日本語フィールド
著者：Yuichiro Nishida 1 , Tsuyoshi Hachiya 2 , Megumi Hara 3 , Chisato Shimanoe 4 , Keitaro Tanaka 3 , Yoichi Sutoh 2 , Atsushi Shimizu 2 , Asahi Hishida 5 , Mineko Tsukamoto 5 , Yuka Kadomatsu 5 6 , Isao Oze 7 , Yuriko N Koyanagi 8 , Nagato Kuriyama 9 , Teruhide Koyama 9 , Rie Ibusuki 10 , Toshiro Takezaki 10 , Hiroaki Ikezaki 11 , Norihiro Furusyo 11 , Naoyuki Takashima 12 , Aya Kadota 12 , Hirokazu Uemura 6 , Sakurako Katsuura-Kamano 6 , Sadao Suzuki 13 , Hiroko Nakagawa-Senda 13 , Kiyonori Kuriki 14 , Haruo Mikami 15 , Yohko Nakamura 15 , Yukihide Momozawa 16 , Michiaki Kubo 16 , Masahiro Nakatochi 17 , Mariko Naito 5 18 , Kenji Wakai 5 , Japan Multi-Institutional Collaborative Cohort Study Group題名：The interaction between ABCA1 polymorphism and physical activity on the HDL-cholesterol levels in a Japanese population発表情報：J Lipid Res 巻: 61 号: 1 ページ: 86-94キーワード：概要：Few studies have investigated the interactions between HDL-C-related SNPs identified by genome-wide association (GWA) study and physical activity (PA) on HDL-C. First, we conducted a sex-stratified GWA study in a discovery sample (2,231 men and 2,431 women) and replication sample (2,599 men and 3,109 women) to identify SNPs influencing log-transformed HDL-C in Japanese participants in the baseline survey of the Japan Multi-Institutional Collaborative Cohort Study. We also replicated previously reported HDL-C-related SNPs in a combined (discovery plus replication) sample (4,830 men and 5,540 women). We then analyzed the interactions of the HDL-C-related SNPs with PA on HDL-C. The sex-stratified GWA analyses identified 11 and 10 HDL-C-related SNPs in men and women as targets for an interaction analysis. Among these, only one interaction of ABCA1 rs1883025 with PA was statistically significant in men, after Bonferroni correction [P-interaction = 0.001 (α = 0.05/21 = 0.002)]. The per-major-allele (C allele) increase in log-transformed HDL-C was lost in men with low PA (β = 0.008) compared with those with medium (β = 0.032) or high PA (β = 0.034). These findings suggest that the benefit of carrying a C allele of ABCA1 rs1883025 on enhancing HDL-C may be attenuated in inactive men.抄録：英語フィールド
Author：Yuichiro Nishida 1 , Tsuyoshi Hachiya 2 , Megumi Hara 3 , Chisato Shimanoe 4 , Keitaro Tanaka 3 , Yoichi Sutoh 2 , Atsushi Shimizu 2 , Asahi Hishida 5 , Mineko Tsukamoto 5 , Yuka Kadomatsu 5 6 , Isao Oze 7 , Yuriko N Koyanagi 8 , Nagato Kuriyama 9 , Teruhide Koyama 9 , Rie Ibusuki 10 , Toshiro Takezaki 10 , Hiroaki Ikezaki 11 , Norihiro Furusyo 11 , Naoyuki Takashima 12 , Aya Kadota 12 , Hirokazu Uemura 6 , Sakurako Katsuura-Kamano 6 , Sadao Suzuki 13 , Hiroko Nakagawa-Senda 13 , Kiyonori Kuriki 14 , Haruo Mikami 15 , Yohko Nakamura 15 , Yukihide Momozawa 16 , Michiaki Kubo 16 , Masahiro Nakatochi 17 , Mariko Naito 5 18 , Kenji Wakai 5 , Japan Multi-Institutional Collaborative Cohort Study GroupTitle：The interaction between ABCA1 polymorphism and physical activity on the HDL-cholesterol levels in a Japanese populationAnnouncement information:J Lipid Res Vol: 61 Issue: 1 Page: 86-94An abstract：Few studies have investigated the interactions between HDL-C-related SNPs identified by genome-wide association (GWA) study and physical activity (PA) on HDL-C. First, we conducted a sex-stratified GWA study in a discovery sample (2,231 men and 2,431 women) and replication sample (2,599 men and 3,109 women) to identify SNPs influencing log-transformed HDL-C in Japanese participants in the baseline survey of the Japan Multi-Institutional Collaborative Cohort Study. We also replicated previously reported HDL-C-related SNPs in a combined (discovery plus replication) sample (4,830 men and 5,540 women). We then analyzed the interactions of the HDL-C-related SNPs with PA on HDL-C. The sex-stratified GWA analyses identified 11 and 10 HDL-C-related SNPs in men and women as targets for an interaction analysis. Among these, only one interaction of ABCA1 rs1883025 with PA was statistically significant in men, after Bonferroni correction [P-interaction = 0.001 (α = 0.05/21 = 0.002)]. The per-major-allele (C allele) increase in log-transformed HDL-C was lost in men with low PA (β = 0.008) compared with those with medium (β = 0.032) or high PA (β = 0.034). These findings suggest that the benefit of carrying a C allele of ABCA1 rs1883025 on enhancing HDL-C may be attenuated in inactive men.