日本語フィールド
著者：*Takashi Tamura, Kenji Wakai, Yingsong Lin, Akiko Tamakoshi, Mai Utada, Kotaro Ozasa, Yumi Sugawara, Ichiro Tsuji, Ayami Ono, Norie Sawada, Shoichiro Tsugane, Hidemi Ito, Chisato Nagata, Tetsuhisa Kitamura, Mariko Naito, Keitaro Tanaka, Taichi Shimazu, Tetsuya Mizoue, Keitaro Matsuo, Mamami Inoue, Research Group for the Development and Evaluation of Cancer Prevention Strategies in Japan題名：Alcohol intake and stomach cancer risk in Japan: a pooled analysis of six cohort studies 発表情報：Cancer Sci 巻: 113 号: 1 ページ: 261-276キーワード：Japan; alcohol intake; cohort study; pooled analysis; stomach cancer概要：The association between alcohol intake and stomach cancer risk remains controversial. We therefore performed a pooled analysis of data from six large-scale Japanese cohort studies with 256,478 participants on this topic. Alcohol intake as ethanol was estimated using a validated questionnaire. The participants were followed for incidence of stomach cancer. We calculated study-specific hazard ratios (HRs) and 95% confidence intervals (CIs) for stomach cancer according to alcohol intake using a Cox regression model. Summary HRs were estimated by pooling the study-specific HRs using a random-effects model. During 4,265,551 person-years of follow-up, 8,586 stomach cancer cases were identified. In men, the multivariate-adjusted HRs (95% CIs) of stomach cancer were 1.00 (0.87-1.15) for occasional drinkers, and 1.00 (0.91-1.11) for <23 g/day, 1.09 (1.01-1.18) for 23 to <46 g/day, 1.18 (1.09-1.29) for 46 to <69 g/day, 1.21 (1.05-1.39) for 69 to <92 g/day, and 1.29 (1.11-1.51) for ?92 g/day ethanol in regular drinkers compared with nondrinkers. In women, the multivariate-adjusted HRs were 0.93 (0.80-1.08) for occasional drinkers, and 0.85 (0.74-0.99) for <23 g/day, and 1.22 (0.98-1.53) for ?23 g/day in regular drinkers compared with nondrinkers. The HRs for proximal and distal cancer in drinkers versus nondrinkers were 1.69 (1.15-2.47) and 1.24 (0.99-1.55) for ?92 g/day in men, and 1.60 (0.76-3.37) and 1.18 (0.88-1.57) for ?23 g/day in women, respectively. Alcohol intake increased stomach cancer risk in men, and heavy drinkers showed a greater point estimate of risk for proximal cancer than for distal cancer. 抄録：英語フィールド
Author：*Takashi Tamura, Kenji Wakai, Yingsong Lin, Akiko Tamakoshi, Mai Utada, Kotaro Ozasa, Yumi Sugawara, Ichiro Tsuji, Ayami Ono, Norie Sawada, Shoichiro Tsugane, Hidemi Ito, Chisato Nagata, Tetsuhisa Kitamura, Mariko Naito, Keitaro Tanaka, Taichi Shimazu, Tetsuya Mizoue, Keitaro Matsuo, Mamami Inoue, Research Group for the Development and Evaluation of Cancer Prevention Strategies in JapanTitle：Alcohol intake and stomach cancer risk in Japan: a pooled analysis of six cohort studies Announcement information:Cancer Sci Vol: 113 Issue: 1 Page: 261-276Keyword：Japan; alcohol intake; cohort study; pooled analysis; stomach cancerAn abstract：The association between alcohol intake and stomach cancer risk remains controversial. We therefore performed a pooled analysis of data from six large-scale Japanese cohort studies with 256,478 participants on this topic. Alcohol intake as ethanol was estimated using a validated questionnaire. The participants were followed for incidence of stomach cancer. We calculated study-specific hazard ratios (HRs) and 95% confidence intervals (CIs) for stomach cancer according to alcohol intake using a Cox regression model. Summary HRs were estimated by pooling the study-specific HRs using a random-effects model. During 4,265,551 person-years of follow-up, 8,586 stomach cancer cases were identified. In men, the multivariate-adjusted HRs (95% CIs) of stomach cancer were 1.00 (0.87-1.15) for occasional drinkers, and 1.00 (0.91-1.11) for <23 g/day, 1.09 (1.01-1.18) for 23 to <46 g/day, 1.18 (1.09-1.29) for 46 to <69 g/day, 1.21 (1.05-1.39) for 69 to <92 g/day, and 1.29 (1.11-1.51) for ?92 g/day ethanol in regular drinkers compared with nondrinkers. In women, the multivariate-adjusted HRs were 0.93 (0.80-1.08) for occasional drinkers, and 0.85 (0.74-0.99) for <23 g/day, and 1.22 (0.98-1.53) for ?23 g/day in regular drinkers compared with nondrinkers. The HRs for proximal and distal cancer in drinkers versus nondrinkers were 1.69 (1.15-2.47) and 1.24 (0.99-1.55) for ?92 g/day in men, and 1.60 (0.76-3.37) and 1.18 (0.88-1.57) for ?23 g/day in women, respectively. Alcohol intake increased stomach cancer risk in men, and heavy drinkers showed a greater point estimate of risk for proximal cancer than for distal cancer. 