日本語フィールド
著者：*Yuta Suzuki, Hidehiro Kaneko, Yuichiro Yano, Akira Okada, Hidetaka Itoh, Kensuke Ueno, Satoshi Matsuoka, Katsuhito Fujiu, Nobuaki Michihata, Taisuke Jo, Norifumi Takeda, Hiroyuki Morita, Isao Yokota, Koichi Node, Hideo Yasunaga, Issei Komuro題名：Dose-dependent relationship of blood pressure and glycemic status with risk of aortic dissection and aneurysm 発表情報：Eur J Prev Cardiol 巻: 29 号: 18 ページ: 2338-2346キーワード：Aortic aneurysm; Aortic dissection; Diabetes; Hypertension概要：Aim: Data on the dose-dependent association of blood pressure (BP) and fasting plasma glucose (FPG) level with the risk of aortic dissection (AD) and aortic aneurysm (AA) are limited.
Methods: This observational cohort study included 3,358,293 individuals registered in a health check-up and claims database in Japan (median age, 43 [36-51] years; 57.2% men). Individuals using BP- or glucose-lowering medications or those with a history of cardiovascular disease were excluded.
Results: In a mean follow-up period of 1,199 ± 950 days, 1,095 and 2,177 cases of AD and AA, respectively, were recorded. Compared with normal/elevated BP, HRs of stage 1 and stage 2 hypertension were 1.89 (95% CI:1.60-2.22) and 5.87 (95% CI:5.03-6.84) for AD and 1.37 (95% CI:1.23-1.52) and 2.17 (95% CI:1.95-2.42) for AA, respectively. Compared with normal FPG, HRs of prediabetes and diabetes were 0.82 (95% CI:0.71-0.94) and 0.48 (95% CI:0.33-0.71) for AD and 0.94 (95% CI:0.85-1.03) and 0.61 (95% CI:0.47-0.79) for AA, respectively. The cubic spline demonstrated that the risk of AD and AA increased with increasing BP but decreased with increasing FPG level. Contour plots using generalized additive models showed that higher SBP and lower FPG level were associated with an elevated risk of AD and AA.
Conclusions: Our analysis showed a dose-dependent increase in the risk of AD or AA with BP and a similar decrease associated with FPG, and also suggested a potential interaction between hypertension and hyperglycemia in the development of AD and AA.抄録：英語フィールド
Author：*Yuta Suzuki, Hidehiro Kaneko, Yuichiro Yano, Akira Okada, Hidetaka Itoh, Kensuke Ueno, Satoshi Matsuoka, Katsuhito Fujiu, Nobuaki Michihata, Taisuke Jo, Norifumi Takeda, Hiroyuki Morita, Isao Yokota, Koichi Node, Hideo Yasunaga, Issei KomuroTitle：Dose-dependent relationship of blood pressure and glycemic status with risk of aortic dissection and aneurysm Announcement information:Eur J Prev Cardiol Vol: 29 Issue: 18 Page: 2338-2346Keyword：Aortic aneurysm; Aortic dissection; Diabetes; HypertensionAn abstract：Aim: Data on the dose-dependent association of blood pressure (BP) and fasting plasma glucose (FPG) level with the risk of aortic dissection (AD) and aortic aneurysm (AA) are limited.
Methods: This observational cohort study included 3,358,293 individuals registered in a health check-up and claims database in Japan (median age, 43 [36-51] years; 57.2% men). Individuals using BP- or glucose-lowering medications or those with a history of cardiovascular disease were excluded.
Results: In a mean follow-up period of 1,199 ± 950 days, 1,095 and 2,177 cases of AD and AA, respectively, were recorded. Compared with normal/elevated BP, HRs of stage 1 and stage 2 hypertension were 1.89 (95% CI:1.60-2.22) and 5.87 (95% CI:5.03-6.84) for AD and 1.37 (95% CI:1.23-1.52) and 2.17 (95% CI:1.95-2.42) for AA, respectively. Compared with normal FPG, HRs of prediabetes and diabetes were 0.82 (95% CI:0.71-0.94) and 0.48 (95% CI:0.33-0.71) for AD and 0.94 (95% CI:0.85-1.03) and 0.61 (95% CI:0.47-0.79) for AA, respectively. The cubic spline demonstrated that the risk of AD and AA increased with increasing BP but decreased with increasing FPG level. Contour plots using generalized additive models showed that higher SBP and lower FPG level were associated with an elevated risk of AD and AA.
Conclusions: Our analysis showed a dose-dependent increase in the risk of AD or AA with BP and a similar decrease associated with FPG, and also suggested a potential interaction between hypertension and hyperglycemia in the development of AD and AA.