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Decreased cytokeratin 7 expression correlates with the progression of cervical squamous cell carcinoma and poor patient outcomes.

発表形態:
原著論文
主要業績:
主要業績
単著・共著:
共著
発表年月:
2019年11月
DOI:
10.1111/jog.14108
会議属性:
指定なし
査読:
有り
リンク情報:

日本語フィールド

著者:
Hashiguchi M, Masuda M, Kai K, Nakao Y, Kawaguchi A, Yokoyama M, Aishima S.
題名:
Decreased cytokeratin 7 expression correlates with the progression of cervical squamous cell carcinoma and poor patient outcomes.
発表情報:
J Obstet Gynaecol Res. 巻: 45 号: 11 ページ: 2228-2236
キーワード:
概要:
Aim: To identify potential biomarkers for tumor progression and patient outcomes in cervical squamous cell carcinoma. Methods: We examined the expressions of CK7 and CK17 as potential markers of the squamo-columnar junction, and podoplanin as a basal cell marker using surgical and biopsy samples of patients in grade 3 cervical intraepithelial neoplasia (n = 30), operable invasive carcinoma (OP group, n = 53) and inoperable invasive carcinoma before radiotherapy and/or chemotherapy (RC group, n = 76). Results: The positive rates of CK7 and podoplanin in invasive carcinoma were significantly lower than those in grade 3 cervical intraepithelial neoplasia (P = 0.001, P < 0.0001). The positive rates of CK7 and podoplanin in the RC group were significantly lower than those in the OP group (P < 0.0001, P = 0.04), while CK17 expression showed significantly higher positivity in the RC group than in the OP group (P < 0.0001). Negative CK7 expression showed a potential impact on overall survival in early-stage patients. In the RC group, the prevalence of cases with post-therapeutic residual carcinoma cells was higher in the CK7-negative group than in the positive group (P = 0.003). We found that decreased expression of CK7 could be a prognostic factor in early-stage cervical cancer patients. Conclusion: This result may provide strategies and suggestions for new treatment options and follow-up practices in managing patients with cervical cancer.
抄録:

英語フィールド

Author:
Hashiguchi M, Masuda M, Kai K, Nakao Y, Kawaguchi A, Yokoyama M, Aishima S.
Title:
Decreased cytokeratin 7 expression correlates with the progression of cervical squamous cell carcinoma and poor patient outcomes.
Announcement information:
J Obstet Gynaecol Res. Vol: 45 Issue: 11 Page: 2228-2236
An abstract:
Aim: To identify potential biomarkers for tumor progression and patient outcomes in cervical squamous cell carcinoma. Methods: We examined the expressions of CK7 and CK17 as potential markers of the squamo-columnar junction, and podoplanin as a basal cell marker using surgical and biopsy samples of patients in grade 3 cervical intraepithelial neoplasia (n = 30), operable invasive carcinoma (OP group, n = 53) and inoperable invasive carcinoma before radiotherapy and/or chemotherapy (RC group, n = 76). Results: The positive rates of CK7 and podoplanin in invasive carcinoma were significantly lower than those in grade 3 cervical intraepithelial neoplasia (P = 0.001, P < 0.0001). The positive rates of CK7 and podoplanin in the RC group were significantly lower than those in the OP group (P < 0.0001, P = 0.04), while CK17 expression showed significantly higher positivity in the RC group than in the OP group (P < 0.0001). Negative CK7 expression showed a potential impact on overall survival in early-stage patients. In the RC group, the prevalence of cases with post-therapeutic residual carcinoma cells was higher in the CK7-negative group than in the positive group (P = 0.003). We found that decreased expression of CK7 could be a prognostic factor in early-stage cervical cancer patients. Conclusion: This result may provide strategies and suggestions for new treatment options and follow-up practices in managing patients with cervical cancer.


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