypertension only in women (P for trend = 0.027). Plasma Hcy level was positively linked with hypertension after controlling for covariates, including folate and vitamin B12.抄録：英語フィールド
Author：*Takashi Tamura, Nagato Kuriyama, Teruhide Koyama, Etsuko Ozaki, Daisuke Matsui, Yuka Kadomatsu, Mineko Tsukamoto, Yoko Kubo, Rieko Okada, Asahi Hishida, Tae Sasakabe, Sayo Kawai, Mariko Naito, Naoyuki Takashima, Aya Kadota, Keitaro Tanaka, Megumi Hara, Sadao Suzuki, Hiroko Nakagawa-Senda, Toshiro Takezaki, Ippei Shimoshikiryo, Hiroaki Ikezaki, Masayuki Murata, Isao Oze, Hidemi Ito, Haruo Mikami, Yohko Nakamura, Kiyonori Kuriki, Kokichi Arisawa, Hirokazu Uemura, Kenji Takeuchi, Kenji WakaiTitle：Association between plasma levels of homocysteine, folate, and vitamin B 12, and dietary folate intake and hypertension in a cross-sectional studyAnnouncement information:Sci Rep Vol: 10 Issue: 1 Page: 18499An abstract：There are few studies examining the association between homocysteine (Hcy) level and the risk of hypertension with consideration for folate and vitamin B12 as related to Hcy level. We simultaneously examined the associations of plasma levels of Hcy, folate, and vitamin B12, and dietary folate intake with the prevalence of hypertension. Participants included 1046 men and 1033 women (mean age ± standard deviation: 56.0 ± 8.9 years) in the Japan Multi-Institutional Collaborative Cohort Study. Dietary folate intake was estimated using a validated food frequency questionnaire. Hypertension was defined based on measured blood pressure and use of antihypertensive medication. A total of 734 participants (35.3%) had hypertension. Multivariate-adjusted odds ratios of hypertension for the highest quartile group of Hcy were 2.36 (95% CI 1.41-3.96) in men and 1.86 (95% CI 1.11-3.11) in women, as compared with the lowest group (P for trend = 0.014 and 0.005, respectively). Dietary folate intake was not correlated with hypertension in both men and women (P for trend = 0.099 and 0.703, respectively). Plasma vitamin B12 was positively associated with hypertension only in women (P for trend = 0.027). Plasma Hcy level was positively linked with hypertension after controlling for covariates, including folate and vitamin B12.