日本語フィールド
著者：Rintaro Sogawa, Chiho Nakashima, Tomomi Nakamura, Koji Takeuchi, Sakiko Kimura, Kazutoshi Komiya, Yutaka Narisawa, Shinya Kimura, Naoko Sueoka-Aragane題名：Association of Genetic Polymorphisms With Afatinib-induced Diarrhoea発表情報：In Vivo 巻: 34 号: 3 ページ: 1415-1419キーワード：概要：Background/aim: Afatinib, a 2nd generation epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) used in treatment of non-small cell lung cancer (NSCLC), causes diarrhoea in over 90% of patients. The association of genetic background with diarrhoea is poorly understood.
Patients and methods: We evaluated the roles of four single nucleotide polymorphisms (SNPs) in ATP binding cassette subfamily B member 1 (ABCB1) and ATP binding cassette subfamily G member 2 (ABCG2) genes-ABCB1 1236 C>T, 2677 G>T/A, and 3435 C>T, and ABCG2 421 C>A-on treatment-induced diarrhoea in 38 patients with NSCLC treated with afatinib.
Results: Diarrhoea occurred more frequently in patients with ABCB1 2677 T(A)/T(A) (14/16, 87.5%) than in patients with non-T(A)/T(A) alleles (8/22, 36.4%) (p=0.003). ABCB1 2677 T(A)/T(A) was significantly predictive of diarrhoea (p=0.002) by multivariable regression analysis.
Conclusion: Afatinib-induced diarrhoea is associated with the SNP ABCB1 2677 T(A)/T(A).抄録：英語フィールド
Author：Rintaro Sogawa, Chiho Nakashima, Tomomi Nakamura, Koji Takeuchi, Sakiko Kimura, Kazutoshi Komiya, Yutaka Narisawa, Shinya Kimura, Naoko Sueoka-AraganeTitle：Association of Genetic Polymorphisms With Afatinib-induced DiarrhoeaAnnouncement information:In Vivo Vol: 34 Issue: 3 Page: 1415-1419An abstract：Background/aim: Afatinib, a 2nd generation epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) used in treatment of non-small cell lung cancer (NSCLC), causes diarrhoea in over 90% of patients. The association of genetic background with diarrhoea is poorly understood.
Patients and methods: We evaluated the roles of four single nucleotide polymorphisms (SNPs) in ATP binding cassette subfamily B member 1 (ABCB1) and ATP binding cassette subfamily G member 2 (ABCG2) genes-ABCB1 1236 C>T, 2677 G>T/A, and 3435 C>T, and ABCG2 421 C>A-on treatment-induced diarrhoea in 38 patients with NSCLC treated with afatinib.
Results: Diarrhoea occurred more frequently in patients with ABCB1 2677 T(A)/T(A) (14/16, 87.5%) than in patients with non-T(A)/T(A) alleles (8/22, 36.4%) (p=0.003). ABCB1 2677 T(A)/T(A) was significantly predictive of diarrhoea (p=0.002) by multivariable regression analysis.
Conclusion: Afatinib-induced diarrhoea is associated with the SNP ABCB1 2677 T(A)/T(A).