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Moderate-to-vigorous physical activity and sedentary behavior are independently associated with renal function: a cross-sectional study

発表形態:
原著論文
主要業績:
主要業績
単著・共著:
共著
発表年月:
2021年10月
DOI:
10.2188/jea.JE20210155
会議属性:
指定なし
査読:
有り
リンク情報:

日本語フィールド

著者:
Megumi Hara, Yuichiro Nishida, Keitaro Tanaka, Chisato Shimanoe, Kayoko Koga, Takuma Furukawa, Yasuki Higaki, Koichi Shinchi, Hiroaki Ikezaki, Masayuki Murata, Kenji Takeuchi, Takashi Tamura, Asahi Hishida, Mineko Tsukamoto, Yuka Kadomatsu, Keitaro Matsuo, Isao Oze, Mikami Haruo, Kusakabe Miho, Toshiro Takezaki, Rie Ibusuki, Sadao Suzuki, Hiroko Nakagawa-Senda, Daisuke Matsui, Teruhide Koyama, Kiyonori Kuriki, Naoyuki Takashima, Yasuyuki Nakamura, Kokichi Arisawa, Sakurako Katsuura-Kamano, Kenji Wakai
題名:
Moderate-to-vigorous physical activity and sedentary behavior are independently associated with renal function: a cross-sectional study
発表情報:
J Epidemiol
キーワード:
chronic kidney disease; glomerular filtration rate; isotemporal substitution model; physical activity; sedentary
概要:
Background: Little is known about whether insufficient moderate-to-vigorous physical activity (MVPA) and longer sedentary behavior (SB) are independently associated with estimated glomerular filtration rate (eGFR) and CKD, whether they interact with known risk factors for CKD, and the effect of replacing sedentary time with an equivalent duration of physical activity on kidney function. Methods: We examined the cross-sectional association of MVPA and SB with eGFR and CKD in 66,603 Japanese cohort study in 14 areas from 2004 to 2013. MVPA and SB were estimated using a self-reported questionnaire, and CKD was defined as eGFR<60 mL/min/1.73 m2. Multiple linear regression analyses, logistic regression analyses, and an isotemporal substitution model were applied. Results: After adjusting for potential confounders, higher MVPA and longer SB were independently associated with higher eGFR (Pfor trend MVPA<0.0001) and lower eGFR (Pfor trend SB<0.0001), and a lower odds ratio (OR) of CKD (adjusted OR of MVPA?20 MET?h/day: 0.76 [95%CI: 0.68-0.85] compared to MVPA<5 MET?h/day) and a higher OR of CKD (adjusted OR of SB?16 h/day: 1.81 [95%CI: 1.52-2.15] compared to SB<7 h/day), respectively. The negative association between MVPA and CKD was stronger in men, and significant interactions between sex and MVPA were detected. Replacing 1 hour of SB with 1 hour of physical activity was associated with about 3 to 4% lower OR of CKD. Conclusions: These findings indicate that replacing SB with physical activity may benefit kidney function, especially in men, adding to the possible evidence on CKD prevention.
抄録:

英語フィールド

Author:
Megumi Hara, Yuichiro Nishida, Keitaro Tanaka, Chisato Shimanoe, Kayoko Koga, Takuma Furukawa, Yasuki Higaki, Koichi Shinchi, Hiroaki Ikezaki, Masayuki Murata, Kenji Takeuchi, Takashi Tamura, Asahi Hishida, Mineko Tsukamoto, Yuka Kadomatsu, Keitaro Matsuo, Isao Oze, Mikami Haruo, Kusakabe Miho, Toshiro Takezaki, Rie Ibusuki, Sadao Suzuki, Hiroko Nakagawa-Senda, Daisuke Matsui, Teruhide Koyama, Kiyonori Kuriki, Naoyuki Takashima, Yasuyuki Nakamura, Kokichi Arisawa, Sakurako Katsuura-Kamano, Kenji Wakai
Title:
Moderate-to-vigorous physical activity and sedentary behavior are independently associated with renal function: a cross-sectional study
Announcement information:
J Epidemiol
Keyword:
chronic kidney disease; glomerular filtration rate; isotemporal substitution model; physical activity; sedentary
An abstract:
Background: Little is known about whether insufficient moderate-to-vigorous physical activity (MVPA) and longer sedentary behavior (SB) are independently associated with estimated glomerular filtration rate (eGFR) and CKD, whether they interact with known risk factors for CKD, and the effect of replacing sedentary time with an equivalent duration of physical activity on kidney function. Methods: We examined the cross-sectional association of MVPA and SB with eGFR and CKD in 66,603 Japanese cohort study in 14 areas from 2004 to 2013. MVPA and SB were estimated using a self-reported questionnaire, and CKD was defined as eGFR<60 mL/min/1.73 m2. Multiple linear regression analyses, logistic regression analyses, and an isotemporal substitution model were applied. Results: After adjusting for potential confounders, higher MVPA and longer SB were independently associated with higher eGFR (Pfor trend MVPA<0.0001) and lower eGFR (Pfor trend SB<0.0001), and a lower odds ratio (OR) of CKD (adjusted OR of MVPA?20 MET?h/day: 0.76 [95%CI: 0.68-0.85] compared to MVPA<5 MET?h/day) and a higher OR of CKD (adjusted OR of SB?16 h/day: 1.81 [95%CI: 1.52-2.15] compared to SB<7 h/day), respectively. The negative association between MVPA and CKD was stronger in men, and significant interactions between sex and MVPA were detected. Replacing 1 hour of SB with 1 hour of physical activity was associated with about 3 to 4% lower OR of CKD. Conclusions: These findings indicate that replacing SB with physical activity may benefit kidney function, especially in men, adding to the possible evidence on CKD prevention.


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